缺血修饰白蛋白在慢性阻塞性肺疾病中的意义
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摘要
目的:缺血修饰白蛋白(ischemia-modified albumin,IMA)是新近发现的氧化应激相关的炎症标志物,本研究探讨其在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)中的血清水平。方法:回顾性分析114例健康对照组与156例COPD患者,其中包括45例稳定期、111例急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)(53例不伴呼吸衰竭、58例伴有呼吸衰竭)中IMA、中性粒细胞淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、C反应蛋白(C-reactive protein,CRP)、脉氧饱和度(pulse oxygen saturation,SpO2)的水平。结果:(1)稳定期、急性加重期患者均较对照组血清IMA水平升高(P <0.05),且急性加重期患者较稳定期患者IMA水平明显升高(P <0.05);(2)伴呼吸衰竭的AECOPD患者血清IMA水平显著高于不伴呼吸衰竭患者(P <0.05);(3)COPD患者血清IMA与NLR及CRP水平均呈正相关(r=0.228,0.385,P均<0.05)。结论:IMA在COPD患者血清中水平明显升高,急性加重期时更加显著;血清IMA水平可能是反映COPD患者全身炎症效应的血清学指标之一。
Objective:Serum ischemia-modified albumin(IMA)is a newly inflammatory marker associated with oxidative stress,and the levels of serum IMA in chronic obstructive pulmonary disease(COPD)patients were researched in this study. Methods:A total of156 patients were retrospectively enrolled in this study,including 45 patients with stable COPD and 111 patients with acute exacerbation of COPD(AECOPD),in which 53 patients without respiratory failure and 58 patients with respiratory failure. A total of114 healthy participants were recruited to the control group. The levels of IMA,neutrophil to lymphocyte ratio(NLR),C-reactive protein(CRP)and pulse oxygen saturation(SpO2)were detected. Results:Compared with the control group,the levels of IMA in stable COPD group and AECOPD group were higher,especially in AECOPD patients(P < 0.05,respectively). The levels of IMA in AECOPD patients with respiratory failure were significantly higher than that in AECOPD patients without respiratory failure(P < 0.05). The levels of IMA show positive correlation with NLR and CRP in COPD patients(r=0.228,0.385,all P < 0.05). Conclusion:Our study indicated that the levels of IMA in COPD patients were significantly higher than those in healthy participants,especially in patients with AECOPD. IMA may be a potential biomarker for evaluating the inflammatory response in COPD patients.
Objective:Serum ischemia-modified albumin(IMA)is a newly inflammatory marker associated with oxidative stress,and the levels of serum IMA in chronic obstructive pulmonary disease(COPD)patients were researched in this study. Methods:A total of156 patients were retrospectively enrolled in this study,including 45 patients with stable COPD and 111 patients with acute exacerbation of COPD(AECOPD),in which 53 patients without respiratory failure and 58 patients with respiratory failure. A total of114 healthy participants were recruited to the control group. The levels of IMA,neutrophil to lymphocyte ratio(NLR),C-reactive protein(CRP)and pulse oxygen saturation(SpO2)were detected. Results:Compared with the control group,the levels of IMA in stable COPD group and AECOPD group were higher,especially in AECOPD patients(P < 0.05,respectively). The levels of IMA in AECOPD patients with respiratory failure were significantly higher than that in AECOPD patients without respiratory failure(P < 0.05). The levels of IMA show positive correlation with NLR and CRP in COPD patients(r=0.228,0.385,all P < 0.05). Conclusion:Our study indicated that the levels of IMA in COPD patients were significantly higher than those in healthy participants,especially in patients with AECOPD. IMA may be a potential biomarker for evaluating the inflammatory response in COPD patients.
引文
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[7] Vyakaranam S,Bhongir AV,Patlolla D,et al. Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy:a pilot study[J]. Int J Reprod Contracept Obstet Gynecol,2015,4(3):611-616
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[10]陈佳娣,张雅文,陈良玉,等.运动指脉氧监测在稳定期慢性阻塞性肺疾病中管理价值探讨[J].南京医科大学学报(自然科学版),2017,37(10):1288-1292
[11]沈浩明,张卫华,吴白平.性别、年龄、白蛋白对缺血修饰性白蛋白测定结果的影响[J].临床与病理杂志,2015,38(8):1481-1486
[12]Paliogiannis P,Fois AG,Sotgia S,et al. Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease:a systematic review and meta-analysis[J]. Biomark Med,2018,12(7):771-781
[13]Vaitkus M,Lavinskiene S,Barkauskiene D,et al. Reactive oxygen species in peripheral blood and sputum neutrophils during bacterial and nonbacterial acute exacerbation of chronic obstructive pulmonary disease[J]. Inflammation,2013,36(6):1485-1493
[14]Corsonello A,Pedone C,Battaglia S,et al. C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)as inflammation markers in elderly patients with stable chronic obstructive pulmonary disease(COPD)[J]. Arch Gerontol Geriatr,2011,53(2):190-195
[15] Paliogiannis P,Fois AG,Sotgia S,et al. The neutrophil-tolymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations:a systematic review and meta-analysis[J]. Eur J Clin Invest,2018,48(8):e12984
[2] Grady ST,Koutrakis P,Hart JE,et al. Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease[J]. Environ Int,2018,115:188-195
[3]王晓月,葛爱,孙培莉,等.高良姜素对臭氧所致COPD气道炎症的影响[J].南京医科大学学报(自然科学版),2016,36(6):700-704
[4] Gurumurthy P,Borra SK,Yeruva RK,et al. Estimation of ischemia modified albumin(IMA)levels in patients with acute coronary syndrome[J]. Indian J Clin Biochem,2014.29(3):367-371
[5] Kahveci H,Tayman C,Laogˇlu F,et al. Serum ischemiamodified albumin in preterm babies with respiratory distress syndrome[J]. Indian J Clin Biochem,2016,31(1):38-42
[6] Yerlikaya FH,Kurban S,Mehmetoglu I,et al. Serum ischemia-modified albumin levels at diagnosis and during treatment of late-onset neonatal sepsis[J]. J Matern Fetal Neonatal Med,2014,27(17):1723-1727
[7] Vyakaranam S,Bhongir AV,Patlolla D,et al. Maternal serum ischemia modified albumin as a marker for hypertensive disorders of pregnancy:a pilot study[J]. Int J Reprod Contracept Obstet Gynecol,2015,4(3):611-616
[8] Collinson PO,Gaze DC. Ischaemia-modified albumin:clinical utility and pitfalls in measurement[J]. J Clin Pathol,2008,61(9):1025-1028
[9] Can U,Yerlikaya FH,Yosunkaya S. Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease[J]. J Chin Med Assoc,2015. 78(12):702-708
[10]陈佳娣,张雅文,陈良玉,等.运动指脉氧监测在稳定期慢性阻塞性肺疾病中管理价值探讨[J].南京医科大学学报(自然科学版),2017,37(10):1288-1292
[11]沈浩明,张卫华,吴白平.性别、年龄、白蛋白对缺血修饰性白蛋白测定结果的影响[J].临床与病理杂志,2015,38(8):1481-1486
[12]Paliogiannis P,Fois AG,Sotgia S,et al. Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease:a systematic review and meta-analysis[J]. Biomark Med,2018,12(7):771-781
[13]Vaitkus M,Lavinskiene S,Barkauskiene D,et al. Reactive oxygen species in peripheral blood and sputum neutrophils during bacterial and nonbacterial acute exacerbation of chronic obstructive pulmonary disease[J]. Inflammation,2013,36(6):1485-1493
[14]Corsonello A,Pedone C,Battaglia S,et al. C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)as inflammation markers in elderly patients with stable chronic obstructive pulmonary disease(COPD)[J]. Arch Gerontol Geriatr,2011,53(2):190-195
[15] Paliogiannis P,Fois AG,Sotgia S,et al. The neutrophil-tolymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations:a systematic review and meta-analysis[J]. Eur J Clin Invest,2018,48(8):e12984
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