电子束降解水溶液中磺胺甲噁唑
|
摘要
磺胺甲噁唑(sulfamethoxazole, SMX)是一种被广泛使用的抗菌类药物.由于传统的污水处理技术很难有效地降解这类废水,故对电子束这一新型高级氧化技术对磺胺甲噁唑的处理效果以及不同影响因素对降解的影响进行了实验研究.结果表明,电子束对于磺胺甲噁唑的降解效果较好,在辐照剂量为5 kGy时,几种质量百分比的目标物几乎被完全降解.通过计算可知,目标物的降解遵循假一级动力学方程;碱性条件和加入适量的双氧水有利于降解;羟基自由基和水合电子在电子束的降解中起到重要的作用.用离子色谱仪和液相色谱质谱联用仪(liquid chromatography-tandem mass spectrometry, LC-MS-MS)检测磺胺甲噁唑降解后的中间产物,并通过中间产物提出可能的降解途径.
Sulfamethoxazole(SMX) is a widely used antibacterial drug. It is hard to degrade effectively in aqueous solutions in a traditional wastewater treatment process. This study focuses on SMX degradation using an advanced oxidation technique, electron beam radiation, to investigate effects of different factors on degradation. The results show that the degradation rate of electron beam for SMX is high. SMX is almost completely degraded at 5 kGy. Degradation of SMX obeys a pseudo first-order kinetic equation. Alkaline condition and proper amount of H_2O_2 are beneficial to the degradation. Hydroxyl radical and electron play an important role in the degradation of electron beam. Intermediates can be detected with ion chromatography(IC) and liquid chromatography-tandem mass spectrometry(LC-MS-MS). Several degradation pathways are proposed.
Sulfamethoxazole(SMX) is a widely used antibacterial drug. It is hard to degrade effectively in aqueous solutions in a traditional wastewater treatment process. This study focuses on SMX degradation using an advanced oxidation technique, electron beam radiation, to investigate effects of different factors on degradation. The results show that the degradation rate of electron beam for SMX is high. SMX is almost completely degraded at 5 kGy. Degradation of SMX obeys a pseudo first-order kinetic equation. Alkaline condition and proper amount of H_2O_2 are beneficial to the degradation. Hydroxyl radical and electron play an important role in the degradation of electron beam. Intermediates can be detected with ion chromatography(IC) and liquid chromatography-tandem mass spectrometry(LC-MS-MS). Several degradation pathways are proposed.
引文
[1]张伦.磺胺类药物产销现状及趋势[J].中国药房, 2005, 16(8):571-574.
[2] Chau N D G, Zita S, Fabrice R, et al. Occurrence and dissipation of the antibiotics sul-famethoxazole, sulfadiazine, trimethoprim, and enrofloxacin in the mekong delta, vietnam[J].PloS One, 2015, 10(7):1-24.
[3] Fatima T, Barbara L B, Tuc D, et al. A 50-year record of quinolone and sulphonamideantimicrobial agents in Seine River sediments[J]. Journal of Soils Sediments, 2011, 11(5):852-859.
[4] Yun Y Y, Gurpal S T, Clinton F W. Pharmaceuticals and organochlorine pesticides in sedi-ments of an urban river in Florida, USA[J]. Journal of Soils Sediments, 2015, 15(4):993-1004.
[5] Han B S, Ko J, Kim J Y, et al. Combined electron-beam and biological treatment of dyeingcomplex wastewater. Pilot plant experiments[J]. Radiation Physics and Chemistry, 2002, 64(1):53-59.
[6] Marc P T, Veronica G M, Miguel A B, et al. Degradation of chlorphenols by means ofadvanced oxidation processes:a general review[J]. Applied Catalysis B:Environmental, 2004,47(4):219-256.
[7] Liu N, Wang T, Zheng M, et al. Radiation induced degradation of antiepileptic drug primidonein aqueous solution[J]. Chemical Engineering Journal, 2015, 270:66-72.
[8] Xu G, Yao J Z, Tang L, et al. Electron beam induced degradation of atrazine in aqueoussolution[J]. Chemical Engineering Journal, 2015, 275:374-380.
[9] Zheng G, Zheng Z, Zheng J B, et al. Degradation of the emerging contaminant ibuprofen inaqueous solution by gamma irradiation[J]. Desalination, 2011, 276(1/2/3):379-385.
[10] Basfar A A, Khan H M, al-Shahrani A A, et al. Trihalomethane treatment using gammairradiation:kinetic modeling of single solute and mixtures[J]. Radiation Physics and Chemistry,2005, 72(5):555-563.
[11] Buxton G V, Greenstock C L, Helman W P, et al. Critical review of rate constants forthe reactions of hydrated electrons, hydrogen atom and hydroxyl radicals(OH/O)in aqueoussolutions[J]. Journal of Physical and Chemical Reference Data, 1988, 17(2):513-886.
[12] Xu G, Bu T T, Wu M H, et al. Electron beam induced degradation of clopyralid in aqueoussolutions[J]. Journal of Radioanalytical and Nuclear Chemistry, 2011, 288(3):759-764.
[13] Amorim D, Kamila P, Lincoln L, et al. Andrade. Electrochemical degradation of sulfamethox-azole and trimethoprim at boron-doped diamond electrode:performance, kinetics and reactionpathway[J]. Separation and Purification Technology, 2013, 120:319-327.
[14] Kim K S, Kam S K, Mok Y S. Elucidation of the degradation pathways of sulfonamide antibioticsin a dielectric barrier discharge plasma system[J]. Chemical Engineering Journal, 2015, 271:31-42.
[15] Wu M H, Bao B R. The application of irradiation technology in environment[M]. Beijing:Chemical Industry Press, 2002:24-33.
[2] Chau N D G, Zita S, Fabrice R, et al. Occurrence and dissipation of the antibiotics sul-famethoxazole, sulfadiazine, trimethoprim, and enrofloxacin in the mekong delta, vietnam[J].PloS One, 2015, 10(7):1-24.
[3] Fatima T, Barbara L B, Tuc D, et al. A 50-year record of quinolone and sulphonamideantimicrobial agents in Seine River sediments[J]. Journal of Soils Sediments, 2011, 11(5):852-859.
[4] Yun Y Y, Gurpal S T, Clinton F W. Pharmaceuticals and organochlorine pesticides in sedi-ments of an urban river in Florida, USA[J]. Journal of Soils Sediments, 2015, 15(4):993-1004.
[5] Han B S, Ko J, Kim J Y, et al. Combined electron-beam and biological treatment of dyeingcomplex wastewater. Pilot plant experiments[J]. Radiation Physics and Chemistry, 2002, 64(1):53-59.
[6] Marc P T, Veronica G M, Miguel A B, et al. Degradation of chlorphenols by means ofadvanced oxidation processes:a general review[J]. Applied Catalysis B:Environmental, 2004,47(4):219-256.
[7] Liu N, Wang T, Zheng M, et al. Radiation induced degradation of antiepileptic drug primidonein aqueous solution[J]. Chemical Engineering Journal, 2015, 270:66-72.
[8] Xu G, Yao J Z, Tang L, et al. Electron beam induced degradation of atrazine in aqueoussolution[J]. Chemical Engineering Journal, 2015, 275:374-380.
[9] Zheng G, Zheng Z, Zheng J B, et al. Degradation of the emerging contaminant ibuprofen inaqueous solution by gamma irradiation[J]. Desalination, 2011, 276(1/2/3):379-385.
[10] Basfar A A, Khan H M, al-Shahrani A A, et al. Trihalomethane treatment using gammairradiation:kinetic modeling of single solute and mixtures[J]. Radiation Physics and Chemistry,2005, 72(5):555-563.
[11] Buxton G V, Greenstock C L, Helman W P, et al. Critical review of rate constants forthe reactions of hydrated electrons, hydrogen atom and hydroxyl radicals(OH/O)in aqueoussolutions[J]. Journal of Physical and Chemical Reference Data, 1988, 17(2):513-886.
[12] Xu G, Bu T T, Wu M H, et al. Electron beam induced degradation of clopyralid in aqueoussolutions[J]. Journal of Radioanalytical and Nuclear Chemistry, 2011, 288(3):759-764.
[13] Amorim D, Kamila P, Lincoln L, et al. Andrade. Electrochemical degradation of sulfamethox-azole and trimethoprim at boron-doped diamond electrode:performance, kinetics and reactionpathway[J]. Separation and Purification Technology, 2013, 120:319-327.
[14] Kim K S, Kam S K, Mok Y S. Elucidation of the degradation pathways of sulfonamide antibioticsin a dielectric barrier discharge plasma system[J]. Chemical Engineering Journal, 2015, 271:31-42.
[15] Wu M H, Bao B R. The application of irradiation technology in environment[M]. Beijing:Chemical Industry Press, 2002:24-33.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |