血清hsCRP、MCP-1、CTRP9、APN、Lp-PLA2、Fractalkine和RANTES因子水平与无症状冠状动脉粥样硬化的关系
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摘要
目的:探讨血清超敏C反应蛋白(hsCRP)、单核细胞趋化蛋白-1 (MCP-1)、C1q/肿瘤坏死因子相关蛋白9(CTRP9)、脂联素(APN)、脂蛋白磷脂酶A2 (Lp-PLA2)、Fractalkine (即趋化因子CX3C)、调节T细胞正常表达和分泌的细胞因子(RANTES)水平与无症状冠状动脉粥样硬化(ACAS)之间的关系。方法:选择我院2015年12月～2016年12月收治的50例ACAS患者作为ACAS组,另选同期50例正常体检者作为正常对照组。检测比较两组血清hsCRP、MCP-1、RANTES、CTRP9、APN、Lp-PLA2、Fractalkine水平。结果:与正常对照组比较,ACAS组血清CTRP9 [(3.70±1.20)×10-2 mg/L比(3.19±1.11)×10-2 mg/L]和APN [(3.85±1.15)mg/L比(3.28±1.01)mg/L]水平显著降低,hsCRP [(32.55±1.55)mg/L比(110.47±1.53)mg/L]、MCP-1 [(480.22±5.38)pg/ml比(600.47±5.43)pg/ml]、RANTES [(2.80±0.20)μg/ml比(4.19±0.22)μg/ml]、Lp-PLA2[(165.88±5.32)mg/L比(199.55±5.35)mg/L]和Fractalkine [(322.40±5.60)pg/ml比(500.64±5.66)pg/ml]水平显著升高,P<0.05或<0.01。结论:与正常对照组比较,无症状冠状动脉粥样硬化患者血清CTRP9和APN水平显著降低,血清hsCRP、MCP-1、RANTES、Lp-PLA2、Fractalkine水平显著升高。检测上述指标可为早期诊断及干预提供有力的科学依据。
Objective:To explore relationship among serum levels of high sensitive C reactive protein(hsCRP),monocyte chemoattractant protein(MCP)-1,C1 q/tumor necrosis factor-related protein(CTRP)9,adiponectin(APN),lipoprotein-associated phospholipase(Lp-PLA)2,Fractalkine(namely,chemotatic factorCX3 C),regulated on activation,normal T-cell expressed and secreted(RANTES)and asymptomatic coronary atherosclerosis(ACAS).Methods:A total of 50 ACAS patients,who were treated in our hospital from Dec 2015 to Dec 2016,were regarded as ACAS group.Another 50 healthy subjects were enrolled as normal control group.Serum levels of hsCRP,MCP-1,RANTES,CTRP9,APN,Lp-PLA2 and Fractalkine were measured and compared between two groups.Results:Compared with healthy control group,there were significant reductions in serum levels of CTRP9[(3.70±1.20)10-2 mg/L vs.(3.19±1.11)10-2 mg/L]and APN [(3.85±1.15)mg/L vs.(3.28±1.01)mg/L],and significant rise in serum levels of hsCRP[(32.55±1.55)mg/L vs.(110.47±1.53)mg/L],MCP-1 [(480.22±5.38)pg/ml vs.(600.47±5.43)pg/ml],RANTES[(2.80±0.20)μg/ml vs.(4.19±0.22)μg/ml],Lp-PLA2[(165.88±5.32)mg/L vs.(199.55±5.35)mg/L]and Fractalkine[(322.40±5.60)pg/ml vs.(500.64±5.66)pg/ml]in ACAS group,P<0.05 or<0.01.Conclusion:Compared with normal control group,there are significant reductions in serum levels of CTRP9 and APN,and significant rise in serum levels of hsCRP,MCP-1,RANTES,Lp-PLA2 and Fractalkine in ACAS patients.Detection of above indexes can provide strong evidence for early diagnosis and intervention.
Objective:To explore relationship among serum levels of high sensitive C reactive protein(hsCRP),monocyte chemoattractant protein(MCP)-1,C1 q/tumor necrosis factor-related protein(CTRP)9,adiponectin(APN),lipoprotein-associated phospholipase(Lp-PLA)2,Fractalkine(namely,chemotatic factorCX3 C),regulated on activation,normal T-cell expressed and secreted(RANTES)and asymptomatic coronary atherosclerosis(ACAS).Methods:A total of 50 ACAS patients,who were treated in our hospital from Dec 2015 to Dec 2016,were regarded as ACAS group.Another 50 healthy subjects were enrolled as normal control group.Serum levels of hsCRP,MCP-1,RANTES,CTRP9,APN,Lp-PLA2 and Fractalkine were measured and compared between two groups.Results:Compared with healthy control group,there were significant reductions in serum levels of CTRP9[(3.70±1.20)10-2 mg/L vs.(3.19±1.11)10-2 mg/L]and APN [(3.85±1.15)mg/L vs.(3.28±1.01)mg/L],and significant rise in serum levels of hsCRP[(32.55±1.55)mg/L vs.(110.47±1.53)mg/L],MCP-1 [(480.22±5.38)pg/ml vs.(600.47±5.43)pg/ml],RANTES[(2.80±0.20)μg/ml vs.(4.19±0.22)μg/ml],Lp-PLA2[(165.88±5.32)mg/L vs.(199.55±5.35)mg/L]and Fractalkine[(322.40±5.60)pg/ml vs.(500.64±5.66)pg/ml]in ACAS group,P<0.05 or<0.01.Conclusion:Compared with normal control group,there are significant reductions in serum levels of CTRP9 and APN,and significant rise in serum levels of hsCRP,MCP-1,RANTES,Lp-PLA2 and Fractalkine in ACAS patients.Detection of above indexes can provide strong evidence for early diagnosis and intervention.
引文
[1]张春阳,黄山,刘志琴.多种动脉粥样硬化细胞因子与冠状动脉狭窄的相关性方程的建立及临床意义[J].中国实验诊断学,2016,16(2):212-216.
[2]杨宏生,许锡荣,沈琪,等.血浆Lp-PLA2水平与动脉粥样硬化脑梗死患者危险因素的相关性[J].中国实用神经疾病杂志,2016,19(18):10-12.
[3]吴倩,胡为民.Lp-PLA2与动脉粥样硬化性脑梗死及颈动脉粥样硬化斑块的关系探讨[J].中西医结合心脑血管病杂志,2013,11(10):1216-1217.
[4]赵立,王士强,鲁晓,等.血清脂蛋白(a)及超敏C反应蛋白浓度在冠状动脉粥样硬化心脏病中的意义[J].安徽医药,2013,17(3):428-429.
[5]赵俊,张黎军.超敏C反应蛋白、尿酸、脑钠肽与冠心病的相关性[J].心血管康复医学杂志,2017,26(2):142-145.
[6]黄萍,杨铮,杨阳,等.冠状动脉粥样硬化性心脏病Lp(a)及脂类水平检测研究[J].中国实验诊断学,2016,20(6):985-986.
[7]刘丽军,马燕霞,邵丽莉,等.冠状动脉介入治疗对冠心病血浆单核细胞趋化因子-1和白细胞介素-6水平的影响(英文)[J].心血管康复医学杂志,2013,22(2):146-149.
[8]Gurudevan S,Garg P,Malik S,et al.Impaired fasting glucose is associated with increased severity of subclinical coronary artery disease compared to patients with diabetes and normal fasting glucose:evaluation by coronary computed tomographic angiography[J].BMJ Open,2016,6(8):e005148.
[9]梁政,李波,王怀龙,等.冠状动脉粥样硬化性心脏病与炎性细胞因子水平变化的相关性[J].新乡医学院学报,2015,32(4):344-346,349.
[10]李明春,陆林,陈秋静,等.血清CTRP9水平与冠心病的关系[J].国际心血管病杂志,2013,40(5):323-325.
[11]陈楚,花颖,陆齐.冠状动脉粥样硬化性心脏病合并2型糖尿病患者血清Lp-PLA2水平与颈动脉内膜中层厚度的关系[J].南通大学学报(医学版),2015,35(6):522-525.
[12]孙健豪,王小雨,侯爽,等.Fractalkine与动脉粥样硬化[J].世界最新医学信息文摘,2016,16(31):27,30.
[2]杨宏生,许锡荣,沈琪,等.血浆Lp-PLA2水平与动脉粥样硬化脑梗死患者危险因素的相关性[J].中国实用神经疾病杂志,2016,19(18):10-12.
[3]吴倩,胡为民.Lp-PLA2与动脉粥样硬化性脑梗死及颈动脉粥样硬化斑块的关系探讨[J].中西医结合心脑血管病杂志,2013,11(10):1216-1217.
[4]赵立,王士强,鲁晓,等.血清脂蛋白(a)及超敏C反应蛋白浓度在冠状动脉粥样硬化心脏病中的意义[J].安徽医药,2013,17(3):428-429.
[5]赵俊,张黎军.超敏C反应蛋白、尿酸、脑钠肽与冠心病的相关性[J].心血管康复医学杂志,2017,26(2):142-145.
[6]黄萍,杨铮,杨阳,等.冠状动脉粥样硬化性心脏病Lp(a)及脂类水平检测研究[J].中国实验诊断学,2016,20(6):985-986.
[7]刘丽军,马燕霞,邵丽莉,等.冠状动脉介入治疗对冠心病血浆单核细胞趋化因子-1和白细胞介素-6水平的影响(英文)[J].心血管康复医学杂志,2013,22(2):146-149.
[8]Gurudevan S,Garg P,Malik S,et al.Impaired fasting glucose is associated with increased severity of subclinical coronary artery disease compared to patients with diabetes and normal fasting glucose:evaluation by coronary computed tomographic angiography[J].BMJ Open,2016,6(8):e005148.
[9]梁政,李波,王怀龙,等.冠状动脉粥样硬化性心脏病与炎性细胞因子水平变化的相关性[J].新乡医学院学报,2015,32(4):344-346,349.
[10]李明春,陆林,陈秋静,等.血清CTRP9水平与冠心病的关系[J].国际心血管病杂志,2013,40(5):323-325.
[11]陈楚,花颖,陆齐.冠状动脉粥样硬化性心脏病合并2型糖尿病患者血清Lp-PLA2水平与颈动脉内膜中层厚度的关系[J].南通大学学报(医学版),2015,35(6):522-525.
[12]孙健豪,王小雨,侯爽,等.Fractalkine与动脉粥样硬化[J].世界最新医学信息文摘,2016,16(31):27,30.