肝素结合蛋白在早期诊断肺炎并发脓毒症中的价值分析
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摘要
目的探讨肝素结合蛋白(HBP)在早期诊断肺炎并发脓毒症中的价值。方法选取240例肺炎并发脓毒症患者及240例健康体检者,均进行HBP、白细胞(WBC)、 C反应蛋白(CRP)、降钙素原(PCT)的检测,比较肺炎并发脓毒症患者与健康体检者的各指标水平,分析不同脓毒症分级患者HBP水平的差异。结果肺炎并发脓毒症患者的HBP、 WBC、 CRP、PCT水平均显著高于健康体检者(P <0.05)。脓毒症休克患者的HBP水平显著高于一般脓毒症、严重脓毒症患者(P <0.05)。结论 HBP水平的提高可提示脓毒症的发生及严重程度,可为临床早期诊断提供依据。
Objective To explore the value of heparin-binding protein(HBP) in the early diagnosis of pneumonia complicated with sepsis. Methods 240 patients with pneumonia complicated with sepsis and 240 healthy subjects were selected, and all the subjects received detection of HBP, white blood cell(WBC), C-reactive protein(CRP) and procalcitonin(PCT). The levels of above indicators were compared between patients with pneumonia complicated with sepsis and healthy subjects, and the differences of HBP among patients with different degree sepsis were analyzed. Results The levels of HBP, WBC, CRP and PCT of patients with pneumonia complicated with sepsis were significantly higher than those of healthy subjects(P <0.05). The HBP level of patients with septic shock was significantly higher than that of patients with mild sepsis and patients with severe sepsis(P <0.05). Conclusions The increase of HBP can indicate the incidence and severity of sepsis, which can provide basis for clinical early diagnosis.
Objective To explore the value of heparin-binding protein(HBP) in the early diagnosis of pneumonia complicated with sepsis. Methods 240 patients with pneumonia complicated with sepsis and 240 healthy subjects were selected, and all the subjects received detection of HBP, white blood cell(WBC), C-reactive protein(CRP) and procalcitonin(PCT). The levels of above indicators were compared between patients with pneumonia complicated with sepsis and healthy subjects, and the differences of HBP among patients with different degree sepsis were analyzed. Results The levels of HBP, WBC, CRP and PCT of patients with pneumonia complicated with sepsis were significantly higher than those of healthy subjects(P <0.05). The HBP level of patients with septic shock was significantly higher than that of patients with mild sepsis and patients with severe sepsis(P <0.05). Conclusions The increase of HBP can indicate the incidence and severity of sepsis, which can provide basis for clinical early diagnosis.
引文
[1]吴述光,侯小丽,马胜喜.重症肺炎并发脓毒症患者血清高迁移率族蛋白B1检测的临床意义[J].新乡医学院学报, 2018, 35(2):143-145, 150.
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[4]张妮,王爱华,杨保旺,等.多重PCR检测在严重脓毒症感染患儿应用的临床意义[J].中华医院感染学杂志, 2016, 26(14):3319-3321.
[5]林振怀,孙武装,蒋晨成.社区获得性肺炎并发脓毒症患者外周血PCT、 CRP及LAC水平的变化[J].现代中西医结合杂志, 2016,25(10):1079-1081.
[6]何勤,樊省廉,李艳.监测血清降钙素原和血小板对肺炎合并脓毒症患儿的预测价值[J].中国临床医生杂志, 2015, 43(10):73-75.
[7]尹琮煦,林镇洲,王胜男,等.血清降钙素原水平对急性卒中患者细菌性肺炎的预测价值:回顾性病例系列研究[J].国际脑血管病杂志, 2015, 23(3):161-165.
[8]朱宏坤.血清肝素结合蛋白在脓毒症患者中的表达与临床意义[J].中国中西医结合急救杂志, 2015, 22(1):75-78.
[2]刘振国,王婷,王顺达,等.重症肺炎并发脓毒症患者血清降钙素原、血乳酸及内毒素水平的相关研究[J].现代检验医学杂志,2017, 32(2):95-97, 164.
[3]贾凯. PCT、 hs-CRP在并发脓毒症的肺炎新生儿中的检测价值[J].湖南师范大学学报(医学版), 2017, 14(4):68-70.
[4]张妮,王爱华,杨保旺,等.多重PCR检测在严重脓毒症感染患儿应用的临床意义[J].中华医院感染学杂志, 2016, 26(14):3319-3321.
[5]林振怀,孙武装,蒋晨成.社区获得性肺炎并发脓毒症患者外周血PCT、 CRP及LAC水平的变化[J].现代中西医结合杂志, 2016,25(10):1079-1081.
[6]何勤,樊省廉,李艳.监测血清降钙素原和血小板对肺炎合并脓毒症患儿的预测价值[J].中国临床医生杂志, 2015, 43(10):73-75.
[7]尹琮煦,林镇洲,王胜男,等.血清降钙素原水平对急性卒中患者细菌性肺炎的预测价值:回顾性病例系列研究[J].国际脑血管病杂志, 2015, 23(3):161-165.
[8]朱宏坤.血清肝素结合蛋白在脓毒症患者中的表达与临床意义[J].中国中西医结合急救杂志, 2015, 22(1):75-78.