中药滋补肝肾方联合308nm准分子激光治疗寻常型白癜风的临床观察
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摘要
目的观察中药滋补肝肾方联合308 nm准分子激光治疗寻常型白癜风肝肾不足证的临床疗效。方法共选取90例白癜风患者,按照随机数字表分为2组,试验组和对照组分别45例。两组均采用308准分子激光治疗,试验组加用中药滋补肝肾方口服治疗,两组疗程均为12周,对比2种治疗方案的临床疗效。结果试验组和对照组有效率分别为93.33%和68.89%,两组比较,差异有统计学意义(P<0.05)。结论中药滋补肝肾方联合308 nm准分子激光治疗白癜风临床疗效显著,值得临床推广。
Objective To observe the clinical efficacy of traditional Chinese medicine nourishing liver and kidney decoction combined with 308 nm excimer laser in the treatment of vitiligo liver and kidney deficiency syndrome. Methods A total of 90 patients with vitiligo were selected and divided into two groups according to random number table. The treatment group and the control group had 45 cases respectively. Both groups were treated with 308 excimer light, and the treatment group plus traditional Chinese medicine nourishing liver and kidney decoction orally, both groups were treated for 12 weeks, then the clinical efficacy of the two treatment options were comparative analyzed. Results The effective rates of the treatment group and the control group were 93.33% and 68.89% respectively, and there was significant difference between the two groups(P<0.05). Conclusion The clinical efficacy of traditional Chinese medicine nourishing liver and kidney decoction combined with 308 nm excimer laser in the treatment of vitiligo is significant, which is worthy of clinical promotion.
Objective To observe the clinical efficacy of traditional Chinese medicine nourishing liver and kidney decoction combined with 308 nm excimer laser in the treatment of vitiligo liver and kidney deficiency syndrome. Methods A total of 90 patients with vitiligo were selected and divided into two groups according to random number table. The treatment group and the control group had 45 cases respectively. Both groups were treated with 308 excimer light, and the treatment group plus traditional Chinese medicine nourishing liver and kidney decoction orally, both groups were treated for 12 weeks, then the clinical efficacy of the two treatment options were comparative analyzed. Results The effective rates of the treatment group and the control group were 93.33% and 68.89% respectively, and there was significant difference between the two groups(P<0.05). Conclusion The clinical efficacy of traditional Chinese medicine nourishing liver and kidney decoction combined with 308 nm excimer laser in the treatment of vitiligo is significant, which is worthy of clinical promotion.
引文
[1]毛常亮,王莒生,杨蓉娅,等.中药治疗白癜风作用机制的研究进展[J].实用皮肤病学杂志,2016,9(3):192-194.
[2]Rezaei N,Gavalas NG,Weetman AP,et al.Autoimmunity as an aetiological factor in vitiligo[J].J Eur Acad Dermatol Venereol,2007,2l(7):865-876.
[3]Guerra L,Dellambra E,Brescia S,et al.Vitiligo:pathogenetic hypotheses and targets for eurrenl therapies[J].Curr Drug Metab,2010,11(5):45l-467.
[4]孟丽亚,王逸飞,魏国,等.308 nm准分子激光对白癜风豚鼠模型Treg及Th17细胞的影响[J].中华物理医学与康复杂志,2015,37(1):11-15.
[5]梁津宁,王秀敏.Th17细胞相关因子在白癜风患者外周血中的表达[J].中国麻风皮肤病杂志,2011,27(2):93-95.
[6]中国中西医结合皮肤性病学会色素病学组.白癜风临床分型及疗效标准(2003年修订稿)[J].中国中西医结合皮肤性病学杂志,2004,3(1):65.
[7]Ezzedine K,Lim HW,Suzuki T,et al.Revised classification/nomenclature of vitiligo and related issues:the Vitiligo Global Issues Consensus Conference[J].Pigment Cell Melanoma Res,2012,25(3):E1-E13.
[8]Sehgal VN,Srivastava G.Vitiligo:compendium of clinicoepidemiological features[J].Indian J Dermatol Venereol Leprol,2007,73(3):149-156.
[9]Halder RM,Chappell JL.Vitiligo update[J].Semin Cutan Med Surg,2009,28(2):86-92.
[10]Lu T,Gao T,Wang A,et al.Vitiligo prevalence study in Shaanxi province,China[J].Int J Dermatol,2007,46(1):47-51.
[11]Alikhan A,Felsten LM,Daly M,et al.Vitiligo:a compre hensive overview Part I.Introduction,epidemiology,quality of life,diagnosis,differential diagnosis,associations,histopathology,etiology,and work-up[J].J Am Acad Dermatol,2011,65(3):473-491.
[12]王辉,王莒生,王萍,等.中药滋补肝肾方对鼠B16黑素瘤细胞酪氨酸酶m RNA表达的调节[J].中国皮肤性病学杂志,2003,17(4):230-231.
[13]朱海莲,李萍,王莒生,等.滋补肝肾方及其拆方对过氧化氢损伤小鼠B16黑素细胞的影响[J].中华中医药杂志,2010,27(4):964-968.
[14]Kostovic K,Nola I,Bucan Z,et al.Treatment of vitiligo:current methmods and new approaches[J].Acta Dermatovennerol Croat,2003,11(3):163-170.
[15]Al-Shobaili HA.Correlation of clinical efficacy and psychosocial impaction vitiligo patients by excimer laser treatment[J].Ann Sa Udi Med,2014,34(2):115-121.
[2]Rezaei N,Gavalas NG,Weetman AP,et al.Autoimmunity as an aetiological factor in vitiligo[J].J Eur Acad Dermatol Venereol,2007,2l(7):865-876.
[3]Guerra L,Dellambra E,Brescia S,et al.Vitiligo:pathogenetic hypotheses and targets for eurrenl therapies[J].Curr Drug Metab,2010,11(5):45l-467.
[4]孟丽亚,王逸飞,魏国,等.308 nm准分子激光对白癜风豚鼠模型Treg及Th17细胞的影响[J].中华物理医学与康复杂志,2015,37(1):11-15.
[5]梁津宁,王秀敏.Th17细胞相关因子在白癜风患者外周血中的表达[J].中国麻风皮肤病杂志,2011,27(2):93-95.
[6]中国中西医结合皮肤性病学会色素病学组.白癜风临床分型及疗效标准(2003年修订稿)[J].中国中西医结合皮肤性病学杂志,2004,3(1):65.
[7]Ezzedine K,Lim HW,Suzuki T,et al.Revised classification/nomenclature of vitiligo and related issues:the Vitiligo Global Issues Consensus Conference[J].Pigment Cell Melanoma Res,2012,25(3):E1-E13.
[8]Sehgal VN,Srivastava G.Vitiligo:compendium of clinicoepidemiological features[J].Indian J Dermatol Venereol Leprol,2007,73(3):149-156.
[9]Halder RM,Chappell JL.Vitiligo update[J].Semin Cutan Med Surg,2009,28(2):86-92.
[10]Lu T,Gao T,Wang A,et al.Vitiligo prevalence study in Shaanxi province,China[J].Int J Dermatol,2007,46(1):47-51.
[11]Alikhan A,Felsten LM,Daly M,et al.Vitiligo:a compre hensive overview Part I.Introduction,epidemiology,quality of life,diagnosis,differential diagnosis,associations,histopathology,etiology,and work-up[J].J Am Acad Dermatol,2011,65(3):473-491.
[12]王辉,王莒生,王萍,等.中药滋补肝肾方对鼠B16黑素瘤细胞酪氨酸酶m RNA表达的调节[J].中国皮肤性病学杂志,2003,17(4):230-231.
[13]朱海莲,李萍,王莒生,等.滋补肝肾方及其拆方对过氧化氢损伤小鼠B16黑素细胞的影响[J].中华中医药杂志,2010,27(4):964-968.
[14]Kostovic K,Nola I,Bucan Z,et al.Treatment of vitiligo:current methmods and new approaches[J].Acta Dermatovennerol Croat,2003,11(3):163-170.
[15]Al-Shobaili HA.Correlation of clinical efficacy and psychosocial impaction vitiligo patients by excimer laser treatment[J].Ann Sa Udi Med,2014,34(2):115-121.