富血小板纤维蛋白对软组织修复作用的研究进展
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摘要
口腔种植体周围良好的软组织愈合情况,有利于种植体周围骨结合及后期美学修复效果。血小板浓缩制品富含白细胞、血小板及各种生长因子,可以有效促进组织愈合。富血小板纤维蛋白作为第二代自体血液浓缩制品,具备成本低、便于制备等优点。本文就富血小板纤维蛋白在种植体周围对软组织修复作用的研究进展作一综述。
Good soft tissue healing around dental implants is beneficial to osseointegration and late aesthetic restoration. Platelet concentrates are rich in white blood cells,platelets and various growth factors,which can effectively promote tissue healing. Platelet rich fibrin,as the second generation autologous blood concentrating product,has the advantages of low cost and easy preparation. In this paper,the research progress of platelet rich fibrin in the healing of soft tissue around implants is reviewed.
Good soft tissue healing around dental implants is beneficial to osseointegration and late aesthetic restoration. Platelet concentrates are rich in white blood cells,platelets and various growth factors,which can effectively promote tissue healing. Platelet rich fibrin,as the second generation autologous blood concentrating product,has the advantages of low cost and easy preparation. In this paper,the research progress of platelet rich fibrin in the healing of soft tissue around implants is reviewed.
引文
[1] Puisys A,Linkevicius T. The influence of mucosal tissue thickening on crestal bone stability around bone-level implants. A prospective controlled clinical trial[J]. Clin Oral Implants Res,2015,26(2):123-129.
[2] Rosano G,Taschieri S,Del FM. Immediate postextraction implant placement using plasma rich in growth factors technology in maxillary premolar region:a new strategy for soft tissue management[J]. J Oral Implantol,2013,39(1):98-102.
[3] Pascale M R D,Sommese L,Casamassimi A,et al. Platelet derivatives in regenerative medicine:an update[J]. Transfus Med Rev,2015,29(1):52-61.
[4] Grambart ST. Sports medicine and platelet-rich plasma:nonsurgical therapy[J]. Clin Podiatr Med Surg,2015,32(1):99-107.
[5] Anitua E. Plasma rich in growth factors:preliminary results of use in the preparation of future sites for implants[J]. Int J Oral Maxillofac Implants,1999,14(4):529-535.
[6] Anitua E,Prado R,Troya M,et al.Implementation of a more physiological plasma rich in growth factor(PRGF)protocol:Anticoagulant removal and reduction in activator concentration[J].Platelets,2016,27(5):459-466.
[7] Anitua E,Sanchez M. The importance of understanding what is platelet-rich growth factor(PRGF)and what is not[J]. J Shoulder Elb Surg,2011,20(1):e23-24.
[8] Choukroun J,Adda F,Schoeffler C,et al. An opportunity in perioimplantology:The PRF[J]. Implantodontie,2001,42:55-62.
[9] Miron RJ,Zucchelli G,Pikos MA,et al. Use of platelet-rich fibrin in regenerative dentistry:a systematic review[J]. Clin Oral Investig,2017,21(6):1913-1927.
[10] Rodella LF,Favero G,Boninsegna R,et al. Growth factors,CD34 positive cells,and fibrin network analysis in concentrated growth factors fraction[J]. Microsc Res Tech,2011,74(8):772-777.
[11] Yu P,Zhai Z,Jin X,et al. Clinical application of platelet-eich fibrin in plastic and reconstructive surgery:a systematic review[J].Aesthetic Plast Surg,2018,42(2):511-519.
[12] Hu Y,Jiang Y,Wang M,et al.Concentratedgrowth factor enhanced fat graft survival:a comparative study[J]. Dermatol Surg,(2018-06-28)[2018-06-26]. http://insights. ovid. com/pubmed? pmid=29894435. Doi:10.1097/DSS.0000000000001337.
[13] Choukroun J. Advanced PRFand i-PRF:Platelet concentrate or blood concentrate?[J].Periodontal Med Clin Pract,2014,1:3.
[14] Mour2o CF,Valiense H,Melo ER,et al.Obtention of injectable platelets rich-fibrin(i-PRF)and its polymerization with bone graft:technical note[C]. Rev Col Bras Cir,2015,42(6):421-423.
[15] Tunal M,zdemir H,Kü9ükodac Z,et al. In vivo evaluation of titanium-prepared platelet-rich fibrin(T-PRF):a new platelet concentrate[J]. Br J Oral Maxillofac Surg,2013,51(5):438-443.
[16] Giannobile WV,Hernandez RA,Finkelman RD,et al. Comparative effects of plateletderived growth factor-BB and insulin-like growth factor-I,individually and in combination,on periodontal regeneration in Macaca fascicularis[J]. J Periodontal Res,1996,31(5):301-312.
[17] Lucarelli E,Beccheroni A,Donati D,et al. Platelet-derived growth factors enhance proliferation of human stromal stem cells[J]. Biomaterials,2003,24(18):3095-3100.
[18] Yu J,Ustach C,Kim HR. Platelet-derived growth factor signaling and human cancer[J].J Biochem Mol Biol,2003,36(1):49-59.
[19] Butt AJ,Firth SM,Baxter RC. The IGF axis and programmed cell death[J]. Immunol Cell Biol,1999,77(3):256-262.
[20] Zachary I. VEGF signalling:integration and multi-tasking in endothelial cell biology[J]. Biochem Soc Trans,2003,31(Pt 6):1171
[21] Kwan Tat S,Padrines M,Theoleyre S,et al. IL-6,RANKL,TNF-alpha/IL-1:interrelations in bone resorption pathophysiology[J]. Cytokine Growth Factor Rev,2004,15(1):49-60.
[22] Hayashi Y,Kobayashi M,Kuwata H,et al. Interferon-gamma and interleukin 4 inhibit interleukin 1beta-induced delayed prostaglandin E(2)generation through suppression of cyclooxygenase-2 expression in human fibroblasts[J]. Cytokine,2000,12(6):603-612.
[23] Louren9o ES,Mour2o CFAB,Leite PEC,et al.The in vitro release of cytokines and growth factors from fibrin membranes produced through horizontal centrifugation[J]. J Biomed Mater Res A,2018,106(5):1373-1380.
[24] Aggarwal BB. Signalling pathways of the TNF superfamily:a double-edged sword[J]. Nat Rev Immunol,2003,3(9):745-756.
[25] Dohan Ehrenfest DM,Diss A,Odin G,et al. In vitro effects of Choukroun's PRF(platelet-rich fibrin)on human gingival fibroblasts,dermal prekeratinocytes,preadipocytes,and maxillofacial osteoblasts in primary cultures[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2009,108(3):341-352.
[26] Lu J,Hao Y,Zhao W,et al. Molecular,Cellular and pharmaceutical aspects of autologous grafts for peri-implant hard and soft tissue defects[J].Curr Pharm Biotechnol,2017,18(1):85-94.
[27] Wang X,Zhang Y,Choukroun J,et al. Behavior of gingival fibroblasts on titanium implant surfaces in combination with either injectable-PRF or PRP[J]. Int J Mol Sci,2017,18(2):331.
[28]徐普,朱亚丽,刘德裕,等.即刻种植即刻负重中PRF对硬组织修复的促进作用[J].中华老年口腔医学杂志,2012,10(5):286-289.
[29] Clark RA. Fibrin and wound healing[J]. Ann NY Acad Sci,2001,936(1):355-367.
[30] Simonpieri A,Del CM,Sammartino G,et al. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. PartⅡ:implant surgery,prosthodontics,and survival[J]. Implant Dent,2009,18(3):220.
[31]刘珍珍,周延民,孙晓琳,等.富血小板纤维蛋白诱导角化龈增量一例[J].中华口腔医学杂志,2017,52(5):314-315.
[32] Marrelli M,Tatullo M. Influence of PRF in the healing of bone and gingival tissues:clinical and histological evaluations[J]. Eur Rev Med Pharmaco,2013,17(14):1958-1962.
[33] Nizam N,Eren G,AkcalA.Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral:A split-mouth histological and histomorphometric study[J].Clin Oral Implants Res,2018,29(1):67-75.
[34] Boora P,Rathee M,Bhoria M. Effect ofplatelet rich fibrin(PRF)on peri-implant soft tissue and crestal bone in one-stage implant placement:a randomized controlled trial[J]. J Clin Diagn Res,2015,9(4):18-21.
[35]郑斌,徐普,陈灵,等.自体骨板联合富血小板纤维蛋白修复美学区即刻种植唇侧骨缺损1例报告[J].中国实用口腔科杂志,2017,10(1):61-64.
[36] Hehn J,Schwenk T,Striegel M,et al. The effect of PRF(platelet-rich fibrin)inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants:results of a randomized, controlled clinical trial[J]. Inter J Implant Dent,2016,2(1):1-10.
[2] Rosano G,Taschieri S,Del FM. Immediate postextraction implant placement using plasma rich in growth factors technology in maxillary premolar region:a new strategy for soft tissue management[J]. J Oral Implantol,2013,39(1):98-102.
[3] Pascale M R D,Sommese L,Casamassimi A,et al. Platelet derivatives in regenerative medicine:an update[J]. Transfus Med Rev,2015,29(1):52-61.
[4] Grambart ST. Sports medicine and platelet-rich plasma:nonsurgical therapy[J]. Clin Podiatr Med Surg,2015,32(1):99-107.
[5] Anitua E. Plasma rich in growth factors:preliminary results of use in the preparation of future sites for implants[J]. Int J Oral Maxillofac Implants,1999,14(4):529-535.
[6] Anitua E,Prado R,Troya M,et al.Implementation of a more physiological plasma rich in growth factor(PRGF)protocol:Anticoagulant removal and reduction in activator concentration[J].Platelets,2016,27(5):459-466.
[7] Anitua E,Sanchez M. The importance of understanding what is platelet-rich growth factor(PRGF)and what is not[J]. J Shoulder Elb Surg,2011,20(1):e23-24.
[8] Choukroun J,Adda F,Schoeffler C,et al. An opportunity in perioimplantology:The PRF[J]. Implantodontie,2001,42:55-62.
[9] Miron RJ,Zucchelli G,Pikos MA,et al. Use of platelet-rich fibrin in regenerative dentistry:a systematic review[J]. Clin Oral Investig,2017,21(6):1913-1927.
[10] Rodella LF,Favero G,Boninsegna R,et al. Growth factors,CD34 positive cells,and fibrin network analysis in concentrated growth factors fraction[J]. Microsc Res Tech,2011,74(8):772-777.
[11] Yu P,Zhai Z,Jin X,et al. Clinical application of platelet-eich fibrin in plastic and reconstructive surgery:a systematic review[J].Aesthetic Plast Surg,2018,42(2):511-519.
[12] Hu Y,Jiang Y,Wang M,et al.Concentratedgrowth factor enhanced fat graft survival:a comparative study[J]. Dermatol Surg,(2018-06-28)[2018-06-26]. http://insights. ovid. com/pubmed? pmid=29894435. Doi:10.1097/DSS.0000000000001337.
[13] Choukroun J. Advanced PRFand i-PRF:Platelet concentrate or blood concentrate?[J].Periodontal Med Clin Pract,2014,1:3.
[14] Mour2o CF,Valiense H,Melo ER,et al.Obtention of injectable platelets rich-fibrin(i-PRF)and its polymerization with bone graft:technical note[C]. Rev Col Bras Cir,2015,42(6):421-423.
[15] Tunal M,zdemir H,Kü9ükodac Z,et al. In vivo evaluation of titanium-prepared platelet-rich fibrin(T-PRF):a new platelet concentrate[J]. Br J Oral Maxillofac Surg,2013,51(5):438-443.
[16] Giannobile WV,Hernandez RA,Finkelman RD,et al. Comparative effects of plateletderived growth factor-BB and insulin-like growth factor-I,individually and in combination,on periodontal regeneration in Macaca fascicularis[J]. J Periodontal Res,1996,31(5):301-312.
[17] Lucarelli E,Beccheroni A,Donati D,et al. Platelet-derived growth factors enhance proliferation of human stromal stem cells[J]. Biomaterials,2003,24(18):3095-3100.
[18] Yu J,Ustach C,Kim HR. Platelet-derived growth factor signaling and human cancer[J].J Biochem Mol Biol,2003,36(1):49-59.
[19] Butt AJ,Firth SM,Baxter RC. The IGF axis and programmed cell death[J]. Immunol Cell Biol,1999,77(3):256-262.
[20] Zachary I. VEGF signalling:integration and multi-tasking in endothelial cell biology[J]. Biochem Soc Trans,2003,31(Pt 6):1171
[21] Kwan Tat S,Padrines M,Theoleyre S,et al. IL-6,RANKL,TNF-alpha/IL-1:interrelations in bone resorption pathophysiology[J]. Cytokine Growth Factor Rev,2004,15(1):49-60.
[22] Hayashi Y,Kobayashi M,Kuwata H,et al. Interferon-gamma and interleukin 4 inhibit interleukin 1beta-induced delayed prostaglandin E(2)generation through suppression of cyclooxygenase-2 expression in human fibroblasts[J]. Cytokine,2000,12(6):603-612.
[23] Louren9o ES,Mour2o CFAB,Leite PEC,et al.The in vitro release of cytokines and growth factors from fibrin membranes produced through horizontal centrifugation[J]. J Biomed Mater Res A,2018,106(5):1373-1380.
[24] Aggarwal BB. Signalling pathways of the TNF superfamily:a double-edged sword[J]. Nat Rev Immunol,2003,3(9):745-756.
[25] Dohan Ehrenfest DM,Diss A,Odin G,et al. In vitro effects of Choukroun's PRF(platelet-rich fibrin)on human gingival fibroblasts,dermal prekeratinocytes,preadipocytes,and maxillofacial osteoblasts in primary cultures[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2009,108(3):341-352.
[26] Lu J,Hao Y,Zhao W,et al. Molecular,Cellular and pharmaceutical aspects of autologous grafts for peri-implant hard and soft tissue defects[J].Curr Pharm Biotechnol,2017,18(1):85-94.
[27] Wang X,Zhang Y,Choukroun J,et al. Behavior of gingival fibroblasts on titanium implant surfaces in combination with either injectable-PRF or PRP[J]. Int J Mol Sci,2017,18(2):331.
[28]徐普,朱亚丽,刘德裕,等.即刻种植即刻负重中PRF对硬组织修复的促进作用[J].中华老年口腔医学杂志,2012,10(5):286-289.
[29] Clark RA. Fibrin and wound healing[J]. Ann NY Acad Sci,2001,936(1):355-367.
[30] Simonpieri A,Del CM,Sammartino G,et al. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. PartⅡ:implant surgery,prosthodontics,and survival[J]. Implant Dent,2009,18(3):220.
[31]刘珍珍,周延民,孙晓琳,等.富血小板纤维蛋白诱导角化龈增量一例[J].中华口腔医学杂志,2017,52(5):314-315.
[32] Marrelli M,Tatullo M. Influence of PRF in the healing of bone and gingival tissues:clinical and histological evaluations[J]. Eur Rev Med Pharmaco,2013,17(14):1958-1962.
[33] Nizam N,Eren G,AkcalA.Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral:A split-mouth histological and histomorphometric study[J].Clin Oral Implants Res,2018,29(1):67-75.
[34] Boora P,Rathee M,Bhoria M. Effect ofplatelet rich fibrin(PRF)on peri-implant soft tissue and crestal bone in one-stage implant placement:a randomized controlled trial[J]. J Clin Diagn Res,2015,9(4):18-21.
[35]郑斌,徐普,陈灵,等.自体骨板联合富血小板纤维蛋白修复美学区即刻种植唇侧骨缺损1例报告[J].中国实用口腔科杂志,2017,10(1):61-64.
[36] Hehn J,Schwenk T,Striegel M,et al. The effect of PRF(platelet-rich fibrin)inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants:results of a randomized, controlled clinical trial[J]. Inter J Implant Dent,2016,2(1):1-10.