5-ALA光动力联合高频电治疗外阴尖锐湿疣男女患者治疗次数和治疗周期差异分析
|
摘要
目的分析5-氨基酮戊酸光动力治疗(5-Aminolevulinic acid Photodynamic Therapy,ALA-PDT)联合高频电治疗外阴尖锐湿疣男女患者治疗次数和治疗周期的差异性,为开展相关治疗提供参考。方法随机选取2011年7月至2016年7月至我科性病治疗室诊治的初发外阴尖锐湿疣患者,根据性别不同分为男性组和女性组,两组均给予ALA-PDT联合高频电治疗,并进行12个月的疗后随访,观察不良反应,对能完成2次以上联合治疗的患者治疗至临床痊愈所需治疗次数和治疗周期进行统计学分析。结果入选患者215例,男108例,女107例,男性组治疗次数平均(3. 60±1. 39)次,治疗周期平均(4. 37±1. 13)周,女性组治疗次数平均(3. 33±1. 26)次,治疗周期平均(4. 23±1. 27)周。经Mann-Whitney U秩和检验,两组治疗次数和治疗周期无统计学差异(P=0. 161、0. 308>0. 05)。结论经长期随访,ALA-PDT联合高频电治疗外阴尖锐湿疣安全、有效,男女患者治疗次数和治疗周期相当,值得推广应用。
Objective To analyze the differences in treatment frequency and treatment cycle between male and female patients with vulvar condyloma acuminatum( CA) treated by 5-aminolevulinic acid photodynamic therapy( ALA-PDT) combined with high frequency ionization,so as to provide reference for related treatment. Methods Patients with primary vulvar CA diagnosed in our department from July 2011 to July 2016 were randomly selected and divided into male group and female group according to gender. Both groups were treated with ALA-PDT combined with high frequency ionization therapy,followed up for 12 months and observed adverse reactions. Statistical analysis was made on the treatment frequency and treatment cycle needed from treatment to clinical recovery for patients who could complete ≥2 combined treatments. Results 215 patients were enrolled,including 108 males and 107 females. The average of treatment frequency and treatment cycle in male group were( 3. 60±1. 39) times and( 4.37±1. 13) weeks,while those in female group were( 3. 33±1. 26) times and( 4. 23±1. 27) weeks. There were no significant statistics differences between two groups about treatment frequency and treatment cycle after Mann-Whitney U rank sum test( P = 0.161,0. 308>0. 05). Conclusion After long-term follow-up,ALA-PDT combined with high frequency ionization therapy for vulvar condyloma acuminatum is safe and effective,and the treatment frequency and treatment cycle of male and female patients is equal,which is worthy of popularization and application.
Objective To analyze the differences in treatment frequency and treatment cycle between male and female patients with vulvar condyloma acuminatum( CA) treated by 5-aminolevulinic acid photodynamic therapy( ALA-PDT) combined with high frequency ionization,so as to provide reference for related treatment. Methods Patients with primary vulvar CA diagnosed in our department from July 2011 to July 2016 were randomly selected and divided into male group and female group according to gender. Both groups were treated with ALA-PDT combined with high frequency ionization therapy,followed up for 12 months and observed adverse reactions. Statistical analysis was made on the treatment frequency and treatment cycle needed from treatment to clinical recovery for patients who could complete ≥2 combined treatments. Results 215 patients were enrolled,including 108 males and 107 females. The average of treatment frequency and treatment cycle in male group were( 3. 60±1. 39) times and( 4.37±1. 13) weeks,while those in female group were( 3. 33±1. 26) times and( 4. 23±1. 27) weeks. There were no significant statistics differences between two groups about treatment frequency and treatment cycle after Mann-Whitney U rank sum test( P = 0.161,0. 308>0. 05). Conclusion After long-term follow-up,ALA-PDT combined with high frequency ionization therapy for vulvar condyloma acuminatum is safe and effective,and the treatment frequency and treatment cycle of male and female patients is equal,which is worthy of popularization and application.
引文
[1]Ying Z,Li X,Dang H.5-aminolevulinic acid-based photodynamic therapy for the treatment of condylomata acuminata in Chinese patients:a meta-analysis[J].Photodermatol Photoimmunol Photomed,2013,29(3):149-159.
[2]潘悉伦,杨戈,林昭春.5-氨基酮戊酸光动力治疗尖锐湿疣的免疫学进展[J].四川医学,2015,36(03):424-426.
[3]李志坚,王佳,叶雪霞.光动力联合CO2激光治疗尿道口、肛门尖锐湿疣的临床效果[J].皮肤病与性病,2018,40(3):358-359.
[4]唐正东.5-氨基酮戊酸光动力疗法联合氩气高频电刀治疗肛管内尖锐湿疣的68例疗效分析[J].中国中西医结合皮肤性病学杂志,2017,16(1):63-65.
[5]中华医学会皮肤性病学分会性病学组,中国医师协会皮肤科分会性病亚专业委员会.尖锐湿疣诊疗指南(2014)[J].中华皮肤科杂志,2014,47(8):598-599.
[6]杨戈,刘爱美,崔凡,等.TLR9-MyD88信号通路相关蛋白在尖锐湿疣皮损中的表达变化[J].中国皮肤性病学杂志,2018,32(11):1272-1276.
[7]黄敖,罗宏,张莲,等.5-氨基酮戊酸光动力疗法治疗尖锐湿疣合并HIV感染25例疗效观察[J].中国皮肤性病学杂志,2018,32(06):733-736.
[8]Mroz P,Yaroslavsky A,Kharkwal GB,et al.Cell death pathways in photodynamic therapy of cancer[J].Cancers(Basel),2011,3(2):2516-2539.
[9]Kessel D,Oleinick NL.Cell Death Pathways Associated with Photodynamic Therapy:An Update[J].Photochem Photobiol,2018,94(2):213-218.
[10]Inguscio V,Panzarini E,Dini L.Autophagy Contributes to the Death/Survival Balance in Cancer PhotoDynamic Therapy[J].Cells,2012,1(3):464-491.
[11]Milla Sanabria L,Rodríguez ME,Cogno IS,et al.Direct and indirect photodynamic therapy effects on the cellular and molecular components of the tumor microenvironment[J].Biochim Biophys Acta,2013,1835(1):36-45.
[12]Merchant S,Korbelik M.Upregulation of genes for C-reactive protein and related pentraxin/complement proteins in photodynamic therapy-treated human tumor cells:enrolment of PI3K/Akt and AP-1[J].Immunobiology,2013,218(6):869-874.
[13]吴英桂,欧伟洪.电离子联合ALA-PDT治疗尖锐湿疣临床效果分析[J].中国性科学,2018,27(3):81-83.
[14]秦萍萍.不同剂量20%盐酸氨基酮戊酸光动力治疗外阴尖锐湿疣临床效果分析[J].河北医科大学学报,2016,37(12):1454-1457.
[15]梁敏奇,黄小耿,李洁霞.不同浓度艾拉溶液对艾拉光动力疗法治疗尖锐湿疣的影响[J].右江医学,2016,44(01):30-33.
[2]潘悉伦,杨戈,林昭春.5-氨基酮戊酸光动力治疗尖锐湿疣的免疫学进展[J].四川医学,2015,36(03):424-426.
[3]李志坚,王佳,叶雪霞.光动力联合CO2激光治疗尿道口、肛门尖锐湿疣的临床效果[J].皮肤病与性病,2018,40(3):358-359.
[4]唐正东.5-氨基酮戊酸光动力疗法联合氩气高频电刀治疗肛管内尖锐湿疣的68例疗效分析[J].中国中西医结合皮肤性病学杂志,2017,16(1):63-65.
[5]中华医学会皮肤性病学分会性病学组,中国医师协会皮肤科分会性病亚专业委员会.尖锐湿疣诊疗指南(2014)[J].中华皮肤科杂志,2014,47(8):598-599.
[6]杨戈,刘爱美,崔凡,等.TLR9-MyD88信号通路相关蛋白在尖锐湿疣皮损中的表达变化[J].中国皮肤性病学杂志,2018,32(11):1272-1276.
[7]黄敖,罗宏,张莲,等.5-氨基酮戊酸光动力疗法治疗尖锐湿疣合并HIV感染25例疗效观察[J].中国皮肤性病学杂志,2018,32(06):733-736.
[8]Mroz P,Yaroslavsky A,Kharkwal GB,et al.Cell death pathways in photodynamic therapy of cancer[J].Cancers(Basel),2011,3(2):2516-2539.
[9]Kessel D,Oleinick NL.Cell Death Pathways Associated with Photodynamic Therapy:An Update[J].Photochem Photobiol,2018,94(2):213-218.
[10]Inguscio V,Panzarini E,Dini L.Autophagy Contributes to the Death/Survival Balance in Cancer PhotoDynamic Therapy[J].Cells,2012,1(3):464-491.
[11]Milla Sanabria L,Rodríguez ME,Cogno IS,et al.Direct and indirect photodynamic therapy effects on the cellular and molecular components of the tumor microenvironment[J].Biochim Biophys Acta,2013,1835(1):36-45.
[12]Merchant S,Korbelik M.Upregulation of genes for C-reactive protein and related pentraxin/complement proteins in photodynamic therapy-treated human tumor cells:enrolment of PI3K/Akt and AP-1[J].Immunobiology,2013,218(6):869-874.
[13]吴英桂,欧伟洪.电离子联合ALA-PDT治疗尖锐湿疣临床效果分析[J].中国性科学,2018,27(3):81-83.
[14]秦萍萍.不同剂量20%盐酸氨基酮戊酸光动力治疗外阴尖锐湿疣临床效果分析[J].河北医科大学学报,2016,37(12):1454-1457.
[15]梁敏奇,黄小耿,李洁霞.不同浓度艾拉溶液对艾拉光动力疗法治疗尖锐湿疣的影响[J].右江医学,2016,44(01):30-33.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |