糜烂性口腔扁平苔藓患者口腔真菌感染因素分析
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摘要
目的:了解糜烂型口腔扁平苔藓(oral lichen planus,OLP)患者口腔真菌感染的患病情况,并分析可能的影响因素。方法:纳入糜烂型OLP患者60例,健康志愿者30例,通过口腔真菌涂片检查,比较两组真菌感染患病率;并分析年龄、病程等因素对患病率的影响。结果:糜烂型OLP患者中真菌涂片阳性率显著高于健康志愿者;在年龄>45岁组的阳性率显著高于年龄≤45岁组,且病程>6月的患者的阳性率显著高于病程≤6月的患者。结论:糜烂型OLP患者是口腔真菌感染的高发人群,且年龄大、病程长的患者患病率更高。这类患者的治疗过程中,应重视口腔真菌感染的预防和治疗。
Objective:To investigate the prevalence of oral fungal infection in patients with erosive oral lichen planus(OLP)and analyze the possible influencing factors.Methods:To compare the prevalence of oral fungal infection,60 patients with erosive OLP and 30 healthy volunteers were enrolled,and oral fungal smear examination was performed.The influence of age and course of disease on the prevalence was analyzed.Results:The oral fungal infection rate of erosive OLP patients was significantly higher than that of healthy volunteers.The infection rate of patients older than 45 years was significantly higher than that of patients 45 years old or less.The infection rate significantly increased in patients with duration longer than 6 months compared with that of patients with duration of 6 months or less.Conclusion:The incidence of oral fungal infection of patients with erosive OLP was higher,especially for the older patients with longer course of disease.
Objective:To investigate the prevalence of oral fungal infection in patients with erosive oral lichen planus(OLP)and analyze the possible influencing factors.Methods:To compare the prevalence of oral fungal infection,60 patients with erosive OLP and 30 healthy volunteers were enrolled,and oral fungal smear examination was performed.The influence of age and course of disease on the prevalence was analyzed.Results:The oral fungal infection rate of erosive OLP patients was significantly higher than that of healthy volunteers.The infection rate of patients older than 45 years was significantly higher than that of patients 45 years old or less.The infection rate significantly increased in patients with duration longer than 6 months compared with that of patients with duration of 6 months or less.Conclusion:The incidence of oral fungal infection of patients with erosive OLP was higher,especially for the older patients with longer course of disease.
引文
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[7] 林姬艳.口腔扁平苔藓患者白色念珠菌检出率及分离株SAP表达的研究[J].实用预防医学,2015,22(10):1258-1259.
[8] 朱建华,赵雯雯,毕庆伟,等.口腔扁平苔藓与念珠菌感染相关性研究[J].医学研究杂志,2010,10(39):97-98.
[9] 曹天翼,陈福祥,唐国瑶,等.抗真菌治疗和年龄因素对OLP角质形成细胞体外培养成功率的影响[J].临床口腔医学杂志,2015,31(12):728-731.
[10] 李云华,立红,张淑芬.中老年人口腔扁平苔藓念珠菌感染因素分析[J].内蒙古预防医学,2000,25(2):53-54.
[2] Kragelund C,Keller MK.The oral microbiome in oral lichen planus during a 1-year randomized clinical trial[J].Oral Dis,2019,25(1):327-338.
[3] Thongprasom K.Oral lichen planus:Challenge and management[J].Oral Dis,2018,24(1-2):172-173.
[4] Zhou L,Cao T,Wang Y,et al.Frequently increased but functionally impaired CD4+CD25+ regulatory T cells in patients with oral lichen planus[J].Inflammation,2016,39(3):1205-1215.
[5] Di Stasio D,Guida A,Salerno C,et al.Oral lichen planus:a narrative review[J].Front Biosci(Elite Ed),2014,6:370-376.
[6] 魏昕,李秉琦,周学东,等.制霉菌素与地塞米松糊剂联合治疗OLP疗效观察[J].临床口腔医学杂志,2003,19(9):568-569.
[7] 林姬艳.口腔扁平苔藓患者白色念珠菌检出率及分离株SAP表达的研究[J].实用预防医学,2015,22(10):1258-1259.
[8] 朱建华,赵雯雯,毕庆伟,等.口腔扁平苔藓与念珠菌感染相关性研究[J].医学研究杂志,2010,10(39):97-98.
[9] 曹天翼,陈福祥,唐国瑶,等.抗真菌治疗和年龄因素对OLP角质形成细胞体外培养成功率的影响[J].临床口腔医学杂志,2015,31(12):728-731.
[10] 李云华,立红,张淑芬.中老年人口腔扁平苔藓念珠菌感染因素分析[J].内蒙古预防医学,2000,25(2):53-54.