低温等离子消融治疗喉肿瘤效果及对免疫功能的影响
|
摘要
目的探讨低温等离子消融术治疗喉肿瘤的效果及对免疫功能的影响。方法选取2015年1月—2016年1月聊城市第二人民医院收治的喉肿瘤86例,按手术方法分为观察组和对照组,每组43例。观察组给予低温等离子消融术,对照组给予常规手术治疗。比较两组手术时间、出血量、住院时间,观察两组治疗前、后免疫球蛋白及C_3和C_4的变化情况。结果观察组手术时间、愈合时间、住院时间短于对照组,术中出血量少于对照组(P<0.05)。两组术前、术后免疫球蛋白及C_3、C_4比较差异无统计学意义(P>0.05)。结论采用低温等离子消融治疗喉肿瘤效果较好,且不影响免疫功能。
Objective To investigate therapeutic effect of hypothermia plasma ablation in treatment of patients with laryngeal tumor and its effect on immune function. Methods A total of 86 patients with laryngeal tumor admitted during January 2015 and January 2016 were divided into observation group( n = 43) and control group( n = 43) according to surgical methods. Observation group was treated with hypothermia plasma ablation,while control group was given conventionally surgical treatment. In two groups,operative time,bleeding volume and hospitalization time were compared,and changes of immune globulin,C_3 and C_4 were observed. Results In observation group,values of operative,healing and hospitalization times and intraoperative bleeding volume were significantly lower than those in control group( P < 0. 05). There were no significant differences in immune globulin,C_3 and C_4 before and after surgery in two groups( P > 0. 05). Conclusion Hypothermia plasma ablation in treatment of patients with laryngeal tumor may achieve good effect without affecting immune function.
Objective To investigate therapeutic effect of hypothermia plasma ablation in treatment of patients with laryngeal tumor and its effect on immune function. Methods A total of 86 patients with laryngeal tumor admitted during January 2015 and January 2016 were divided into observation group( n = 43) and control group( n = 43) according to surgical methods. Observation group was treated with hypothermia plasma ablation,while control group was given conventionally surgical treatment. In two groups,operative time,bleeding volume and hospitalization time were compared,and changes of immune globulin,C_3 and C_4 were observed. Results In observation group,values of operative,healing and hospitalization times and intraoperative bleeding volume were significantly lower than those in control group( P < 0. 05). There were no significant differences in immune globulin,C_3 and C_4 before and after surgery in two groups( P > 0. 05). Conclusion Hypothermia plasma ablation in treatment of patients with laryngeal tumor may achieve good effect without affecting immune function.
引文
[1]黄少波,廖艳萍,徐志坚,等.低温等离子消融治疗喉良恶性肿瘤疗效观察[J].中外医学研究,2014,12(23):140-141.
[2]董玉科,李玉杰,于敏,等.早期声门型喉癌应用低温等离子刀射频消融治疗的临床效果[J].中外医疗,2015,34(10):85-86.
[3]崔树林,张悦,李文静,等.等离子射频消融术治疗声门型喉癌疗效分析[J].中国医疗器械信息,2016,22(20):14-16.
[4]孙玉满,杨俊泉,曹渤海,等.早期喉癌手术阴性切缘组织中PCNA、COX-2表达与肿瘤局部复发的关系[J].临床与实验病理学杂志,2014,30(4):408-410,414.
[5]郑乃彩,方渭清,王孝阳,等.喉癌患者本人知情前后情绪和免疫功能变化的对比研究[J].中国医师进修杂志,2013,36(36):4-7.
[6]刘宏侠,梁振,孙玉满,等.早期喉癌手术切缘组织p53和c-myc表达与局部复发的关系[J].诊断病理学杂志,2014,21(1):23-24,28.
[7]刘国钧,陈波蓓,凡启军,等.儿童复发性喉乳头状瘤的手术间隔Logistic回归分析及手术时机的选择[J].中国耳鼻咽喉头颈外科,2014,21(10):550-552.
[8]刘炜炜.不同剂量右美托咪定抑制喉部肿瘤手术气管切开插管中应激反应的效果比较[J].医学临床研究,2015,32(11):2170-2172.
[9]岑瑞祥,万浪,彭聪,等.低温等离子刀联合匹多莫德治疗小儿喉乳头状瘤的疗效分析[J].河北医科大学学报,2015,30(4):416-418.
[10]赵卫民,黄武,廖兰芳,等.显微喉镜下等离子射频手术治疗早期声门型喉癌33例临床分析[J].广西医科大学学报,2014,31(4):690-691.
[11]金明学.高压氧对咽喉肿瘤术后创口延迟愈合的疗效观察[J].中国继续医学教育,2016,8(8):108-109.
[12]郭炜,罗德红,李琳,等.动态增强MRI定量评估喉及下咽鳞癌同步放化疗近期疗效研究[J].放射学实践,2016,31(8):685-688.
[13]尹显祥,张珺.匹多莫德辅助喉镜手术治疗小儿喉乳头状瘤的疗效观察[J].医学临床研究,2013,30(8):1574-1575,1578.
[14]曾晓,李甸源,曾艳,等.晚期喉癌术后患者行同期放化疗与单纯放疗的临床疗效比较及预后分析[J].肿瘤防治研究,2014,41(5):423-425.
[15]Castillo Farías F,Cobeta I,Souviron R,et al.In-office cup biopsy and laryngeal cytology versus operating room biopsy for the diagnosis of pharyngolaryngeal tumors:Efficacy and cost-effectiveness[J].Head Neck,2015,37(10):1483-1487.
[16]李依霞,崔园园,崔豹,等.扩散加权成像对非手术喉癌和下咽癌患者同步放化疗前后的疗效评价[J].磁共振成像,2016,7(3):185-190.
[17]郭会义,曾荣华.双孔支撑喉镜视频下等离子切除咽喉肿瘤68例[J].长江大学学报:自科版,2016,13(6):32-33.
[18]张惠荣,李会琴,张丹,等.咽喉肿瘤术后患者出院培训指导的效果评价[J].中国护理管理,2015,10(2):230-233.
[19]Lee H S,Kim S W,Hong J C,et al.Papillary thyroid carcinoma with exclusive involvement of a functioning recurrent laryngeal nerve may be treated using a shaving technique:reply[J].World J Surg,2015,39(7):1853-1854.
[20]李峰.耳鼻喉肿瘤的病理特点、发病规律及发病趋势分析[J].临床和实验医学杂志,2016,15(4):399-402.
[21]骆小华,王朝永,黄水仙,等.喉部分切除术与氩气刀治疗早期喉癌的并发症比较研究[J].重庆医学,2016,45(31):4377-4379.
[22]赵国锋,胡艳红,王东海,等.喉肿瘤患者术前C反应蛋白检测的临床意义[J].中国耳鼻咽喉头颈外科,2014,21(8):433-434.
[2]董玉科,李玉杰,于敏,等.早期声门型喉癌应用低温等离子刀射频消融治疗的临床效果[J].中外医疗,2015,34(10):85-86.
[3]崔树林,张悦,李文静,等.等离子射频消融术治疗声门型喉癌疗效分析[J].中国医疗器械信息,2016,22(20):14-16.
[4]孙玉满,杨俊泉,曹渤海,等.早期喉癌手术阴性切缘组织中PCNA、COX-2表达与肿瘤局部复发的关系[J].临床与实验病理学杂志,2014,30(4):408-410,414.
[5]郑乃彩,方渭清,王孝阳,等.喉癌患者本人知情前后情绪和免疫功能变化的对比研究[J].中国医师进修杂志,2013,36(36):4-7.
[6]刘宏侠,梁振,孙玉满,等.早期喉癌手术切缘组织p53和c-myc表达与局部复发的关系[J].诊断病理学杂志,2014,21(1):23-24,28.
[7]刘国钧,陈波蓓,凡启军,等.儿童复发性喉乳头状瘤的手术间隔Logistic回归分析及手术时机的选择[J].中国耳鼻咽喉头颈外科,2014,21(10):550-552.
[8]刘炜炜.不同剂量右美托咪定抑制喉部肿瘤手术气管切开插管中应激反应的效果比较[J].医学临床研究,2015,32(11):2170-2172.
[9]岑瑞祥,万浪,彭聪,等.低温等离子刀联合匹多莫德治疗小儿喉乳头状瘤的疗效分析[J].河北医科大学学报,2015,30(4):416-418.
[10]赵卫民,黄武,廖兰芳,等.显微喉镜下等离子射频手术治疗早期声门型喉癌33例临床分析[J].广西医科大学学报,2014,31(4):690-691.
[11]金明学.高压氧对咽喉肿瘤术后创口延迟愈合的疗效观察[J].中国继续医学教育,2016,8(8):108-109.
[12]郭炜,罗德红,李琳,等.动态增强MRI定量评估喉及下咽鳞癌同步放化疗近期疗效研究[J].放射学实践,2016,31(8):685-688.
[13]尹显祥,张珺.匹多莫德辅助喉镜手术治疗小儿喉乳头状瘤的疗效观察[J].医学临床研究,2013,30(8):1574-1575,1578.
[14]曾晓,李甸源,曾艳,等.晚期喉癌术后患者行同期放化疗与单纯放疗的临床疗效比较及预后分析[J].肿瘤防治研究,2014,41(5):423-425.
[15]Castillo Farías F,Cobeta I,Souviron R,et al.In-office cup biopsy and laryngeal cytology versus operating room biopsy for the diagnosis of pharyngolaryngeal tumors:Efficacy and cost-effectiveness[J].Head Neck,2015,37(10):1483-1487.
[16]李依霞,崔园园,崔豹,等.扩散加权成像对非手术喉癌和下咽癌患者同步放化疗前后的疗效评价[J].磁共振成像,2016,7(3):185-190.
[17]郭会义,曾荣华.双孔支撑喉镜视频下等离子切除咽喉肿瘤68例[J].长江大学学报:自科版,2016,13(6):32-33.
[18]张惠荣,李会琴,张丹,等.咽喉肿瘤术后患者出院培训指导的效果评价[J].中国护理管理,2015,10(2):230-233.
[19]Lee H S,Kim S W,Hong J C,et al.Papillary thyroid carcinoma with exclusive involvement of a functioning recurrent laryngeal nerve may be treated using a shaving technique:reply[J].World J Surg,2015,39(7):1853-1854.
[20]李峰.耳鼻喉肿瘤的病理特点、发病规律及发病趋势分析[J].临床和实验医学杂志,2016,15(4):399-402.
[21]骆小华,王朝永,黄水仙,等.喉部分切除术与氩气刀治疗早期喉癌的并发症比较研究[J].重庆医学,2016,45(31):4377-4379.
[22]赵国锋,胡艳红,王东海,等.喉肿瘤患者术前C反应蛋白检测的临床意义[J].中国耳鼻咽喉头颈外科,2014,21(8):433-434.