近年链霉菌次生代谢产物研究进展
|
摘要
链霉菌属微生物可合成生物碱、蒽醌、内酯、黄酮及酚类等结构多样的次生代谢产物;同时,这些代谢物质还具备拮抗微生物、抗肿瘤、酶抑制等多种生物活性。但随着链霉菌代谢产物研究在20世纪70年代达到巅峰后,在随后的20年间新物质的发现比率不断下降;该领域研究的未来发展前景如何一直是关注的热点。本文依据2005—2013年期间链霉菌次生代谢研究报道数据,针对新化合物数量、结构类型、生物活性及菌株采样环境进行分类统计分析,并对典型新化合物进行介绍。分析结果表明:针对链霉菌次生代谢产物研究,自2009年以来新结构活性化合物数量逐年增多;随着新技术、新方法的普及,链霉菌这一传统先导化合物研究材料依然具备重要的研究价值。
Streptomyces can synthesize a diversity of secondary metabolites such as alkaloids, anthraquinones, flavonoids, lactones and phenolic compounds which also have biological activities of microorbial antagonistic, antitumor, enzyme inhibition and so on. With the Streptomyces metabolites research reached its climax in the 1970 s, the discovery ratio of new structure compounds was on the decline during the next 20 years. The future developing trend is always the focus of attention in this field. Based on the recent reports of Streptomyces secondary metabolism studies from 2005—2013, the statistical analysis was classified according to the number of new compounds, structural type, biological activity and strain sampling environment, and the typical new compounds were also introduced. The analysis shows that, since 2009 the number of new compounds with biological activities is increasing year by year. It was speculated that with the popularization of new technology and new method, Streptomyces, as a traditional object for lead compound discovery, still has important research value.
Streptomyces can synthesize a diversity of secondary metabolites such as alkaloids, anthraquinones, flavonoids, lactones and phenolic compounds which also have biological activities of microorbial antagonistic, antitumor, enzyme inhibition and so on. With the Streptomyces metabolites research reached its climax in the 1970 s, the discovery ratio of new structure compounds was on the decline during the next 20 years. The future developing trend is always the focus of attention in this field. Based on the recent reports of Streptomyces secondary metabolism studies from 2005—2013, the statistical analysis was classified according to the number of new compounds, structural type, biological activity and strain sampling environment, and the typical new compounds were also introduced. The analysis shows that, since 2009 the number of new compounds with biological activities is increasing year by year. It was speculated that with the popularization of new technology and new method, Streptomyces, as a traditional object for lead compound discovery, still has important research value.
引文
[1]雷健,赫卫清,王以光.链霉菌形态分化和次级代谢调控机制的研究进展[J].药物生物技术,2007,14(3):225-229.
[2]刘志恒,姜成林.放线菌现代微生物学与生物技术[M].北京:科学出版社,2004:96-103.
[3]Thompson C J,Fink D,Nguyen L D.Principles of microbial alchemy:Insights from the Streptomyces coelicolor genome sequence[J].Genome Biol,2002,3:reviews 1020.1(7):129-137.
[4]曾文兵,王锦,段学辉.从链霉菌中发现新抗生素的趋势分析[J].2004,22(4):293-296.
[5]Berdy J.Bioactive microbial metabolites[J].J Antibiot,2005,58(1):1-26.
[6]Berdy J.Antibiotics:present and future[J].Orv Hetil,2013,154(15):563-573.
[7]李娜,王凤山,厉保秋.肽类抗生素的研究进展[J].中国生化药物杂志,2007,28(3):216-219.
[8]Newman D J,Cragg G M.Natural products as sources of new drugs over the 30 years from 1981 to 2010[J].J Nat Prod,2012,75(3):311-335.
[9]Takagi M,Shin-Ya K.New species of actinomycetes do not always produce new compounds with high frequency[J].J Antibiot(Tokyo),2011,64(10):699-701.
[10]Manam R R,Teisan S,White D J,et al.Lajollamycin,a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus[J].J Nat Prod,2005,68(2):240-243.
[11]Park H J,Lee J Y,Hwang I S,et al.Isolation and antifungal and Antioomycete activities of staurosporine from Streptomyces roseoflavus strain LS-A24[J].J Agric Food Chem,2006,54(8):3041-3046.
[12]Wang J,Soisson S M,Young K,et al.Platensimycin is a selective FabF inhibitor with potent antibiotic properties[J].Nature,2006,441(7091):358-361.
[13]Wang J,Kodali S,Lee S H,et al.Discovery of platencin,a dual FabF and FabH inhibitor with in vivo antibiotic properties[J].PNAS,2007,104(18):7612-7616.
[14]Paululat T,Kulik A,Hausmann H,et al.Grecocyclines:New angucyclines from Streptomyces sp.Acta 1362[J].Eur J Org Chem,2010,2010(12):2344-2350.
[15]Huijsduijnen R H V,Bombrun A,Swinnen D.Selecting protein tyrosine phosphatases as drug targets[J].Drug Discov Today,2002,7(19):1013-1019.
[16]Supong K,Thawai C,Suwanborirux K,et al.Antimalarial and antitubercular C-glycosylated benzaanthraquinones from the marine-derived Streptomyces sp.BCC45596[J].Phytochem Lett,2012,5(3):651-656.
[17]Potterat O,Puder C,Wagner K,et al.Chlorocyclinones A-D,chlorinated angucyclinones from Streptomyces sp.strongly antagonizing rosiglitazone-induced PPAR-gamma activation[J].J Nat Prod,2007,70(12):1934-1938.
[18]Helaly S E,Kulik A,Zinecker H,et al.Langkolide,a 32-membered macrolactone antibiotic produced by Streptomyces sp.Acta 3062[J].J Nat Prod,2012,75(6):1018-1024.
[19]Carr G,Williams D E,Diaz-Marrero A R,et al.Bafilomycins produced in culture by Streptomyces spp.isolated from marine habitats are potent inhibitors of autophagy[J].J Nat Prod,2010,73(3):422-427.
[20]Chen G,Lin B,Lin Y,et al.A new fungicide produced by a Streptomyces sp.GAAS7310[J].J Antibiot(Tokyo),2005,58(8):519-522.
[21]Yang L Y,Wang J D,Zhang J,et al.New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3[J].Bioorg Med Chem Lett,2013,23:5710-5713.
[22]Arasu M V,Duraipandiyan V,Ignacimuthu S.Antibacterial and antifungal activities of polyketide metabolite from marine Streptomyces sp.AP-123 and its cytotoxic effect[J].Chemosphere,2013,90(2):479-487.
[23]Fujita Y,Kasuya A,Matsushita Y,et al.Structural elucidation of A-74528,an inhibitor for 2',5'-phosphodiesterase isolated from Streptomyces sp[J].Bioorg Med Chem Lett,2005,15(19):4317-4321.
[24]Fukumoto A,Kim Y P,Matsumoto A,et al.Cyslabdan,a new potentiator of imipenem activity against methicillinresistant Staphylococcus aureus,produced by Streptomyces sp.K04-0144[J].J Antibiot(Tokyo),2008,61(1):1-6.
[25]Takada K,Kajiwara H,Imamura N.Oridamycins A and B,anti-saprolegnia parasitica indolosesquiterpenes isolated from Streptomyces sp.KS84[J].J Nat Prod,2010,73(4):698-701.
[26]Singh J P,Tamang S,Rajamohanan P R,et al.Isolation,structure,and functional elucidation of a modified pentapeptide,cysteine protease inhibitor(CPI-2081)from Streptomyces species 2081 that exhibit inhibitory effect on cancer cell migration[J].J Med Chem,2010,53(14):5121-5128.
[27]Bitzer J,Streibel M,Langer H J,et al.First Y-type actinomycins from Streptomyces with divergent structureactivity relationships for antibacterial and cytotoxic properties[J].Org Biomol Chem,2009,7(3):444-450.
[28]Meng P,Guo Y,Zhang Q,et al.A novel aminooligosaccharide isolated from the culture of Streptomyces strain PW63 8 is a potent inhibitor of a-amylase[J].Carbohydr Res,2011,346(13):1898-1902.
[29]Schleissner C,Perez M,Losada A,et al.Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment[J].J Nat Prod,2011,74(7):1590-1596.
[30]Huang R,Ding Z G,Long Y F,et al.A new isoflavone derivative from Streptomyces sp.YIM GS3536[J].Chem Nat Comp,2013,48(6):966-969.
[31]Arumugam M,Mitra A,Jaisankar P,et al.Isolation of an unusual metabolite 2-allyloxyphenol from a marine actinobacterium,its biological activities and applications[J].Appl Microbiol Biotechnol,2010,86(1):109-117.
[32]徐丽华,李文均,刘志恒,等.放线菌系统学—原理、方法及实践[M].北京:科学出版社,2007.
[2]刘志恒,姜成林.放线菌现代微生物学与生物技术[M].北京:科学出版社,2004:96-103.
[3]Thompson C J,Fink D,Nguyen L D.Principles of microbial alchemy:Insights from the Streptomyces coelicolor genome sequence[J].Genome Biol,2002,3:reviews 1020.1(7):129-137.
[4]曾文兵,王锦,段学辉.从链霉菌中发现新抗生素的趋势分析[J].2004,22(4):293-296.
[5]Berdy J.Bioactive microbial metabolites[J].J Antibiot,2005,58(1):1-26.
[6]Berdy J.Antibiotics:present and future[J].Orv Hetil,2013,154(15):563-573.
[7]李娜,王凤山,厉保秋.肽类抗生素的研究进展[J].中国生化药物杂志,2007,28(3):216-219.
[8]Newman D J,Cragg G M.Natural products as sources of new drugs over the 30 years from 1981 to 2010[J].J Nat Prod,2012,75(3):311-335.
[9]Takagi M,Shin-Ya K.New species of actinomycetes do not always produce new compounds with high frequency[J].J Antibiot(Tokyo),2011,64(10):699-701.
[10]Manam R R,Teisan S,White D J,et al.Lajollamycin,a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus[J].J Nat Prod,2005,68(2):240-243.
[11]Park H J,Lee J Y,Hwang I S,et al.Isolation and antifungal and Antioomycete activities of staurosporine from Streptomyces roseoflavus strain LS-A24[J].J Agric Food Chem,2006,54(8):3041-3046.
[12]Wang J,Soisson S M,Young K,et al.Platensimycin is a selective FabF inhibitor with potent antibiotic properties[J].Nature,2006,441(7091):358-361.
[13]Wang J,Kodali S,Lee S H,et al.Discovery of platencin,a dual FabF and FabH inhibitor with in vivo antibiotic properties[J].PNAS,2007,104(18):7612-7616.
[14]Paululat T,Kulik A,Hausmann H,et al.Grecocyclines:New angucyclines from Streptomyces sp.Acta 1362[J].Eur J Org Chem,2010,2010(12):2344-2350.
[15]Huijsduijnen R H V,Bombrun A,Swinnen D.Selecting protein tyrosine phosphatases as drug targets[J].Drug Discov Today,2002,7(19):1013-1019.
[16]Supong K,Thawai C,Suwanborirux K,et al.Antimalarial and antitubercular C-glycosylated benzaanthraquinones from the marine-derived Streptomyces sp.BCC45596[J].Phytochem Lett,2012,5(3):651-656.
[17]Potterat O,Puder C,Wagner K,et al.Chlorocyclinones A-D,chlorinated angucyclinones from Streptomyces sp.strongly antagonizing rosiglitazone-induced PPAR-gamma activation[J].J Nat Prod,2007,70(12):1934-1938.
[18]Helaly S E,Kulik A,Zinecker H,et al.Langkolide,a 32-membered macrolactone antibiotic produced by Streptomyces sp.Acta 3062[J].J Nat Prod,2012,75(6):1018-1024.
[19]Carr G,Williams D E,Diaz-Marrero A R,et al.Bafilomycins produced in culture by Streptomyces spp.isolated from marine habitats are potent inhibitors of autophagy[J].J Nat Prod,2010,73(3):422-427.
[20]Chen G,Lin B,Lin Y,et al.A new fungicide produced by a Streptomyces sp.GAAS7310[J].J Antibiot(Tokyo),2005,58(8):519-522.
[21]Yang L Y,Wang J D,Zhang J,et al.New nemadectin congeners with acaricidal and nematocidal activity from Streptomyces microflavus neau3 Y-3[J].Bioorg Med Chem Lett,2013,23:5710-5713.
[22]Arasu M V,Duraipandiyan V,Ignacimuthu S.Antibacterial and antifungal activities of polyketide metabolite from marine Streptomyces sp.AP-123 and its cytotoxic effect[J].Chemosphere,2013,90(2):479-487.
[23]Fujita Y,Kasuya A,Matsushita Y,et al.Structural elucidation of A-74528,an inhibitor for 2',5'-phosphodiesterase isolated from Streptomyces sp[J].Bioorg Med Chem Lett,2005,15(19):4317-4321.
[24]Fukumoto A,Kim Y P,Matsumoto A,et al.Cyslabdan,a new potentiator of imipenem activity against methicillinresistant Staphylococcus aureus,produced by Streptomyces sp.K04-0144[J].J Antibiot(Tokyo),2008,61(1):1-6.
[25]Takada K,Kajiwara H,Imamura N.Oridamycins A and B,anti-saprolegnia parasitica indolosesquiterpenes isolated from Streptomyces sp.KS84[J].J Nat Prod,2010,73(4):698-701.
[26]Singh J P,Tamang S,Rajamohanan P R,et al.Isolation,structure,and functional elucidation of a modified pentapeptide,cysteine protease inhibitor(CPI-2081)from Streptomyces species 2081 that exhibit inhibitory effect on cancer cell migration[J].J Med Chem,2010,53(14):5121-5128.
[27]Bitzer J,Streibel M,Langer H J,et al.First Y-type actinomycins from Streptomyces with divergent structureactivity relationships for antibacterial and cytotoxic properties[J].Org Biomol Chem,2009,7(3):444-450.
[28]Meng P,Guo Y,Zhang Q,et al.A novel aminooligosaccharide isolated from the culture of Streptomyces strain PW63 8 is a potent inhibitor of a-amylase[J].Carbohydr Res,2011,346(13):1898-1902.
[29]Schleissner C,Perez M,Losada A,et al.Antitumor actinopyranones produced by Streptomyces albus POR-04-15-053 isolated from a marine sediment[J].J Nat Prod,2011,74(7):1590-1596.
[30]Huang R,Ding Z G,Long Y F,et al.A new isoflavone derivative from Streptomyces sp.YIM GS3536[J].Chem Nat Comp,2013,48(6):966-969.
[31]Arumugam M,Mitra A,Jaisankar P,et al.Isolation of an unusual metabolite 2-allyloxyphenol from a marine actinobacterium,its biological activities and applications[J].Appl Microbiol Biotechnol,2010,86(1):109-117.
[32]徐丽华,李文均,刘志恒,等.放线菌系统学—原理、方法及实践[M].北京:科学出版社,2007.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |