提高白藜芦醇含量方法的研究进展
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摘要
白藜芦醇以其抑制脂质过氧化、调节抗氧化相关酶活性以及抗菌抗炎的生物学功能和天然、无毒副作用的特点引起了人们的广泛关注。本综述在详细介绍白藜芦醇的理化性质、生物学活性及其在植物体内的生物合成和调控过程的基础上,总结并分析了外源因子对白藜芦醇的影响,其中主要包括物理因子,化学因子等非生物胁迫的方法以及霉类生物的接种感染的生物学方法,且提出了白藜芦醇未来研究的方法和方向,以及白藜芦醇合成工艺中存在的不足,以期为将来白藜芦醇合成工艺的改进与创新及其商业化开发提供经验借鉴。
Resveratrol is a kind of natural chemical without toxic or side effects, that has attracted great attention due to its biological role of lipid peroxidation inhibition, antioxidant enzyme activity regulation as well as anti-inflammatory function. The review is a detailed introduction about the physicochemical properties, biological activities of resveratrol and its biosynthesis and regulation processes in plants. This paper also summarizes and analyzes the effects of exogenous factors on resveratrol, including physical factors, chemical factors and other abiotic stress methods, as well as biological methods for inoculation of moldy organisms. At the end of the paper,the methods and directions of future research on resveratrol and the shortcomings in the synthesis process of resveratrolare put forward, in order to provide experience for the improvement and innovation of resveratrol synthesis process and its commercial development.
Resveratrol is a kind of natural chemical without toxic or side effects, that has attracted great attention due to its biological role of lipid peroxidation inhibition, antioxidant enzyme activity regulation as well as anti-inflammatory function. The review is a detailed introduction about the physicochemical properties, biological activities of resveratrol and its biosynthesis and regulation processes in plants. This paper also summarizes and analyzes the effects of exogenous factors on resveratrol, including physical factors, chemical factors and other abiotic stress methods, as well as biological methods for inoculation of moldy organisms. At the end of the paper,the methods and directions of future research on resveratrol and the shortcomings in the synthesis process of resveratrolare put forward, in order to provide experience for the improvement and innovation of resveratrol synthesis process and its commercial development.
引文
Bao H.M.,2016,Study on the changes of components during the germination of peanut,Shipin Yanjiu Yu Kaifa(Food Research and Development),37(17):42-45(鲍会梅,2016,花生发芽过程中成分变化的研究,食品研究与开发,7(17):42-45)
Dai H.J.,Fan Y.,and Zhang Y.,2014,Effect of ethephon and fosetyl-aluminum on the content of resveratrol in the wine grape peel,Beifang Yuanyi(Northern Horticulture),(3):1-5(代红军,范永,张燕,2014,乙烯利和乙磷铝对酿酒葡萄果皮白藜芦醇含量的影响,北方园艺,(3):1-5)
Dang W.,Yu X.H.,and Cao W.,2003,Advance in the research of resveratrol synthas,Zhiwuxue Tongbao(Chinese Bulletin of Botany),20(2):152-159(党尉,尉亚辉,曹炜,2003,白藜芦醇合酶的研究进展,植物学通报,20(2):152-159)
Fu Y.Q.,and Li D.,2014,Resveratrol,Yingyang Xuebao(Acta Nutrimenta Sinica),36(1):13-16(付元庆,李铎,2014,白藜芦醇,营养学报,36(1):13-16)
Huang W.W.,Huang S.E.,Li J.L.,and Li Z.H.,2010,Advances on extraction,determination and biological action of resveratrol,Shipin Yu Jixie(Food&Machinery),26(6):148-152(黄卫文,黄寿恩,黎继烈,李忠海,2010,白藜芦醇的提取、检测技术及其生物活性研究进展,食品与机械,26(6):148-152)
Hung L.M.,Su M.J.,Chu W.K.,Chiao C.W.,Chan W.F.,and Chen J.K.,2002,The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy,Br.J.Pharmacol.,135(7):1627-1633
Ingham J.L.,1976,3,5,4'-Trihydroxystilbene as a phytoalexin from groundnuts Arachis hypogaea,Phytochemistry,15(11):1791-1793
Langcake P.,and Pryce R.J.,1976,The production of resveratrol by vitis vinifera and other members of the Vitaceae as a response to infection or injury,Physiological Plant Pathology,9(1):77-86
Li J.,Xiong Y.X.,Zeng J.G.,and Zhang Y.,2013,Research progress of resveratrol,Zhongguo Xiandai Zhongyao(Modern Chinese Medicine),15(2):100-108(李洁,熊兴耀,曾建国,张莹,2013,白藜芦醇的研究进展,中国现代中药,15(2):100-108)
Li J.M.,Ma L.Y.,and Liu Y.N.,2004,Inducement of UV on the resveratrol in harvested grape,Zhongwai Putao Yu Putaojiu(Sino-Overseas Grapevine&Wine),(4):16-19(李景明,马丽艳,刘艳娜,2004,葡萄采后紫外线(UV)处理对白藜芦醇的诱导作用,中外葡萄与葡萄酒,(4):16-19)
Li X.D.,Zheng X.B.,Yan S.T.,and Li S.H.,2007,Effects of salicylic acid(SA),ultraviolet(UV-B and UV-C)on resveratrol inducement in the skin of harvested grape berries,Guoshu Xuebao(Journal of Fruit Science),24(1):30-33(李晓东,郑先波,闫树堂,李绍华,2007,水杨酸和紫外线对诱导采后葡萄果皮内白藜芦醇合成作用研究,果树学报,24(1):30-33)
Li X.K.,Li H.Y.,Li S.,Song N.N.,Hou X.D.,Zhou W.H.,Cui Y.H.,and Ma L.,2016,Advances in study on resveratrol,Zhongcaoyao(Chinese Traditional and Herbal Drugs),47(14):2568-2578(李先宽,李赫宇,李帅,宋宁宁,侯晓东,周文华,崔雨禾,马琳,2016,白藜芦醇研究进展,中草药,47(14):2568-2578)
Liswidowati,Melchior F.,Hohmann F.,Schwer B.,and Kindl H.,1991,Induction of stilbene synthase by Botrytis cinerea in cultured grapevine cells,Planta,183(2):307-314
Liu L.P.,Gong F.,and Zhao X.N.,2005,Sallcylic acid-mediated signal transduction pathway associated with stress resistance of plants,Zhongguo Nongxue Tongbao(Chinese A-gricultural Science Bulletin),21(7):227-229(刘悦萍,宫飞,赵晓萌,2005,水杨酸介导的信号转导途径与植物抗逆性,中国农学通报,21(7):227-229)
Liu S.N.,Shao S.L.,Sui W.J.,Zhang W.W.,Zhao B.,and Chen W.W.,2015,Resveratrol induces the apoptosis of human lung cancer A549 cells,Jiyinzuxue Yu Yingyong Shengwuxue(Genomics and Applied Biology),34(4):685-691(刘盛楠,邵淑丽,隋文静,张伟伟,赵彬,陈微微,2015,白藜芦醇诱导肺癌A549细胞凋亡,基因组学与应用生物学,34(4):685-691)
Luo K.,Wang Q.F.,Zhang D.,and Li J.M.,2007,Research on the inducement of resveratrol in grapevine leaves by ultraviolet,Zhongwai Putao Yu Putaojiu(Sino-Overseas Grapevine&Wine),(4):4-6(罗葵,王琴飞,张岱,李景明,2007,葡萄叶片中白藜芦醇的紫外线诱导研究,中外葡萄与葡萄酒,(4):4-6)
Ma N.,Wang J.F.,Xu F.,Li Y.,and Li J.,2009,Reviews of reseaches on resveratrol,Changsha Yixueyuan Xuebao(Journal of Changsha Medical College),6(1):43-48(马宁,王建芬,徐芳,李媛,李娟,2009,白藜芦醇的研究概述,长沙医学院学报,6(1):43-48)
Medina-Bolivar F.,Condori J.,Rimando A.M.,Hubstenberger J.,Shelton K.,O'Keefe S.F.,Bennett S.,and Dolan M.C.,2007,Pro-duction and secretion of resveratrol in hairy root cultures of peanut,Phytochemistry,68(14):1992-2003
Ren X.L.,Xing F.,and Xie L.L.,2008,The research and application prospect of peanut esveratrol,Shipinyanjiu Yu Kaifa(Food Research and Development),29(5):163-166(任秀莲,邢峰,解利利,2008,花生中白藜芦醇的研究现状及应用展望,食品研究与开发,29(5):163-166)
Rong R.F.,Feng S.Q.,and Dai Y.Q.,2005,Effect of UV-C irradiation on infection and resverstrol of postharvest grape,Baoxian Yu Jiagong(Storage and Process),5(3):8-9(荣瑞芬,冯双庆,戴蕴青,2005,短波紫外线照射对葡萄采后发病率及白藜芦醇化合物的影响,保鲜与加工,5(3):8-9)
Schroder G.,and Brown J.W.,and Schroder J.,1988,Molecular analysis of resveratrol synthase:cDNA,genomic clones and relationship with chalcone synthase,Eur.J.Biochem.,172(1):161-169
Shi L.,Liu Y.,and Xu X.H.,2016,Research progression of resveratrol on its physiology function,Shipin Yu Yaopin(Food and Drug),8(11):5-8(史丽,刘燕,许现辉,2016,白藜芦醇的生物活性研究进展,食品与药品,8(11):5-8)
Tang J.J.,2011,Activity and mechanism of multi-conjugated resveratrol analogs and curcumionoids as antioxidants and cancer chemopreventive agents,Dissertation for Ph.D.,Lanzhou University,Supervisor:Zhou B.,pp.1-18(汤江江,2011,长共轭链白藜芦醇和姜黄素类似物的抗氧化和癌预防活性机制研究,兰州大学,导师:周波,pp.1-18)
Tian L.R.,Liao B.S.,Huang J.Q.,Wang S.Y.,Lei Y.,Yan L.Y.,and Li D.,2008,Research progress on resveratrol in peanut,Zhongguo Youliao Zuowu Xuebao(Chinese Journal of Oil Crop Sciences),30(4):522-528(田立荣,廖伯寿,黄家权,王圣玉,雷永,晏立英,李栋,2008,花生白藜芦醇研究进展,中国油料作物学报,30(4):522-528)
Wang H.M.,2016,Mechanism of Resistance to aflatoxia production in peanut,Dissertation Ph.D.,Chinese Academy of A-gricultural Sciences,Supervisor:Liao B.S.,pp.73-88(王后苗,2016,花生抗黄曲霉产毒机制的研究,中国农业科学院,导师:廖伯寿,pp.73-88)
Wang K.L.,Zhao X.H.,Zu Y.G.,and Li J.L.,2015,Distribution of resveratrol in different parts of several plants,Zhiwu Yanjiu(Bulletin of Botanical Research),35(4):638-640(王崑仑,赵修华,祖元刚,李家磊,2015,白藜芦醇在几种植物中各部位的分布,植物研究,35(4):638-640)
Wang Q.F.,Wang B.,Zhang R.L.,Ying D.S.,Wang M.,and Li L.P.,2016,Changes of resveratrol content in seedling leaves of different peanut varieties induced by H2O2,Xinan Nongye Xuebao(Southwest China Journal of Agricultural Science),29(9):2086-2092(王琴飞,汪彪,张如莲,应东山,王明,李莉萍,2016,H2O2诱导不同品种花生叶片中白藜芦醇合成变化,西南农业学报,29(9):2086-2092)
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Xiao L.X.,Lu Q.N.,and Li R.G.,2015,Advances in resveratrol studies,Xiandai Nongye Keji(Moder n Agricultural Science and Technology),13(24):264-265(肖林霞,卢其能,李润根,2015,白藜芦醇的研究进展,现代农业科技,13(24):264-265)
Xin P.,Wang Y.Z.,and Sun S.Q.,2012,The applications of hairy root cultures in the research of phytochemical and recombinant protein production,Shizhen Guoyi Guoyao(Lishizhen Medicine and Materia Medica Research),23(11):2750-2752(辛萍,王有志,孙世芹,2012,毛状根培养在植物化学成分和重组药物蛋白研究中的应用,时珍国医国药,23(11):2750-2752)
Yao Q.S.,Jiang J.G.,Shan C.M.,Wu Y.Y.,and Yu M.,2012,High frequency induction of peanut hairy roots and NAAand 2,4-D effects on the growth of peanut hairy roots and resveratrol content,Yaowu Shengwu Jishu(Pharmaceutical Biotechnology),19(6):507-511(姚庆收,姜吉刚,单长民,武玉永,于敏,2012,花生毛状根的高频诱导及NAA和2,4-D对花生毛状根生长和白藜芦醇含量的影响,药物生物技术,19(6):507-511)
Yin X.J.,2016,Transcriptome analysis of vitis.amurensis berries and resveratrol regulation mechanism research,Thesis for M.S.,Northwest A&F University,Supervisor:Wang X.P.,pp.15-27(殷向静,2016,山葡萄果实转录组分析及白藜芦醇调控机理研究,硕士学位论文,西北农林科技大学,导师:王西平,pp.15-27)
Yu M.,2016,Research on resveratrol accumulation and regulation mechanism in the process of peanut germination,Dissertation for Ph.D.,Shenyang Agricultural University,Supervisor:Wang Q.,pp.40-68(于淼,2016,花生发芽过程中白黎芦醇富集技术与机理硏究,博士学位论文,沈阳农业大学,导师:王强,pp.40-68)
Zhang N.,and Liu J.L.,2008,Effects of UV-C and salicylic acid on resveratrol and polydatin induction in leaves of reynoutria japonica,Xibei Zhiwu Xuebao(Acta Botanica Boreali-Occidentalia Sinica),28(5):990-994(张楠,刘建利,2008,UV-C和水杨酸对虎杖叶中白藜芦醇和虎杖苷的诱导作用,西北植物学报,28(5):990-994)
Zhang Y.T.,Huang J.Q.,Lou Q.R.,Yan L.Y.,Lei Y.,and Liao B.S.,2012,Changes in activities of protected enzymes and content of resveratrol in peanut infected with ralstonia solanacearum,Huabei Nongxuebao(Acta Agriculturae Boreali-Sinica),27(6):152-157(张月婷,黄家权,娄庆任,晏立英,雷永,廖伯寿,2012,青枯菌侵染后花生体内保护酶活性及白藜芦醇含量的变化研究,华北农学报,27(6):152-157)
Dai H.J.,Fan Y.,and Zhang Y.,2014,Effect of ethephon and fosetyl-aluminum on the content of resveratrol in the wine grape peel,Beifang Yuanyi(Northern Horticulture),(3):1-5(代红军,范永,张燕,2014,乙烯利和乙磷铝对酿酒葡萄果皮白藜芦醇含量的影响,北方园艺,(3):1-5)
Dang W.,Yu X.H.,and Cao W.,2003,Advance in the research of resveratrol synthas,Zhiwuxue Tongbao(Chinese Bulletin of Botany),20(2):152-159(党尉,尉亚辉,曹炜,2003,白藜芦醇合酶的研究进展,植物学通报,20(2):152-159)
Fu Y.Q.,and Li D.,2014,Resveratrol,Yingyang Xuebao(Acta Nutrimenta Sinica),36(1):13-16(付元庆,李铎,2014,白藜芦醇,营养学报,36(1):13-16)
Huang W.W.,Huang S.E.,Li J.L.,and Li Z.H.,2010,Advances on extraction,determination and biological action of resveratrol,Shipin Yu Jixie(Food&Machinery),26(6):148-152(黄卫文,黄寿恩,黎继烈,李忠海,2010,白藜芦醇的提取、检测技术及其生物活性研究进展,食品与机械,26(6):148-152)
Hung L.M.,Su M.J.,Chu W.K.,Chiao C.W.,Chan W.F.,and Chen J.K.,2002,The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy,Br.J.Pharmacol.,135(7):1627-1633
Ingham J.L.,1976,3,5,4'-Trihydroxystilbene as a phytoalexin from groundnuts Arachis hypogaea,Phytochemistry,15(11):1791-1793
Langcake P.,and Pryce R.J.,1976,The production of resveratrol by vitis vinifera and other members of the Vitaceae as a response to infection or injury,Physiological Plant Pathology,9(1):77-86
Li J.,Xiong Y.X.,Zeng J.G.,and Zhang Y.,2013,Research progress of resveratrol,Zhongguo Xiandai Zhongyao(Modern Chinese Medicine),15(2):100-108(李洁,熊兴耀,曾建国,张莹,2013,白藜芦醇的研究进展,中国现代中药,15(2):100-108)
Li J.M.,Ma L.Y.,and Liu Y.N.,2004,Inducement of UV on the resveratrol in harvested grape,Zhongwai Putao Yu Putaojiu(Sino-Overseas Grapevine&Wine),(4):16-19(李景明,马丽艳,刘艳娜,2004,葡萄采后紫外线(UV)处理对白藜芦醇的诱导作用,中外葡萄与葡萄酒,(4):16-19)
Li X.D.,Zheng X.B.,Yan S.T.,and Li S.H.,2007,Effects of salicylic acid(SA),ultraviolet(UV-B and UV-C)on resveratrol inducement in the skin of harvested grape berries,Guoshu Xuebao(Journal of Fruit Science),24(1):30-33(李晓东,郑先波,闫树堂,李绍华,2007,水杨酸和紫外线对诱导采后葡萄果皮内白藜芦醇合成作用研究,果树学报,24(1):30-33)
Li X.K.,Li H.Y.,Li S.,Song N.N.,Hou X.D.,Zhou W.H.,Cui Y.H.,and Ma L.,2016,Advances in study on resveratrol,Zhongcaoyao(Chinese Traditional and Herbal Drugs),47(14):2568-2578(李先宽,李赫宇,李帅,宋宁宁,侯晓东,周文华,崔雨禾,马琳,2016,白藜芦醇研究进展,中草药,47(14):2568-2578)
Liswidowati,Melchior F.,Hohmann F.,Schwer B.,and Kindl H.,1991,Induction of stilbene synthase by Botrytis cinerea in cultured grapevine cells,Planta,183(2):307-314
Liu L.P.,Gong F.,and Zhao X.N.,2005,Sallcylic acid-mediated signal transduction pathway associated with stress resistance of plants,Zhongguo Nongxue Tongbao(Chinese A-gricultural Science Bulletin),21(7):227-229(刘悦萍,宫飞,赵晓萌,2005,水杨酸介导的信号转导途径与植物抗逆性,中国农学通报,21(7):227-229)
Liu S.N.,Shao S.L.,Sui W.J.,Zhang W.W.,Zhao B.,and Chen W.W.,2015,Resveratrol induces the apoptosis of human lung cancer A549 cells,Jiyinzuxue Yu Yingyong Shengwuxue(Genomics and Applied Biology),34(4):685-691(刘盛楠,邵淑丽,隋文静,张伟伟,赵彬,陈微微,2015,白藜芦醇诱导肺癌A549细胞凋亡,基因组学与应用生物学,34(4):685-691)
Luo K.,Wang Q.F.,Zhang D.,and Li J.M.,2007,Research on the inducement of resveratrol in grapevine leaves by ultraviolet,Zhongwai Putao Yu Putaojiu(Sino-Overseas Grapevine&Wine),(4):4-6(罗葵,王琴飞,张岱,李景明,2007,葡萄叶片中白藜芦醇的紫外线诱导研究,中外葡萄与葡萄酒,(4):4-6)
Ma N.,Wang J.F.,Xu F.,Li Y.,and Li J.,2009,Reviews of reseaches on resveratrol,Changsha Yixueyuan Xuebao(Journal of Changsha Medical College),6(1):43-48(马宁,王建芬,徐芳,李媛,李娟,2009,白藜芦醇的研究概述,长沙医学院学报,6(1):43-48)
Medina-Bolivar F.,Condori J.,Rimando A.M.,Hubstenberger J.,Shelton K.,O'Keefe S.F.,Bennett S.,and Dolan M.C.,2007,Pro-duction and secretion of resveratrol in hairy root cultures of peanut,Phytochemistry,68(14):1992-2003
Ren X.L.,Xing F.,and Xie L.L.,2008,The research and application prospect of peanut esveratrol,Shipinyanjiu Yu Kaifa(Food Research and Development),29(5):163-166(任秀莲,邢峰,解利利,2008,花生中白藜芦醇的研究现状及应用展望,食品研究与开发,29(5):163-166)
Rong R.F.,Feng S.Q.,and Dai Y.Q.,2005,Effect of UV-C irradiation on infection and resverstrol of postharvest grape,Baoxian Yu Jiagong(Storage and Process),5(3):8-9(荣瑞芬,冯双庆,戴蕴青,2005,短波紫外线照射对葡萄采后发病率及白藜芦醇化合物的影响,保鲜与加工,5(3):8-9)
Schroder G.,and Brown J.W.,and Schroder J.,1988,Molecular analysis of resveratrol synthase:cDNA,genomic clones and relationship with chalcone synthase,Eur.J.Biochem.,172(1):161-169
Shi L.,Liu Y.,and Xu X.H.,2016,Research progression of resveratrol on its physiology function,Shipin Yu Yaopin(Food and Drug),8(11):5-8(史丽,刘燕,许现辉,2016,白藜芦醇的生物活性研究进展,食品与药品,8(11):5-8)
Tang J.J.,2011,Activity and mechanism of multi-conjugated resveratrol analogs and curcumionoids as antioxidants and cancer chemopreventive agents,Dissertation for Ph.D.,Lanzhou University,Supervisor:Zhou B.,pp.1-18(汤江江,2011,长共轭链白藜芦醇和姜黄素类似物的抗氧化和癌预防活性机制研究,兰州大学,导师:周波,pp.1-18)
Tian L.R.,Liao B.S.,Huang J.Q.,Wang S.Y.,Lei Y.,Yan L.Y.,and Li D.,2008,Research progress on resveratrol in peanut,Zhongguo Youliao Zuowu Xuebao(Chinese Journal of Oil Crop Sciences),30(4):522-528(田立荣,廖伯寿,黄家权,王圣玉,雷永,晏立英,李栋,2008,花生白藜芦醇研究进展,中国油料作物学报,30(4):522-528)
Wang H.M.,2016,Mechanism of Resistance to aflatoxia production in peanut,Dissertation Ph.D.,Chinese Academy of A-gricultural Sciences,Supervisor:Liao B.S.,pp.73-88(王后苗,2016,花生抗黄曲霉产毒机制的研究,中国农业科学院,导师:廖伯寿,pp.73-88)
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