利培酮和奥氮平治疗首发精神分裂症患者对其认知功能的影响对比
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摘要
目的探讨利培酮和奥氮平治疗首发精神分裂症患者对其认知功能的影响。方法选择2015年12月至2016年12月收治的93例首发精神分裂症患者,随机分为对照组(n=46)与观察组(n=47),对照组采用利培酮治疗,观察组采用奥氮平治疗,比较两组患者认知功能、症状改善情况及药物不良反应发生情况。结果两组患者治疗后韦氏记忆量表(Wechsler Memory Scale,WMS)即刻逻辑、即刻视觉记忆、延迟逻辑、延迟视觉记忆及神经心理成套试验(Halstead-Reitan,HR)数字广度评分均有所上升(P<0.05),且观察组治疗后即刻逻辑、延迟逻辑、数字广度评分明显高于对照组(P<0.05),两组即刻视觉记忆、延迟视觉记忆比较无明显差异(P> 0.05);两组治疗前阳性与阴性症状量表(Positive And Negative Symptom Scale,PANSS)阳性症状、阴性症状及一般精神病理症状比较无明显差异(P> 0.05),治疗后观察组PANSS各项评分均低于对照组(P<0.05);两组药物不良反应方面比较差异无统计学意义(P> 0.05)。结论奥氮平治疗首发精神分裂症患者疗效确切,患者对药物耐受性强,不良反应少,其对患者认知功能及精神病症状的改善作用优于利培酮。
Objective To investigate the effects of risperidone and olanzapine on cognitive function in patients with first-episode schizophrenia. Methods Ninety-three patients with first-episode schizophrenia admitted from December 2015 to December 2016 were randomly divided into the control group(n=46) and the observation group(n=47). The control group was treated with risperidone. The treatment of olanzapine was used to compare the cognitive function, symptom improvement and adverse drug reactions in the two groups. Results The two groups of patients with Wechsler Memory Scale(WMS) immediate logic, immediate visual memory, delay logic, delayed visual memory and neuropsychological test(Halstead-Reitan, HR) digital breadth scores increased(P< 0.05). The immediate logic,delay logic, and digital breadth scores of the observation group were significantly higher than those of the control group(P< 0.05). There was no significant difference between the two groups in immediate visual memory and delayed visual memory(P> 0.05). There were no significant differences between the two groups in the Positive and Negative Symptom Scale(PANSS) positive symptoms, negative symptoms and general psychopathological symptoms(P> 0.05).The scores of PANSS in the observation group were lower than those in the control group(P< 0.05). There was no significant difference in adverse drug reactions between the two groups(P> 0.05). Conclusion Olanzapine is effective in the treatment of patients with first-episode schizophrenia. The patient is highly tolerant to drugs and has few adverse reactions. It is better than risperidone in improving the cognitive function and psychotic symptoms of patients.
Objective To investigate the effects of risperidone and olanzapine on cognitive function in patients with first-episode schizophrenia. Methods Ninety-three patients with first-episode schizophrenia admitted from December 2015 to December 2016 were randomly divided into the control group(n=46) and the observation group(n=47). The control group was treated with risperidone. The treatment of olanzapine was used to compare the cognitive function, symptom improvement and adverse drug reactions in the two groups. Results The two groups of patients with Wechsler Memory Scale(WMS) immediate logic, immediate visual memory, delay logic, delayed visual memory and neuropsychological test(Halstead-Reitan, HR) digital breadth scores increased(P< 0.05). The immediate logic,delay logic, and digital breadth scores of the observation group were significantly higher than those of the control group(P< 0.05). There was no significant difference between the two groups in immediate visual memory and delayed visual memory(P> 0.05). There were no significant differences between the two groups in the Positive and Negative Symptom Scale(PANSS) positive symptoms, negative symptoms and general psychopathological symptoms(P> 0.05).The scores of PANSS in the observation group were lower than those in the control group(P< 0.05). There was no significant difference in adverse drug reactions between the two groups(P> 0.05). Conclusion Olanzapine is effective in the treatment of patients with first-episode schizophrenia. The patient is highly tolerant to drugs and has few adverse reactions. It is better than risperidone in improving the cognitive function and psychotic symptoms of patients.
引文
[1]赵瑾,张燕,晁阳阳,等.利培酮和奥氮平对首发精神分裂症患者治疗前后认知功能的对比观察[J].中华医学杂志,2016,96(37):2960-2964.
[2]胡乃启,张朋,宋宁,等.利培酮联合奥氮平对首发精神分裂症患者血清同型半胱氨酸水平和认知功能及临床疗效的影响[J].河北医学,2016,22(11):1837-1839.
[3]史利利.利培酮联合奥氮平治疗精神分裂症患者疗效及对糖脂代谢的影响[J].临床合理用药杂志,2016,9(2):46-47.
[4]刘怀斌,侯凌峰,王小红,等.奥氮平与利培酮对精神分裂症患者脂代谢的影响[J].河北北方学院学报(自然科学版),2016,32(6):4-7.
[5]张喜艳.奥氮平和利培酮及阿立哌唑治疗慢性精神分裂症认知功能损害的疗效分析[J].中国现代医生,2015,53(1):34-36.
[6]周围.奥氮平与利培酮对首发精神分裂症患者记忆功能及P300的影响[J].深圳中西医结合杂志,2015,25(8):3-4.
[2]胡乃启,张朋,宋宁,等.利培酮联合奥氮平对首发精神分裂症患者血清同型半胱氨酸水平和认知功能及临床疗效的影响[J].河北医学,2016,22(11):1837-1839.
[3]史利利.利培酮联合奥氮平治疗精神分裂症患者疗效及对糖脂代谢的影响[J].临床合理用药杂志,2016,9(2):46-47.
[4]刘怀斌,侯凌峰,王小红,等.奥氮平与利培酮对精神分裂症患者脂代谢的影响[J].河北北方学院学报(自然科学版),2016,32(6):4-7.
[5]张喜艳.奥氮平和利培酮及阿立哌唑治疗慢性精神分裂症认知功能损害的疗效分析[J].中国现代医生,2015,53(1):34-36.
[6]周围.奥氮平与利培酮对首发精神分裂症患者记忆功能及P300的影响[J].深圳中西医结合杂志,2015,25(8):3-4.