颈内动脉血流动力学研究:多尺度单、双向耦合模型对比
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摘要
目的比较多尺度单、双向耦合模型所得颈内动脉中血流动力学差异,为后续研究提供模型选择的参考依据。方法基于1例颈内动脉轻度狭窄患者的核磁图像,构建其Willis环集中参数模型及颈内动脉三维模型,通过单、双向耦合构建两种不同的多尺度模型。结果随着狭窄程度的增加,两种耦合方式下颈内动脉入口及出口血流量、血压均随之减小,颈内动脉低时间平均剪切力和高振荡因子的分布区域均大体上随着狭窄程度增加而增大。双向耦合在70%狭窄时大脑前动脉血管段剪切力较低、振荡因子较高,后交通动脉出现流向改变,与单向耦合结果差异显著。结论在狭窄程度较低时,两种耦合方式的结果大体一致,在70%狭窄时存在显著差异。双向耦合的结果更接近生理参数。研究结果可以更好地应用于脑血管病的血流动力学研究。
Objective To compare the hemodynamic characteristics in internal carotid artery models, which were obtained by multi-scale unidirectional and bidirectional coupling models, so as to provide references for selecting models in further studies. Methods Based on the nuclear magnetic resonance image of one patient with mild stenosis of internal carotid artery, the lumped parameter model of the circle of Willis and the three-dimensional model of internal carotid artery were constructed. Those two different multi-scale models were constructed by unidirectional and bidirectional coupling. Results With the increase of stenosis degree, the inlet and outlet blood pressure and the outlet blood flow of internal carotid artery all decreased under two kinds of coupling method. The distribution of low time average wall shear stress(TAWSS) and high oscillatory shear index(OSI) of the internal carotid artery both increased with the increase of stenosis degree under two kinds of coupling method in general. The anterior cerebral artery segment showed lower shear stress and higher OSI with bidirectional coupling in 70% stenosis, and the blood flow direction of posterior communicating artery was changed, which was significantly different from unidirectional coupling results. Conclusions At a low degree of stenosis, the result of those two kinds of coupling method were consistent in general, but there was a significant difference in 70% stenosis, and the result of bidirectional coupling was closer to physiological parameters. The research findings can be better applied to the hemodynamic study of cerebrovascular diseases.
Objective To compare the hemodynamic characteristics in internal carotid artery models, which were obtained by multi-scale unidirectional and bidirectional coupling models, so as to provide references for selecting models in further studies. Methods Based on the nuclear magnetic resonance image of one patient with mild stenosis of internal carotid artery, the lumped parameter model of the circle of Willis and the three-dimensional model of internal carotid artery were constructed. Those two different multi-scale models were constructed by unidirectional and bidirectional coupling. Results With the increase of stenosis degree, the inlet and outlet blood pressure and the outlet blood flow of internal carotid artery all decreased under two kinds of coupling method. The distribution of low time average wall shear stress(TAWSS) and high oscillatory shear index(OSI) of the internal carotid artery both increased with the increase of stenosis degree under two kinds of coupling method in general. The anterior cerebral artery segment showed lower shear stress and higher OSI with bidirectional coupling in 70% stenosis, and the blood flow direction of posterior communicating artery was changed, which was significantly different from unidirectional coupling results. Conclusions At a low degree of stenosis, the result of those two kinds of coupling method were consistent in general, but there was a significant difference in 70% stenosis, and the result of bidirectional coupling was closer to physiological parameters. The research findings can be better applied to the hemodynamic study of cerebrovascular diseases.
引文
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[13] DEBBICH A,KERKNI A,ABDALLAH AB,et al.Hemodynamic modeling in a stenosed internal carotid artery [C]// Proceedings of International Conference on Computer Graphics,Imaging and Visualization.Australia:IEEE,2016:358-363.
[14] HAN Y,PARK H,KWON SU,et al.Clinical outcomes of carotid endarterectomy in patients with carotid artery tandem lesions [J].Stroke,2014,45(11):3443-3446
[15] ROULEAU PA,GILBERTSON J,BROWN RD,et al.Carotid artery tandem lesions:Frequency of angiographic detection and consequences for endarterectomy [J].Am J Neuroradiol,1999,20(4):621-625.
[2] PIASTRA M,PIZZA A,TONI F,et al.Bedside monitoring of cerebral blood flow in traumatic bilateral internal carotid artery injury [J].J Neurosurg Anesth,2016,29(3):377-379.
[3] WANG BH,LEUNG A,LOWNIE SP.Circle of Willis collateral during temporary internal carotid artery occlusion ii:Observations from computed tomography angiography [J].Can J Neurol Sci,2016,43(4):538-542.
[4] LIU H,LIANG F,WONG J,et al.Multi-scale modeling of hemodynamics in the cardiovascular system [J].Acta Mech Sinic,2015,31(4):446-464.
[5] LAGANà K,BALOSSINO R,MIGLIAVACCA F,et al.Multiscale modeling of the cardiovascular system:Application to the study of pulmonary and coronary perfusions in the univentricular circulation [J].J Biomech,2005,38(38):29-41.
[6] KASHEFI A,MAHDINIA M,FIROOZABADI B,et al.Multidimensional modeling of the stenosed carotid artery:A novel CAD approach accompanied by an extensive lumped model [J].Acta Mech Sinic,2014,30(2):259-273.
[7] LIANG F,OSHIMA M,HUANG H,et al.Numerical study of cerebroarterial hemodynamic changes following carotid artery operation:A comparison between multiscale modeling and stand-alone three-dimensional modeling [J].J Biomech,2015,137(10):101011(1)-101011(12).
[8] RYU J,HU X,SHADDEN SC.A coupled lumped-parameter and distributed network model for cerebral pulse-wave hemodynamics [J].J Biomech,2015,137(10):101009(1)-101009(22).
[9] ZHANG C,WANG L,LI X,et al.Modeling the circle of Willis to assess the effect of anatomical variations on the development of unilateral internal carotid artery stenosis [J].Bio-Med Mater Eng,2014,24(1):491-499.
[10] BARNETT HJ,GUNTON RW,ELIASZIW M,et al.Causes and severity of ischemic stroke in patients with internal carotid artery stenosis [J].J Am Med Assoc,2000,283(11):1429-1436.
[11] 金龙,乔爱科.颈动脉易损斑块的生物力学机制和破裂风险评价指标[J].医用生物力学,2016,31(1):89-94.JING L,QIAO AK.Biomechanical mechanism and quantitative assessment indices for vulnerable carotid plaques [J].J Med Biomech,2016,31(1):89-94.
[12] ANTONOVA N,DONG X,TOSHEVA P,et al.Numerical analysis of 3D blood flow and common carotid artery hemodynamics in the carotid artery bifurcation with stenosis [J].Clin Hemorheol Microcirc,2014,57(2):159-168.
[13] DEBBICH A,KERKNI A,ABDALLAH AB,et al.Hemodynamic modeling in a stenosed internal carotid artery [C]// Proceedings of International Conference on Computer Graphics,Imaging and Visualization.Australia:IEEE,2016:358-363.
[14] HAN Y,PARK H,KWON SU,et al.Clinical outcomes of carotid endarterectomy in patients with carotid artery tandem lesions [J].Stroke,2014,45(11):3443-3446
[15] ROULEAU PA,GILBERTSON J,BROWN RD,et al.Carotid artery tandem lesions:Frequency of angiographic detection and consequences for endarterectomy [J].Am J Neuroradiol,1999,20(4):621-625.
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