利培酮联合低剂量安非他酮对精神分裂症患者阴性症状的疗效
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摘要
目的本研究探讨安非他酮对精神分裂症患者阴性症状的干预效果。方法以某精神病医院住院精神分裂症患者80例为研究对象,研究组在原有利培酮剂量不变的基础上,联用安非他酮150mg/d,对照组原有利培酮剂量不变。两组患者分别于治疗前、治疗后8周后分别接受量表评估。采用阳性与阴性症状量表(PANSS)评定治疗前后患者精神病性症状的变化;以副反应反应量表(TESS)及化验和辅助检查进行安全性评估。结果 PANSS总分及阴性症状分量表分差异有统计学意义(P<0.05)。组间比较以上评估差异有统计学意义(P<0.05),研究组优于对照组。结论利培酮联合低剂量安非他酮可以改善精神分裂症患者的阴性症状。
Objective The research is to explore the effect of bupropion on negative symptom in patients with schizophrenia. Method We selected 80 cases of hospitalized patients with schizophrenia who are use risperidone only from A mental hospital,Patients were randomly divided into the Study Group and the Control Group,the study group added bupropion(150 mg,qd),the control group added placebo instead. The two groups were evaluated before and after 8 weeks of treatment respectively. The positive and negative symptom scale(PANSS)was used to evaluate the changes of psychotic symptoms before and after treatment. The side effects scale(TESS)and laboratory tests and auxiliary examinations were used for safety assessment. Result Study group :After 8 weeks of treatment,There was a significant change in the total score of PANSS and the scale of negative symptoms(P<0.05). The study group was better than the control group. Conclusion Low-dose bupropion combined with risperidone may improve the negative symptom of patients with schizophrenia.
Objective The research is to explore the effect of bupropion on negative symptom in patients with schizophrenia. Method We selected 80 cases of hospitalized patients with schizophrenia who are use risperidone only from A mental hospital,Patients were randomly divided into the Study Group and the Control Group,the study group added bupropion(150 mg,qd),the control group added placebo instead. The two groups were evaluated before and after 8 weeks of treatment respectively. The positive and negative symptom scale(PANSS)was used to evaluate the changes of psychotic symptoms before and after treatment. The side effects scale(TESS)and laboratory tests and auxiliary examinations were used for safety assessment. Result Study group :After 8 weeks of treatment,There was a significant change in the total score of PANSS and the scale of negative symptoms(P<0.05). The study group was better than the control group. Conclusion Low-dose bupropion combined with risperidone may improve the negative symptom of patients with schizophrenia.
引文
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2.中华医学会精神科分会.中国精神疾病分类方案与诊断标准[M].第3版.济南:山东科学技术出版社,2010:175-176.
3.徐逸,陆峥.精神分裂症患者认知功能障碍评估与治疗[J].世界临床药物,2016,37(1):8-11.
4.Emslry R,Kilian S,Phahladira L.How long should antipsychotic treatment be continued after a single episode of schizophrenia?[J].Curr Opin Psychiatry,2016,29(3):224-229.
5.Miyamoto S,Duncan GE,Marx CE,et al.Treatments for schizophrenia:a critical review of pharmacology and mechanisms of action of antipsychotic drugs[J].Molecular Psychiatry,2005,10(1):79.
6.司天梅.精神分裂症首次发作患者早期治疗对预后的影响[J].中华精神科杂志,2018,51(1):68-69.
7.Milev P,Ho B C,Arndt S,et al.Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia:a longitudinal first-episode study with 7-year follow up[J].Am J Psychiatry,2005,162(3):495-506
8.郝伟,于欣.精神病学[M].第7版.北京:人民卫生出版社,2014:93-99.
9.江春运.去甲肾上腺素与精神病理[J].国外医学:精神病学分册,2003,30(4):196-198.
10.Wilkes S.Bupropion[J].Drugs Today,2006,42(10):671-681.
11.Tsoi DT,Porwal MWebster AC.Efficacy and safety of bupropion for smoking cessation and reduction in schizophrenia:systematic review and meta-analysis[J].British Journal of Psychiatry the Journal of Mental Science,2010,196(5):346.