枸杞延缓衰老的研究进展
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摘要
分别从枸杞的果实、叶和根3部分,阐述其延缓衰老的作用机制,为其进一步系统研究提供参考和借鉴。认为枸杞作为我国药食兼用的植物资源,有抗氧化、神经保护、抗衰老、清除自由基、抗辐射、降血糖、抗炎等功效,尤其有较好的抗衰老作用。
In this paper, the mechanism of delaying aging is expounded from the three parts of Lycium's fruit, leaf and root, to provide reference and reference for further systematic research. As a plant resource for both medicine and food in China, Lycium shows the effects of anti-oxidation, neuroprotection, anti-aging, free radical scavenging, anti-radiation, hypoglycemic and anti-inflammatory, especially with good anti-aging effects.
In this paper, the mechanism of delaying aging is expounded from the three parts of Lycium's fruit, leaf and root, to provide reference and reference for further systematic research. As a plant resource for both medicine and food in China, Lycium shows the effects of anti-oxidation, neuroprotection, anti-aging, free radical scavenging, anti-radiation, hypoglycemic and anti-inflammatory, especially with good anti-aging effects.
引文
[1]XIA X,JIANG Q,MCDERMOTT J,et al.Aging and Alzheimer's disease:Comparison and associations from molecular to system level[J].Aging Cell,2018,6(2):12802.
[2]SIMIONI C,ZAULI G,MARTELLI A M,et al.Oxidative stress:role of physical exercise and antioxidant nutraceuticals in adulthood and aging[J].Oncotarget,2018,9(24):17181-17198.
[3]BUTTERFIELD DA.Perspectives on Oxidative Stress in Alzheimer's Disease and Predictions of Future Research Emphases[J].J Alzheimers Dis,2018,64(1):469-479.
[4]SIDDIQUE Y H,NAZ F,JYOTI S.Effect of capsaicin on the oxidative stress and dopamine content in the transgenic Drosophila model of Parkinson's disease[J].Acta Biol Hung,2018,69(2):115-124.
[5]OBERACKER T,BAJORAT J,ZIOLA S,et al.Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging[J].FEBS Lett,2018,13(1):5-7.
[6]PRASAD KN,WU M,BONDY S C.Telomere shortening during aging:Attenuation by antioxidants and anti-inflammatory agents[J].Mech Ageing Dev,2017,16(4):61-66.
[7]MACH J,HHIZER-PAJKOS A,KANE A,et al.The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats[J].Exp Gerontol,2015,67(1):54-61.
[8]SALMINEN A,KAUPPINEN A,KAARNIRANTA K.E-merging role of NF-κB signaling in the induction of senescence-associated secretory phenotype(SASP)[J].Cell Signal.2012,24(4):835-845.
[9]周晶,李光华.枸杞的化学成分与药理作用研究综述[J].辽宁中医药大学学报,2009,26(6):22-24.
[10]AMEGASE H,FARNSWORTH NR.A review of botanical characteristics,phytochemistry,clinical relevance in efficacy and safety of Lycium barbarum fruit(Goji)[J].Food Res Inter,2011,44(7):1702-1707.
[11]CHANG R C C,SO KF.Use of anti-aging herbal medicine,Lycium barbarum,against aging-associated diseases.What do we know so far?[J].Cell Mol Neurobiol,2008,28(5):643-652.
[12]赵明宇.枸杞子的药理作用及临床应用研究[J].北方药学,2018,15(4):156.
[13]LUO Q,CAI Y,YAN J,et al.Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum[J].Life Sci,2004,76(1):137-149.
[14]程桂花.枸杞子抗衰老作用的临床研究[J].中国医药指南,2012,10(34):287-288.
[15]计晶晶,韩丽莎,徐军,等.枸杞对D-半乳糖致衰老小鼠学习记忆影响[J].中国公共卫生,2007,23(3):359-360.
[16]孙伟,苗珍花,王亚娜,等.宁夏枸杞全果对自然衰老小鼠认知及其脑组织中α7nAChR表达的影响[J].山东医药,2010,50(30):31-33.
[17]徐曼妮,张欣文,徐思红.枸杞胶囊对果蝇的延缓衰老作用[J].同济大学学报(医学版),2001,22(4):6-7,13.
[18]LUO Q,CAI Y,YAN J,et al.Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum[J].Life Sci,2004,76(1):137-149.
[19]周旋.枸杞多糖粗提物抗衰老作用及其与信号传导系统Ca2+-CaM的相关性研究[D].乌鲁木齐:新疆农业大学,2009.
[20]YI R,LIU X M,DONG Q,et al.A Study of Lycium Barbarum Polysaccharides(LBP)Extraction Technology and Its Anti-Aging Effect[J].Afr J Tradit Complement Altern Med,2013,10(4):171-174.
[21]任丹.枸杞多糖对AD模型小鼠海马齿状回神经发生和小胶质细胞的影响[D].南宁:广西医科大学,2009.
[22]GAO S M,DU J L,HEI Q H,et al.Lycium barbarum polysaccharide protects against neurotoxicity via the Nrf2-HO-1 pathway[J].Exp Ther Med,2017,14(5):4919-4927.
[23]WU C X,WANG T F,YU J Q,et al.Lycium barbarum Polysaccharide Pretreatment Attenuates Cerebral Ischemic Reperfusion Injury by Inhibiting Apoptosis in Mice[J].Zhong Yao Cai,2015,38(7):1454-1459.
[24]ZHU J,ZHANG Y,SHEN Y,et al.Lycium barbarum polysaccharides induce Toll-like receptor 2-and 4-mediated phenotypic and functional maturation of murine dendritic cells via activation of NF-κB[J].Mol Med Rep,2013,8(8):1216-1220.
[25]ZHAO B T,JEONG S Y,HWANGBO K,et al.Quantitative analysis of betaine in Lycii Fructus by HILIC-ELSD[J].Arch Pharm Res,2013,36(1):1231-1237.
[26]IM AR,LEE HJ,YOUN U J,et al.Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice[J].Mol Med Rep,2016,13(1):823-828.
[27]GO E K,JUNG K J,KIM J Y,et al.Betaine suppresses proinflammatory signaling during aging:the involvement of nuclear factor-kappaB via nuclear factorinducing kinase/IkappaB kinase and mitogen-activated protein kinases[J].J Gerontol A Biol Sci Med Sci,2005,60(1):1252-1264.
[28]GO E K,JUNG K J,KIM J M,et al.Betaine modulates age-related NF-kappaB by thiol-enhancing action[J].Biol Pharm Bull.2007,30(1):2244-2249.
[29]张自萍,黄文波,廖国玲,等.枸杞子提取液抗氧化活性的研究[J].西北植物学报,2007,27(5):943-946.
[30]AMAGASE H,SUN B,NANCE D M.Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects[J].J Med Food.2009,12(5):1159-1165.
[31]ZHANG Q,DU X,XU Y,et al.The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer’s disease[J].Exp Ther Med,2013,5(5):1528-1530.
[32]GAO J,CHEN C,LIU Y,et al.Lycium barbarum polysaccharide improves traumatic cognition via reversing imbalance of apoptosis/regeneration in hippocampal neurons after stress[J].Life Sci,2015,12(1):124-134.
[33]晏林,张静,刘翔宇,等.枸杞子提取物对改善小鼠学习记忆影响[J].中国公共卫生,2015,31(12):1613-1615.
[34]WU B Y,ZOU J H,MENG S C.Effect of wolfberry fruit and epimedium on DNA synthesis of the agingyouth 2BS fusion cells[J].Zhongguo Zhong Xi Yi Jie He Za Zhi,2003,23(12):926-928.
[35]邹俊华,梁红业,闵凌峰,等.枸杞子的抗衰老功效及增强DNA修复能力的作用[J].中国临床康复,2005,9(11):132-133.
[36]马晓燕,吴茂玉,朱风涛,等.枸杞籽油的生理功能及提取方法的研究进展[J].中国果菜,2013,33(5):37-40.
[37]吴璟,张晓艳,李红兵,等.枸杞籽油对慢性脑低灌注损伤大鼠的保护作用[J].华西药学杂志,2013,28(2):150-151.
[38]陈雅林,谭芳,彭勇.枸杞叶的研究进展[J].中国药学杂志,2017,52(5):358-361.
[39]全娜,王琦,李宣仪,等.枸杞叶、果的抗氧化和抗DNA损伤活性研究[J].天然产物研究与开发,2018,30(1):134-140.
[40]PREZJIM N J,SERRANO J,TABERNERO M,et al.Bioavailability of phenolic antioxidants associated with dietary fiber:plasma antioxidant capacity after acute and long-term intake in humans[J].Plant Food Hum Nut,2009,64(2):102-110.
[41]徐少清.枸杞叶总黄酮对小鼠脑缺血再灌注的保护作用[D].兰州:兰州大学,2016.
[42]徐龙飞.枸杞叶总黄酮的提取及其对染铅小鼠学习记忆的影响[D].兰州:兰州大学,2013.
[43]吕燕红.枸杞叶总黄酮对UVB照射致无毛小鼠皮肤光损伤的防护作用研究[D].兰州:兰州大学,2016.
[44]李进,李淑珍,冯文娟,等.黑果枸杞叶总黄酮的体外抗氧化活性研究[J].食品科学,2010,31(13):259-262.
[45]陈海军.宁夏无果枸杞芽提取物对自然衰老小鼠的抗衰老作用研究[D].银川:宁夏医科大学,2014.
[46]韩怀钦,卢经纬,陈海军,等.宁夏无果枸杞叶提取物对衰老小鼠海马神经细胞增殖及凋亡的影响[J].神经解剖学杂志,2017,33(1):29-35.
[47]水栋.枸杞叶醇提物中对小胶质细胞保护作用成分的研究[D].银川:宁夏医科大学,2015.
[48]马天宇,王磊,金铃和,等.地骨皮化学成分及生物活性研究[J].中国果菜,2018,38(5):9-13.
[49]霍揽明,郑新恒,陈芳,等.地骨皮水提取物的化学成分[J].暨南大学学报(自然科学与医学版),2017,38(5):443-449.
[50]张秀云,周凤琴.地骨皮药理及临床应用研究进展[J].广州化工,2012,40(7):48-49,59.
[51]陈忻,周建平,李玉红.大黄等中药抗自由基损伤研究[J].北京中医,1995,14(5):48-49.
[52]金凌洁.表面活性剂、超声、酶解组合协同提取地骨皮有效成分的工艺研究[D].上海:华东理工大学,2012.
[53]段淑芳,叶真,黄琦,等.地骨皮调控H2O2所致内皮细胞凋亡的有效部位及相关信号通路研究[J].中华中医药学刊,2010,28(10):2162-2166.
[54]王迎昌,叶真.地骨皮提取液对H2O2诱导的人脐静脉内皮细胞凋亡的影响[J].中华中医药学刊,2010,28(7):1405-1408.
[2]SIMIONI C,ZAULI G,MARTELLI A M,et al.Oxidative stress:role of physical exercise and antioxidant nutraceuticals in adulthood and aging[J].Oncotarget,2018,9(24):17181-17198.
[3]BUTTERFIELD DA.Perspectives on Oxidative Stress in Alzheimer's Disease and Predictions of Future Research Emphases[J].J Alzheimers Dis,2018,64(1):469-479.
[4]SIDDIQUE Y H,NAZ F,JYOTI S.Effect of capsaicin on the oxidative stress and dopamine content in the transgenic Drosophila model of Parkinson's disease[J].Acta Biol Hung,2018,69(2):115-124.
[5]OBERACKER T,BAJORAT J,ZIOLA S,et al.Enhanced expression of thioredoxin-interacting-protein regulates oxidative DNA damage and aging[J].FEBS Lett,2018,13(1):5-7.
[6]PRASAD KN,WU M,BONDY S C.Telomere shortening during aging:Attenuation by antioxidants and anti-inflammatory agents[J].Mech Ageing Dev,2017,16(4):61-66.
[7]MACH J,HHIZER-PAJKOS A,KANE A,et al.The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats[J].Exp Gerontol,2015,67(1):54-61.
[8]SALMINEN A,KAUPPINEN A,KAARNIRANTA K.E-merging role of NF-κB signaling in the induction of senescence-associated secretory phenotype(SASP)[J].Cell Signal.2012,24(4):835-845.
[9]周晶,李光华.枸杞的化学成分与药理作用研究综述[J].辽宁中医药大学学报,2009,26(6):22-24.
[10]AMEGASE H,FARNSWORTH NR.A review of botanical characteristics,phytochemistry,clinical relevance in efficacy and safety of Lycium barbarum fruit(Goji)[J].Food Res Inter,2011,44(7):1702-1707.
[11]CHANG R C C,SO KF.Use of anti-aging herbal medicine,Lycium barbarum,against aging-associated diseases.What do we know so far?[J].Cell Mol Neurobiol,2008,28(5):643-652.
[12]赵明宇.枸杞子的药理作用及临床应用研究[J].北方药学,2018,15(4):156.
[13]LUO Q,CAI Y,YAN J,et al.Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum[J].Life Sci,2004,76(1):137-149.
[14]程桂花.枸杞子抗衰老作用的临床研究[J].中国医药指南,2012,10(34):287-288.
[15]计晶晶,韩丽莎,徐军,等.枸杞对D-半乳糖致衰老小鼠学习记忆影响[J].中国公共卫生,2007,23(3):359-360.
[16]孙伟,苗珍花,王亚娜,等.宁夏枸杞全果对自然衰老小鼠认知及其脑组织中α7nAChR表达的影响[J].山东医药,2010,50(30):31-33.
[17]徐曼妮,张欣文,徐思红.枸杞胶囊对果蝇的延缓衰老作用[J].同济大学学报(医学版),2001,22(4):6-7,13.
[18]LUO Q,CAI Y,YAN J,et al.Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum[J].Life Sci,2004,76(1):137-149.
[19]周旋.枸杞多糖粗提物抗衰老作用及其与信号传导系统Ca2+-CaM的相关性研究[D].乌鲁木齐:新疆农业大学,2009.
[20]YI R,LIU X M,DONG Q,et al.A Study of Lycium Barbarum Polysaccharides(LBP)Extraction Technology and Its Anti-Aging Effect[J].Afr J Tradit Complement Altern Med,2013,10(4):171-174.
[21]任丹.枸杞多糖对AD模型小鼠海马齿状回神经发生和小胶质细胞的影响[D].南宁:广西医科大学,2009.
[22]GAO S M,DU J L,HEI Q H,et al.Lycium barbarum polysaccharide protects against neurotoxicity via the Nrf2-HO-1 pathway[J].Exp Ther Med,2017,14(5):4919-4927.
[23]WU C X,WANG T F,YU J Q,et al.Lycium barbarum Polysaccharide Pretreatment Attenuates Cerebral Ischemic Reperfusion Injury by Inhibiting Apoptosis in Mice[J].Zhong Yao Cai,2015,38(7):1454-1459.
[24]ZHU J,ZHANG Y,SHEN Y,et al.Lycium barbarum polysaccharides induce Toll-like receptor 2-and 4-mediated phenotypic and functional maturation of murine dendritic cells via activation of NF-κB[J].Mol Med Rep,2013,8(8):1216-1220.
[25]ZHAO B T,JEONG S Y,HWANGBO K,et al.Quantitative analysis of betaine in Lycii Fructus by HILIC-ELSD[J].Arch Pharm Res,2013,36(1):1231-1237.
[26]IM AR,LEE HJ,YOUN U J,et al.Orally administered betaine reduces photodamage caused by UVB irradiation through the regulation of matrix metalloproteinase-9 activity in hairless mice[J].Mol Med Rep,2016,13(1):823-828.
[27]GO E K,JUNG K J,KIM J Y,et al.Betaine suppresses proinflammatory signaling during aging:the involvement of nuclear factor-kappaB via nuclear factorinducing kinase/IkappaB kinase and mitogen-activated protein kinases[J].J Gerontol A Biol Sci Med Sci,2005,60(1):1252-1264.
[28]GO E K,JUNG K J,KIM J M,et al.Betaine modulates age-related NF-kappaB by thiol-enhancing action[J].Biol Pharm Bull.2007,30(1):2244-2249.
[29]张自萍,黄文波,廖国玲,等.枸杞子提取液抗氧化活性的研究[J].西北植物学报,2007,27(5):943-946.
[30]AMAGASE H,SUN B,NANCE D M.Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects[J].J Med Food.2009,12(5):1159-1165.
[31]ZHANG Q,DU X,XU Y,et al.The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer’s disease[J].Exp Ther Med,2013,5(5):1528-1530.
[32]GAO J,CHEN C,LIU Y,et al.Lycium barbarum polysaccharide improves traumatic cognition via reversing imbalance of apoptosis/regeneration in hippocampal neurons after stress[J].Life Sci,2015,12(1):124-134.
[33]晏林,张静,刘翔宇,等.枸杞子提取物对改善小鼠学习记忆影响[J].中国公共卫生,2015,31(12):1613-1615.
[34]WU B Y,ZOU J H,MENG S C.Effect of wolfberry fruit and epimedium on DNA synthesis of the agingyouth 2BS fusion cells[J].Zhongguo Zhong Xi Yi Jie He Za Zhi,2003,23(12):926-928.
[35]邹俊华,梁红业,闵凌峰,等.枸杞子的抗衰老功效及增强DNA修复能力的作用[J].中国临床康复,2005,9(11):132-133.
[36]马晓燕,吴茂玉,朱风涛,等.枸杞籽油的生理功能及提取方法的研究进展[J].中国果菜,2013,33(5):37-40.
[37]吴璟,张晓艳,李红兵,等.枸杞籽油对慢性脑低灌注损伤大鼠的保护作用[J].华西药学杂志,2013,28(2):150-151.
[38]陈雅林,谭芳,彭勇.枸杞叶的研究进展[J].中国药学杂志,2017,52(5):358-361.
[39]全娜,王琦,李宣仪,等.枸杞叶、果的抗氧化和抗DNA损伤活性研究[J].天然产物研究与开发,2018,30(1):134-140.
[40]PREZJIM N J,SERRANO J,TABERNERO M,et al.Bioavailability of phenolic antioxidants associated with dietary fiber:plasma antioxidant capacity after acute and long-term intake in humans[J].Plant Food Hum Nut,2009,64(2):102-110.
[41]徐少清.枸杞叶总黄酮对小鼠脑缺血再灌注的保护作用[D].兰州:兰州大学,2016.
[42]徐龙飞.枸杞叶总黄酮的提取及其对染铅小鼠学习记忆的影响[D].兰州:兰州大学,2013.
[43]吕燕红.枸杞叶总黄酮对UVB照射致无毛小鼠皮肤光损伤的防护作用研究[D].兰州:兰州大学,2016.
[44]李进,李淑珍,冯文娟,等.黑果枸杞叶总黄酮的体外抗氧化活性研究[J].食品科学,2010,31(13):259-262.
[45]陈海军.宁夏无果枸杞芽提取物对自然衰老小鼠的抗衰老作用研究[D].银川:宁夏医科大学,2014.
[46]韩怀钦,卢经纬,陈海军,等.宁夏无果枸杞叶提取物对衰老小鼠海马神经细胞增殖及凋亡的影响[J].神经解剖学杂志,2017,33(1):29-35.
[47]水栋.枸杞叶醇提物中对小胶质细胞保护作用成分的研究[D].银川:宁夏医科大学,2015.
[48]马天宇,王磊,金铃和,等.地骨皮化学成分及生物活性研究[J].中国果菜,2018,38(5):9-13.
[49]霍揽明,郑新恒,陈芳,等.地骨皮水提取物的化学成分[J].暨南大学学报(自然科学与医学版),2017,38(5):443-449.
[50]张秀云,周凤琴.地骨皮药理及临床应用研究进展[J].广州化工,2012,40(7):48-49,59.
[51]陈忻,周建平,李玉红.大黄等中药抗自由基损伤研究[J].北京中医,1995,14(5):48-49.
[52]金凌洁.表面活性剂、超声、酶解组合协同提取地骨皮有效成分的工艺研究[D].上海:华东理工大学,2012.
[53]段淑芳,叶真,黄琦,等.地骨皮调控H2O2所致内皮细胞凋亡的有效部位及相关信号通路研究[J].中华中医药学刊,2010,28(10):2162-2166.
[54]王迎昌,叶真.地骨皮提取液对H2O2诱导的人脐静脉内皮细胞凋亡的影响[J].中华中医药学刊,2010,28(7):1405-1408.