浅析面瘫动物模型的制备与比较
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摘要
目的对面瘫动物不同模型相关文献进行检索,分析各种模型制备方法的优缺点,探寻适合不同研究类型模型的制备方法,从而为面瘫动物模型的制备提供实验依据。方法检索近十年来面瘫动物模型制备的相关文献,对各种实验动物及造模方法进行归纳总结。结果目前面瘫模型制备使用较多的动物有大鼠、小鼠、日本大耳白兔等,造模方法有面神经切断法、压榨法、牵拉法等。结论目前面瘫模型的制备方法较多,各有优缺点,根据研究目的不同选择不同的造模方法,才能给针灸治疗面瘫提供科学依据。
Objective To search the relevant literature of different models of facial paralysis, analyze the advantages and disadvantages of various models, and explore the production method suitable for different types of models, so as to provide experimental evidence for making animal models of facial paralysis. Method The related literatures about animal models of facial paralysis have been searched in the past decade, and various experimental animals and modeling method have been summarized. Result At present, most animals used in facial paralysis model are rats, mice and Japanese white rabbits. The method of facial nerve transection, compression and traction are the method of modeling. Conclusion There are many ways to make facial paralysis model, each has its own advantages and disadvantages. According to different research purposes, it is possible to explain the acupuncture treatment of facial paralysis.
Objective To search the relevant literature of different models of facial paralysis, analyze the advantages and disadvantages of various models, and explore the production method suitable for different types of models, so as to provide experimental evidence for making animal models of facial paralysis. Method The related literatures about animal models of facial paralysis have been searched in the past decade, and various experimental animals and modeling method have been summarized. Result At present, most animals used in facial paralysis model are rats, mice and Japanese white rabbits. The method of facial nerve transection, compression and traction are the method of modeling. Conclusion There are many ways to make facial paralysis model, each has its own advantages and disadvantages. According to different research purposes, it is possible to explain the acupuncture treatment of facial paralysis.
引文
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[2] Choi J W,Park Y H.Facial Nerve Paralysis in Patients With Chronic Ear Infections:Surgical Outcomes and Radiologic Analysis[J].Clin Exp Otorhinolaryngol,2015,8(3):218-223.
[3] Gagyor I,Madhok V B,Daly F,et al.Antiviral treatment for Bell's palsy (idiopathicfacial paralysis)[J].Cochrane Database Syst Rev,2015,11:CD001869.
[4] 李健东,赵亮,王佳,等.贝尔麻痹的发病诱因调查[J].中国耳鼻咽喉头颈外科,2006,13(2):95-96.
[5] 戴晓蓉,王继华,陈杰,等.神经电生理检测指标对周围性面神经麻痹的预后判断价值[J].中国临床神经科学,2014,22(4):421-425.
[6] 王拥军.神经内科学高级教程[M].北京:人民军医出版社,2014.
[7] Vakharia K.Bell's Palsy[J].Facial Plast Surg Clin North Am,2016,24(1):1-10.
[8] 王俊,虞彬艳,周斯斯,等.粗针神道穴平刺对周围性面瘫大鼠面神经基因表达谱的影响[J].中华中医药杂志,2016,31(1):287-291.
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[11] 李昕蓉,张勤修.面瘫动物模型的研究现状[J].中华中医药杂志,2012,27(11):2903-2906.
[12] 彭晓华,孙运花,李瑛,等.面神经损伤动物模型的实验观察[J].四川中医,2009,27(12):20-21.
[13] Jang C H,Cho Y B,Choi C H.Effect of ginkgo biloba extract on recovery after facial nerve crush injury in the rat[J].Int J Pediatr Otorhi-nolaryngol,2012,76(12):1823-1826.
[14] 虞彬艳,宣丽华,吕善广,等.粗针督脉平刺治疗缺血性面瘫大鼠的机制探讨[J].上海针灸杂志,2015,34(3):256-259.
[15] 王杰,戴春富,赵晖,等.大鼠缺血性面神经瘫痪动物模型的建立[J].临床耳鼻咽喉头颈外科杂志,1999,13(10):464-465.
[16] 苏莉莎,冯俊,杜经纬,等.葛根素对面运动神经元的营养保护作用[J].贵阳医学院学报,2013,38(6):632-634.
[17] Hato N,Kohno H,Yamada H,et al.Role of nitric oxide in the on-set of facial nerve palsy by HSV-1 infection[J].JAMA Otolaryngol Head Neck Surg,2013,139(12):1339-1342.
[18] 古林涛,王海波,李建峰,等.病毒性面瘫小鼠脾脏糖皮质激素受体表达的研究[J].山东大学学报,2012,50(3):44-49.
[19] 卫彦,寇吉友.电针对兔实验性周围性面瘫干预作用量效关系的影响[J].上海针灸杂志,2014,33(6):589-591.
[20] 王宇娟,李克勇,刘景全,等.建立“人工面神经技术”恢复周围性面瘫兔的闭眼功能[J].现代生物医学进展,2011,11(15):2828-2831.
[21] 朱鴷.面神经离断伤后核团微环境中NG2蛋白表达和NG2阳性细胞反应的研究[D].上海:第二军医大学,2010.
[22] 孙健,董玙,谢富强,等.骨形态发生蛋白 2 与壳聚糖神经支架复合体修复兔面神经损伤[J].中国组织工程研究与临床康复,2008,12(10):1811-1813.
[23] 唐宏智,陈大帅,李瑛.面瘫不同动物模型的制备与比较[J].河南中医,2013,33(6):947-948.
[24] 王恺,徐丽蓉,罗德懦,等.家兔急性实验性面神经损伤的组织病理观察[J].华西医科大学学报,2001,32(1):70-72.
[25] 牙祖蒙,陈宗基,王建华,等.弦式加载法延长面神经模型的建立[J].中国修复重建外科杂志,2000,14(2):90-92.
[26] Zealear D L,Bryant G L Jr,Logan M B,et al.An investigation of acutefacial paralys is in an mials induced by exposu re of the tym-panicmem-brane to cold air:Otolaryngol[J].Head Neck Surg,1995,113(6):760-765.
[27] Kumoi T,Iritani H,Nishmiura Y,et al.Anmial model for ische-mic facial nerve paralysis with select ivevascular embolization[J].AnnOtol Rhinol Laryngo,1992,101(5):423-429.
[28] 王杰,戴春富,赵晖,等.大鼠缺血性面神经瘫痪动物模型的建立[J].临床耳鼻咽喉科杂志,1999,13(10):464-465.
[29] Carreno M,Llorente J,Melón S,et al.Use of double PCR in an experimental mode of HSV-1 infection of the facial nerve[J].Acta Otorrinolaringol Esp,1999,50(7):512-518.
[30] Jiang T,Wang H B,Fan Z M,et al.Prevention of facial nerve paralysis induced by herpes simplex virus type 1(HSV-1) in mouse and establishment of a relapse model induced by reactiva-tion of latent HSV-1[J].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2007,42(9):683-686.
[31] Wang H B,Feng H Y,Fan Z M,et al.Experimental study of thefacial nerve paralysis induced by herpes simplex virus type 1 in-fection in mice[J].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2006,41(1):13-16.
[2] Choi J W,Park Y H.Facial Nerve Paralysis in Patients With Chronic Ear Infections:Surgical Outcomes and Radiologic Analysis[J].Clin Exp Otorhinolaryngol,2015,8(3):218-223.
[3] Gagyor I,Madhok V B,Daly F,et al.Antiviral treatment for Bell's palsy (idiopathicfacial paralysis)[J].Cochrane Database Syst Rev,2015,11:CD001869.
[4] 李健东,赵亮,王佳,等.贝尔麻痹的发病诱因调查[J].中国耳鼻咽喉头颈外科,2006,13(2):95-96.
[5] 戴晓蓉,王继华,陈杰,等.神经电生理检测指标对周围性面神经麻痹的预后判断价值[J].中国临床神经科学,2014,22(4):421-425.
[6] 王拥军.神经内科学高级教程[M].北京:人民军医出版社,2014.
[7] Vakharia K.Bell's Palsy[J].Facial Plast Surg Clin North Am,2016,24(1):1-10.
[8] 王俊,虞彬艳,周斯斯,等.粗针神道穴平刺对周围性面瘫大鼠面神经基因表达谱的影响[J].中华中医药杂志,2016,31(1):287-291.
[9] 韦英姿,宣丽华.周围性面瘫动物模型的制备与应用现状[J].江西中医药大学学报,2014,26(6):90-93.
[10] 张微,孙运花,史庆卫,等.电针对面神经损伤兔面神经超微结构的影响[J].针刺研究,2012,37(4):296-301.
[11] 李昕蓉,张勤修.面瘫动物模型的研究现状[J].中华中医药杂志,2012,27(11):2903-2906.
[12] 彭晓华,孙运花,李瑛,等.面神经损伤动物模型的实验观察[J].四川中医,2009,27(12):20-21.
[13] Jang C H,Cho Y B,Choi C H.Effect of ginkgo biloba extract on recovery after facial nerve crush injury in the rat[J].Int J Pediatr Otorhi-nolaryngol,2012,76(12):1823-1826.
[14] 虞彬艳,宣丽华,吕善广,等.粗针督脉平刺治疗缺血性面瘫大鼠的机制探讨[J].上海针灸杂志,2015,34(3):256-259.
[15] 王杰,戴春富,赵晖,等.大鼠缺血性面神经瘫痪动物模型的建立[J].临床耳鼻咽喉头颈外科杂志,1999,13(10):464-465.
[16] 苏莉莎,冯俊,杜经纬,等.葛根素对面运动神经元的营养保护作用[J].贵阳医学院学报,2013,38(6):632-634.
[17] Hato N,Kohno H,Yamada H,et al.Role of nitric oxide in the on-set of facial nerve palsy by HSV-1 infection[J].JAMA Otolaryngol Head Neck Surg,2013,139(12):1339-1342.
[18] 古林涛,王海波,李建峰,等.病毒性面瘫小鼠脾脏糖皮质激素受体表达的研究[J].山东大学学报,2012,50(3):44-49.
[19] 卫彦,寇吉友.电针对兔实验性周围性面瘫干预作用量效关系的影响[J].上海针灸杂志,2014,33(6):589-591.
[20] 王宇娟,李克勇,刘景全,等.建立“人工面神经技术”恢复周围性面瘫兔的闭眼功能[J].现代生物医学进展,2011,11(15):2828-2831.
[21] 朱鴷.面神经离断伤后核团微环境中NG2蛋白表达和NG2阳性细胞反应的研究[D].上海:第二军医大学,2010.
[22] 孙健,董玙,谢富强,等.骨形态发生蛋白 2 与壳聚糖神经支架复合体修复兔面神经损伤[J].中国组织工程研究与临床康复,2008,12(10):1811-1813.
[23] 唐宏智,陈大帅,李瑛.面瘫不同动物模型的制备与比较[J].河南中医,2013,33(6):947-948.
[24] 王恺,徐丽蓉,罗德懦,等.家兔急性实验性面神经损伤的组织病理观察[J].华西医科大学学报,2001,32(1):70-72.
[25] 牙祖蒙,陈宗基,王建华,等.弦式加载法延长面神经模型的建立[J].中国修复重建外科杂志,2000,14(2):90-92.
[26] Zealear D L,Bryant G L Jr,Logan M B,et al.An investigation of acutefacial paralys is in an mials induced by exposu re of the tym-panicmem-brane to cold air:Otolaryngol[J].Head Neck Surg,1995,113(6):760-765.
[27] Kumoi T,Iritani H,Nishmiura Y,et al.Anmial model for ische-mic facial nerve paralysis with select ivevascular embolization[J].AnnOtol Rhinol Laryngo,1992,101(5):423-429.
[28] 王杰,戴春富,赵晖,等.大鼠缺血性面神经瘫痪动物模型的建立[J].临床耳鼻咽喉科杂志,1999,13(10):464-465.
[29] Carreno M,Llorente J,Melón S,et al.Use of double PCR in an experimental mode of HSV-1 infection of the facial nerve[J].Acta Otorrinolaringol Esp,1999,50(7):512-518.
[30] Jiang T,Wang H B,Fan Z M,et al.Prevention of facial nerve paralysis induced by herpes simplex virus type 1(HSV-1) in mouse and establishment of a relapse model induced by reactiva-tion of latent HSV-1[J].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2007,42(9):683-686.
[31] Wang H B,Feng H Y,Fan Z M,et al.Experimental study of thefacial nerve paralysis induced by herpes simplex virus type 1 in-fection in mice[J].Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2006,41(1):13-16.