医药磁性氧化铁纳米材料的研究和发展
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摘要
以氧化铁纳米颗粒为代表的医药磁性纳米材料,近年来在医学健康领域得到越来越多的重视.作为唯一得到食品药品监督管理局(FDA)批准,可临床使用的无机功能纳米材料,氧化铁纳米颗粒在纳米生物医学的研究和应用中发挥着至关重要的作用.本文将聚焦于氧化铁纳米颗粒等医药磁性纳米材料,主要基于本实验室的相关研究工作,介绍该领域的研究和发展.主要从如下几个方面进行论述:医药磁性氧化铁纳米材料的制备、医药磁性氧化铁纳米材料的磁学性质、医药磁性氧化铁纳米材料的生物效应、医药磁性氧化铁纳米材料的组装和性质调控以及医药磁性纳米材料及技术的发展趋势.
Medical magnetic nanomaterials refer to magnetic nanomaterials owning specific biological effects and therapeutic functions which are promising in clinical medicine. A good case in this point is the iron-based magnetic nanomaterials. As the only inorganic nanomaterials approved by FDA for clinical use, iron oxide nanoparticles play a vital role in fundamental research and clinical application of nanomedicine. This feature article mainly focused on the state-of-art of iron oxide nanoparticles on the basis of our own works. The following sections were included in this feature article: Preparation and magnetic property, biological effects, assembly and future development, which was intended to clarify the particularity, importance and complexity of magnetic nanomaterials applied in clinical medicine. Although thermal decomposition method can get iron oxide nanocrystals with better morphology, coprecipitation method is more suitable for the use in clinic. This issue will be emphasized. Superparamagnetism is a prominent advantage of magnetic nanomaterials for medical applications, which is closely related to their size and morphology. The biological effects of iron oxide nanoparticles are versatile and can be regulated by chemical composition, morphology and surface modification. In recent years, some new biological effects of iron oxide nanoparticles still have been found, such as the enzymatic effect. Another outstanding property of magnetic nanomaterials is that the collective property can be regulated by control of assembled structures and interactions between the nanoparticles without changing the property of monomers. Here, the magnetic field-controlled assembly of magnetic nanoparticles and the property regulation will be discussed in detail. In the future, we should firstly further investigate the synthesis of medical magnetic nanomaterials of high performance and expand the clinical applicability. Certainly, the new clinical nanodrugs should be developed. Then, the biological effects of magnetic nanomaterials in the presence of magnetic field should be explored deeply, from which we may discover some new paradigms for the clinic. Finally, the novel characterization techniques and strategies for diagnosis and treatment should be developed. We believe the magnetic nanomaterials will make the society more glorious.
Medical magnetic nanomaterials refer to magnetic nanomaterials owning specific biological effects and therapeutic functions which are promising in clinical medicine. A good case in this point is the iron-based magnetic nanomaterials. As the only inorganic nanomaterials approved by FDA for clinical use, iron oxide nanoparticles play a vital role in fundamental research and clinical application of nanomedicine. This feature article mainly focused on the state-of-art of iron oxide nanoparticles on the basis of our own works. The following sections were included in this feature article: Preparation and magnetic property, biological effects, assembly and future development, which was intended to clarify the particularity, importance and complexity of magnetic nanomaterials applied in clinical medicine. Although thermal decomposition method can get iron oxide nanocrystals with better morphology, coprecipitation method is more suitable for the use in clinic. This issue will be emphasized. Superparamagnetism is a prominent advantage of magnetic nanomaterials for medical applications, which is closely related to their size and morphology. The biological effects of iron oxide nanoparticles are versatile and can be regulated by chemical composition, morphology and surface modification. In recent years, some new biological effects of iron oxide nanoparticles still have been found, such as the enzymatic effect. Another outstanding property of magnetic nanomaterials is that the collective property can be regulated by control of assembled structures and interactions between the nanoparticles without changing the property of monomers. Here, the magnetic field-controlled assembly of magnetic nanoparticles and the property regulation will be discussed in detail. In the future, we should firstly further investigate the synthesis of medical magnetic nanomaterials of high performance and expand the clinical applicability. Certainly, the new clinical nanodrugs should be developed. Then, the biological effects of magnetic nanomaterials in the presence of magnetic field should be explored deeply, from which we may discover some new paradigms for the clinic. Finally, the novel characterization techniques and strategies for diagnosis and treatment should be developed. We believe the magnetic nanomaterials will make the society more glorious.
引文
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43 Wang Q W,Chen B,Ma F,et al.Magnetic iron oxide nanoparticles accelerate osteogenic differentiation of mesenchymal stem cells via modulation of long noncoding RNA INZEB2.Nano Res,2017,10:626-642
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2 Wang T,Zhou Y,Lei C,et al.Magnetic impedance biosensor:A review.Biosens Bioelectron,2017,90:418-435
3 Angelovski G,Tóthé.Strategies for sensing neurotransmitters with responsive MRI contrast agents.Chem Soc Rev,2017,46:324-336
4 Conde-Leboran I,Baldomir D,Martinez-Boubeta C,et al.A single picture explains diversity of hyperthermia response of magnetic nanoparticles.J Phys Chem C,2015,119:15698-15706
5 Ulbrich K,HoláK,?ubr V,et al.Targeted drug delivery with polymers and magnetic nanoparticles:Covalent and noncovalent approaches,release control,and clinical studies.Chem Rev,2016,116:5338-5431
6 Chen R,Romero G,Christiansen M G,et al.Wireless magnetothermal deep brain stimulation.Science,2015,12:1261821-1261827
7 Gahramanov S,Muldoon L L,Varallyay C G,et al.Pseudoprogression of Glioblastoma after chemo-and radiation therapy:Diagnosis by using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging with ferumoxytol versus gadoteridol and correlation with survival.Radiology,2013,266:842-852
8 Fredrickson J,Serkova N J,Wyatt S K,et al.Clinical translation of ferumoxytol-based vessel size imaging(VSI):Feasibility in a phase Ioncology clinical trial population.Magnet Reson Med,2017,77:814-825
9 Yu E Y,Bishop M,Zheng B,et al.Magnetic particle imaging:A novel in vivo imaging platform for cancer detection.Nano Lett,2017,17:1648-1654
10 Ye D W,Li Y,Gu N.Magnetic labeling of natural lipid encapsulations with iron-based nanoparticles.Nano Res,2018,11:2970-2991
11 McCarthy J R,Weissleder R.Multifunctional magnetic nanoparticles for targeted imaging and therapy.Adv Drug Delivery Rev,2008,60:1241-1251
12 Ali A,Zafar H,Zia M,et al.Synthesis,characterization,applications,and challenges of iron oxide nanoparticles.Nanotechnol Sci Appl,2016,9:49-67
13 Ling D S,Lee N Y,Hyeon T W.Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications.Acc Chem Res,2015,48:1276-1285
14 Frey N A,Peng S,Cheng K,et al.Magnetic nanoparticles:Synthesis,functionalization,and applications in bioimaging and magnetic energy storage.Chem Soc Rev,2009,38:2532-2542
15 Hao R,Xing R J,Xu Z C,et al.Synthesis,functionalization,and biomedical applications of multifunctional magnetic nanoparticles.Adv Mater,2010,22:2729-2742
16 Gobbo O L,Sjaastad K,Radomski M W,et al.Magnetic nanoparticles in cancer theranostics.Theranostics,2015,5:1249-1263
17 Wu L,Mendoza-Garcia A,Li Q,et al.Organic phase syntheses of magnetic nanoparticles and their applications.Chem Rev,2016,116:10473-10512
18 Ma M,Zhang Y,Yu W,et al.Preparation and characterization of magnetite nanoparticles coated by amino silane.Colloids Surfaces A,2003,212:219-226
19 Sun Y K,Duan L,Guo Z R,et al.An improved way to prepare superparamagnetic magnetite/silica core-shell nanoparticles for possible biological application.J Mag Mag Mater,2005,285:65-70
20 Chen Z P,Zhang Y,Zhang S,et al.Preparation and characterization of water-soluble monodisperse magnetic iron oxide nanoparticles via surface double-exchange with DMSA.Colloids Surfaces A,2008,316:210-216
21 Zhang S,Bian Z P,Gu C R,et al.Preparation of anti-human cardiac troponin I immunomagnetic nanoparticles and biological activity assays.Colloids Surfaces B,2007,55:143-148
22 Chen B,Li Y,Zhang X Q,et al.An efficient synthesis of ferumoxytol induced by alternating-current magnetic field.Mater Lett,2016,170:93-96
23 Hu L,Zhang R R,Chen Q W.Synthesis and assembly of nanomaterials under magnetic fields.Nanoscale,2014,6:14064-14105
24 Sun J F,Sui Y X,Wang C Y,et al.The investigation of frequency response for the magnetic nanoparticulate assembly induced by time-varied magnetic field.Nanoscale Res Lett,2011,6:453-458
25 Chen B,Sun J F,Fan F G,et al.Ferumoxytol of ultrahigh magnetization produced by hydrocooling and magnetically internal heating co-precipitation.Nanoscale,2018,10:7369-7376
26 Zhao Z H,Zhou Z J,Bao J F,et al.Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging.Nat Commun,2013,4:2266-2272
27 Xie J,Yan C Z,Zhang Y,et al.Shape evolution of“multibranched”Mn-Zn ferrite nanostructures with high performance:A transformation of nanocrystals into nanoclusters.Chem Mater,2013,25:3702-3709
28 Ma M,Wu Y,Zhou J,et al.Size dependence of specific power absorption of Fe3O4 particles in AC magnetic field.J Mag Mag Mater,2004,268:33-39
29 Lee H,Shin T H,Cheon J W,et al.Recent developments in magnetic diagnostic systems.Chem Rev,2015,115:10690-10724
30 Wang X Y,Zhou X J.Magnetic resonance imaging in personalized medicine.Sci China Life Sci,2017,60:1-4
31 Liu Y,Li M X,Yang F,et al.Magnetic drug delivery systems.Sci China Mater,2017,60:471-486
32 Lee J H,Jang J T,Choi J S,et al.Exchange-coupled magnetic nanoparticles for efficient heat induction.Nat Nanotechnol,2011,6:418-422
33 Liu X L,Yang Y,Ng C T,et al.Magnetic vortex nanorings:A new class of hyperthermia agent for highly efficient in vivo regression of tumors.Adv Mater,2015,27:1939-1944
34 Zhang H,Li L,Liu X L,et al.Ultrasmall ferrite nanoparticles synthesized via dynamic simultaneous thermal decomposition for high-performance and multifunctional T1 magnetic resonance imaging contrast agent.ACS Nano,2017,11:3614-3631
35 Liu H Y,Sun J F,Wang H Y,et al.Quantitative evaluation of the total magnetic moments of colloidal magnetic nanoparticles:A kinetics-based method.ChemPhysChem,2015,16:1598-1602
36 Arruebo M,Fernández-Pacheco R,Ibarra M R,et al.Magnetic nanoparticles for drug delivery.Nano Today,2007,2:22-32
37 Lee N Y,Yoo D W,Ling D S,et al.Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy.Chem Rev,2015,115:10637-10689
38 Kinoshita R,Ishima Y,Vtg C,et al.Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer.Biomaterials,2017,140:162-169
39 Li Y,Gu N.Thermodynamics of charged nanoparticle adsorption on charge-neutral membranes:A simulation study.J Phys Chem B,2010,114:2749-2754
40 Lin X B,Gu N.Surface properties of encapsulating hydrophobic nanoparticles regulates the main phase transition temperature of lipid bilayers:A simulation study.Nano Res,2014,7:1195-1204
41 Liu D F,Wu W,Ling J J,et al.Effective PEGylation of iron oxide nanoparticles for high performance in vivo cancer imaging.Adv Funct Mater,2011,21:1498-1504
42 Yang C P,Xiong F,Wang J,et al.Anti-ABCG2 monoclonal antibody in combination with paclitaxel nanoparticles against cancer stem-like cell activity in multiple myeloma.Nanomedicine,2013,9:45-60
43 Wang Q W,Chen B,Ma F,et al.Magnetic iron oxide nanoparticles accelerate osteogenic differentiation of mesenchymal stem cells via modulation of long noncoding RNA INZEB2.Nano Res,2017,10:626-642
44 Xie J,Zhang Y,Yan C Y,et al.High-performance PEGylated Mn-Zn ferrite nanocrystals as a passive-targeted agent for magnetically induced cancer theranostics.Biomaterials,2014,35:9126-9136
45 Xie J,Yan C Y,Yan Y,et al.Multi-modal Mn-Zn ferrite nanocrystals for magnetically-induced cancer targeted hyperthermia:A comparison of passive and active targeting effects.Nanoscale,2016,8:16902-16915
46 Jia Z Y,Song L N,Zang F C,et al.Active-target T1-weighted MR imaging of tiny hepatic tumor via RGD Modified ultra-small Fe3O4nanoprobes.Theranostics,2016,6:1780-1791
47 Yang F,Chen P,He W,et al.Bubble microreactors triggered by an alternating magnetic field as diagnostic and therapeutic delivery devices.Small,2010,6:1300-1305
48 Duan L,Yang F,He W,et al.A Multi-gradient targeting drug delivery system based on RGD-l-TRAIL-labeled magnetic microbubbles for cancer theranostics.Adv Funct Mater,2016,26:8313-8324
49 Liu Y,Yang F,Yuan C X,et al.Magnetic Nanoliposomes as in situ microbubble bombers for multimodality image-guided cancer theranostics.ACS Nano,2017,11:1509-1519
50 Gao L Z,Zhuang J,Nie L,et al.Intrinsic peroxidase-like activity of ferromagnetic nanoparticles.Nat Nanotechnol,2007,2:577-583
51 Wei H,Wang E K.Nanomaterials with enzyme-like characteristics(nanozymes):Next-generation artificial enzymes.Chem Soc Rev,2013,42:6060-6093
52 Chen Z W,Yin J J,Zhou Y T,et al.Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity.ACS Nano,2012,6:4001-4012
53 Zhang W,Hu S L,Yin J J,et al.Prussian blue nanoparticles as multienzyme mimetics and reactive oxygen species scavengers.J Am Chem Soc,2016,138:5860-5865
54 Ling D S,Park W,Park S J,et al.Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors.J Am Chem Soc,2014,136:5647-5655
55 Zhou Z J,Zhao Z H,Zhang H,et al.Interplay between longitudinal and transverse contrasts in Fe3O4 nanoplates with(111)exposed surfaces.ACS Nano,2014,8:7976-7985
56 Zhang H,Liu X L,Zhang Y F,et al.Magnetic nanoparticles based cancer therapy:Current status and applications.Sci China Life Sci,2018,61:400-414
57 Zeng C J,Chen Y X,Kirschbaum K,et al.Emergence of hierarchical structural complexities in nanoparticles and their assembly.Science,2016,354:1580-1584
58 Niederberger M.Multiscale nanoparticle assembly:From particulate precise manufacturing to colloidal processing.Adv Funct Mater,2017,27:1703647
59 Singh G,Chan H,Udayabhaskararao T,et al.Magnetic field-induced self-assembly of iron oxide nanocubes.Faraday Discuss,2015,181:403-421
60 Bharti B,Fameau A L,Rubinstein M,et al.Nanocapillarity-mediated magnetic assembly of nanoparticles into ultraflexible filaments and reconfigurable networks.Nat Mater,2015,14:1104-1109
61 Sun J F,Zhang Y,Chen Z P,et al.Fibrous aggregation of magnetite nanoparticles induced by a time-varied magnetic field.Angew Chem Int Ed,2007,46:4767-4770
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