艾滋病合并淋巴瘤的临床病例分析

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英文篇名：Clinical Case Analysis of AIDS with Lymphoma 作者：曹廷智 英文作者：CAO Ting-zhi;Department of Infectious Diseases,Subject One,Shenzhen Third People's Hospital; 关键词：性病门诊 ; 淋巴瘤 ; 病例临床特征 英文关键词：STD clinic;;Lymphoma;;Clinical features of cases 中文刊名：YXXX 英文刊名：Medical Information 机构：深圳市第三人民医院感染一科; 出版日期：2019-06-01 出版单位：医学信息 年：2019 期：v.32;No.490 基金：深圳市科技创新项目(编号:JCYJ20180228162229889) 语种：中文; 页：YXXX201911060 页数：2 CN：11 ISSN：61-1278/R 分类号：199-200

摘要

目的探究艾滋病合并淋巴瘤的病例临床特征。方法选取2014年2月～2019年2月的25例艾滋病合并淋巴瘤患者为研究对象,分析患者临床表现、免疫指标、临床病理,患者的治疗效果及治疗前后生活质量评分。结果 25例患者均有浅表淋巴结肿大,23例间断性发热,20例体重下降。其中18例患者因肿瘤就诊,经HIV筛查确诊艾滋病,6例为先感染艾滋病,后发现肿瘤;CD4+T淋巴细胞为21～391 g/μl,平均为(136.74±21.78)g/μl;临床分期为Ⅰ期8例(32.00%),Ⅱ期7例(28.00%),Ⅲ期4例(16.00%),Ⅳ期6例(24.00%);治疗有效率为15例(60.00%)。治疗后患者的生活质量评分为(17.45±2.72)分,低于治疗前的(24.78±2.67)分,差异有统计学意义(P=0.0000)。结论艾滋病合并淋巴瘤伴随多种临床症状,其免疫力低下,需及时给予有效治疗,改善预后。
        objective To investigate the clinical features of cases of AIDS with lymphoma. Methods 25 patients with AIDS and lymphoma from February 2014 to February 2019 were enrolled in the study. The clinical manifestations, immune parameters, clinical pathology, treatment effect and quality of life before and after treatment were analyzed. Results 25 patients had superficial lymphadenopathy, 23 patients had intermittent fever, and20 patients had weight loss. Among them, 18 patients were diagnosed with cancer due to tumor diagnosis, 6 cases were diagnosed with AIDS by HIV screening, and 6 cases were infected with AIDS. CD4~+T lymphocytes were 21～391 g/μl, with an average of(136.74±21.78) g/μl; The clinical stage was 8 cases(32.00%) in stage I, 7 cases(28.00%) in stage II, 4 cases(16.00%) in stage III, and 6 cases(24.00%) in stage IV. The effective rate was15 cases(60.00%). The quality of life score of the patients after treatment was(17.45 ±2.72) points, which was lower than that before treatment(24.78±2.67), and the difference was statistically significant(P=0.0000). Conclusion AIDS complicated with lymphoma is associated with a variety of clinical symptoms, and its immunity is low. It is necessary to give effective treatment in time to improve the prognosis.

引文

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