基于层级规则树的跨平台基因表达数据分类
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摘要
基因检测技术运用至今已积累大量来自不同平台的数据,针对传统数据分类模式难以在不同平台间进行有效迁移的问题,提出一种基于层级规则树的基因表达数据分类算法k-HRT。设计数据转换与规则预筛选策略,实现算法的快速挖掘,以解决由跨平台特性所带来的大规模数据问题。在真实基因表达数据集上的实验结果表明,相对k-TSP算法、SVM-RFE算法,k-HRT算法能够有效提高分类精度。
The application of genetic testing technology has accumulated a large amount of data from different platforms.To address the problem that it is difficult to migrate traditional data classification modes across different platforms,this paper proposes a gene expression data classification algorithm k-HRT based on Hierarchy Rule Tree(HRT).The strategy of data conversion and rule pre-screening is designed to realize the fast mining of the algorithm to solve the large-scale data problems caused by cross-platform characteristics.Experimental results on real gene expression datasets show that,compared with k-TSP algorithm and SVM-RFE algorithm,k-HRT algorithm can effectively improve classification accuracy.
The application of genetic testing technology has accumulated a large amount of data from different platforms.To address the problem that it is difficult to migrate traditional data classification modes across different platforms,this paper proposes a gene expression data classification algorithm k-HRT based on Hierarchy Rule Tree(HRT).The strategy of data conversion and rule pre-screening is designed to realize the fast mining of the algorithm to solve the large-scale data problems caused by cross-platform characteristics.Experimental results on real gene expression datasets show that,compared with k-TSP algorithm and SVM-RFE algorithm,k-HRT algorithm can effectively improve classification accuracy.
引文
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[8] CAI Ruichu,HAO Zhifeng,YANG Xiaowei,et al.An efficient gene selection algorithm based on mutual information[J].Neurocomputing,2009,72(4-6):991-999.
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[18] TAN Qihua,ZHAO Jinghua,LI Shuxia,et al.Differential and correlation analyses of microarray gene expression data in the CEPH Utah families[J].Genomics,2008,92(2):94-100.
[19] GLERUM D M,SHTANKO A,TZAGOLOFF A.Charac-terization of COX17,a yeast gene involved in copper metabolism and assembly of cytochrome oxidase[J].Journal of Biological Chemistry,1996,271(24):14504-14509.
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