结核感染T细胞检测对COPD并肺结核患者的临床诊断价值研究
|
摘要
目的研究结核感染T细胞检测对慢性阻塞性肺疾病(COPD)并肺结核患者的临床诊断价值。方法选取本院收治的60例疑诊COPD并肺结核患者,均行结核菌素试验(TST)、结核感染T细胞检测(T-SPOT.TB),对比两种检测方法的诊断价值。结果所有患者均完成检验,确诊38例COPD合并肺结核, T-SPOT.TB检测敏感度为89.47%(34/38)、特异性为86.36%(19/22),假阳性率为13.64%(3/22)。确诊的38例COPD合并肺结核患者中, T-SPOT.TB检出34例,阳性检出率为89.47%;TST检出14例,阳性检出率为36.84%(14/38);T-SPOT.TB阳性检出率显著高于TST,差异有统计学意义(X~2=22.6190,P<0.05)。结论 T-SPOT.TB可有效提高COPD并肺结核患者阳性检出率,效果显著,值得借鉴。
Objective To study the clinical diagnostic value of T cell detection of tuberculosis infection in patients with chronic obstructive pulmonary disease(COPD) and pulmonary tuberculosis. Methods A total of 60 suspected COPD patients with pulmonary tuberculosis in our hospital were selected and tested by tuberculin test(TST) and tuberculous infection of T cells spot test(T-SPOT.TB). The diagnostic value of the two methods were compared. Results All patients completed the test and confirmed 38 cases of COPD with tuberculosis. The sensitivity of T-SPOT.TB detection was 89.47%(34/38), the specificity was 86.36%(19/22), and the false positive rate was 13.64%(3/22). Among the 38 patients with COPD and pulmonary tuberculosis, 34 cases were detected by T-SPOT.TB, the positive detection rate was 89.47%; 14 cases were detected by TST, and the positive detection rate was 36.84%(14/38). The positive detection rate of T-SPOT.TB is significantly higher than TST, and the difference was statistically significant(X~2=22.6190, P<0.05). Conclusion T-SPOT.TB can effectively improve the positive detection rate of COPD and tuberculosis patients, and the effect is remarkable. It is worth learning.
Objective To study the clinical diagnostic value of T cell detection of tuberculosis infection in patients with chronic obstructive pulmonary disease(COPD) and pulmonary tuberculosis. Methods A total of 60 suspected COPD patients with pulmonary tuberculosis in our hospital were selected and tested by tuberculin test(TST) and tuberculous infection of T cells spot test(T-SPOT.TB). The diagnostic value of the two methods were compared. Results All patients completed the test and confirmed 38 cases of COPD with tuberculosis. The sensitivity of T-SPOT.TB detection was 89.47%(34/38), the specificity was 86.36%(19/22), and the false positive rate was 13.64%(3/22). Among the 38 patients with COPD and pulmonary tuberculosis, 34 cases were detected by T-SPOT.TB, the positive detection rate was 89.47%; 14 cases were detected by TST, and the positive detection rate was 36.84%(14/38). The positive detection rate of T-SPOT.TB is significantly higher than TST, and the difference was statistically significant(X~2=22.6190, P<0.05). Conclusion T-SPOT.TB can effectively improve the positive detection rate of COPD and tuberculosis patients, and the effect is remarkable. It is worth learning.
引文
[1]欧利.结核感染T细胞检测对COPD并肺结核患者的临床诊断意义.医学理论与实践, 2017, 30(1):104-106.
[2]郭新美,尹丽霞,寇昌伟,等.结核感染T细胞斑点试验诊断老年患者肺结核的应用研究.中华医院感染学杂志, 2015,25(12):2647-2648.
[3]罗槑,徐园红,吴桂辉,等.结核感染T细胞检测在菌阴性肺结核诊断中的应用价值.国际检验医学杂志, 2016, 37(8):1035-1036.
[4]张立,孙海柏,侯志丽,等.结核感染T细胞检测技术的临床应用研究.中华医院感染学杂志, 2014, 24(22):5465-5466.
[5]相洁,袁益坤,王忠,等.结核感染T细胞斑点试验在诊断COPD伴肺结核中的临床意义.湖南师范大学学报(医学版),2015, 12(6):90-92.
[6]马苗,罗百灵,顾其华,等.结核感染T细胞斑点试验对肺结核病的临床诊断价值研究.现代生物医学进展, 2013, 13(36):7043-7047.
[7]李林阳,陈林利,李琦.结核感染T细胞斑点试验对肺结核的临床诊断价值.中华肺部疾病杂志(电子版), 2014, 7(6):32-36.
[2]郭新美,尹丽霞,寇昌伟,等.结核感染T细胞斑点试验诊断老年患者肺结核的应用研究.中华医院感染学杂志, 2015,25(12):2647-2648.
[3]罗槑,徐园红,吴桂辉,等.结核感染T细胞检测在菌阴性肺结核诊断中的应用价值.国际检验医学杂志, 2016, 37(8):1035-1036.
[4]张立,孙海柏,侯志丽,等.结核感染T细胞检测技术的临床应用研究.中华医院感染学杂志, 2014, 24(22):5465-5466.
[5]相洁,袁益坤,王忠,等.结核感染T细胞斑点试验在诊断COPD伴肺结核中的临床意义.湖南师范大学学报(医学版),2015, 12(6):90-92.
[6]马苗,罗百灵,顾其华,等.结核感染T细胞斑点试验对肺结核病的临床诊断价值研究.现代生物医学进展, 2013, 13(36):7043-7047.
[7]李林阳,陈林利,李琦.结核感染T细胞斑点试验对肺结核的临床诊断价值.中华肺部疾病杂志(电子版), 2014, 7(6):32-36.