柴胡加龙骨牡蛎汤治疗孤独症谱系障碍儿童问题行为临床研究
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摘要
目的:观察柴胡加龙骨牡蛎汤治疗孤独症谱系障碍儿童问题行为的临床疗效。方法:将孤独症谱系障碍儿童60例,遵从患儿口服中药意愿,采用非随机方法分为试验组30例、对照组30例,试验组在特殊教育基础上服用柴胡加龙骨牡蛎汤,对照组仅采用特殊教育,观察治疗前后2组疗效,对患儿进行孤独症儿童行为评定(ABC)评分,同时进行自拟症状评分。结果:治疗前,2组患儿ABC评分及自拟症状总分比较,差异无统计学意义(P> 0.05)。2组患儿治疗后评分较治疗前均有明显降低,差异有统计学意义(P <0.01)。治疗后,2组间ABC评分、自拟症状总分比较,试验组较对照组下降明显,差异有统计学意义(P <0.01)。治疗前,2组患儿各项自拟症状评分比较,差异无统计学意义(P> 0.05)。治疗后,试验组各项自拟症状评分均较前下降(P <0.01),对照组仅语言方面评分较前下降(P <0.01)。治疗后,自拟症状评分在情绪行为、胃肠症状及睡眠方面试验组较对照组下降明显,差异有统计学意义(P <0.01)。2组间总有效率比较,差异无统计学意义(P> 0.05)。试验组显效率86.7%,对照组56.7%,2组显效率比较,差异有统计学意义(P <0.01)。结论:柴胡加龙骨牡蛎汤对改善孤独症谱系障碍儿童问题行为有效,同时能够减少患儿并发症。
Objective:To observe the clinical effect of Chaihu Jia Longgu Muli tang for problem behavior of children with autism spectrum disorders. Methods:According to the willingness of children in the oral administration of Chinese medicine,60 cases of children with autism spectrum disorders were divided into the experiment group and the control group via non-randomized method,30 cases in each group. The control group received special education,while the experiment group additionally received the oral administration of Chaihu Jia Longgu Muli tang. Observed the clinical effect in both groups before and after treatment,and assessed the scores of autism behavior checklist(ABC) and self-made symptom scores. Results:Before treatment,comparing the scores of ABC and the total self-made symptom scores of children in both groups,there was no significant difference being found(P > 0.05). After treatment, each score above of children in both groups was all significantly lower than that before treatment, difference being significant(P < 0.01). After treatment, when comparing the scores of ABC and the total self-made symptom scores in-between the two groups, each score in the experiment group was decreased more significantly than that in the control group, difference being significant(P < 0.01). Before treatment,comparing each item of self-made symptom scores in both groups,there was no significant difference being found(P > 0.05)After treatment,each item of self-made symptom scores in the experiment group lower than that before treatment(P < 0.01),and the score of language in the control group was lower than that before treatment(P < 0.01). After treatment, the self-made symptom scores of such dimensions as emotional behavior, gastrointestinal symptoms and sleep in the experiment group were decreased more significantly than those in the control group,difference being significant(P < 0.01).Comparing the total effective rate in-between the two groups,there was no significant difference being found(P > 0.05). The obvious effective rate was 86.7% in the experiment group and 56.7% in the control group,difference being significant(P <0.01). Conclusion: Chaihu Jia Longgu Muli tang has effect in improving problem behavior of children with autism spectrum disorders,which can also reduce the complications of children.
Objective:To observe the clinical effect of Chaihu Jia Longgu Muli tang for problem behavior of children with autism spectrum disorders. Methods:According to the willingness of children in the oral administration of Chinese medicine,60 cases of children with autism spectrum disorders were divided into the experiment group and the control group via non-randomized method,30 cases in each group. The control group received special education,while the experiment group additionally received the oral administration of Chaihu Jia Longgu Muli tang. Observed the clinical effect in both groups before and after treatment,and assessed the scores of autism behavior checklist(ABC) and self-made symptom scores. Results:Before treatment,comparing the scores of ABC and the total self-made symptom scores of children in both groups,there was no significant difference being found(P > 0.05). After treatment, each score above of children in both groups was all significantly lower than that before treatment, difference being significant(P < 0.01). After treatment, when comparing the scores of ABC and the total self-made symptom scores in-between the two groups, each score in the experiment group was decreased more significantly than that in the control group, difference being significant(P < 0.01). Before treatment,comparing each item of self-made symptom scores in both groups,there was no significant difference being found(P > 0.05)After treatment,each item of self-made symptom scores in the experiment group lower than that before treatment(P < 0.01),and the score of language in the control group was lower than that before treatment(P < 0.01). After treatment, the self-made symptom scores of such dimensions as emotional behavior, gastrointestinal symptoms and sleep in the experiment group were decreased more significantly than those in the control group,difference being significant(P < 0.01).Comparing the total effective rate in-between the two groups,there was no significant difference being found(P > 0.05). The obvious effective rate was 86.7% in the experiment group and 56.7% in the control group,difference being significant(P <0.01). Conclusion: Chaihu Jia Longgu Muli tang has effect in improving problem behavior of children with autism spectrum disorders,which can also reduce the complications of children.
引文
[1]李堃,郗春艳.孤独症谱系障碍共患注意力缺陷多动障碍的临床研究[J].国际儿科学杂志,2016,43(4):299-300.
[2]佚名.24个专业104个病种中医临床路径(试行)[M].北京:国家中医药管理局医政司,2012:473-475.
[3]朱莎,钟艳,江淑娟,等.孤独症行为量表和克氏孤独症行为量表在孤独症谱系障碍中的应用分析[J].医学临床研究,2017,34(5):1026-1027.
[4]郭晓琳.中医对自闭症的认识及治疗现状[J].中医儿科杂志,2010,6(5):48-51.
[5]郭延庆.应用行为分析与儿童行为管理[M].北京:华夏出版社,2018:111-187.
[6]余明,刘靖,李雪,等.高功能与低功能学龄期孤独症儿童共患病研究[J].中国实用儿科杂志,2014,29(11):865-870.
[7]杨德爽,孟州令,国文文,等.柴胡加龙骨牡蛎汤对多发性抽动症模型大鼠行为学和多巴胺系统的影响[J].中国中西结合杂志,2018,38(1):76-79.
[8]高黎,贾春华,马淬兰,等.柴胡加龙骨牡蛎汤治疗抑郁症Meta分析[J].河南中医,2016,38(2):206-210.
[9]袁金英,杨健.柴胡加龙骨牡蛎汤加味治疗注意力缺陷多动障碍32例临床观察[J].河北中医,2012,34(12):1814-1815.
[2]佚名.24个专业104个病种中医临床路径(试行)[M].北京:国家中医药管理局医政司,2012:473-475.
[3]朱莎,钟艳,江淑娟,等.孤独症行为量表和克氏孤独症行为量表在孤独症谱系障碍中的应用分析[J].医学临床研究,2017,34(5):1026-1027.
[4]郭晓琳.中医对自闭症的认识及治疗现状[J].中医儿科杂志,2010,6(5):48-51.
[5]郭延庆.应用行为分析与儿童行为管理[M].北京:华夏出版社,2018:111-187.
[6]余明,刘靖,李雪,等.高功能与低功能学龄期孤独症儿童共患病研究[J].中国实用儿科杂志,2014,29(11):865-870.
[7]杨德爽,孟州令,国文文,等.柴胡加龙骨牡蛎汤对多发性抽动症模型大鼠行为学和多巴胺系统的影响[J].中国中西结合杂志,2018,38(1):76-79.
[8]高黎,贾春华,马淬兰,等.柴胡加龙骨牡蛎汤治疗抑郁症Meta分析[J].河南中医,2016,38(2):206-210.
[9]袁金英,杨健.柴胡加龙骨牡蛎汤加味治疗注意力缺陷多动障碍32例临床观察[J].河北中医,2012,34(12):1814-1815.
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