儿童肝母细胞瘤的影像学诊断价值
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摘要
目的探讨影像学评估儿童肝母细胞瘤(HB)的诊断价值。方法回顾性分析21例影像疑诊为HB的患者资料,其中16例病理证实为HB,5例病理证实为其它肿瘤。19例行CT检查,18例行超声检查,2例行MRI检查。采用Fisher确切概率法评估影像学征象与HB的相关性,并评价CT与超声诊断符合率的差异性。结果 CT、超声的诊断符合率分别为73.6%、77.8%,差异无统计学意义。结论 HB具有一些特征性的影像学表现,有助于确诊。影像学检查能很好的发现、定位HB,且对确定血管侵犯及转移有很大帮助。
Objective To investigate the diagnostic value of imaging in hepatoblastoma(HB) of Children. Methods Datas of 21 patients with HB which was suspected by imaging diagnosis were retrospectively evaluated,16 of them were confirmed by pathology, and 5 of them were confirmed to be other tumors by pathology.19 patients were performed with CT; 18 patients were performed with Ultrasonography; 2 patients were performed with MRI.Relationship between imaging signs and HB were tested by Fisher exact test,the difference of diagnostic coincidence rate between CT and Ultrasonograpy was also assessed. Results The diagnostic accuracy rate of CT and Ultrasound were 73.6%,77.8% respectively, and the difference was not statistically significant. Conclusion HB has some characteristic iconographical performances which help to make a definite diagnosis.Imaging examination was very helpfull to identify and locate HB, and useful in determining vascular invasion and metastasis.
Objective To investigate the diagnostic value of imaging in hepatoblastoma(HB) of Children. Methods Datas of 21 patients with HB which was suspected by imaging diagnosis were retrospectively evaluated,16 of them were confirmed by pathology, and 5 of them were confirmed to be other tumors by pathology.19 patients were performed with CT; 18 patients were performed with Ultrasonography; 2 patients were performed with MRI.Relationship between imaging signs and HB were tested by Fisher exact test,the difference of diagnostic coincidence rate between CT and Ultrasonograpy was also assessed. Results The diagnostic accuracy rate of CT and Ultrasound were 73.6%,77.8% respectively, and the difference was not statistically significant. Conclusion HB has some characteristic iconographical performances which help to make a definite diagnosis.Imaging examination was very helpfull to identify and locate HB, and useful in determining vascular invasion and metastasis.
引文
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[4]Yi Z,Zhang W,Tang S,et al.A single-center retrospective study of pediatric hepatoblastoma[J].Oncology Letters,2016,12(5):3919-3925.
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[6]Czauderna P,Lopezterrada D,Hiyama E,et al.Hepatoblastoma state of the art:pathology,genetics,risk stratification,and chemotherapy[J].Current Opinion in Pediatrics,2014,26(1):19-28.
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[9]Tanaka Y,Inoue T,Horie H.International pediatric liver cancer pathological classification:current trend[J].International Journal of Clinical Oncology,2013,18(6):946-954.
[10]Giorgio Perilongo MD,Marcio Malogolowkin MD,James Feusner MD.Hepatoblastoma clinical research:Lessons learned and future challenges[J].Pediatric Blood&Cancer,2012,59(5):818-821.
[11]白凤森,袁新宇,闫洧淳,等.儿童肝母细胞瘤CT征象及其与病理的关系[J].中国医学影像技术,2017,33(9):1297-1300.
[12]白凤森,闫淯淳,郭宏伟,等.基于PRETEXT分期的肝母细胞瘤影像表现研究[J].生物医学工程与临床,2017,21(5):280-284.
[13]刘亚超,沈智辉,党浩丹,等.PET/CT在儿童肝母细胞瘤中的诊断作用[J].中国临床医学影像杂志,2016,27(1):22-24.
[14]Cistaro A,Treglia G,Pagano M,et al.A comparison between 18F-FDG PET/CT imaging and biological and radiological findings in restaging of hepatoblastoma patients[J].BioMed Research International,2013(2013):709037.
[15]李杰,陈静静,李强,等.肝母细胞瘤CT与彩色多普勒超声诊断价值比较[J].中国临床医学影像杂志,2015,26(2):88-94.
[2]金晟,施诚仁.儿童肝母细胞瘤研究现状[J].临床儿科杂志,2014,32(10):988-992.
[3]王天怡,潘慈,汤静燕,等.儿童肝母细胞瘤74例随访研究[J].中华儿科杂志,2017,55(5):364-368.
[4]Yi Z,Zhang W,Tang S,et al.A single-center retrospective study of pediatric hepatoblastoma[J].Oncology Letters,2016,12(5):3919-3925.
[5]姚东亚,罗源,盛光耀.儿童肝母细胞瘤36例预后分析[J].临床儿科杂志,2017,35(2):121-124.
[6]Czauderna P,Lopezterrada D,Hiyama E,et al.Hepatoblastoma state of the art:pathology,genetics,risk stratification,and chemotherapy[J].Current Opinion in Pediatrics,2014,26(1):19-28.
[7]孙静静,高举.儿童肝母细胞瘤的诊治进展[J].中华实用儿科临床杂志,2017,32(15):1195-1197.
[8]Rojas Y,Guillerman RP,Zhang W,et al.Relapse surveillance in AFP-positive hepatoblastoma:re-evaluating the role of imaging[J].Pediatric Radiology,2014,44(10):1275-1280.
[9]Tanaka Y,Inoue T,Horie H.International pediatric liver cancer pathological classification:current trend[J].International Journal of Clinical Oncology,2013,18(6):946-954.
[10]Giorgio Perilongo MD,Marcio Malogolowkin MD,James Feusner MD.Hepatoblastoma clinical research:Lessons learned and future challenges[J].Pediatric Blood&Cancer,2012,59(5):818-821.
[11]白凤森,袁新宇,闫洧淳,等.儿童肝母细胞瘤CT征象及其与病理的关系[J].中国医学影像技术,2017,33(9):1297-1300.
[12]白凤森,闫淯淳,郭宏伟,等.基于PRETEXT分期的肝母细胞瘤影像表现研究[J].生物医学工程与临床,2017,21(5):280-284.
[13]刘亚超,沈智辉,党浩丹,等.PET/CT在儿童肝母细胞瘤中的诊断作用[J].中国临床医学影像杂志,2016,27(1):22-24.
[14]Cistaro A,Treglia G,Pagano M,et al.A comparison between 18F-FDG PET/CT imaging and biological and radiological findings in restaging of hepatoblastoma patients[J].BioMed Research International,2013(2013):709037.
[15]李杰,陈静静,李强,等.肝母细胞瘤CT与彩色多普勒超声诊断价值比较[J].中国临床医学影像杂志,2015,26(2):88-94.