脑心通胶囊联合阿托伐他汀片对急性缺血性脑卒中的临床疗效
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摘要
目的探讨脑心通胶囊联合阿托伐他汀片对急性缺血性脑卒中的临床疗效。方法选取2016年6月至2018年5月在莒南县中医医院住院的急性缺血性脑卒中患者76例,按随机数字表法分为观察组和对照组,每组38例。比较2组患者血清同型半胱氨酸(Hcy)、胱抑素-C(Cys-C)、超敏C反应蛋白(hs-CRP)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及临床疗效,并采用简易精神状态检查(MMSE)和画钟测试(CDT)评估2组患者认知功能水平。结果治疗后,2组患者血清Hcy、Cys-C、hs-CRP、TC、TG、LDL-C和HDL-C水平均优于治疗前,且观察组患者各指标水平明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,2组患者MMSE评分和CDT评分均高于治疗前,且观察组患者评分明显高于对照组,差异均有统计学意义(P<0.05)。观察组患者治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论采用脑心通胶囊联合阿托伐他汀片治疗急性缺血性脑卒中有助于减轻炎性反应,调节血脂水平,改善患者认知功能,提高临床疗效。
Objective To explore the clinical effect of Naoxintong capsule combined with atorvastatin tablets on acute ischemic stroke.Methods 76 patients with acute ischemic stroke hospitalized in Junan Hospital of Traditional Chinese Medicine from June 2016 to May 2018 were divided into the observation group and the control group according to random number table method,38 cases in each group.The serum levels of homocysteine(Hcy),cystatin-C(Cys-C),hypersensitive C-reactive protein(hs-CRP),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and the clinical efficacy were compared between the two groups.Simple Mental State Examination(MMSE)and Clock Painting Test(CDT)were used to assess cognitive function in the two groups.Results After treatment,the serum levels of Hcy,Cys-C,hsCRP,TC,TG,LDL-C and HDL-C in the two groups were better than those before treatment,and the levels of each index in the observation group were significantly better than those in the control group,with statistical significance(P<0.05).After treatment,the scores of MMSE and CDT in the two groups were higher than those before treatment,and the scores in the observation group were significantly higher than those in the control group(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Conclusion Naoxintong capsule combined with atorvastatin tablets in the treatment of acute ischemic stroke is helpful to alleviate inflammatory response,regulate blood lipid level,improve cognitive function of patients,and improve clinical efficacy.
Objective To explore the clinical effect of Naoxintong capsule combined with atorvastatin tablets on acute ischemic stroke.Methods 76 patients with acute ischemic stroke hospitalized in Junan Hospital of Traditional Chinese Medicine from June 2016 to May 2018 were divided into the observation group and the control group according to random number table method,38 cases in each group.The serum levels of homocysteine(Hcy),cystatin-C(Cys-C),hypersensitive C-reactive protein(hs-CRP),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and the clinical efficacy were compared between the two groups.Simple Mental State Examination(MMSE)and Clock Painting Test(CDT)were used to assess cognitive function in the two groups.Results After treatment,the serum levels of Hcy,Cys-C,hsCRP,TC,TG,LDL-C and HDL-C in the two groups were better than those before treatment,and the levels of each index in the observation group were significantly better than those in the control group,with statistical significance(P<0.05).After treatment,the scores of MMSE and CDT in the two groups were higher than those before treatment,and the scores in the observation group were significantly higher than those in the control group(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Conclusion Naoxintong capsule combined with atorvastatin tablets in the treatment of acute ischemic stroke is helpful to alleviate inflammatory response,regulate blood lipid level,improve cognitive function of patients,and improve clinical efficacy.
引文
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[9]解红,刘学政,刘新桥.进展性缺血性脑卒中的发病机制和危险因素研究进展[J].中西医结合心脑血管病杂志,2016,14(6):612-614.
[10]THALIN C,DEMERS M,BLOMGREN B,et al.NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation[J].Thromb Res,2016,139:56-64.
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[12]王英,张昱,王小艺,等.基于Meta分析的脑心通胶囊药物经济学分析[J].中国循证心血管医学杂志,2016,8(11):1379-1385.
[13]方泽鲁,曹国彬,曹志恺,等.脑心通胶囊治疗烟雾病慢性脑缺血的临床疗效[J].中国老年学杂志,2017,37(12):2929-2931.
[14]耿潇,陈璐,赵步长,等.基于血清蛋白组学初步探讨脑心通胶囊防治心脑血管疾病的作用机制[J].中国中药杂志,2016,41(15):2864-2871.
[15]朱伟,赵合庆.脑心通胶囊治疗脑梗死及对血液流变学和血脂的影响[J].中国血液流变学杂志,2007,17(4):552-553.
[16]张敬贤,张克峰,刘阿庆.步长脑心通对冠心病血脂异常者的调脂抗氧化作用[J].心血管康复医学杂志,2002,11(2):163-165.
[17]刘松华.脑心通胶囊联合辛伐他汀治疗冠心病并高脂血症的临床分析[J].光明中医,2016,31(22):3334-3335.
[18]李群,脑心通胶囊联合辛伐他汀治疗冠心病合并高脂血症疗效观察[J].中医临床研究,2016(3):36-38.
[19]武胜涛,张羽,李富慧.脑心通胶囊联合依达拉奉治疗急性脑梗死的疗效分析[J].中国药房,2017,28(9):1184-1187.
[20]LIU M,LIU X,WANG H,et al.Metabolomics study on the effects of Buchang Naoxintong capsules for treating cerebral ischemia in rats using UPLC-Q/TOF-MS[J].J Ethnopharmacol,2016,180:1-11.
[21]周红霞,王兴元,范利娟,等.阿托伐他汀在急性缺血性脑卒中患者中的临床研究[J].中国临床药理学杂志,2016,32(1):72-74.
[22]杨卿青,宋欢,全斌,等.急性脑梗死与血清炎性因子的相关性研究[J].沈阳医学院学报,2016,18(6):430-433.
[23]GLUECK CJ,WANG P.Testosterone therapy,thrombosis,thrombophilia,cardiovascular events[J].Metabolism,2014,63(8):989-994.
[24]李春燕.老年脑梗死血清同型半胱氨酸与血糖和脂蛋白及血尿酸相关性分析[J].中国实用医刊,2015,42(11):41-42.
[25]HELMERSSON-KARLQVIST J,ARNLOVJ,CARLSSON AC,et al.Increased urinary cystatin C indicated higher risk of cardiovascular death in a community cohort[J].Atherosclerosis,2014,234(1):108-113.
[26]欧阳红玲,田尧宇,郝春雪.hs-CRP持续升高与进展性脑梗死的关系研究[J].中国现代医学杂志,2017,27(29):118-122.
[27]许岱昀.缺血性脑卒中后血管性认知障碍相关影响因素分析[J].中国基层医药,2014,21(6):896-898.
[2]宓特,屈传强,王翔,等.不同部位急性脑梗死的认知功能障碍特点分析[J].中华医学杂志.,2016,96(15):1205-1207.
[3]刘深,王宏涛,魏聪,等.通心络胶囊治疗缺血性脑卒中作用机制研究进展[J].中草药,2017,48(11):2321-2334.
[4]徐健强,赵国军,王燕,等.阿托伐他汀的抗炎作用及其机制的研究进展[J].中国动脉硬化杂志,2016,24(4):419-423.
[5]张功和,吴节荣,周猛,等.同型半胱氨酸、胱抑素c和超敏c反应蛋白在动脉粥样硬化中的临床意义[J].国际检验医学杂志,2016,37(20):2818-2819.
[6]MEI ZG,TAN LJ,WANG JF,et al.Fermented Chinese formula ShuanTong-Ling attenuates ischemic stroke by inhibiting inflammation and apoptosis[J].Neural Regen Res,2017,12(3):425-432.
[7]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[8]巫嘉陵,王纪佐,王世民,等.脑卒中患者临床神经功能缺损程度评分的信度与效度[J].中华神经科杂志,2009,42(2):75-78.
[9]解红,刘学政,刘新桥.进展性缺血性脑卒中的发病机制和危险因素研究进展[J].中西医结合心脑血管病杂志,2016,14(6):612-614.
[10]THALIN C,DEMERS M,BLOMGREN B,et al.NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation[J].Thromb Res,2016,139:56-64.
[11]李伟霞,张书琦,赵艺丹,等.脑心通胶囊化学成分、药理作用及临床应用研究进展[J].中国中药杂志,2018,43(10):1998-2005.
[12]王英,张昱,王小艺,等.基于Meta分析的脑心通胶囊药物经济学分析[J].中国循证心血管医学杂志,2016,8(11):1379-1385.
[13]方泽鲁,曹国彬,曹志恺,等.脑心通胶囊治疗烟雾病慢性脑缺血的临床疗效[J].中国老年学杂志,2017,37(12):2929-2931.
[14]耿潇,陈璐,赵步长,等.基于血清蛋白组学初步探讨脑心通胶囊防治心脑血管疾病的作用机制[J].中国中药杂志,2016,41(15):2864-2871.
[15]朱伟,赵合庆.脑心通胶囊治疗脑梗死及对血液流变学和血脂的影响[J].中国血液流变学杂志,2007,17(4):552-553.
[16]张敬贤,张克峰,刘阿庆.步长脑心通对冠心病血脂异常者的调脂抗氧化作用[J].心血管康复医学杂志,2002,11(2):163-165.
[17]刘松华.脑心通胶囊联合辛伐他汀治疗冠心病并高脂血症的临床分析[J].光明中医,2016,31(22):3334-3335.
[18]李群,脑心通胶囊联合辛伐他汀治疗冠心病合并高脂血症疗效观察[J].中医临床研究,2016(3):36-38.
[19]武胜涛,张羽,李富慧.脑心通胶囊联合依达拉奉治疗急性脑梗死的疗效分析[J].中国药房,2017,28(9):1184-1187.
[20]LIU M,LIU X,WANG H,et al.Metabolomics study on the effects of Buchang Naoxintong capsules for treating cerebral ischemia in rats using UPLC-Q/TOF-MS[J].J Ethnopharmacol,2016,180:1-11.
[21]周红霞,王兴元,范利娟,等.阿托伐他汀在急性缺血性脑卒中患者中的临床研究[J].中国临床药理学杂志,2016,32(1):72-74.
[22]杨卿青,宋欢,全斌,等.急性脑梗死与血清炎性因子的相关性研究[J].沈阳医学院学报,2016,18(6):430-433.
[23]GLUECK CJ,WANG P.Testosterone therapy,thrombosis,thrombophilia,cardiovascular events[J].Metabolism,2014,63(8):989-994.
[24]李春燕.老年脑梗死血清同型半胱氨酸与血糖和脂蛋白及血尿酸相关性分析[J].中国实用医刊,2015,42(11):41-42.
[25]HELMERSSON-KARLQVIST J,ARNLOVJ,CARLSSON AC,et al.Increased urinary cystatin C indicated higher risk of cardiovascular death in a community cohort[J].Atherosclerosis,2014,234(1):108-113.
[26]欧阳红玲,田尧宇,郝春雪.hs-CRP持续升高与进展性脑梗死的关系研究[J].中国现代医学杂志,2017,27(29):118-122.
[27]许岱昀.缺血性脑卒中后血管性认知障碍相关影响因素分析[J].中国基层医药,2014,21(6):896-898.