窄谱中波紫外线联合复方卡力孜然酊治疗150例白癜风的效果及预后观察
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摘要
目的探究窄谱中波紫外线(NB-UVB)联合复方卡力孜然酊(KT)治疗白癜风的效果。方法选取150例白癜风患者为受试对象,依照随机数表将其分为联合组(n=75)与对照组(n=75)。联合组予以NB-UVB照射联合外搽KT治疗,对照组仅予以NB-UVB照射治疗。比较两组患者治疗前及治疗3个月后血清白细胞介素-17(IL-17)水平、皮损区面积、自信心[Rosenberg自信心评分量表(RSES)]变化情况,分析两组治疗效果及治疗过程中不良反应发生情况差异。结果治疗3个月后,两组患者血清IL-17水平、皮损区面积、RSES评分均较治疗前获得明显改善,且联合组改善效果更佳(P均<0.05);联合组患者治疗效果显著优于对照组(P<0.05),而组间不良反应发生率比较则均无统计学意义(P均>0.05)。结论 NB-UVB联合KT方案可安全有效的应用于白癜风治疗。
Objective To explore the effecst of narrow-band ultraviolet(NB-UVB) combined with compound Kaliziran tincture(KT in the treatment of vitiligo. Methods A total of 150 patients with vitiligo were selected as subjects and were divided into combined group(n=75) and control group(n=75) according to the random number table method. Combined group was given NB-UVB irradiation combined with external application of KT, and control group was only treated with NB-UVB. The changes of serum interleukin-17(IL-17) level, skin lesion area and self-esteem [Rosenberg SelfEsteem Scale(RSES)] were compared between the two groups before and after 3 months of treatment. The treatment effects and occurrence of adverse reactions during treatment were analyzed in the two groups. Results After 3 months of treatment, the serum IL-17 level, skin lesion area and RSES score in the two groups were significantly improved compared with those before treatment, and the improvements were better in combined group(all P<0.05).The treatment effects in combined group were significantly better than those in control group(P<0.05), and there was no statistically significant difference in the incidence rate of adverse reactions between the groups(all P>0.05).Conclusion NB-UVB combined with KT regimen can be safely and effectively applied to vitiligo treatment.
Objective To explore the effecst of narrow-band ultraviolet(NB-UVB) combined with compound Kaliziran tincture(KT in the treatment of vitiligo. Methods A total of 150 patients with vitiligo were selected as subjects and were divided into combined group(n=75) and control group(n=75) according to the random number table method. Combined group was given NB-UVB irradiation combined with external application of KT, and control group was only treated with NB-UVB. The changes of serum interleukin-17(IL-17) level, skin lesion area and self-esteem [Rosenberg SelfEsteem Scale(RSES)] were compared between the two groups before and after 3 months of treatment. The treatment effects and occurrence of adverse reactions during treatment were analyzed in the two groups. Results After 3 months of treatment, the serum IL-17 level, skin lesion area and RSES score in the two groups were significantly improved compared with those before treatment, and the improvements were better in combined group(all P<0.05).The treatment effects in combined group were significantly better than those in control group(P<0.05), and there was no statistically significant difference in the incidence rate of adverse reactions between the groups(all P>0.05).Conclusion NB-UVB combined with KT regimen can be safely and effectively applied to vitiligo treatment.
引文
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[4]秦凯炜.413例儿童和成人白癜风患者的临床特点比较[J].安徽医药,2015,19(1):146-147.
[5]张晓冬,林涛生,张艳.窄谱中波紫外线联合复方卡力孜然酊治疗白癜风临床疗效观察[J].临床皮肤科杂志,2015,44(7):457-458.
[6]谢勇,盛国荣,顾锐龙.退白汤联合窄谱中波紫外线治疗白癜风的对照研究[J].中国实验方剂学杂志,2012,18(12):266-269.
[7]杨宪鲁,王海燕,苏芳,等.NB—UVB治疗对寻常型稳定期白癜风患者外周血IL-17,IL-23的影响[J].中国皮肤性病学杂志,2013,27(11):1103-1104.
[8]詹凌.窄谱中波紫外线联合复方卡力孜然酊治疗寻常型白癜风的疗效[J].广东医学,2013,34(3):441-443.
[9]谭颖,凌芝雄,曾丽玲.复方卡力孜然酊联合0.05%地奈德乳膏治疗面部稳定期白癜风疗效观察[J].实用医学杂志,2014,30(16):2694-2695.
[10]徐贤挺,许洁,陈彬,等.白癜风患者心理状况及相关因素分析[J].中国麻风皮肤病杂志,2015,31(12):761-762.
[2]欧阳恒.白癜风诊断与治疗[M].北京:人民军医出版社,2013:16-39,56-62.
[3]李金辉,王克玉.白癜风患者心理应激和免疫功能状态分析[J].中国麻风皮肤病杂志,2013,29(3):178-180.
[4]秦凯炜.413例儿童和成人白癜风患者的临床特点比较[J].安徽医药,2015,19(1):146-147.
[5]张晓冬,林涛生,张艳.窄谱中波紫外线联合复方卡力孜然酊治疗白癜风临床疗效观察[J].临床皮肤科杂志,2015,44(7):457-458.
[6]谢勇,盛国荣,顾锐龙.退白汤联合窄谱中波紫外线治疗白癜风的对照研究[J].中国实验方剂学杂志,2012,18(12):266-269.
[7]杨宪鲁,王海燕,苏芳,等.NB—UVB治疗对寻常型稳定期白癜风患者外周血IL-17,IL-23的影响[J].中国皮肤性病学杂志,2013,27(11):1103-1104.
[8]詹凌.窄谱中波紫外线联合复方卡力孜然酊治疗寻常型白癜风的疗效[J].广东医学,2013,34(3):441-443.
[9]谭颖,凌芝雄,曾丽玲.复方卡力孜然酊联合0.05%地奈德乳膏治疗面部稳定期白癜风疗效观察[J].实用医学杂志,2014,30(16):2694-2695.
[10]徐贤挺,许洁,陈彬,等.白癜风患者心理状况及相关因素分析[J].中国麻风皮肤病杂志,2015,31(12):761-762.