IRF8与神经病理性痛的关系研究
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摘要
神经病理性痛是一种病理机制比较复杂的慢性疼痛综合征,活化的小胶质细胞参与神经病理性痛的发生发展,而且干扰素调节因子8(IRF8)是调控小胶质细胞活化的关键转录因子。因此,本文通过厘清梳理IRF8与神经病理性痛的关系来探讨神经病理性痛的发病机制。
Neuropathic pain is a chronic pain syndrome with complex pathological mechanism.Activated microglia is involved in the development and maintenance of neuropathic pain.Moreover,interferon regulatory factor 8(IRF8) is the key transcription factors for modulation of microglia activation.Therefore,this article would explore the pathogenesis of neuropathic pain by clarifying the relationship between IRF8 and neuropathic pain.
Neuropathic pain is a chronic pain syndrome with complex pathological mechanism.Activated microglia is involved in the development and maintenance of neuropathic pain.Moreover,interferon regulatory factor 8(IRF8) is the key transcription factors for modulation of microglia activation.Therefore,this article would explore the pathogenesis of neuropathic pain by clarifying the relationship between IRF8 and neuropathic pain.
引文
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[14]Tsuda M,Masuda T,Inoue K,et al.P2X4 receptors and neuropathic pain[J].Front Cell Neurosci,2013,7:191.
[15]Masuda T,wamoto S,Yoshinaga R,et al.Transcription factor IRF5 drives P2X4R+reactive microglia gating neuropathic pain[J].Nat Commun,2014,5:3771.
[16]Kazuhide INOUE.Purinergic signaling in microglia in the pathogenesis of neuropathic pain[J].Proc Jpn Acad Ser B Phys Biol Sci,2017,93(4):174-182.
[17]Simanta P,Shibin M,Vipul S,et al.A role for IRF8 in B cell anergy[J].J Immunol,2013,191(12):10.
[18]Britta W,Thomas O,Vogler,et al.Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia[J].Nat Med,2015,21(10):1172-1181.
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[20]Yuko Y,Ryusuke Y,Hiroaki Yoshii,et al.The transcription factor IRF8 activates integrin-mediated TGFβsignaling and promotes neuroinflammation[J].Immunity,2014,40(2):187-198.
[21]Hambleton S,Salem S,Bustamante J,et al.IRF8 mutations and human dendritic-cell immunodeficiency[J].N Engl J Med,2011,365:127-138.
[22]Lessard CJ,Adrianto I,Ice J,et al.Identification of IRF8,TMEM39A,and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study[J].Am J Hum Genet,2012,90:648-660.
[23]Jiang DS,Wei X,Zhang XF,et al.IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signaling[J].Nat Commun,2014,14(5):3303.
[24]Marquis JF.Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis[J].PLo S Genet,2011,7:e1002097.
[25]Alter KM.Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8(IRF-8)that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc[J].J Biol Chem,2008,283:2724-2733.
[2]Politis AD,Sivo J,Driggers PH,et al.Modulation of interferon consensus sequence binding protein mRNA in murine peritoneal macrophages.Induction by IFN-gamma and downregulation by IFN-alpha,dexamethasone,and protein kinase inhibitors[J].J Immunol,1992,148:801-807.
[3]Jun-ichi S,Naohiro A,Shouta K,et al.A comprehensive profile of Ch IP-Seq-Based PU.1/Spi1 target genes in microglia gene[J].Regul Syst Bio,2014,8:127-139.
[4]Masuda T,Tsuda M,Yoshinaga R,et al.IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype[J].Cell Rep,2012,1(4):334-340.
[5]Zhao J,Jeong H,Kong,et al.IRF-8/interferon(IFN)consensus sequence-binding protein is involved in Tolllike receptor(TLR)signaling and contributes to the crosstalk between TLR and IFN-gamma signaling pathways[J].J Biol Chem,2006,281(15):10073-10080.
[6]Wang H,Lee CH,Qi C,et al.IRF8 regulates B-cell lineage specification,commitment,and differentiation[J].Blood,2008,112(10):4028-4038.
[7]Hambleton S,Salem S,Bustamanteet J,et al.IRF8 mutations and human dendritic-cell immunodeficiency[J].N Engl J Med,2011,365:127-138.
[8]David L,Luis B,Philippe G,et al.The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation[J].J Exp Med,2016,213(4):585-603.
[9]Masuda T,Nishimoto N,Tomiyama D,et al.IRF8 is a transcriptional determinant for microglial motility[J].Purinergic Signalling,2014,10:515-521.
[10]Horiuchi M,Wakayama K,Itoh A,et al.Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia[J].J Neuroinflam,2012,9:227.
[11]刘荣国,徐雪汝,米立梅.鞘内注射IRF8反义寡核苷酸对CCI模型大鼠痛阈的影响[J].中国疼痛医学杂志,2015,21(5):351-356.
[12]方向宇,徐雪汝,刘荣国.脉冲射频大鼠CCI模型DRG对脊髓小胶质细胞IRF8表达的影响[J].中国疼痛医学杂志,2016,22(11):816-820.
[13]Masuda T,Tsuda M,Tozaki SH,et al.Microglial regulation of neuropathic pain[J].J Pharmacol Sci,2013,121(2):89-94.
[14]Tsuda M,Masuda T,Inoue K,et al.P2X4 receptors and neuropathic pain[J].Front Cell Neurosci,2013,7:191.
[15]Masuda T,wamoto S,Yoshinaga R,et al.Transcription factor IRF5 drives P2X4R+reactive microglia gating neuropathic pain[J].Nat Commun,2014,5:3771.
[16]Kazuhide INOUE.Purinergic signaling in microglia in the pathogenesis of neuropathic pain[J].Proc Jpn Acad Ser B Phys Biol Sci,2017,93(4):174-182.
[17]Simanta P,Shibin M,Vipul S,et al.A role for IRF8 in B cell anergy[J].J Immunol,2013,191(12):10.
[18]Britta W,Thomas O,Vogler,et al.Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia[J].Nat Med,2015,21(10):1172-1181.
[19]Holtschke T,L9hler J,Kanno YF,et al.Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene[J].Cell,1996,87:307-317.
[20]Yuko Y,Ryusuke Y,Hiroaki Yoshii,et al.The transcription factor IRF8 activates integrin-mediated TGFβsignaling and promotes neuroinflammation[J].Immunity,2014,40(2):187-198.
[21]Hambleton S,Salem S,Bustamante J,et al.IRF8 mutations and human dendritic-cell immunodeficiency[J].N Engl J Med,2011,365:127-138.
[22]Lessard CJ,Adrianto I,Ice J,et al.Identification of IRF8,TMEM39A,and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study[J].Am J Hum Genet,2012,90:648-660.
[23]Jiang DS,Wei X,Zhang XF,et al.IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signaling[J].Nat Commun,2014,14(5):3303.
[24]Marquis JF.Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis[J].PLo S Genet,2011,7:e1002097.
[25]Alter KM.Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8(IRF-8)that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc[J].J Biol Chem,2008,283:2724-2733.
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