米索前列醇不同给药途径用于绝经后妇女取器的临床效果观察
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摘要
目的:探讨米索前列醇不同给药途径用于绝经后取出宫内节育器的临床效果。方法:选取自愿要求取器的绝经后健康妇女168例,随机分为3组,分别于术前3h一次性口服、舌下分次含服和阴道穹隆放置米索前列醇0.6mg,观察临床效果。结果:宫颈软化、术中疼痛、术中出血情况和取器时间3组差异无统计学意义(P>0.05);用药后恶心呕吐、腹痛腹泻发生率口服组(39.3%30.4%)高于舌下含服(5.3%,5.3%)和阴道放置组(1.8%,7.1%)(P<0.05);发热寒战、头痛头晕、手心瘙痒等副作用发生率口服组(26.8%,8.9%,32.1%)和舌下含服组(26.8%,8.9%,33.9%)高于阴道置药组(1.8%,0,1.8%)(P<0.05)。结论:阴道穹隆放置米索前列醇是绝经后取器术前的宫颈准备的一种有效、安全的用药途径。
Objective: To study the clinical effect of misoprostol in different administration for the cervical preparation of postmenopausal women before removing intrauterine device(IUD). Methods: 168 postmenopausal and health women who voluntary required to remove IUD were divided into three groups. 3 hours before operation, the women in group A were given 0.6 mg misoprostol oral, the women in group B were given 0.6 mg misoprostol under the tongue, and the women in group C were given 0.6 mg misoprostol in vagina. The clinical effect of women were observed and compared. Results: There were no statistical significant different in the cervical softening degree, intraoperative pain degree, operative time and intraoperative bleeding volume among the three groups(P>0.05). The rate of gastrointestinal side effects of women in group A was significant higher than that of women in group B and C(P<0.05), and the rates of chills, fever, headache, dizziness and itchy hands of women in group A and group B were significant higher than those of women in group C(P<0.05). Conclusion: The misoprostol given in vagina for the cervical preparation of postmenopausal women before removing IUD is effective and safety.
Objective: To study the clinical effect of misoprostol in different administration for the cervical preparation of postmenopausal women before removing intrauterine device(IUD). Methods: 168 postmenopausal and health women who voluntary required to remove IUD were divided into three groups. 3 hours before operation, the women in group A were given 0.6 mg misoprostol oral, the women in group B were given 0.6 mg misoprostol under the tongue, and the women in group C were given 0.6 mg misoprostol in vagina. The clinical effect of women were observed and compared. Results: There were no statistical significant different in the cervical softening degree, intraoperative pain degree, operative time and intraoperative bleeding volume among the three groups(P>0.05). The rate of gastrointestinal side effects of women in group A was significant higher than that of women in group B and C(P<0.05), and the rates of chills, fever, headache, dizziness and itchy hands of women in group A and group B were significant higher than those of women in group C(P<0.05). Conclusion: The misoprostol given in vagina for the cervical preparation of postmenopausal women before removing IUD is effective and safety.
引文
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[4] 朱志红,李颖,杨春玲,等.不同途径给予米索前列醇配伍盐酸丁卡因胶浆用于钳刮术的临床效果观察[J].中国计划生育学杂志,2013,21(10):694-696.
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[2] 中华医学会计划生育分会.临床诊疗指南与技术操作规范计划生育分册[M].北京:人民卫生出版社,2017:14.
[3] 李琼.米索前列醇3种给药途径用于无痛人工流产术前扩张宫颈的疗效比较[J].中国药房,2014,25(12):1089-1091.
[4] 朱志红,李颖,杨春玲,等.不同途径给予米索前列醇配伍盐酸丁卡因胶浆用于钳刮术的临床效果观察[J].中国计划生育学杂志,2013,21(10):694-696.
[5] 周菊贤,崔佳锦,刘小媛.米索前列醇用于负压吸宫术前宫颈准备疗效评价[J].实用妇产科杂志,2010,26(10):778-780.
[6] 杨宝峰.药理学[M].第8版.北京:人民卫生出版社,2013:7-9.
[7] 钟洁霞,李君,余碧霞,等.我院 2016 年米索前列醇的副作用情况与用药安全分析[J].中国当代医学,2017,24(19):166-169.