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羟基喜树碱致死性不良反应的发生机制分析
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摘要
<正>羟基喜树碱(10-hydroxycamptothecin,HCPT)是植物来源的拓扑异构酶I抑制剂,是喜树(Camptotheca acuminata)有效成分喜树碱的衍生物。在我国,HCTP被批准用于治疗转移性结直肠癌~([1-3])。在结构上,HCTP与伊利替康的药理活性代谢物7-乙基-10-羟基喜树碱(SN-38)的差别只有一个乙基
        
引文
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