血小板/淋巴细胞比值在舒张性心力衰竭诊断和预后评估中的价值
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摘要
目的探讨血小板/淋巴细胞比值(PLR)在舒张性心力衰竭(DHF)诊断和预后评估中的价值。方法选择80例DHF患者为观察组,40例健康志愿者为对照组,比较两组PLR值,并分析PLR对DHF的诊断价值。根据受试者工作特征(ROC)曲线的最佳截断值将DHF患者分为低值组和高值组,比较两组患者的临床资料及随访1年的死亡率。结果 DHF组的PLR高于对照组(P <0.05)。PLR和E/A比值诊断DHF的ROC曲线下面积分别为0.745和0.771,二者曲线下面积比较差异无统计学意义(P> 0.05)。PLR的最佳截断值为158.65,低值组与高值组的年龄、左心室射血分数、左心室舒张末期内径、左心室收缩末期内径比较,差异均无统计学意义(均P> 0.05);与低值组相比,高值组中具有高血压史和心梗史患者比例更高,左心室后壁厚度和E/Ea比值更高,E/A比值更低(均P <0.05)。随访1年,低值组的死亡率低于高值组(P <0.05)。结论 PLR对DHF具有较高的诊断和预后评估价值,且与DHF患者的临床特征密切相关。
引文
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[2]Garg N,Senthilkumar A,Nusair MB,et al.Heart failure with a normal left ventricular ejection fraction:epidemiology,pathophysiology,diagnosis and management[J].Am J Med Sci,2013,346(2):129-136.
[3]Deng AY.Genetics of systolic and diastolic heart failure[J].J Hypertens,2013,31(1):3-13.
[4]Paulus WJ,Tsch9pe C,Sanderson JE,et al.How to diagnose diastolic heart failure:a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology[J].Eur Heart J,2007,28(20):2 539-2 550.
[5]González JR,Armengol L,SoléX,et al.SNPassoc:an Rpackage to perform whole genome association studies[J].Bioinformatics,2007,23(5):644-645.
[6]Ndrepepa G,Braun S,Iijima R,et al.Total leucocyte count,but not C-reactive protein,predicts 1-year mortality in patients with acute coronary syndromes treated with percutaneous coronary intervention[J].Clin Sci(Lond),2009,116(8):651-658.
[7]Papa A,Emdin M,Passino C,et al.Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease[J].Clin Chim Acta,2008,395(1/2):27-31.
[8]Nú1ez J,Mi1ana G,BodíV,et al.Low lymphocyte count and cardiovascular diseases[J].Curr Med Chem,2011,18(21):3 226-3 233.
[9]Ugur M,Gul M,Bozbay M,et al.The relationship between platelet to lymphocyte ratio and the clinical outcomes in STelevation myocardial infarction underwent primary coronary intervention[J].Blood Coagul Fibrinolysis,2014,25(8):806-811.
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