趋化因子MIF CCL23与急性脑梗死相关性研究
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摘要
目的探究血清中巨噬细胞迁移抑制因子(MIF)和CC类趋化因子配体23(CCL23)的浓度与急性脑梗死(ACI)的相关性。方法选择2018年3月至2018年6月安徽省立医院神经内科的ACI患者79例为试验组,并按急性卒中治疗Org 10 172试验(TOAST)分型分为大动脉粥样硬化(LAA)型、心源性栓塞(CCE)型、小动脉闭塞(SAO)型3个亚组,其中LAA亚组29例、CCE亚组17例、SAO亚组33例;同期选择安徽省立医院体检中心的健康者79例为对照组。测定两组对象入院时MIF、CCL23浓度等指标,并运用美国国立卫生院神经功能缺损评分量表(NIHSS)、Barthel指数量表和改良RANKIN量表(mRS)对ACI患者进行评估,分析MIF、CCL23与各指标的相关性。结果试验组患者MIF浓度为(1 317. 36±275. 46) pg/mL,CCL23浓度为(153. 03±39. 73) pg/mL,高于对照组,差异有统计学意义(P <0. 05)。MIF、CCL23浓度与NIHSS评分、mRS评分呈正相关(P <0. 05),与Barthel评分呈负相关(P <0. 05)。CCE亚组与LAA亚组的MIF、CCL23浓度均高于SAO亚组,差异有统计学意义(P <0. 05)。ROC曲线示MIF对ACI的诊断价值高于CCL23。结论趋化因子MIF、CCL23对ACI患者的诊断具有一定的提示意义,两者可作为评估神经功能缺损程度及早期预后的生物学标志物,及开发新型ACI治疗方法的潜在靶点。
引文
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[2]ASARE Y,SCHMITT M,BERNHAGEN J.The vascular biology of macrophage migration inhibitory factor(MIF)[J].Thromb Haemost,2013,109(2013):109.
[3]KIM J,KIM Y S,KO J.CKβ8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKCδ/NF-κB and is involved in inflammatory responses[J].Life Sci,2010,86(9/10):300-308.
[4]INáCIO A R,RUSCHER K,WIELOCH T.Enriched environment downregulates macrophage migration inhibitory factor and increases parvalbumin in the brain following experimental stroke[J].Neurobiol Dis,2011,41(2):270-278.
[5]SIMATS A,GARCíA-BERROCOSO T,PENALBA A,et al.CCL 23:a new CC chemokine involved in human brain damage[J].J Intern Med,2018,283(5):461-475.
[6]王志宏,韩仲岩.急性缺血性脑卒中的TOAST分型标准[J].临床神经病学杂志,2007,20(5):392.
[7]刘鸣,蒲传强.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[8]LI Y S,CHEN W,LIU S,et al.Serum macrophage migration inhibitory factor levels are associated with infarct volumes and long-term outcomes in patients with acute ischemic stroke[J].Int J Neurosci,2017,127(6):539-546.
[9]WAN C,LI Z.Serum macrophage migration inhibitory factor is correlated with atrial fibrillation[J].J Clin Lab Anal,2018,32(2):e22225.
[10]LIU Y,TSAI Y,TANG S,et al.Cytokine MIF enhances bloodbrain barrier permeability:impact for therapy in ischemic stroke[J].Sci Rep,2018,8(1):743.