褐藻糖胶药理活性研究进展
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摘要
褐藻糖胶是一类来自于海洋褐藻和无脊椎动物的杂多糖,主要成分为硫酸化的岩藻糖及少量的半乳糖、甘露糖、木糖及糖醛酸等。现有研究表明,褐藻糖胶具有诸多药理活性,如抗氧化、抗肿瘤、抗凝血、免疫调节、抗菌抗病毒、降糖降血脂、神经保护等。本文对褐藻糖胶目前研究的主要药理活性进行了总结,以期为其进一步研究和开发提供参考。
Fucoidan is a marine heteropolysaccharide extracted from brown algae and marine invertebrates.The structure of fucoidan is very complex which is mainly composed of sulfated fucose,a small amount of galactose,mannose,xylose and glucuronic acid.Fucoidan has important pharmacological activities such as anti-oxidation,anti-tumor,anticoagulant,immune regulation,antibacterial and anti-viral,hypoglycemic and hypolipidemic,neuroprotection.In this paper,we summarized the main pharmacological activities of fucoidan in order to provide references for further research and development.
Fucoidan is a marine heteropolysaccharide extracted from brown algae and marine invertebrates.The structure of fucoidan is very complex which is mainly composed of sulfated fucose,a small amount of galactose,mannose,xylose and glucuronic acid.Fucoidan has important pharmacological activities such as anti-oxidation,anti-tumor,anticoagulant,immune regulation,antibacterial and anti-viral,hypoglycemic and hypolipidemic,neuroprotection.In this paper,we summarized the main pharmacological activities of fucoidan in order to provide references for further research and development.
引文
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[24]Soeda S,Sakaguchi S,Shimeno H,et al.Fibrinolytic and anticoagulant activities of highly sulfated Fucoidan[J].Biochem Pharmacol,1992,43(8):1853-1858.
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[2]Wei W,Wang S X,Guan H S.The antiviral activities and mechanisms of marine polysaccharides:an overview[J].Mar Drugs,2012,10(12):2795-2816.
[3]Ustyuzhanina N E,Bilan M I,Ushakova N A,et al.Fucoidans:pro-or antiangiogenic agents[J].Glycobiology,2014,24(12):1265-1274.
[4]Cheng S W,Chen C N,Feng Z B,et al.Water extraction and antioxidant activity of Fucoidan from Laminaria japonica[J].Food Sci,2010,31(9):1-5.
[5]Zhang Q B,Peng-Zhan Y U,Zhou G F,et al.Studies on antioxidant activities of Fucoidan from Laminaria japonica[J].Chin Tradit Herbal Drugs,2003,34(9):824-826.
[6]Hifney A F,Fawzy M A,Abdel-Gawad K M,et al.Industrial optimization of Fucoidan extraction from Sargassum sp.and its potential antioxidant and emulsifying activities[J].Food Hydrocol,2016,54(2):77-88.
[7]Marudhupandi T,Kumar T T,Senthil S L,et al.In vitro antioxidant properties of Fucoidan fractions from Sargassum tenerrimum[J].Pak J Biol Sci,2014,17(3):402-407.
[8]Mak W,Hamid N,Liu T,et al.Fucoidan from New Zealand Undaria pinnatifida:Monthly variations and determination of antioxidant activities[J].Carbohydr Polym,2013,95(1):606-614.
[9]Hou Y,Wang J,Jin W,et al.Degradation of Laminaria japonica,Fucoidan by hydrogen peroxide and antioxidant activities of the degradation products of different molecular weights[J].Carbohydr Polym,2012,87(1):153-159.
[10]Lim S,Choi J I,Park H.Antioxidant activities of Fucoidan degraded by gamma irradiation and acidic hydrolysis[J].Radiat Phys Chem,2015,109:23-26.
[11]Hye-Jin B,Hong J Y,Sang-Cheol K,et al.The Anticancer effect of Fucoidan in PC-3prostate cancer cells[J].Mar Drugs,2013,11(8):2982-2999.
[12]Yamasaki Y,Yamasaki M,Tachibana H,et al.Important role ofβ1-integrin in Fucoidan-induced apoptosis via caspase-8activation[J].Biosci Biotechnol Biochem,2012,76(6):1163-1168.
[13]Chen S,Zhao Y,Zhang Y,et al.Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades[J].Plos One,2014,9(9):e108157.
[14]喻松霞,李剑.CXCL12-CXCR4/CXCR7轴信号传导通路与肿瘤细胞生物学特性的关系[J].基础医学与临床,2012,32(3):349-353.
[15]Schneider T,Ehrig K,Liewert I,et al.Interference with the CXCL12/CXCR4axis as potential antitumor strategy:superiority of a sulfated galactofucan from the brown,alga Saccharina latissima and Fucoidan over heparins[J].Glycobiology,2015,25(8):812-824.
[16]Maruyama H,Tamauchi H,Iizuka M,et al.The role of NK cells in antitumor activity of dietary Fucoidan from Undaria pinnatifida sporophylls(Mekabu)[J].Planta Medica,2006,72(15):1415-1417.
[17]Li B,Zhao R X,Wei X J.Anticoagulant activity of Fucoidan from Hizikia fusiforme[J].Agro Food Ind Hi Tech,2008,19(1):22-24.
[18]Wang J,Zhang Q B,Zhang Z S,et al.In-vitro anticoagulant activity of Fucoidan derivatives from brown seaweed Laminaria japonica[J].Chin J Oceanol Limnol,2011,29(3):679-685.
[19]Lapikova E S,Drozd N N,Makarov V A,et al.Influence of intravenous injection of Fucoidan from brown seaweed Fucus evanescens by plasma rabbits anticoagulant activity and neutralisation by sulphate protamin of Fucoidans antithrombin activity in vitro[J].Patol Fiziol Eksp Ter,2012,2(2):42.
[20]Nishino T,Aizu Y,Nagumo T.The influence of sulfate content and molecular weight of a fucan sulfate from the brown seaweed Ecklonia kurome,on its antithrombin activity[J].Thromb Res,1991,64(6):723.
[21]Cheng Z L,Wang S.Study on Anticoagulant Activities in vitro of Fucoidan and Fucoidan/Collagen Blends[J].JFun Polym,2003,16(4):557-560.
[22]Mauray S,Sternberg C,Theveniaux J,et al.Venous antithrombotic and anticoagulant activities of a Fucoidan fraction[J].Thromb Haemost,1995,74(5):1280-1285.
[23]Colliec S,Fischer A M,Tapon-Bretaudiere J,et al.Anticoagulant properties of a fuco?dan fraction[J].Thromb Res,1991,64(2):143-154.
[24]Soeda S,Sakaguchi S,Shimeno H,et al.Fibrinolytic and anticoagulant activities of highly sulfated Fucoidan[J].Biochem Pharmacol,1992,43(8):1853-1858.
[25]Zhanga Z,Tillc S,Knappec S,et al.Screening of complex Fucoidans from four brown algae species as procoagulant agents[J].Carbohydr Polym,2015,115(115):677-685.
[26]Zhang Z,Till S,Jiang C,et al.Structure-activity relationship of the pro-and anticoagulant effects of Fucus vesiculosus Fucoidan[J].Thromb Haemost,2014,111(3):429-437.
[27]Abuajah C I,Ogbonna A C,Osuji C M.Functional components and medicinal properties of food:a review[J].JFood Sci Technol,2015,52(5):2522-2529.
[28]Zapopozhets T S,Besednova N N,Iun L.Antibacterial and immunomodulating activity of Fucoidan[J].Antibiot Khimioter,1995,40(2):9-13.
[29]Cao R A,Lee Y,You S.Water soluble sulfated-fucans with immune-enhancing properties from Ecklonia cava[J].Int J Biol Macromol,2014,67(3):303-311.
[30]Yoo Y C,Kim W J,Kim S Y,et al.Immunomodulating activity of a Fucoidan isolated from Korean Undaria pinnatifida sporophyll[J].Choryu Hakhoe chi,2007,22(4):333-338.
[31]Tissot B,Montdargent B,Chevolot L,et al.Interaction of Fucoidan with the proteins of the complement classical pathway[J].Biochimica Et Biophysica Acta Proteins Proteomics,2003,1651(1/2):5-16.
[32]Galebskaia L V,Riumina E V,Bogomaz T A,et al.The mechanisms of Fucoidan action on human complement[J].Biomed Khim,2003,49(6):542.
[33]Iwamoto K,Hiragun T,Takahagi S,et al.Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis[J].Arch Dermatol Res,2011,303(6):425-431.
[34]Yang J H.Topical application of Fucoidan improves atopic dermatitis symptoms in NC/Nga mice[J].Phytother Res,2012,26(12):1898-1903.
[35]Chmit M,Kanaan H,Habib J,et al.Antibacterial and antibiofilm activities of polysaccharides,essential oil,and fatty oil extracted from Laurus nobilis,growing in Lebanon[J].Asian Pac J Trop Med,2014,7:546-552.
[36]Liu M,Liu Y,Cao M J,et al.Antibacterial activity and mechanisms of depolymerized Fucoidans isolated from Laminaria japonica[J].Carbohydr Polym,2017,172:294-305.
[37]Rajeshkumar S.Phytochemical constituents of Fucoidan(Padina tetrastromatica)and its assisted AgNPs for enhanced antibacterial activity[J].IET Nanobiotechnol,2017,11(3):292-299.
[38]Karmakar P,Pujol C A,Damonte E B,et al.Polysaccharides from Padina tetrastromatica:structural features,chemical modification and antiviral activity[J].Carbohydr Polym,2010,80(2):513-520.
[39]Mandal P,Mateu C G,Chattopadhyay K,et al.Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica[J].Antivir Chem Chemother,2007,18(3):153-162.
[40]Adhikari U,Mateu C G,Chattopadhyay K,et al.Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum[J].Phytochemistry,2006,67(22):2474-2482.
[41]Yang X D,Liu C G,Tian Y J,et al.Inhibitory effect of Fucoidan on hypoglycemia in diabetes mellitus anim[J].Int J Clini Exp Med,2017,10(5):8529-8534.
[42]Vinoth K T,Lakshmanasenthil S,Geetharamani D,et al.Fucoidan--aα-D-glucosidase inhibitor from Sargassum wightii with relevance to type 2diabetes mellitus therapy[J].Int J Biol Macromol,2015,72:1044-1047.
[43]Lin H V,Tsou Y C,Chen Y T,et al.Effects of low-molecular-weight Fucoidan and high stability fucoxanthin on glucose homeostasis,lipid metabolism,and liver function in a mouse model of type II Diabetes[J].Mar Drugs,2017,15(4):113.
[44]Kim K J,Lee O H,Lee H C,et al.Effect of Fucoidan on expression of Diabetes mellitus related genes in mouse adipocytes[J].Food Sci Biotechnol,2007,16(2):42-47.
[45]Jeong Y T,Kim Y D,Jung Y M,et al.Low molecular weight Fucoidan improves endoplasmic reticulum stress-reduced insulin sensitivity through AMP-activated protein kinase activation in L6myotubes and restores lipid homeostasis in a mouse model of type 2diabetes[J].Mol Pharmacol,2013,84(1):147-157.
[46]Liang Z,Zheng Y,Wang J,et al.Low molecular weight Fucoidan ameliorates streptozotocin-induced hyper-responsiveness of aortic smooth muscles in type 1diabetes rats[J].J Ethnopharmacol,2016,191:341-349.
[47]Wang Y,Nie M,Lu Y,et al.Fucoidan exerts protective effects against diabetic nephropathy related to spontaneous diabetes through the NF-κB signaling pathway in vivo and in vitro[J].Int J Mol Med,2015,35(4):1067-1073.
[48]Chen S,Wang W,Cai L,et al.The Regulatory effect of sargassum Fucoidan on the lipid metabolism related enzymes and cholesterol synthesis key enzyme of hyperlipidemic mice[J].J Chin Inst Food Sci Technol,2017,17(2):10-16.
[49]Park J,Yeom M,Hahm D H.Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation[J].J Pharmacol Sci,2016,131(2):84-92.
[50]Nelson E D,Ramberg J E,Talitha B,et al.Neurologic effects of exogenous saccharides:A review of controlled human,animal,andin vitrostudies[J].Nutr Neurosci,2012,15(4):149-162.
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