AT1R基因多态性与高血压患者左室舒张功能不全的相关性

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英文篇名：Correlation between AT1R gene polymorphism and left ventricular diastolic dysfunction in patients with hypertension 作者：陈伟达 ; 崔珑饶 ; 董天崴 英文作者：CHEN Wei-da;CUI Long-rao;DONG Tian-wei;The First Department of Cardiology, the First Affiliated Hospital of Jiamusi University; 关键词：原发性高血压 ; AT1R基因 ; 左室舒张功能不全 ; 肾素-血管紧张素-醛固酮系统 英文关键词：Essential hypertension;;AT1R gene;;Left ventricular diastolic dysfunction;;Renin-angiotensin-aldosterone system 中文刊名：ZGUD 英文刊名：China Modern Medicine 机构：佳木斯大学附属第一医院心内一科; 出版日期：2019-04-28 出版单位：中国当代医药 年：2019 期：v.26;No.535 基金：黑龙江省卫生计生委科研课题(2017-381) 语种：中文; 页：ZGUD201912002 页数：4 CN：12 ISSN：11-5786/R 分类号：10-13

摘要

目的研究血管紧张素Ⅱ-1型受体(AT1R)多态性与高血压患者左室舒张功能不全的相关性。方法选取2018年1～5月我院收治的100例原发性高血压(EH)患者作为研究对象,检测所有入选患者AT1R基因分型,测量其血压[收缩压(SBP)、舒张压(DBP)]、心率(HR)、左室舒张功能指标[舒张早期峰值血流速度(EPFV)、舒张晚期峰值血流速度(APFV)、EPFV/APFV、E峰减速度时间(DT)、等容舒张时间(IVRT)、二尖瓣口舒张早期E波的峰值流速/二尖瓣环运动的峰值速度比值(E/Em)]、肾素-血管紧张素-醛固酮系统(RAAS)指标[血浆醛固酮(ALD)、血管紧张素Ⅱ(AngⅡ)]、血浆B型钠尿肽(BNP),并分析各项指标与AT1R基因分型的相关性。结果三种基因类型的SBP、DBP、HR、左室舒张功能各项超声指标、血浆BNP及RAAS指标比较,差异有统计学意义(P<0.05)。AT1R基因不同类型与SBP、DBP、HR、ALD、AngⅡ、BNP、APFV、IVRT、DT、E/Em均成正相关(r均≥0.3,P<0.05);AT1R基因不同类型(AA、AC、CC)与EPVF、EPFV/APFV均成负相关(|r|均≥0.3,P<0.05)。AngⅡ、ALD与SBP、DBP、HR、BNP、APFV、IVRT、DT、E/Em均成正相关(r均≥0.3,P<0.05);AngⅡ、ALD与EPVF、EPFV/APFV均成负相关(|r|均≥0.3,P<0.05)。结论 AT1R基因多态性与EH患者的血压、HR、血浆BNP水平、左室舒张功能指标、RAAS指标具有明确的相关性。
        Objective To study the correlation between angiotensin Ⅱ type 1 receptor(AT1 R) polymorphism and left ventricular diastolic dysfunction(LVDD) in patients with hypertension. Methods One hundred patients with essential hypertension(EH) admitted to our hospital from January to May 2018 were selected as the research objects. The AT1 R genotyping in all selected patients was detected. The blood pressure(systolic blood pressure [SBP], diastolic blood pressure [DBP]), heart rate(HR), left ventricular diastolic function index(early diastolic peak blood flow velocity [EPFV],late diastolic peak blood flow velocity [APFV], EPFV/APFV, E-peak deceleration time [DT], isovolumic relaxation time[IVRT], peak velocity of early E-wave of mitral valve diastolic/peak velocity ratio of mitral annulus motion [E/Em]),renin-angiotensin-aldosterone system(RAAS) index(aldosterone [ALD], angiotensin Ⅱ [Ang Ⅱ ]) and plasma B-type natriuretic peptide(BNP) were measured among different genes, and the correlation between various indicators and AT1 R genotyping was analyzed. Results There were significant differences in SBP, DBP, HR, left ventricular diastolic function, plasma BNP and RAAS among the three gene types(P<0.05). There were positive correlations between different types of AT1 R gene(type AA, AC, CC) and SBP, DBP, HR, ALD, AngⅡ, BNP, APFV, IVRT, DT and E/Em(r≥0.3,P<0.05). The different types of AT1 R gene(type AA, AC, CC) were negatively correlated with EPVF and EPFV/APFV(|r|≥0.3, P<0.05). Ang II and ALD were positively correlated with SBP, DBP, HR, BNP, APFV, IVRT, DT and E/Em(r≥0.3, P<0.05). Ang II and ALD were negatively correlated with EPVF and EPFV/APFV(|r|≥0.3, P<0.05). Conclusion The AT1 R gene polymorphism has a clear correlation with blood pressure, HR, plasma BNP level, left ventricular diastolic function index and RAAS index in EH patients.

引文

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