冬虫夏草多糖抑制肝纤维化作用机制的研究进展
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摘要
肝纤维化是肝脏对各种慢性损伤的一种修复反应过程,主要是由于肝脏中纤维组织增生和分解不平衡,导致肝脏纤维结缔组织过度沉积,是多种慢性肝脏疾病的共同中间环节,在这一病理过程中,细胞与细胞因子之间相互作用,使肝脏细胞外基质代谢紊乱,造成纤维组织在肝脏内沉积过多,最后导致肝纤维化,其持续恶化会逐步发展成肝硬化,甚至肝癌。由于肝纤维化及肝硬化早期可以逆转,因此控制肝纤维化这一可逆过程,对于肝硬化和肝癌的预防及治疗至关重要。冬虫夏草作为我国特有的名贵药用真菌之一,受到科学工作者的普遍关注与研究,其药理作用广泛。冬虫夏草中含量最高的生物活性物质冬虫夏草多糖,近年来研究发现其具有抗肝纤维化的作用,随着分子生物学技术的应用,国内外对于中药抗肝纤维化机制的研究逐渐向细胞分子水平深入。本文将分别从与肝纤维化发生有关的细胞基础、细胞因子、胶原酶以及脂质过氧化层面,探讨冬虫夏草多糖对肝纤维化形成的抑制作用,以阐明其具体作用机制,为抗肝纤维化药物的研制提供参考。
Hepatic fibrosis is a repair process of the liver in response to various chronic injuries. The unbalanced proliferation and decomposition of fibrous tissue in the liver causes the excessive deposition of fibrous connective tissue in the liver. Hepatic fibrosis is a common intermediate link in a variety of chronic liver diseases.In this pathological process,the interaction between cells and cytokines leads to the disorder of liver extracellular matrix metabolism,which results in excessive deposition of fibrous tissue in the liver,and eventually causes liver fibrosis. After continuous deterioration,it would gradually develop into liver cirrhosis and even liver cancer.Because liver fibrosis and liver cirrhosis can be reversed in the early stage,it is very important to control the reversible process of liver fibrosis for the prevention and treatment of liver cirrhosis and liver cancer. Cordyceps,as one of valuable medicinal fungi in China,has been given widespread attention from scientific workers,with broad pharmacological actions. Cordyceps polysaccharide is the highest content of bioactive substances in Cordyceps.Recent studies have found that it has an anti-hepatic fibrosis effect. With the application of molecular biology technology,researches on the anti-liver fibrosis mechanism of traditional Chinese medicine at home and abroad have been gradually deepened into the cellular and molecular levels. This paper will investigate the preventive effect of Cordyceps polysaccharide in terms of cell basis,cytokines,collagenase and lipid peroxidation level that are related to liver fibrosis,so as to clarify the specific action mechanism on anti-hepatic fibrosis,and provide a reference for the development of anti-hepatic fibrosis drugs.
Hepatic fibrosis is a repair process of the liver in response to various chronic injuries. The unbalanced proliferation and decomposition of fibrous tissue in the liver causes the excessive deposition of fibrous connective tissue in the liver. Hepatic fibrosis is a common intermediate link in a variety of chronic liver diseases.In this pathological process,the interaction between cells and cytokines leads to the disorder of liver extracellular matrix metabolism,which results in excessive deposition of fibrous tissue in the liver,and eventually causes liver fibrosis. After continuous deterioration,it would gradually develop into liver cirrhosis and even liver cancer.Because liver fibrosis and liver cirrhosis can be reversed in the early stage,it is very important to control the reversible process of liver fibrosis for the prevention and treatment of liver cirrhosis and liver cancer. Cordyceps,as one of valuable medicinal fungi in China,has been given widespread attention from scientific workers,with broad pharmacological actions. Cordyceps polysaccharide is the highest content of bioactive substances in Cordyceps.Recent studies have found that it has an anti-hepatic fibrosis effect. With the application of molecular biology technology,researches on the anti-liver fibrosis mechanism of traditional Chinese medicine at home and abroad have been gradually deepened into the cellular and molecular levels. This paper will investigate the preventive effect of Cordyceps polysaccharide in terms of cell basis,cytokines,collagenase and lipid peroxidation level that are related to liver fibrosis,so as to clarify the specific action mechanism on anti-hepatic fibrosis,and provide a reference for the development of anti-hepatic fibrosis drugs.
引文
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