膳食营养素与炎症性肠病关系研究进展
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摘要
炎症性肠病(inflammation bowel disease,IBD)是一组以肠道炎症性细胞浸润、肠黏膜受损为主要表现的肠道慢性炎症病变,包括溃疡性结肠炎和克罗恩氏病。流行病学调查结果显示,高脂摄入增加IBD的发病风险,IBD的发病率与居民动物蛋白摄入量的增加有一定的关联性,膳食纤维摄入量与IBD发病率呈负相关。IBD的发病机制复杂,主要包括遗传因素和环境因素,其中饮食是重要的环境因素之一;目前膳食营养干预是防治IBD的有效策略。本文综述了近年来膳食脂肪、蛋白质、碳水化合物三大营养素对IBD发病机制影响方面的研究,并从膳食营养素的角度综合分析了IBD的饮食干预治疗策略。
Inflammatory bowel disease(IBD) is a group of chronic inflammatory intestinal disorders characterized by intestinal inflammatory cell infiltration and intestinal mucosal damage, including ulcerative colitis and Crohn's disease.Epidemiological findings indicated that high fat intake increased the risk of developing IBD, the incidence of IBD was associated with increased intake of animal proteins, and dietary fiber intake was negatively correlated with the incidence of IBD. The pathogenesis of IBD is complex, including genetic factors and environmental factors, of which diet is one of the most important environmental factors. Currently, dietary nutrition intervention is an effective strategy for the prevention and control of IBD. In this review we summarize recent studies on the effects of dietary fat, proteins and carbohydrates on the pathogenesis of IBD, and analyze dietary intervention strategies against IBD from the perspective of dietary nutrients.
Inflammatory bowel disease(IBD) is a group of chronic inflammatory intestinal disorders characterized by intestinal inflammatory cell infiltration and intestinal mucosal damage, including ulcerative colitis and Crohn's disease.Epidemiological findings indicated that high fat intake increased the risk of developing IBD, the incidence of IBD was associated with increased intake of animal proteins, and dietary fiber intake was negatively correlated with the incidence of IBD. The pathogenesis of IBD is complex, including genetic factors and environmental factors, of which diet is one of the most important environmental factors. Currently, dietary nutrition intervention is an effective strategy for the prevention and control of IBD. In this review we summarize recent studies on the effects of dietary fat, proteins and carbohydrates on the pathogenesis of IBD, and analyze dietary intervention strategies against IBD from the perspective of dietary nutrients.
引文
[1]迟玉聚,王洁贞.膳食营养与慢性疾病[J].中国食物与营养,2003,8:55-56.DOI:10.3969/j.issn.1006-9577.2003.08.019.
[2]庞广昌,陈庆森,胡志和,等.食品营养与免疫代谢关系研究进展[J].食品科学,2018,39(1):1-15.DOI:10.7506/spkx1002-6630-201801001.
[3]刘天宇,曹海龙,谢润祥,等.高脂饮食促进炎症性肠病发生的机制研究进展[J].国际消化病杂志,2017,37(1):1-3.DOI:10.3969/j.issn.1673-534X.2017.01.001.
[4]郑萍,靖大道.炎症性肠病[M].西安:第四军医大学出版社,2008:2.
[5]REGUEIRO M D,GREER J B,HANAUER S B,et al.Established management paradigms in IBD:treatment targetsand therapeutic tools[J].The American Journal of Gastroenterology,2016(3):8-16.DOI:10.1038/ajgsup.2016.16.
[6]FEAGAN B G,SANDBORN W J,D’HAENS G,et al.Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn’s disease:a randomised,double-blind,placebo-controlled phase 2 study[J].The Lancet,2017,389:1699-1709.DOI:10.1016/S0140-6736(17)30570-6.
[7]李亮成.炎症性肠病的临床表现[J].山西医药杂志,1993(2):93-94.
[8]陈志芬,邓长生.炎症性肠病的临床表现、诊断及鉴别诊断[J].实用医学杂志,2003(5):451-452.DOI:10.3969/j.issn.1006-5725.2003.05.004.
[9]KAMM M A.Rapid changes in epidemiology of inflammatory bowel disease[J].The Lancet,2017,390:2741-2742.DOI:10.1016/S0140-6736(17)32669-7.
[10]NG S C,SHI H Y,HAMIDI N.Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century:a systematic review of population-based studies[J].The Lancet,2017,390:2769-2778.DOI:10.1016/S0140-6736(17)32448-0.
[11]DOLAN K T,CHANG E B.Diet,gut microbes,and the pathogenesis of inflammatory bowel diseases[J].Molecular Nutrition&Food Research,2017,61(1):1600129.DOI:10.1002/mnfr.201600129.
[12]BILSBOROUGH J,TARGAN S R,SNAPPER S B.Therapeutic targets in inflammatory bowel disease:current and future[J].The American Journal of Gastroenterology,2016,3:27-37.DOI:10.1038/ajgsup.2016.18.
[13]MILLER T L,LEE D,GIEFER M,et al.Nutritional therapy in very early-onset inflammatory bowel disease:a case report[J].Digestive Diseases and Sciences,2017,62(8):2196-2200.DOI:10.1007/s10620-017-4616-9.
[14]郭小芹.IL-17/IL-17R通路在炎症性肠病中的免疫调节机制研究[D].北京:中国人民解放军军事医学科学院,2013:13-14;67-68.
[15]DIXON L J,KABI A,NICKERSON K P,et al.Combinatorial effects of diet and genetics on inflammatory bowel disease pathogenesis[J].Inflammatory Bowel Diseases,2015,21(4):912-922.DOI:10.1097/MIB.0000000000000289.
[16]ANANTHAKRISHNAN A N,BERNSTEIN C N,ILIOPOULOS D.Environmental triggers in IBD:a review of progress and evidence[J].Nature Reviews Gastroenterology&Hepatology,2018,15:39-49.DOI:10.1038/nrgastro.2017.136.
[17]ROSSI O,VAN BERKEL L A,CHAIN F,et al.Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses[J].Scientific Reports,2016,6:18507.DOI:10.1038/srep18507.
[18]MARRACK P,SARRABAYROUSE G,BOSSARD C,et al.CD4CD8ααlymphocytes,a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease[J].PLoS Biology,2014,12(4):e1001833,DOI:10.1371/journal.pbio.1001833.
[19]COHEN-PORADOSU R,MCLOUGHLIN R M,LEE J C,et al.Bacteroides fragilis-stimulated interleukin-10 contains expanding disease[J].The Journal of Infectious Diseases,2011,204(3):363-371.DOI:10.1093/infdis/jir277.
[20]ROUND J L,LEE S M,LI J,et al.The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota[J].Science,2011,332:974-977.DOI:10.1126/science.1206095.
[21]TAKAHASHI K,NISHIDA A,FUJIMOTO T,et al.Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn’s disease[J].Digestion,2016,93(1):59-65.DOI:10.1159/000441768.
[22]SAVKOVIC S D,KOUTROURIS A,HECHT G.PKC zeta participates in activation of inflammatory response induced by enteropathogenic E.coli[J].American Journal of Physiology-Cell Physiology,2002,285:512-521.DOI:10.1152/ajpcell.00444.2002.
[23]DAHAN S,BUSUTTIL V,IMBERT V,et al.Enterohemorrhagic Escherichia coli infection induces interleukin-8 production via activation of mitogenactivated protein kinases and the transcription factors NF-kappaB and AP-1 in T84 cells[J].Infection and Immunity,2002,70(5):2304-2310.DOI:10.1128/IAI.70.5.2304-2310.2002.
[24]ROLHION N,DARFEUILLE-MICHAUD A.Adherent-invasive Escherichia coli in inflammatory bowel disease[J].Inflammatory Bowel Diseases,2007,13(10):1277-1283.DOI:10.1136/gutjnl-2017-314903.
[25]SHAWKI A,MCCOLE D F.Mechanisms of intestinal epithelial barrier dysfunction by adherent-invasive Escherichia coli[J].Cellular and Molecular Gastroenterology and Hepatology,2017,3(1):41-50.DOI:10.1016/j.jcmgh.2016.10.004.
[26]LOUBINOUX J,BRONOWICKI J P,PEREIRA I A,et al.Sulfatereducing bacteria in human feces and their association with infammatory bowel diseases[J].FEMS Microbiology Ecology,2002,40(2):107-112.DOI:10.1111/j.1574-6941.2002.tb00942.x.
[27]SAWIN E A,DE WOLFE T J,AKTAS B,et al.Glycomacropeptide is a prebiotic that reduces Desulfovibrio bacteria,increases cecal short-chain fatty acids,and is anti-inflammatory in mice[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2015,309:G590-G601.DOI:10.1152/ajpgi.00211.2015.
[28]SIGALL-BONEH R,LEVINE A,LOMER M,et al.Research gaps in diet and nutrition in inflammatory bowel disease.a topical review by D-ECCO Working Group[Dietitians of ECCO][J].Journal of Crohn’s&Colitis,2017,11(12):1407-1419.DOI:10.1093/ecco-jcc/jjx109.
[29]谢华,何良梅,刘瑶,等.肠道菌群与炎症性肠病[J].赣南医学院学报,2017,37(4):659-663.DOI:10.3969/j.issn.1001-5779.2017.04.050.
[30]ALEKSANDROVA K,ROMERO-MOSQUERA B,HERNANDEZV.Diet,gut microbiome and epigenetics:emerging links with inflammatory bowel diseases and prospects for management and prevention[J].Nutrients,2017,9:E962.DOI:10.3390/nu9090962.
[31]ANDERSEN V,HOLMSKOV U,SORENSEN S B,et al.A proposal for a study on treatment selection and lifestyle recommendations in chronic inflammatory diseases:a Danish multidisciplinary collaboration on prognostic factors and personalised medicine[J].Nutrients,2017,9(5):E499.DOI:10.3390/nu9050499.
[32]JANTCHOU P,MOROIS S,CLAVEL-CHAPELON F,et al.Animal protein intake and risk of inflammatory bowel disease:the E3Nprospective study[J].The American Journal of Gastroenterology,2010,105(10):2195-2201.DOI:10.1038/ajg.2010.192.
[33]JOWETT S L,SEAL C J,PEARCE M S,et al.Influence of dietary factors on the clinical course of ulcerative colitis:a prospective cohort study[J].Gut,2004,53(10):1479-1484.DOI:10.1136/gut.2003.024828.
[34]ANDERSEN V,OLSEN A,CARBONNEL F,et al.Diet and risk of inflammatory bowel disease[J].Digestive and Liver Disease,2012,44(3):185-194.DOI:10.1016/j.dld.2011.10.001.
[35]石玲燕,张培趁,林春景,等.炎症性肠病危险因素的病例对照研究[J].中国全科医学,2011,14(11):1188-1190.DOI:10.3969/j.issn.1007-9572.2011.11.009.
[36]ANANTHAKRISHNAN A N,KHALILI H,KONIJETI G G,et al.A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis[J].Gastroenterology,2013,145(5):970-977.DOI:10.1053/j.gastro.2013.07.050.
[37]TASSON L,CANOVA C,VETTORATO M G,et al.Influence of diet on the course of inflammatory bowel disease[J].Digestive Diseases and Sciences,2017,62(8):2087-2094.DOI:10.1007/s10620-017-4620-0.
[38]SCAIOLI E,LIVERANI E,BELLUZZI A.The Imbalance between n-6/n-3 polyunsaturated fatty acids and inflammatory bowel disease:a comprehensive review and future therapeutic perspectives[J].International Journal of Molecular Sciences,2017,18(12):E2619.DOI:10.3390/ijms18122619.
[39]路媛媛,颜克松,樊超男,等.n-3多不饱和脂肪酸对肥胖小鼠肠道菌群的影响[J].中国儿童保健杂志,2014,22(11):1157-1160.DOI:10.11852/zgetbjzz2014-22-11-12.
[40]COSTEA I,MACK D R,LEMAITRE R N,et al.Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn’s disease[J].Gastroenterology,2014,146(4):929-931.DOI:10.1053/j.gastro.2013.12.034.
[41]冉影,周璐,王邦茂.饮食对肠道菌群的影响[J].中华临床营养杂志,2013,5(21):305-308.DOI:10.3760/cma.j.issn.1674-635X.2013.05.008.
[42]URANGA J A,L PEZ-MIRANDA V,LOMB F,et al.Food,nutrients and nutraceuticals affecting the course of inflammatory bowel disease[J].Pharmacological Reports,2016,68(4):816-826.DOI:10.1016/j.pharep.2016.05.002.
[43]王永辉,李培兵,于晓明,等.高蛋白膳食对限食大鼠肠道抗氧化功能的影响[J].营养学报,2009,31(2):145-147;151.DOI:10.3321/j.issn:0512-7955.2009.02.015.
[44]ORTEGA-GONZáLEZ M,CAPITáN-CA?ADAS F,REQUENAP,et al.Validation of bovine glycomacropeptide as an intestinal antiinflammatory nutraceutical in the lymphocyte-transfer model of colitis[J].The British Journal of Nutrition,2014,111(7):1202-1212.DOI:10.1017/S0007114513003590.
[45]王志凡,杨秀琳,陈旺盛,等.抗性淀粉对饮食诱导肥胖大鼠排便状况及肠道菌群的影响[J].动物营养学报,2016,28(5):1626-1632.DOI:10.3969/j.issn.1006-267x.2016.03.000.
[46]MASLOWSKI K M,MACKAY C R.Diet,gut microbiota and immune responses[J].Nature Immunology,2011,12(1):5-9.DOI:10.1038/ni0111-5.
[47]张晨,宓林,于晓峰.饮食与炎症性肠病研究进展[J].国际消化病杂志,2017,37(6):344-347.
[48]MONTELEONE I,MACDONALD T T,PALLONE F,et al.The aryl hydrocarbon receptor ininflammatory bowel disease:linking the environment to disease pathogenesis[J].Current Opinionin in Gastroenterology,2012,28(4):310-313.DOI:10.1097/MOG.0b013e328352ad69.
[49]ALTOMARE R,DAMIANO G,ABRUZZO A,et al.Enteral nutrition support to treat malnutrition in inflammatory bowel disease[J].Nutrients,2015,7(4):2125-2133.DOI:10.3390/nu7042125.
[50]LIM H S,KIM S K,HONG S J.Food elimination diet and nutritional deficiency in patients with inflammatory bowel disease[J].Clinical Nutrition Research,2018,7(1):48-55.DOI:10.7762/cnr.2018.7.1.48.
[51]MARTíNEZ GóMEZ M J,MELIáN FERNáNDEZ C,ROMEODONLO M.Nutrition in inflammatory bowel disease[J].Nutricion Hospitalaria,2016,33(Suppl 4):59-62.DOI:10.20960/nh.348.
[52]HOLT E M,STEFFEN L M,MORAN A,et al.Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents[J].Journal of the American Dietetic Association,2009,109(3):414-421.DOI:10.1016/j.jada.2008.11.036.
[53]DAMASKOS D,KOLIOS G.Probiotics and prebiotics in inflammatory bowel disease:microflora on the scope[J].British Journal of Clinical Pharmacology,2008,65(4):453-467.DOI:10.1111/j.1365-2125.2008.03265.x.
[54]SCALABRINO G.Vitamin-regulated cytokines and growth factors in the CNS and elsewhere[J].Journal of Neurochemistry,2009,111(6):1309-1326.
[55]FERGUSON L R.Nutrigenomics and inflammatory bowel diseases[J].Expert Review of Clinical Immunology,2010,6(4):573-583.DOI:10.1586/eci.10.43.
[56]LARUSSA T,IMENEO M,LUZZA F.Potential role of nutraceutical compounds in inflammatory bowel disease[J].World Journal of Gastroenterology,2017,23(14):2483-2492.DOI:10.3748/wjg.v23.i14.2483.
[57]SCHWALFENBERG G K.A review of the critical role of vitamin Din the functioning of the immune system and the clinical implications of vitamin D deficiency[J].Molecular Nutrition&Food Research,2011,55(1):96-108.DOI:10.1002/mnfr.201000174.
[58]MATHUR J,NAING S,MILLS P,et al.A randomized clinical trial of vitamin D3(cholecalciferol)in ulcerative colitis patients with hypovitaminosis D3[J].PeerJ,2017,5:e3654.DOI:10.7717/peerj.3654.
[59]RAPOZO D C,BERNARDAZZI C,DE SOUZA H S.Diet and microbiota in inflammatory bowel disease:the gut in disharmony[J].World Journal of Gastroenterology,2017,23(12):2124-2140.DOI:10.3748/wjg.v23.i12.2124.
[60]JOSTINS L,RIPKE S,WEERSMA R K,et al.Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease[J].Nature,2012,491:119-124.DOI:10.1038/nature11582.
[61]PENDYALA S,WALKER J M,HOLT P R.A high-fat diet is associated with endotoxemia thatoriginates from the gut[J].Gastroenterology,2012,142(5):1100-11101.DOI:10.1053/j.gastro.2012.01.034.
[62]STAPPENBECK T S,RIOUX J D,MIZOGUCHI A,et al.Crohn disease:a current perspective on genetics,autophagy and immunity[J].Autophagy,2014,7(4):355-374.DOI:10.4161/auto.7.2.13074.
[63]SUBRAMANIAN S,BLANTON L V,FRESE S A,et al.Cultivating healthy growth and nutrition through the gut microbiota[J].Cell,2015,161(1):36-48.DOI:10.1016/j.cell.2015.03.013.
[64]YATSUNENKO T,REY F E,MANARY M J,et al.Human gut microbiome viewed across age and geography[J].Nature,2012,486:222-227.DOI:10.1038/nature11053.
[2]庞广昌,陈庆森,胡志和,等.食品营养与免疫代谢关系研究进展[J].食品科学,2018,39(1):1-15.DOI:10.7506/spkx1002-6630-201801001.
[3]刘天宇,曹海龙,谢润祥,等.高脂饮食促进炎症性肠病发生的机制研究进展[J].国际消化病杂志,2017,37(1):1-3.DOI:10.3969/j.issn.1673-534X.2017.01.001.
[4]郑萍,靖大道.炎症性肠病[M].西安:第四军医大学出版社,2008:2.
[5]REGUEIRO M D,GREER J B,HANAUER S B,et al.Established management paradigms in IBD:treatment targetsand therapeutic tools[J].The American Journal of Gastroenterology,2016(3):8-16.DOI:10.1038/ajgsup.2016.16.
[6]FEAGAN B G,SANDBORN W J,D’HAENS G,et al.Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn’s disease:a randomised,double-blind,placebo-controlled phase 2 study[J].The Lancet,2017,389:1699-1709.DOI:10.1016/S0140-6736(17)30570-6.
[7]李亮成.炎症性肠病的临床表现[J].山西医药杂志,1993(2):93-94.
[8]陈志芬,邓长生.炎症性肠病的临床表现、诊断及鉴别诊断[J].实用医学杂志,2003(5):451-452.DOI:10.3969/j.issn.1006-5725.2003.05.004.
[9]KAMM M A.Rapid changes in epidemiology of inflammatory bowel disease[J].The Lancet,2017,390:2741-2742.DOI:10.1016/S0140-6736(17)32669-7.
[10]NG S C,SHI H Y,HAMIDI N.Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century:a systematic review of population-based studies[J].The Lancet,2017,390:2769-2778.DOI:10.1016/S0140-6736(17)32448-0.
[11]DOLAN K T,CHANG E B.Diet,gut microbes,and the pathogenesis of inflammatory bowel diseases[J].Molecular Nutrition&Food Research,2017,61(1):1600129.DOI:10.1002/mnfr.201600129.
[12]BILSBOROUGH J,TARGAN S R,SNAPPER S B.Therapeutic targets in inflammatory bowel disease:current and future[J].The American Journal of Gastroenterology,2016,3:27-37.DOI:10.1038/ajgsup.2016.18.
[13]MILLER T L,LEE D,GIEFER M,et al.Nutritional therapy in very early-onset inflammatory bowel disease:a case report[J].Digestive Diseases and Sciences,2017,62(8):2196-2200.DOI:10.1007/s10620-017-4616-9.
[14]郭小芹.IL-17/IL-17R通路在炎症性肠病中的免疫调节机制研究[D].北京:中国人民解放军军事医学科学院,2013:13-14;67-68.
[15]DIXON L J,KABI A,NICKERSON K P,et al.Combinatorial effects of diet and genetics on inflammatory bowel disease pathogenesis[J].Inflammatory Bowel Diseases,2015,21(4):912-922.DOI:10.1097/MIB.0000000000000289.
[16]ANANTHAKRISHNAN A N,BERNSTEIN C N,ILIOPOULOS D.Environmental triggers in IBD:a review of progress and evidence[J].Nature Reviews Gastroenterology&Hepatology,2018,15:39-49.DOI:10.1038/nrgastro.2017.136.
[17]ROSSI O,VAN BERKEL L A,CHAIN F,et al.Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses[J].Scientific Reports,2016,6:18507.DOI:10.1038/srep18507.
[18]MARRACK P,SARRABAYROUSE G,BOSSARD C,et al.CD4CD8ααlymphocytes,a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease[J].PLoS Biology,2014,12(4):e1001833,DOI:10.1371/journal.pbio.1001833.
[19]COHEN-PORADOSU R,MCLOUGHLIN R M,LEE J C,et al.Bacteroides fragilis-stimulated interleukin-10 contains expanding disease[J].The Journal of Infectious Diseases,2011,204(3):363-371.DOI:10.1093/infdis/jir277.
[20]ROUND J L,LEE S M,LI J,et al.The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota[J].Science,2011,332:974-977.DOI:10.1126/science.1206095.
[21]TAKAHASHI K,NISHIDA A,FUJIMOTO T,et al.Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn’s disease[J].Digestion,2016,93(1):59-65.DOI:10.1159/000441768.
[22]SAVKOVIC S D,KOUTROURIS A,HECHT G.PKC zeta participates in activation of inflammatory response induced by enteropathogenic E.coli[J].American Journal of Physiology-Cell Physiology,2002,285:512-521.DOI:10.1152/ajpcell.00444.2002.
[23]DAHAN S,BUSUTTIL V,IMBERT V,et al.Enterohemorrhagic Escherichia coli infection induces interleukin-8 production via activation of mitogenactivated protein kinases and the transcription factors NF-kappaB and AP-1 in T84 cells[J].Infection and Immunity,2002,70(5):2304-2310.DOI:10.1128/IAI.70.5.2304-2310.2002.
[24]ROLHION N,DARFEUILLE-MICHAUD A.Adherent-invasive Escherichia coli in inflammatory bowel disease[J].Inflammatory Bowel Diseases,2007,13(10):1277-1283.DOI:10.1136/gutjnl-2017-314903.
[25]SHAWKI A,MCCOLE D F.Mechanisms of intestinal epithelial barrier dysfunction by adherent-invasive Escherichia coli[J].Cellular and Molecular Gastroenterology and Hepatology,2017,3(1):41-50.DOI:10.1016/j.jcmgh.2016.10.004.
[26]LOUBINOUX J,BRONOWICKI J P,PEREIRA I A,et al.Sulfatereducing bacteria in human feces and their association with infammatory bowel diseases[J].FEMS Microbiology Ecology,2002,40(2):107-112.DOI:10.1111/j.1574-6941.2002.tb00942.x.
[27]SAWIN E A,DE WOLFE T J,AKTAS B,et al.Glycomacropeptide is a prebiotic that reduces Desulfovibrio bacteria,increases cecal short-chain fatty acids,and is anti-inflammatory in mice[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2015,309:G590-G601.DOI:10.1152/ajpgi.00211.2015.
[28]SIGALL-BONEH R,LEVINE A,LOMER M,et al.Research gaps in diet and nutrition in inflammatory bowel disease.a topical review by D-ECCO Working Group[Dietitians of ECCO][J].Journal of Crohn’s&Colitis,2017,11(12):1407-1419.DOI:10.1093/ecco-jcc/jjx109.
[29]谢华,何良梅,刘瑶,等.肠道菌群与炎症性肠病[J].赣南医学院学报,2017,37(4):659-663.DOI:10.3969/j.issn.1001-5779.2017.04.050.
[30]ALEKSANDROVA K,ROMERO-MOSQUERA B,HERNANDEZV.Diet,gut microbiome and epigenetics:emerging links with inflammatory bowel diseases and prospects for management and prevention[J].Nutrients,2017,9:E962.DOI:10.3390/nu9090962.
[31]ANDERSEN V,HOLMSKOV U,SORENSEN S B,et al.A proposal for a study on treatment selection and lifestyle recommendations in chronic inflammatory diseases:a Danish multidisciplinary collaboration on prognostic factors and personalised medicine[J].Nutrients,2017,9(5):E499.DOI:10.3390/nu9050499.
[32]JANTCHOU P,MOROIS S,CLAVEL-CHAPELON F,et al.Animal protein intake and risk of inflammatory bowel disease:the E3Nprospective study[J].The American Journal of Gastroenterology,2010,105(10):2195-2201.DOI:10.1038/ajg.2010.192.
[33]JOWETT S L,SEAL C J,PEARCE M S,et al.Influence of dietary factors on the clinical course of ulcerative colitis:a prospective cohort study[J].Gut,2004,53(10):1479-1484.DOI:10.1136/gut.2003.024828.
[34]ANDERSEN V,OLSEN A,CARBONNEL F,et al.Diet and risk of inflammatory bowel disease[J].Digestive and Liver Disease,2012,44(3):185-194.DOI:10.1016/j.dld.2011.10.001.
[35]石玲燕,张培趁,林春景,等.炎症性肠病危险因素的病例对照研究[J].中国全科医学,2011,14(11):1188-1190.DOI:10.3969/j.issn.1007-9572.2011.11.009.
[36]ANANTHAKRISHNAN A N,KHALILI H,KONIJETI G G,et al.A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis[J].Gastroenterology,2013,145(5):970-977.DOI:10.1053/j.gastro.2013.07.050.
[37]TASSON L,CANOVA C,VETTORATO M G,et al.Influence of diet on the course of inflammatory bowel disease[J].Digestive Diseases and Sciences,2017,62(8):2087-2094.DOI:10.1007/s10620-017-4620-0.
[38]SCAIOLI E,LIVERANI E,BELLUZZI A.The Imbalance between n-6/n-3 polyunsaturated fatty acids and inflammatory bowel disease:a comprehensive review and future therapeutic perspectives[J].International Journal of Molecular Sciences,2017,18(12):E2619.DOI:10.3390/ijms18122619.
[39]路媛媛,颜克松,樊超男,等.n-3多不饱和脂肪酸对肥胖小鼠肠道菌群的影响[J].中国儿童保健杂志,2014,22(11):1157-1160.DOI:10.11852/zgetbjzz2014-22-11-12.
[40]COSTEA I,MACK D R,LEMAITRE R N,et al.Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn’s disease[J].Gastroenterology,2014,146(4):929-931.DOI:10.1053/j.gastro.2013.12.034.
[41]冉影,周璐,王邦茂.饮食对肠道菌群的影响[J].中华临床营养杂志,2013,5(21):305-308.DOI:10.3760/cma.j.issn.1674-635X.2013.05.008.
[42]URANGA J A,L PEZ-MIRANDA V,LOMB F,et al.Food,nutrients and nutraceuticals affecting the course of inflammatory bowel disease[J].Pharmacological Reports,2016,68(4):816-826.DOI:10.1016/j.pharep.2016.05.002.
[43]王永辉,李培兵,于晓明,等.高蛋白膳食对限食大鼠肠道抗氧化功能的影响[J].营养学报,2009,31(2):145-147;151.DOI:10.3321/j.issn:0512-7955.2009.02.015.
[44]ORTEGA-GONZáLEZ M,CAPITáN-CA?ADAS F,REQUENAP,et al.Validation of bovine glycomacropeptide as an intestinal antiinflammatory nutraceutical in the lymphocyte-transfer model of colitis[J].The British Journal of Nutrition,2014,111(7):1202-1212.DOI:10.1017/S0007114513003590.
[45]王志凡,杨秀琳,陈旺盛,等.抗性淀粉对饮食诱导肥胖大鼠排便状况及肠道菌群的影响[J].动物营养学报,2016,28(5):1626-1632.DOI:10.3969/j.issn.1006-267x.2016.03.000.
[46]MASLOWSKI K M,MACKAY C R.Diet,gut microbiota and immune responses[J].Nature Immunology,2011,12(1):5-9.DOI:10.1038/ni0111-5.
[47]张晨,宓林,于晓峰.饮食与炎症性肠病研究进展[J].国际消化病杂志,2017,37(6):344-347.
[48]MONTELEONE I,MACDONALD T T,PALLONE F,et al.The aryl hydrocarbon receptor ininflammatory bowel disease:linking the environment to disease pathogenesis[J].Current Opinionin in Gastroenterology,2012,28(4):310-313.DOI:10.1097/MOG.0b013e328352ad69.
[49]ALTOMARE R,DAMIANO G,ABRUZZO A,et al.Enteral nutrition support to treat malnutrition in inflammatory bowel disease[J].Nutrients,2015,7(4):2125-2133.DOI:10.3390/nu7042125.
[50]LIM H S,KIM S K,HONG S J.Food elimination diet and nutritional deficiency in patients with inflammatory bowel disease[J].Clinical Nutrition Research,2018,7(1):48-55.DOI:10.7762/cnr.2018.7.1.48.
[51]MARTíNEZ GóMEZ M J,MELIáN FERNáNDEZ C,ROMEODONLO M.Nutrition in inflammatory bowel disease[J].Nutricion Hospitalaria,2016,33(Suppl 4):59-62.DOI:10.20960/nh.348.
[52]HOLT E M,STEFFEN L M,MORAN A,et al.Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents[J].Journal of the American Dietetic Association,2009,109(3):414-421.DOI:10.1016/j.jada.2008.11.036.
[53]DAMASKOS D,KOLIOS G.Probiotics and prebiotics in inflammatory bowel disease:microflora on the scope[J].British Journal of Clinical Pharmacology,2008,65(4):453-467.DOI:10.1111/j.1365-2125.2008.03265.x.
[54]SCALABRINO G.Vitamin-regulated cytokines and growth factors in the CNS and elsewhere[J].Journal of Neurochemistry,2009,111(6):1309-1326.
[55]FERGUSON L R.Nutrigenomics and inflammatory bowel diseases[J].Expert Review of Clinical Immunology,2010,6(4):573-583.DOI:10.1586/eci.10.43.
[56]LARUSSA T,IMENEO M,LUZZA F.Potential role of nutraceutical compounds in inflammatory bowel disease[J].World Journal of Gastroenterology,2017,23(14):2483-2492.DOI:10.3748/wjg.v23.i14.2483.
[57]SCHWALFENBERG G K.A review of the critical role of vitamin Din the functioning of the immune system and the clinical implications of vitamin D deficiency[J].Molecular Nutrition&Food Research,2011,55(1):96-108.DOI:10.1002/mnfr.201000174.
[58]MATHUR J,NAING S,MILLS P,et al.A randomized clinical trial of vitamin D3(cholecalciferol)in ulcerative colitis patients with hypovitaminosis D3[J].PeerJ,2017,5:e3654.DOI:10.7717/peerj.3654.
[59]RAPOZO D C,BERNARDAZZI C,DE SOUZA H S.Diet and microbiota in inflammatory bowel disease:the gut in disharmony[J].World Journal of Gastroenterology,2017,23(12):2124-2140.DOI:10.3748/wjg.v23.i12.2124.
[60]JOSTINS L,RIPKE S,WEERSMA R K,et al.Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease[J].Nature,2012,491:119-124.DOI:10.1038/nature11582.
[61]PENDYALA S,WALKER J M,HOLT P R.A high-fat diet is associated with endotoxemia thatoriginates from the gut[J].Gastroenterology,2012,142(5):1100-11101.DOI:10.1053/j.gastro.2012.01.034.
[62]STAPPENBECK T S,RIOUX J D,MIZOGUCHI A,et al.Crohn disease:a current perspective on genetics,autophagy and immunity[J].Autophagy,2014,7(4):355-374.DOI:10.4161/auto.7.2.13074.
[63]SUBRAMANIAN S,BLANTON L V,FRESE S A,et al.Cultivating healthy growth and nutrition through the gut microbiota[J].Cell,2015,161(1):36-48.DOI:10.1016/j.cell.2015.03.013.
[64]YATSUNENKO T,REY F E,MANARY M J,et al.Human gut microbiome viewed across age and geography[J].Nature,2012,486:222-227.DOI:10.1038/nature11053.