南京及周边地区糖化血红蛋白诊断糖尿病的截点值

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英文篇名：Study on cut-off point of glycosylated hemoglobin in diagnosis for diabetes mellitus in Nanjing and its surrounding areas 作者：朱芝娴 ; 李思洋 ; 朱小飞 英文作者：ZHU Zhixian;LI Siyang;ZHU Xiaofei;Department of Clinical Laboratory,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine; 关键词：糖尿病 ; 糖调节受损 ; 糖化血红蛋白 ; 诊断截点值 英文关键词：diabetes mellitus;;impaired glucose regulation;;glycosylated hemoglobin;;diagnostic cut-off point 中文刊名：JYYL 英文刊名：Laboratory Medicine and Clinic 机构：南京中医药大学附属医院检验科; 出版日期：2019-05-28 出版单位：检验医学与临床 年：2019 期：v.16 基金：国家自然科学基金资助项目(81503368) 语种：中文; 页：JYYL201910002 页数：4 CN：10 ISSN：50-1167/R 分类号：11-14

摘要

目的研究南京及其周边地区糖化血红蛋白(HbA1c)应用于糖尿病及糖调节受损(IGR)筛查与诊断的可行性,并预测其最佳的诊断截点值。方法将该院就诊的糖尿病患者及糖尿病高危人群共2 767例作为研究对象,行葡萄糖耐量试验,用空腹血糖及糖耐量试验2h血糖进行分组,检测HbA1c,并利用受试者工作特征曲线寻找诊断最佳截点值。结果南京及其周边地区健康、糖尿病及IGR人群的HbA1c比较,差异均有统计学意义(P<0.05),且随着病情的严重程度,HbA1c结果呈上升趋势。HbA1c诊断糖尿病的最佳截点值为6.45%,而诊断IGR的最佳截点值为6.05%。结论南京及其周边地区可以尝试采用6.05%与6.45%分别作为HbA1c诊断IGR与糖尿病的截点值。
        Objective To study the feasibility of glycosylated hemoglobin(HbA1 c)applying in screening and diagnosis for diabetes mellitus and impaired glucose regulation in Nanjing and its surrounding areas,and to predict the best diagnostic cut-off point.Methods A total of 2 767 objects with diabetes mellitus and the highrisk group of diabetes mellitus were selected from our hospital.Those objects were divided into three groups according to fasting blood glucose and 2 hblood glucose.The glycosylated hemoglobin was detected and the receiver operator characteristics analysis curve was used to find the best cut-off point for diagnosis within the three groups.Results There were significant differences on glycosylated hemoglobin among normal people,diabetes mellitus and impaired glucose regulation in Nanjing and its surrounding areas,the differences showed statistical significance and the results of glycosylated hemoglobin increased with the severity of the disease.The best cut-off point for glycosylated hemoglobin was 6.45%for diabetes mellitus and 6.05%for impaired glucose regulation.Conclusion 6.05%and 6.45%could be used as diagnostic cut-off points for impaired glucose regulation and diabetes mellitus in Nanjing and its surrounding areas.

引文

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