摘要
环状RNA是一种新型内源性长链非编码RNA,由外显子或内含子经套索驱动或内含子配对形成的无5′帽端和3′尾端的共价闭合环状结构,不受RNA外切酶影响。环状RNA作为微小RNA(miRNA)海绵体,能调控亲代基因转录和剪切,又与蛋白质相互作用、参与蛋白质翻译等。越来越多的研究表明,环状RNA参与到结直肠癌的病程中,对结直肠癌细胞的生长、转移、侵袭等发挥调控作用,有望成为结直肠癌临床诊断和预测的新的生物标志物。作者对环状RNA的功能及其与结直肠癌发生发展的关系作一综述。
引文
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