翼状胬肉侵入角膜面积和深度与角膜散光及角膜地形图的相关性分析
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摘要
目的探究翼状胬肉侵入角膜面积和深度与角膜散光及角膜地形图的相关性。方法选取2017年1月～2018年1月本院收治的56例翼状胬肉患者进行回顾性研究,对所有患者采用胬肉切除联合角膜缘干细胞移植术进行治疗,分析术前术后的角膜散光度,侵入角膜面积和深度及角膜地形图相关性、翼状胬肉形态与散光的关系及Orbscanò 3mm区域散光值。结果相对于术前,术后患者的角膜散光度改善显著(P <0.05);宽度、面积与患者的角膜表面呈现显著的不对称指数,角膜规则指数及呈现一定的正相关性,宽度和面积和角膜散光无相关性,同时翼状胬肉的长度和角膜表面的角膜表面呈现一定的不对称指数,即为角膜规则指数和角膜散光呈现明显的正相关;术前术后患者的翼状胬肉形态、散光的关系及Orbscanò 3mm区域散光值差异显著(P <0.05)。结论翼状胬肉切除术可有效减少患者的角膜散光,进而改善术前角膜地形图的不规则形态,综合提高患者的视力及视觉质量,值得临床深究。
Objective To investigate the correlation between corneal area and depth of pterygium invasion and corneal astigmatism and corneal topography. Methods A retrospective study of 56 patients with pterygium admitted to our hospital from January 2017 to January 2018 was conducted.All patients were treated with pterygium excision combined with limbal stem cell transplantation.Cortical astigmatism,invasive corneal area and depth and correlation of corneal topography,relationship between pterygium morphology and astigmatism,and astigmatism in Orbscanò 3mm region. Results Compared with preoperative corneal astigmatism,postoperative corneal astigmatism improved significantly,P < 0.05;width,area and patient's corneal surface showed significant asymmetry index,corneal rule index and showed a certain positive correlation,width and area.There is no correlation with corneal astigmatism,and the length of pterygium and the corneal surface of the cornea surfaced exhibit a certain asymmetry index,which is a significant positive correlation between corneal rule index and corneal astigmatism;pterygium morphology of patients before and after surgery.The relationship between astigmatism and the astigmatism value in the Orbscanò 3mm region was significant,P < 0.05. Conclusion Pterygium excision can effectively reduce corneal astigmatism,improve the irregular shape of preoperative corneal topography,comprehensively improve the visual and visual quality of patients,and it is worthy of clinical investigation.
Objective To investigate the correlation between corneal area and depth of pterygium invasion and corneal astigmatism and corneal topography. Methods A retrospective study of 56 patients with pterygium admitted to our hospital from January 2017 to January 2018 was conducted.All patients were treated with pterygium excision combined with limbal stem cell transplantation.Cortical astigmatism,invasive corneal area and depth and correlation of corneal topography,relationship between pterygium morphology and astigmatism,and astigmatism in Orbscanò 3mm region. Results Compared with preoperative corneal astigmatism,postoperative corneal astigmatism improved significantly,P < 0.05;width,area and patient's corneal surface showed significant asymmetry index,corneal rule index and showed a certain positive correlation,width and area.There is no correlation with corneal astigmatism,and the length of pterygium and the corneal surface of the cornea surfaced exhibit a certain asymmetry index,which is a significant positive correlation between corneal rule index and corneal astigmatism;pterygium morphology of patients before and after surgery.The relationship between astigmatism and the astigmatism value in the Orbscanò 3mm region was significant,P < 0.05. Conclusion Pterygium excision can effectively reduce corneal astigmatism,improve the irregular shape of preoperative corneal topography,comprehensively improve the visual and visual quality of patients,and it is worthy of clinical investigation.
引文
[1]黄旺斌.翼状胬肉与角膜散光关系的研究进展[J].医学综述,2014,20(4):673-675.
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[3]赵玲,肖光华,刘铭,等.翼状胬肉侵入角膜面积和深度与角膜散光及角膜地形图的关系观察[J].内蒙古中医药,2013,32(10):38-39.
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[6]邹晶,喻理,许博涵,等.肝素结合性表皮生长因子在翼状胬肉中的表达及意义[J].眼科新进展,2015,35(3):214-217.
[7]熊毅,杨森,唐建明.生物羊膜和角膜绷带镜作为辅助材料用于治疗翼状胬肉的临床效果对比分析[J].眼科新进展,2018,38(4):378-381.
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[9]曹端荣,龚静青,金玲,等.瘦素及血管内皮生长因子在复发性翼状胬肉中的表达与意义[J].卫生职业教育,2018(1):151-152.
[10]李娟,朴天华,王睿,等.中老年翼状胬肉患者癌胚抗原相关细胞黏附分子6和血管内皮生长因子表达与微血管密度的关系[J].中国老年学杂志,2017,37(6):1497-1499.
[11]彭畅,蒋正轩,梁坤,等.翼状胬肉中血管内皮生长因子、内皮抑素的表达以及新生血管生成情况[J].安徽医科大学学报,2014(5):645-648.
[12]张淑琦,唐孟苏,范忠义.小牛血去蛋白提取物眼用凝胶对翼状胬肉术后干眼的临床研究[J].临床军医杂志,2015(7):720-722.
[13]李梦琪,李璇,应阿珣,等.原发性翼状胬肉与干眼相关性的临床研究[J].河北医药,2017,39(3):468-470.
[14]陈俊杰,蓝育青,吴共发,等.VEGF诱导对翼状胬肉成纤维细胞血管生成拟态影响的研究[J].中华眼科医学杂志(电子版),2017,7(1):12-17.
[15]凌耿强,马东营,何瑞星,等.肿瘤细胞微环境对胶质瘤血管生成拟态形成的影响[J].中国医药生物技术,2017,12(2):134-138.
[2]张杨,温积权.翼状胬肉与眼角膜内皮细胞的关系研究[J].中国全科医学,2016,19(12):1435-1438.
[3]赵玲,肖光华,刘铭,等.翼状胬肉侵入角膜面积和深度与角膜散光及角膜地形图的关系观察[J].内蒙古中医药,2013,32(10):38-39.
[4]涂晶晶,费秋香.原发性翼状胬肉与微血管密度的关系研究[J].西南国防医药,2017(12):1310-1312.
[5]邓莹莹,周霞,孙荣,等.翼状胬肉手术前后对比敏感度和角膜地形图改变的比较[J].临床眼科杂志,2013,21(2):117-119.
[6]邹晶,喻理,许博涵,等.肝素结合性表皮生长因子在翼状胬肉中的表达及意义[J].眼科新进展,2015,35(3):214-217.
[7]熊毅,杨森,唐建明.生物羊膜和角膜绷带镜作为辅助材料用于治疗翼状胬肉的临床效果对比分析[J].眼科新进展,2018,38(4):378-381.
[8]张玮.翼状胬肉大小与角膜散光的关系[J].国际眼科杂志,2013,13(1):177-178.
[9]曹端荣,龚静青,金玲,等.瘦素及血管内皮生长因子在复发性翼状胬肉中的表达与意义[J].卫生职业教育,2018(1):151-152.
[10]李娟,朴天华,王睿,等.中老年翼状胬肉患者癌胚抗原相关细胞黏附分子6和血管内皮生长因子表达与微血管密度的关系[J].中国老年学杂志,2017,37(6):1497-1499.
[11]彭畅,蒋正轩,梁坤,等.翼状胬肉中血管内皮生长因子、内皮抑素的表达以及新生血管生成情况[J].安徽医科大学学报,2014(5):645-648.
[12]张淑琦,唐孟苏,范忠义.小牛血去蛋白提取物眼用凝胶对翼状胬肉术后干眼的临床研究[J].临床军医杂志,2015(7):720-722.
[13]李梦琪,李璇,应阿珣,等.原发性翼状胬肉与干眼相关性的临床研究[J].河北医药,2017,39(3):468-470.
[14]陈俊杰,蓝育青,吴共发,等.VEGF诱导对翼状胬肉成纤维细胞血管生成拟态影响的研究[J].中华眼科医学杂志(电子版),2017,7(1):12-17.
[15]凌耿强,马东营,何瑞星,等.肿瘤细胞微环境对胶质瘤血管生成拟态形成的影响[J].中国医药生物技术,2017,12(2):134-138.