试探中医时间医学与胃肠动力学的内在联系
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摘要
中医时间医学是中医学不可分割的一部分,从宏观角度上反映着人体生理活动和脏腑活动的节律。现代胃肠动力学发现,胃肠道的消化、运动能力也有相对固定的时间节律性。本文通过对两者节律性的对比分析,探究两者之间的内在联系,以期更好的指导临床。
TCM chronomedicine theory is an integral part of Chinese medicine. From a macro perspective, it reflects the rhythm of human physiological activities and organs activities. The modern gastrointestinal dynamics discovered some regularity related to time exist in gastrointestinal digestion, secretion and motility. The author made comparative analysis of the rhythmicity, explore relations between TCM Chronomedicine theory and gastrointestinal dynamics in order to guide clinic treatment.
TCM chronomedicine theory is an integral part of Chinese medicine. From a macro perspective, it reflects the rhythm of human physiological activities and organs activities. The modern gastrointestinal dynamics discovered some regularity related to time exist in gastrointestinal digestion, secretion and motility. The author made comparative analysis of the rhythmicity, explore relations between TCM Chronomedicine theory and gastrointestinal dynamics in order to guide clinic treatment.
引文
[1]Goo RH,Moore JG,Greenberg E,et al.Circadian Variation in gastric emptying of meals in human[J].Gastroenterology,1987,93(2):515.
[2]Kumar D,Wingate D,Ruckebusch Y.Circadian variation in the propaga-tion velocity of the migrating motor complex[J].Gastroenterology,1986,91(4):926-930.
[3]Narducci F,Bassotti G,Gaburri M,et al.Twenty four hour manometric re-cording of colonic motor activity in healthy man[J].Gut,1987,28(1):17-25.
[4]Auwerda JJ,Bac DJ,Schouten WR.Circadian rhythm of rectal motor com-plexes[J].Dis Colon Rectum,2001,44(9):1328-1332.
[5]Larsen KR,Moore JG,Dayton MT.Circadian rhythms of gastric mucus ef-flux and residual mucus gel in the fasting rat stomach[J].Dig Dis Sci,1991,36(11):1550-1555.
[6]Pasley JN,Burns ER,Rayford PL.Circadian variations of gastrointestinal peptides and cell proliferation in rats:effects of adrenalectomy[J].Re-cent Prog Horm Res,1994,49(3):59-65.
[7]P.C.Konturek,T.Brzozowski,S.J.Konturek.Gut Clock:Implication of Circadian Rhythms in the Gastrointestinal Tract[J].Journal of Physiology and Pharmacology,2011,62(2):139-150.
[8]Hisham G.Qandeel,Fernando Alonso,David J.Hernandez,etc.Role of Vagal Innervation in Diurnal Rhythm of Intestinal Peptide Transporter1(PEPT1)[J].J Gastrointest Surg,2009,13(11):1976-1985.
[9]Toku Takahashi.Mechanism of Interdigestive Migrating Motor Complex[J].J Neurogastroenterol Motil,2012,18(3):246-257.
[10]Dantas RO,Aben-Athar CG.Spects of sleep effects on the digestive tract[J].Arq Gastroenterol,2002,39(1):55-59.
[11]Hoogerwerf WA,Shahinian VB,Cornélissen G,et al.Rhythmic hanges in colonic motility are regulated by period genes[J].Am J Physiol Gas-trointest Liver Physiol,2010,298(2):G143-150.
[12]周吕,柯美主编.胃肠动力学-基础与临床[M].北京:科学出版社,1999:560.
[13]Nojkov B,Rubenstein JH,Chey WD,Hoogerwerf WA.The impact of ro-tating shift work on the prevalence of irritable bowel syndrome in nurses[J].Am J Gastroenterol,2010,105(4):842-847.
[14]Lu WZ,Gwee KA,Moochhalla S,Ho KY.Melatonin improves bowel symptoms in female patients with irritable bowel syndrome:a doubleblind placebo-controlled study[J].Aliment Pharmacol Ther,2005,22(10):927-934.
[15]程霞,徐汤苹,汤德安,等.不同时辰电针足三里对小白鼠胃肠运动机能的影响[J].天津中医学院学报,1987,4(4):33-34.
[16]程霞,杨介宾,宋开源,等.子午流注纳甲法对消化性溃疡患者胃酸分泌、血浆胃泌素及前列腺素E水平的影响[J].中西医结合杂志,1991,11(2):91-93.
[2]Kumar D,Wingate D,Ruckebusch Y.Circadian variation in the propaga-tion velocity of the migrating motor complex[J].Gastroenterology,1986,91(4):926-930.
[3]Narducci F,Bassotti G,Gaburri M,et al.Twenty four hour manometric re-cording of colonic motor activity in healthy man[J].Gut,1987,28(1):17-25.
[4]Auwerda JJ,Bac DJ,Schouten WR.Circadian rhythm of rectal motor com-plexes[J].Dis Colon Rectum,2001,44(9):1328-1332.
[5]Larsen KR,Moore JG,Dayton MT.Circadian rhythms of gastric mucus ef-flux and residual mucus gel in the fasting rat stomach[J].Dig Dis Sci,1991,36(11):1550-1555.
[6]Pasley JN,Burns ER,Rayford PL.Circadian variations of gastrointestinal peptides and cell proliferation in rats:effects of adrenalectomy[J].Re-cent Prog Horm Res,1994,49(3):59-65.
[7]P.C.Konturek,T.Brzozowski,S.J.Konturek.Gut Clock:Implication of Circadian Rhythms in the Gastrointestinal Tract[J].Journal of Physiology and Pharmacology,2011,62(2):139-150.
[8]Hisham G.Qandeel,Fernando Alonso,David J.Hernandez,etc.Role of Vagal Innervation in Diurnal Rhythm of Intestinal Peptide Transporter1(PEPT1)[J].J Gastrointest Surg,2009,13(11):1976-1985.
[9]Toku Takahashi.Mechanism of Interdigestive Migrating Motor Complex[J].J Neurogastroenterol Motil,2012,18(3):246-257.
[10]Dantas RO,Aben-Athar CG.Spects of sleep effects on the digestive tract[J].Arq Gastroenterol,2002,39(1):55-59.
[11]Hoogerwerf WA,Shahinian VB,Cornélissen G,et al.Rhythmic hanges in colonic motility are regulated by period genes[J].Am J Physiol Gas-trointest Liver Physiol,2010,298(2):G143-150.
[12]周吕,柯美主编.胃肠动力学-基础与临床[M].北京:科学出版社,1999:560.
[13]Nojkov B,Rubenstein JH,Chey WD,Hoogerwerf WA.The impact of ro-tating shift work on the prevalence of irritable bowel syndrome in nurses[J].Am J Gastroenterol,2010,105(4):842-847.
[14]Lu WZ,Gwee KA,Moochhalla S,Ho KY.Melatonin improves bowel symptoms in female patients with irritable bowel syndrome:a doubleblind placebo-controlled study[J].Aliment Pharmacol Ther,2005,22(10):927-934.
[15]程霞,徐汤苹,汤德安,等.不同时辰电针足三里对小白鼠胃肠运动机能的影响[J].天津中医学院学报,1987,4(4):33-34.
[16]程霞,杨介宾,宋开源,等.子午流注纳甲法对消化性溃疡患者胃酸分泌、血浆胃泌素及前列腺素E水平的影响[J].中西医结合杂志,1991,11(2):91-93.
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