妊娠期病毒感染与不良妊娠结局
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摘要
妊娠期病毒感染可造成很多不良的妊娠结局,妊娠期的病毒感染比如风疹病毒、巨细胞病毒、弓形虫、单纯疱疹病毒等,这些病毒感染所引起的疾病统称为TORCH综合征,此外常见的还有人微小病毒B19。其感染的共同特征为病毒可通过胎盘引起宫内感染,而感染的孕妇常无症状或症状轻微,妊娠期病毒感染发生在不同的孕周对妊娠结局所产生的影响也不同。本文就妊娠期病毒感染的发病情况,传播途径及相关预后作简要综述,旨在提高对其认识,进一步减少妊娠期病毒感染及其不良预后的发生。
Pregnancy parvovirus infection can cause a lot of adverse pregnancy outcomes of pregnancy, parvovirus infection such as rubella virus, cytomegalovirus, Toxoplasma gondii, herpes simplex virus, parvovirus infection caused by these diseases are called TORCH syndrome, in addition there are common B19 virus. The common characteristics of the virus infection can cause intrauterine infection through the placenta, and infected pregnant women often have no symptoms or mild symptoms of pregnancy, infections have influence on pregnancy outcome in different gestational weeks with. In this paper, the incidence, transmission route and related prognosis of parvovirus infection in pregnancy were reviewed, in order to improve the understanding of it, and further reduce the incidence of viral infection and adverse prognosis in pregnancy.
Pregnancy parvovirus infection can cause a lot of adverse pregnancy outcomes of pregnancy, parvovirus infection such as rubella virus, cytomegalovirus, Toxoplasma gondii, herpes simplex virus, parvovirus infection caused by these diseases are called TORCH syndrome, in addition there are common B19 virus. The common characteristics of the virus infection can cause intrauterine infection through the placenta, and infected pregnant women often have no symptoms or mild symptoms of pregnancy, infections have influence on pregnancy outcome in different gestational weeks with. In this paper, the incidence, transmission route and related prognosis of parvovirus infection in pregnancy were reviewed, in order to improve the understanding of it, and further reduce the incidence of viral infection and adverse prognosis in pregnancy.
引文
[1]Sima Rasti,Fatemesh Sadat Ghasemi,Amir Abdoli,et al.To RCH“coinfections”are associated with increased risk of abortion in pregnant women[J].Congenital Anomalies,2016,56(4):73-78.
[2]张宁,闫素文,封志纯,等.妊娠期To RCH筛查指南[J].解放军杂志,2014,26(01):102-116.
[3]乔桂兰,薄五海.风疹病毒感染与畸形[J].中国优生与遗传杂志,1998,6(01):116-117.
[4]肖兵,万虹,谢成彬,等.6018例孕前及孕早期妇女风疹及巨细胞病毒感染状况的分析[J].实用妇产科杂志,2013,29(07):509-512.
[5]Kristina M.Adams Waldorf,Ryan M.Mc Adams.Influence of infection During Pregnancy on Fetal Development[J].Reproduction,2013,146(5):151-162.
[6]林建华,蒋萌.风疹病毒感染对妊娠结局的影响[J].中国实用妇科与产科杂志,2011,27(08):567-569.
[7]陈润莉,侯红斌,莫浩联,等.妊娠期妇女风疹病毒感染状况分析[J].中国热带医学,2015,15(07):833-835.
[8]Michelle Silasi,Ingrid Cardenas,Ja-Young Kwon,et al.Viral Infections During Pregnancy[J].Am J Reprod Immunol,2015,73(15):199-213.
[9]徐婉芳,刘彦慧.弓形体、风疹病毒、巨细胞病毒、单纯疱疹病毒病原体检测与自然流产的相关性研究[J].当代医学,2013,9(308):22-23.
[10]郑云飞,杜季梅,胡燕.妊娠期风疹病毒感染对孕妇及胎儿的影响[J].中国妇产科杂志,2002,37(07):391-394.
[11]饶华祥,侯玉英.刚地弓形虫感染致胎盘损伤作用的研究进展[J].中国病原生物学杂志,2008,3(04):318-320.
[12]张燕萍,宋任浩.孕妇弓形虫感染妊娠结局及危险因素调查[J].中国血吸虫病防治杂志,2014,26(02):221-223.
[13]A.E.Lange,J.R.Thyrian,S.Wetzka,et al.The impact of socioeconomic factors on the efficiency of voluntary toxoplasmosis screening during pregnancy:a population-based study[J].BMC Pregnancy and Childbirth,2016,16(1):197-206.
[14]谢素瑛,谢霖崇.孕妇弓形虫感染与异常妊娠[J].中国热带医学,2011,11(04):507-510.
[15]Hemah Andiappan,Veeranoot Nissapatorn,Nongyao Sawangjaroen,et al.Knowledge and practice on Toxoplasma infection in pregnant women from Malaysia,Philippines,and Thailand[J].Original Research Artiocle,2014,5(291):1-8.
[16]吕元聪,广西弓形虫病研究概况[J].中国寄生虫病防治杂志,2001,14(4):302-305.
[17]肖长纪,杨慧霞.妊娠期微小病毒B19、水痘带状疱疹病毒及弓形虫感染的临床实践指南[J].中华围产医学杂志,2015,18(12):885-888.
[18]沈凤贤,吕时铭.妊娠期巨细胞病毒感染诊断研究进展[J].国际妇产科学杂志,2013,40(01):10-13.
[19]彭冰,刘兴会.妊娠期人巨细胞病毒感染及预后[J].中国实用妇科与产科杂志,2009,25(11):815-818.
[20]Ichiro Morioka,Ayako Sonoyama,Shinya Tairaku,et al.Awareness of and knowledge about mother-to-child infections in Japanese pregnant women[J].Congenital Anomalies,2014,54:35-40.
[21]徐婉芳,刘彦慧.弓形体、风疹病毒、巨细胞病毒、单纯疱疹病毒病原体检测与自然流产的相关性研究[J].当代医学,2013,19(09):22-23.
[22]董彦亮.妊娠期单纯疱疹病毒感染与不良妊娠结局[J].中国实用妇科与产科杂志,2011,(08):572-576.
[23]Vlasova MA,Ostrovskaia OV,L'vov ND,et al.The effect of symptomfree genital herpes on the course and outcome of preg-nancy[J].Vopr Virusol,1991,36(6):501-503.
[24]Peng Zhu,Yu-Jiang Chen,Jia-Hu Hao,et al.Maternal depressive symptoms related to Epstein-Barr virus reactivation in late pregnancy[J].Scientific Reports,2013,10(3):96-101.
[25]Joan Crane,MD,St.John’s NL,William Mundle,et al.Parvovirus B19Infection in Pregnancy[J].JObstet Gynaecol Can,2014,36(12):1107-1116.
[26]彭燕,莫吉祥,罗利萍,等.湖南湘潭地区育龄妇女人微小病毒B19流行病学调查[J].现代预防医学,2014,41(06):997-999.
[27]Ayaka Kawabe,Yasushi Takai,Jun-lchi Tamaru,et al.Placental abruption possibly due to parvovirus B19 infection[J].Springer Plus,2016,5:1280-1285.
[28]Nahid Rahbar,Saeid Valizadeh,Raheb Ghorbani,et al.Prevalence of Parvovirus B19 Specific Antibody in Pregnant Women with Spontaneous Abortion[J].Original Article,2013,53(3):168-172.
[29]Jonathan Lassen,Anne K.V.Jensen,Peter Bager,et al.Parvovirus B19Infection in the First Trimester of Pregnancy and Risk of Fetal Loss:A Population-based Case-Control Study[J].American Journal of Epidemiology,2012,176(9):803-807.
[30]Guillaume Mace,Marine Sauvan,Vanina Castaigne,et al.Clinical presentation and outcome of 20 fetuses with parvovirus B19 infection complicated by severe anemia and/or fetal hydrops[J].Prenatal Diagnisis,2014,34(4):1023-1030.
[31]罗青清,骆名恋,邹丽.“妊娠期微小病毒B19感染的临床实践指南”解读[J].中国实用妇科与产科杂志,2016,32(06):502-504.
[32]Lisa M.Christian,Ph D,Jay D.lams,et al.Epstein-Barr virus reactivation during pregnancy and postpartum:Effects of race and racial discrimnation[J].Brain Behav Immun,2012,26(8):1280-1287.
[33]张宁.妊娠期TORCH筛查结果的判读[J].沈阳医学院学报,2011,13(04):242-246.
[2]张宁,闫素文,封志纯,等.妊娠期To RCH筛查指南[J].解放军杂志,2014,26(01):102-116.
[3]乔桂兰,薄五海.风疹病毒感染与畸形[J].中国优生与遗传杂志,1998,6(01):116-117.
[4]肖兵,万虹,谢成彬,等.6018例孕前及孕早期妇女风疹及巨细胞病毒感染状况的分析[J].实用妇产科杂志,2013,29(07):509-512.
[5]Kristina M.Adams Waldorf,Ryan M.Mc Adams.Influence of infection During Pregnancy on Fetal Development[J].Reproduction,2013,146(5):151-162.
[6]林建华,蒋萌.风疹病毒感染对妊娠结局的影响[J].中国实用妇科与产科杂志,2011,27(08):567-569.
[7]陈润莉,侯红斌,莫浩联,等.妊娠期妇女风疹病毒感染状况分析[J].中国热带医学,2015,15(07):833-835.
[8]Michelle Silasi,Ingrid Cardenas,Ja-Young Kwon,et al.Viral Infections During Pregnancy[J].Am J Reprod Immunol,2015,73(15):199-213.
[9]徐婉芳,刘彦慧.弓形体、风疹病毒、巨细胞病毒、单纯疱疹病毒病原体检测与自然流产的相关性研究[J].当代医学,2013,9(308):22-23.
[10]郑云飞,杜季梅,胡燕.妊娠期风疹病毒感染对孕妇及胎儿的影响[J].中国妇产科杂志,2002,37(07):391-394.
[11]饶华祥,侯玉英.刚地弓形虫感染致胎盘损伤作用的研究进展[J].中国病原生物学杂志,2008,3(04):318-320.
[12]张燕萍,宋任浩.孕妇弓形虫感染妊娠结局及危险因素调查[J].中国血吸虫病防治杂志,2014,26(02):221-223.
[13]A.E.Lange,J.R.Thyrian,S.Wetzka,et al.The impact of socioeconomic factors on the efficiency of voluntary toxoplasmosis screening during pregnancy:a population-based study[J].BMC Pregnancy and Childbirth,2016,16(1):197-206.
[14]谢素瑛,谢霖崇.孕妇弓形虫感染与异常妊娠[J].中国热带医学,2011,11(04):507-510.
[15]Hemah Andiappan,Veeranoot Nissapatorn,Nongyao Sawangjaroen,et al.Knowledge and practice on Toxoplasma infection in pregnant women from Malaysia,Philippines,and Thailand[J].Original Research Artiocle,2014,5(291):1-8.
[16]吕元聪,广西弓形虫病研究概况[J].中国寄生虫病防治杂志,2001,14(4):302-305.
[17]肖长纪,杨慧霞.妊娠期微小病毒B19、水痘带状疱疹病毒及弓形虫感染的临床实践指南[J].中华围产医学杂志,2015,18(12):885-888.
[18]沈凤贤,吕时铭.妊娠期巨细胞病毒感染诊断研究进展[J].国际妇产科学杂志,2013,40(01):10-13.
[19]彭冰,刘兴会.妊娠期人巨细胞病毒感染及预后[J].中国实用妇科与产科杂志,2009,25(11):815-818.
[20]Ichiro Morioka,Ayako Sonoyama,Shinya Tairaku,et al.Awareness of and knowledge about mother-to-child infections in Japanese pregnant women[J].Congenital Anomalies,2014,54:35-40.
[21]徐婉芳,刘彦慧.弓形体、风疹病毒、巨细胞病毒、单纯疱疹病毒病原体检测与自然流产的相关性研究[J].当代医学,2013,19(09):22-23.
[22]董彦亮.妊娠期单纯疱疹病毒感染与不良妊娠结局[J].中国实用妇科与产科杂志,2011,(08):572-576.
[23]Vlasova MA,Ostrovskaia OV,L'vov ND,et al.The effect of symptomfree genital herpes on the course and outcome of preg-nancy[J].Vopr Virusol,1991,36(6):501-503.
[24]Peng Zhu,Yu-Jiang Chen,Jia-Hu Hao,et al.Maternal depressive symptoms related to Epstein-Barr virus reactivation in late pregnancy[J].Scientific Reports,2013,10(3):96-101.
[25]Joan Crane,MD,St.John’s NL,William Mundle,et al.Parvovirus B19Infection in Pregnancy[J].JObstet Gynaecol Can,2014,36(12):1107-1116.
[26]彭燕,莫吉祥,罗利萍,等.湖南湘潭地区育龄妇女人微小病毒B19流行病学调查[J].现代预防医学,2014,41(06):997-999.
[27]Ayaka Kawabe,Yasushi Takai,Jun-lchi Tamaru,et al.Placental abruption possibly due to parvovirus B19 infection[J].Springer Plus,2016,5:1280-1285.
[28]Nahid Rahbar,Saeid Valizadeh,Raheb Ghorbani,et al.Prevalence of Parvovirus B19 Specific Antibody in Pregnant Women with Spontaneous Abortion[J].Original Article,2013,53(3):168-172.
[29]Jonathan Lassen,Anne K.V.Jensen,Peter Bager,et al.Parvovirus B19Infection in the First Trimester of Pregnancy and Risk of Fetal Loss:A Population-based Case-Control Study[J].American Journal of Epidemiology,2012,176(9):803-807.
[30]Guillaume Mace,Marine Sauvan,Vanina Castaigne,et al.Clinical presentation and outcome of 20 fetuses with parvovirus B19 infection complicated by severe anemia and/or fetal hydrops[J].Prenatal Diagnisis,2014,34(4):1023-1030.
[31]罗青清,骆名恋,邹丽.“妊娠期微小病毒B19感染的临床实践指南”解读[J].中国实用妇科与产科杂志,2016,32(06):502-504.
[32]Lisa M.Christian,Ph D,Jay D.lams,et al.Epstein-Barr virus reactivation during pregnancy and postpartum:Effects of race and racial discrimnation[J].Brain Behav Immun,2012,26(8):1280-1287.
[33]张宁.妊娠期TORCH筛查结果的判读[J].沈阳医学院学报,2011,13(04):242-246.