氨基酸对内质网应激影响的研究进展
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摘要
内质网应激(ERS)的发生参与了人体多种疾病的发生、发展。精准、有效的干预和调控ERS成为近年来关注的热点。氨基酸作为构成人体所需蛋白质的营养元素,同时,也是人体内重要的信号传导分子。通过氨基酸对ERS反应的干预和调节很可能是一个重要且未开发的领域,有望成为探求恶性肿瘤、心血管疾病等新防治策略的潜在靶点。因此,该文将近年来氨基酸对细胞ERS反应影响的研究进展作一综述。
The occurrence of endoplasmic reticulum stress(ERS)is involved in the development of various diseases in human body.Accurate and effective intervention and regulation of ERS has become a hot spot in recent years.Amino acids are the nutrients that make up the proteins that people need,and they are also important signal transduction molecules in the human body.Intervention and regulation of ERS stress by amino acids is likely to be an important and unexplored area,and it is expected to become a potential target for new prevention strategies such as malignant tumors and cardiovascular diseases.Therefore,in this article,we will briefly review the research progress of the effects of amino acids on cellular ERS stress in recent years.
The occurrence of endoplasmic reticulum stress(ERS)is involved in the development of various diseases in human body.Accurate and effective intervention and regulation of ERS has become a hot spot in recent years.Amino acids are the nutrients that make up the proteins that people need,and they are also important signal transduction molecules in the human body.Intervention and regulation of ERS stress by amino acids is likely to be an important and unexplored area,and it is expected to become a potential target for new prevention strategies such as malignant tumors and cardiovascular diseases.Therefore,in this article,we will briefly review the research progress of the effects of amino acids on cellular ERS stress in recent years.
引文
[1] CELLI J,TSOLIS R M.Bacteria,the endoplasmic reticulum and the unfolded protein response:friends or foes?[J].Nat Rev Microbiol,2015,13(2):71-82.
[2] NISHITOH H.CHOP is a multifunctional transcription factor in the ER stress response[J].J Biochem,2012,151(3):217-219.
[3] MAUREL M,CHEVET E,TAVERNIER J,et al.Getting RIDD of RNA:IRE1in cell fate regulation[J].Trends Biochem Sci,2014,39(5):245-254.
[4] SONG B,SCHEUNER D,RON D,et al.Chop deletion reduces oxidative stress,improves beta cell function,and promotes cell survival in multiple mouse models of diabetes[J].J Clin Invest,2008,118(10):3378-3389.
[5] KARAGOZ G,CHEN V,SCHAEFER J,et al.An unfolded protein-induced conformational Switch activates mammalian IRE1[J].Mol Biol Cell,2017,6:e30700.
[6] GARCIA-NAVAS R,MUNDER M,MOLLINEDO F.Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes[J].Autophagy,2012,8(11):1557-1576.
[7] BOBAK Y,KURLISHCHUK Y,VYNNYTSKA-MYRONOVSKA B,et al.Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells[J].Int J Biochem Cell Biol,2016,70:29-38.
[8] MA Y,HENDERSHOT L M.The role of the unfolded protein response in tumour development:friend or foe?[J].Nat Rev Cancer,2004,4(12):966-977.
[9] DEKA K,SINGH A,CHAKRABORTY S,et al.Protein arginylation regulates cellular stress response by stabilizing HSP70and HSP40transcripts[J].Cell Death Discov,2016,2:16074.
[10]OLIVEIRA G P,DE ABREU M G,PELOSI P A.Exogenous Glutamine in Respiratory Diseases:Myth or Reality?[J].Nutrients,2016,8(2):76.
[11]HENSLEY C T,WASTI A T,DEBERARDINIS R J.Glutamine and cancer:cell biology,physiology,and clinical opportunities[J].J Clin Invest,2013,123(9):3678-3684.
[12]SHANWARE N P,BRAY K,ENG C H,et al.Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion[J].Nat Commun,2014,5:4900.
[13]QING G,LI B,VU A,et al.ATF4regulates MYC-Mediated neuroblastoma cell death upon glutamine deprivation[J].Cancer Cell,2012,22(5):631-644.
[14]DILSHARA M G,JEONG J W,Prasad Tharanga Jayasooriya R G,et al.Glutamine deprivation sensitizes human breast cancer MDA-MB-231cells to TRIAL-mediated apoptosis[J].Biochem Biophys Res Commun,2017,485(2):440-445.
[15]CRESPO I,SAN-MIGUEL B,PRAUSE C,et al.Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-Induced colitis[J].PLoS One,2012,7(11):e50407.
[16]HOSSAIN G S,VAN THIENEN J V,WERSTUCK G H,et al.TDAG51is induced by homocysteine,promotes detachment-mediated programmed cell death,and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia[J].J Biol Chem,2003,278(32):30317-30327.
[17]AUSTIN R C,LENTZ S R,WERSTUCK G H.Role of hyperhomocysteinemia in endothelial dysfunction and atherothromboticdisease[J].Cell Death Differ,2004,11Suppl 1:S56-64.
[18]AI Y,SUN Z,PENG C,et al.Homocysteine induces hepatic steatosis involving ER stress response in high methionine Diet-Fed mice[J].Nutrients,2017,9(4):E346.
[19]MARTINON F,CHEN XI,LEE A H,et al.TLR activation of the transcription factor XBP1regulates innate immune responses in macrophages[J].Nat Immunol,2010,11(5):411-418.
[20]WOO C W,KUTZLER L,KIMBALL S R,et al.Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B[J].Nat Cell Biol,2012,14(2):192-200.
[21]GARG A D,KACZMAREK A,KRYSKO O A,et al.ER stress-induced inflammation:does it aid or impede disease progression?[J].Trends Mol Med,2012,18(10):589-598.
[22]OCHOA C D,WU R F,TERADA L S.ROS signaling and ER stress in cardiovascular disease[J].Mol Aspects Med,2018,63:18-29.
[23]LEE J H,WON S M,SUH J,et al.Induction of the unfolded protein response and cell death pathway in Alzheimer′s disease,but not in aged Tg2576mice[J].Exp Mol Med,2010,42(5):386-394.
[24]SILVA R M,RIES V,OO T F,et al.CHOP/GADD153is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism[J].J Neurochem,2005,95(4):974-986.
[25]JHENG J R,HO J Y,HORNG J T.ER stress,autophagy,and RNA viruses[J].Front Microbiol,2014,5:388.
[26]TIROSH B,IWAKOSHI N N,LILLEY B N,et al.Human cytomegalovirus protein US11provokes an unfolded protein response that May facilitate the degradation of class I major histocompatibility complex products[J].J Virol,2005,79(5):2768-2779.
[27]BAIRD M,WOON ANG P,CLARK I,et al.The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner[J].Lab Invest,2013,93(1):112-122.
[28]AKAZAWA Y,ISOMOTO H,MATSUSHIMA K,et al.Endoplasmic reticulum stress contributes to helicobacter pylori VacA-Induced apoptosis[J].PLoS One,2013,8(12):e82322.
[2] NISHITOH H.CHOP is a multifunctional transcription factor in the ER stress response[J].J Biochem,2012,151(3):217-219.
[3] MAUREL M,CHEVET E,TAVERNIER J,et al.Getting RIDD of RNA:IRE1in cell fate regulation[J].Trends Biochem Sci,2014,39(5):245-254.
[4] SONG B,SCHEUNER D,RON D,et al.Chop deletion reduces oxidative stress,improves beta cell function,and promotes cell survival in multiple mouse models of diabetes[J].J Clin Invest,2008,118(10):3378-3389.
[5] KARAGOZ G,CHEN V,SCHAEFER J,et al.An unfolded protein-induced conformational Switch activates mammalian IRE1[J].Mol Biol Cell,2017,6:e30700.
[6] GARCIA-NAVAS R,MUNDER M,MOLLINEDO F.Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes[J].Autophagy,2012,8(11):1557-1576.
[7] BOBAK Y,KURLISHCHUK Y,VYNNYTSKA-MYRONOVSKA B,et al.Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells[J].Int J Biochem Cell Biol,2016,70:29-38.
[8] MA Y,HENDERSHOT L M.The role of the unfolded protein response in tumour development:friend or foe?[J].Nat Rev Cancer,2004,4(12):966-977.
[9] DEKA K,SINGH A,CHAKRABORTY S,et al.Protein arginylation regulates cellular stress response by stabilizing HSP70and HSP40transcripts[J].Cell Death Discov,2016,2:16074.
[10]OLIVEIRA G P,DE ABREU M G,PELOSI P A.Exogenous Glutamine in Respiratory Diseases:Myth or Reality?[J].Nutrients,2016,8(2):76.
[11]HENSLEY C T,WASTI A T,DEBERARDINIS R J.Glutamine and cancer:cell biology,physiology,and clinical opportunities[J].J Clin Invest,2013,123(9):3678-3684.
[12]SHANWARE N P,BRAY K,ENG C H,et al.Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion[J].Nat Commun,2014,5:4900.
[13]QING G,LI B,VU A,et al.ATF4regulates MYC-Mediated neuroblastoma cell death upon glutamine deprivation[J].Cancer Cell,2012,22(5):631-644.
[14]DILSHARA M G,JEONG J W,Prasad Tharanga Jayasooriya R G,et al.Glutamine deprivation sensitizes human breast cancer MDA-MB-231cells to TRIAL-mediated apoptosis[J].Biochem Biophys Res Commun,2017,485(2):440-445.
[15]CRESPO I,SAN-MIGUEL B,PRAUSE C,et al.Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-Induced colitis[J].PLoS One,2012,7(11):e50407.
[16]HOSSAIN G S,VAN THIENEN J V,WERSTUCK G H,et al.TDAG51is induced by homocysteine,promotes detachment-mediated programmed cell death,and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia[J].J Biol Chem,2003,278(32):30317-30327.
[17]AUSTIN R C,LENTZ S R,WERSTUCK G H.Role of hyperhomocysteinemia in endothelial dysfunction and atherothromboticdisease[J].Cell Death Differ,2004,11Suppl 1:S56-64.
[18]AI Y,SUN Z,PENG C,et al.Homocysteine induces hepatic steatosis involving ER stress response in high methionine Diet-Fed mice[J].Nutrients,2017,9(4):E346.
[19]MARTINON F,CHEN XI,LEE A H,et al.TLR activation of the transcription factor XBP1regulates innate immune responses in macrophages[J].Nat Immunol,2010,11(5):411-418.
[20]WOO C W,KUTZLER L,KIMBALL S R,et al.Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B[J].Nat Cell Biol,2012,14(2):192-200.
[21]GARG A D,KACZMAREK A,KRYSKO O A,et al.ER stress-induced inflammation:does it aid or impede disease progression?[J].Trends Mol Med,2012,18(10):589-598.
[22]OCHOA C D,WU R F,TERADA L S.ROS signaling and ER stress in cardiovascular disease[J].Mol Aspects Med,2018,63:18-29.
[23]LEE J H,WON S M,SUH J,et al.Induction of the unfolded protein response and cell death pathway in Alzheimer′s disease,but not in aged Tg2576mice[J].Exp Mol Med,2010,42(5):386-394.
[24]SILVA R M,RIES V,OO T F,et al.CHOP/GADD153is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism[J].J Neurochem,2005,95(4):974-986.
[25]JHENG J R,HO J Y,HORNG J T.ER stress,autophagy,and RNA viruses[J].Front Microbiol,2014,5:388.
[26]TIROSH B,IWAKOSHI N N,LILLEY B N,et al.Human cytomegalovirus protein US11provokes an unfolded protein response that May facilitate the degradation of class I major histocompatibility complex products[J].J Virol,2005,79(5):2768-2779.
[27]BAIRD M,WOON ANG P,CLARK I,et al.The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner[J].Lab Invest,2013,93(1):112-122.
[28]AKAZAWA Y,ISOMOTO H,MATSUSHIMA K,et al.Endoplasmic reticulum stress contributes to helicobacter pylori VacA-Induced apoptosis[J].PLoS One,2013,8(12):e82322.