阿卡波糖片联合甘精胰岛素治疗糖尿病患者的临床效果分析
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摘要
目的针对糖尿病患者采用阿卡波糖片联合甘精胰岛素的治疗方案进行治疗,分析其临床效果。方法选取本院2017年2月至2018年1月收治的122例老年2型糖尿病患者按照随机数字法分成两组,实验组61例行以阿卡波糖片联合甘精胰岛素治疗方案,对照组61例行以阿卡波糖片治疗方案,对比两组患者的临床治疗有效率、不良反应发生率、血糖情况。结果实验组患者接受治疗后,其治疗有效的患者例数及占比优于对照组,且不良反应情况要优于对照组,组间数据比较差异具有统计学意义(P<0.05);治疗前两组患者的血糖情况以及生命体征指标比较差异无统计学意义,治疗后实验组患者的血糖情况显著优于对照组,对比差异具有统计学意义(P<0.05)。结论对比单纯使用阿卡波糖片,联合甘精胰岛素治疗对于老年糖尿病患者的治疗效果更为显著,能够显著缓解患者的血糖情况,而且安全性高,该治疗方式适合在临床推广使用。
Objective To treat patients with diabetes mellitus with acarbose tablets combined with insulin glargine treatment, and analyze its clinical effects. Methods A total of 122 elderly patients with type 2 diabetes admitted to our hospital from February 2017 to January 2018 were enrolled according to the random number method. 61 patients in the experimental group were treated with acarbose tablets combined with insulin glargine treatment. A total of 61 patients were treated with acarbose tablets, and the clinical treatment efficiency, adverse reaction rate, and blood glucose were compared between the two groups. Results After treatment, the number of patients with effective treatment was better than that of the control group,and the adverse reactions were better than the control group. The difference between the groups was statistically significant(P<0.05). There was no significant difference in blood glucose status and vital signs between the two groups. After treatment, the blood glucose level of the experimental group was significantly better than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Compared with the simple use of acarbose tablets, the combination of insulin glargine treatment is more effective in the treatment of elderly patients with diabetes,can significantly relieve the patient' s blood sugar, and is highly safe. This treatment is suitable for clinical use.
Objective To treat patients with diabetes mellitus with acarbose tablets combined with insulin glargine treatment, and analyze its clinical effects. Methods A total of 122 elderly patients with type 2 diabetes admitted to our hospital from February 2017 to January 2018 were enrolled according to the random number method. 61 patients in the experimental group were treated with acarbose tablets combined with insulin glargine treatment. A total of 61 patients were treated with acarbose tablets, and the clinical treatment efficiency, adverse reaction rate, and blood glucose were compared between the two groups. Results After treatment, the number of patients with effective treatment was better than that of the control group,and the adverse reactions were better than the control group. The difference between the groups was statistically significant(P<0.05). There was no significant difference in blood glucose status and vital signs between the two groups. After treatment, the blood glucose level of the experimental group was significantly better than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Compared with the simple use of acarbose tablets, the combination of insulin glargine treatment is more effective in the treatment of elderly patients with diabetes,can significantly relieve the patient' s blood sugar, and is highly safe. This treatment is suitable for clinical use.
引文
[1]代艳.联合应用甘精胰岛素与阿卡波糖片治疗老年糖尿病的疗效分析[J].中国现代药物应用,2018,12(5):127-128.
[2]刘勇华,涂萍,吴和平.甘精胰岛素注射液联合格列美脲片和阿卡波糖片治疗磺脲类药物治疗失效的2型糖尿病患者效果分析[J].黑龙江医学,2018,42(1):63-64.
[3]王贵锋,白玉晓,娄东亮,等.甘精胰岛素联合阿卡波糖片治疗老年糖尿病的效果观察[J].医学理论与实践,2017,30(8):1144-1145.
[4] Zannad F, Stough WG, Lipicky RJ, et al. Assessment of cardiovascular risk of new drugs for the treatment of diabetes mellitus:risk assessment vs. risk aversion[J]. European Heart Journal Cardiovascular Pharmacotherapy, 2016,2(3):200.
[5]罗敏,曹洁.甘精胰岛素联合阿卡波糖片治疗老年糖尿病疗效与安全性评价[J].临床医药文献电子杂志,2017,4(29):5687,5690.
[6]李冬玲,李远,陈燕铭.甘精胰岛素联合格列美脲和阿卡波糖治疗磺脲类药物治疗失效的2型糖尿病的疗效观察[J].现代药物与临床,2017,32(3):423-427.
[7] Zhang Y, Chen Z, Wang T, et al. Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase[J]. Oncotarget, 2016,7(26):39302-39315.
[8]张海影,史博,鲁国玲.老年糖尿病患者采用甘精胰岛素联合阿卡波糖治疗对BMI等的影响[J].实用糖尿病杂志,2017,13(1):45-46.
[9]杨华,许学忠,祁平,等.甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究[J].中国临床药理学杂志,2017,33(3):219-221.
[10] Oridupa OA, Folasire OF, Owolabi AJ, et al. Effect of Traditional Treatment of Diabetes Mellitus with Xanthosoma sagittifolium on the Male Reproductive System of Alloxan-Induced Diabetic Wistar Rats[J].Drug Research, 2017,67(6):337-342.
[11]朱芳慧.地特胰岛素联合阿卡波糖片在2型糖尿病治疗中的疗效观察[J].临床医药文献电子杂志,2016,3(38):7659,7662.
[12]李晓蕾.甘精胰岛素、格列美脲、阿卡波糖片联合治疗继发性磺脲类失效的2型糖尿病患者的临床效果观察[D].安徽医科大学,2016.
[13]曾燕.国产与进口阿卡波糖片治疗Ⅱ型糖尿病的系统评价[J].深圳中西医结合杂志,2016,26(16):138-139.
[14]王安才.阿卡波糖片联合二甲双胍治疗2型糖尿病的临床疗效[J].临床合理用药杂志,2015,8(27):43-44.
[15]唐渊红.阿卡波糖片联合甘精胰岛素治疗糖尿病患者的临床效果分析[J].海峡药学,2015,27(2):161-162.
[16] Wang Tianzhan. Treating type 2 diabetes mellitus patients complicated with metabolic syndrome by benefiting Qi dissolving method[J]. China Medical Abstracts(Internal Medicine), 2016,33(4):199.
[17] Dhuha Tarik Nassar, Omran S Habib, Abbas Ali Mansour. Predictors of hypoglycemia in insulin-treated patients with type 2 diabetes mellitus in Basrah[J].World Journal of Diabetes, 2016,7(18):470-480.
[18] Chang-yu pan. Potential value of the Asian Treat to Target Lantus Study(ATLAS)for type 2 diabetes management in China:safety and efficacy of two treatment algorithms using insulin glargine[J]. China Medical Abstracts(Internal Medicine), 2016,33(1):22.
[2]刘勇华,涂萍,吴和平.甘精胰岛素注射液联合格列美脲片和阿卡波糖片治疗磺脲类药物治疗失效的2型糖尿病患者效果分析[J].黑龙江医学,2018,42(1):63-64.
[3]王贵锋,白玉晓,娄东亮,等.甘精胰岛素联合阿卡波糖片治疗老年糖尿病的效果观察[J].医学理论与实践,2017,30(8):1144-1145.
[4] Zannad F, Stough WG, Lipicky RJ, et al. Assessment of cardiovascular risk of new drugs for the treatment of diabetes mellitus:risk assessment vs. risk aversion[J]. European Heart Journal Cardiovascular Pharmacotherapy, 2016,2(3):200.
[5]罗敏,曹洁.甘精胰岛素联合阿卡波糖片治疗老年糖尿病疗效与安全性评价[J].临床医药文献电子杂志,2017,4(29):5687,5690.
[6]李冬玲,李远,陈燕铭.甘精胰岛素联合格列美脲和阿卡波糖治疗磺脲类药物治疗失效的2型糖尿病的疗效观察[J].现代药物与临床,2017,32(3):423-427.
[7] Zhang Y, Chen Z, Wang T, et al. Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase[J]. Oncotarget, 2016,7(26):39302-39315.
[8]张海影,史博,鲁国玲.老年糖尿病患者采用甘精胰岛素联合阿卡波糖治疗对BMI等的影响[J].实用糖尿病杂志,2017,13(1):45-46.
[9]杨华,许学忠,祁平,等.甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究[J].中国临床药理学杂志,2017,33(3):219-221.
[10] Oridupa OA, Folasire OF, Owolabi AJ, et al. Effect of Traditional Treatment of Diabetes Mellitus with Xanthosoma sagittifolium on the Male Reproductive System of Alloxan-Induced Diabetic Wistar Rats[J].Drug Research, 2017,67(6):337-342.
[11]朱芳慧.地特胰岛素联合阿卡波糖片在2型糖尿病治疗中的疗效观察[J].临床医药文献电子杂志,2016,3(38):7659,7662.
[12]李晓蕾.甘精胰岛素、格列美脲、阿卡波糖片联合治疗继发性磺脲类失效的2型糖尿病患者的临床效果观察[D].安徽医科大学,2016.
[13]曾燕.国产与进口阿卡波糖片治疗Ⅱ型糖尿病的系统评价[J].深圳中西医结合杂志,2016,26(16):138-139.
[14]王安才.阿卡波糖片联合二甲双胍治疗2型糖尿病的临床疗效[J].临床合理用药杂志,2015,8(27):43-44.
[15]唐渊红.阿卡波糖片联合甘精胰岛素治疗糖尿病患者的临床效果分析[J].海峡药学,2015,27(2):161-162.
[16] Wang Tianzhan. Treating type 2 diabetes mellitus patients complicated with metabolic syndrome by benefiting Qi dissolving method[J]. China Medical Abstracts(Internal Medicine), 2016,33(4):199.
[17] Dhuha Tarik Nassar, Omran S Habib, Abbas Ali Mansour. Predictors of hypoglycemia in insulin-treated patients with type 2 diabetes mellitus in Basrah[J].World Journal of Diabetes, 2016,7(18):470-480.
[18] Chang-yu pan. Potential value of the Asian Treat to Target Lantus Study(ATLAS)for type 2 diabetes management in China:safety and efficacy of two treatment algorithms using insulin glargine[J]. China Medical Abstracts(Internal Medicine), 2016,33(1):22.