红细胞比容与冠心病相关性的研究进展
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摘要
近年来,关于红细胞比容与心血管系统疾病,尤其是与冠心病之间的相关性引起诸多关注。临床研究结论不尽相同,有学者认为红细胞比容与冠心病风险呈正相关,甚至红细胞比容可能成为冠心病新的危险因素和预测因子。也有学者认为两者呈负相关或者非线性关系,甚至并无明显相关性。中医对于两者的相关性研究主要集中在部分中药可以降低患者的红细胞比容,从而降低血黏度和血栓风险,两者的确切相关性及机制目前尚未统一。
In recent years, there has been much concern about the correlation between hematocrit and cardiovascular diseases, especially coronary heart disease. However, the conclusions of the study are not the same. Some scholars believe that hematocrit is positively correlated with the risk of coronary heart disease, and hematocrit may become a new risk factor and predictor of coronary heart disease. Another scholars hold that they are negatively correlated or nonlinear, and there is no obvious correlation. The TCM research on the correlation between the two is mainly focused on that some Chinese medicines can reduce the hematocrit of patients, thereby reducing blood viscosity and thrombosis risk. The exact correlation and mechanism of the two have not been unified yet.
In recent years, there has been much concern about the correlation between hematocrit and cardiovascular diseases, especially coronary heart disease. However, the conclusions of the study are not the same. Some scholars believe that hematocrit is positively correlated with the risk of coronary heart disease, and hematocrit may become a new risk factor and predictor of coronary heart disease. Another scholars hold that they are negatively correlated or nonlinear, and there is no obvious correlation. The TCM research on the correlation between the two is mainly focused on that some Chinese medicines can reduce the hematocrit of patients, thereby reducing blood viscosity and thrombosis risk. The exact correlation and mechanism of the two have not been unified yet.
引文
[1]MAYER G A.Hematocrit and coronary heart disease[J].Can Med Assoc J,1965,93(22):1151-1153.
[2]BRUN J F,VARLETMARIE E,RICHOU M,et al.Seeking the optimal hematocrit:May hemorheological modelling provide a solution[J].Clin Hemorheol Microcirc,2018,69(6):1-9.
[3]GOTOH S,HATA J,NINOMIYA T,et al.Hematocrit and the risk of cardiovascular disease in a Japanese community:The Hisayama Study[J].Atherosclerosis,2015,242(1):199-204.
[4]GAGNON D R,ZHANG T J,BRAND F N,et al.Hematocrit and the risk of cardiovascular disease-the Framingham study:a 34-year follow-up[J].Am Heart J,1994,127(3):674-682.
[5]JIN Y Z,ZHENG D H,DUAN Z Y,et al.Relationship between hematocrit level and cardiovascular risk factors in a community-based population[J].J Clin Lab Anal,2015,29(4):289-293.
[6]COGLIANESE E E,QURESHI M M,VASAN R S,et al.Usefulness of the blood hematocrit level to predict development of heart failure in a community[J].Am J Cardiol,2012,109(2):241-245.
[7]WANNAMETHEE G,SHAPER A G,WHINCUP P H.Ischaemic heart disease:association with haematocrit in the British Regional Heart Study[J].J Epidemiol Community Health,1994,48(2):112-118.
[8]TOSS F,NORDSTROM A,NORDSTROM P.Association between hematocrit in late adolescence and subsequent myocardial infarction in Swedish men[J].Int J Cardiol,2013,168(4):3588-3593.
[9]KUNNAS T,SOLAKIVI T,HUUSKONEN K,et al.Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study,a 28-year follow-up[J].Prev Med,2009,49(1):45-47.
[10]SORLIE P D,GARCIA-PALMIERI M R,COSTAS R J,et al.Hematocrit and risk of coronary heart disease:the Puerto Rico Health Program[J].Am Heart J,1981,101(4):456-461.
[11]GOUBALI A,VOUKIKLARIS G,KRITSIKIS S,et al.Relation of hematocrit values to coronary heart disease,arterial hypertension,and respiratory impairment in occupational and population groups of the Athens area[J].Angiology,1995,46(8):719-725.
[12]杨倩倩,崔建国,王树娟,等.红细胞比容与老年冠心病患者冠状动脉病变的相关性研究[J].中华老年心脑血管病杂志,2017,19(4):370-373.
[13]KENYERES P,JURICSKAY I,TARSOLY P,et al.Low hematocrit per blood viscosity ratio as a mortality risk factor in coronary heart disease[J].Clin Hemorheol Microcirc,2008,38(1):51-56.
[14]陈继升,沈法荣,金红峰,等.红细胞压积与冠状动脉病变的相关性研究[J].心脑血管病防治,2013,13(5):355-358.
[15]PAUL L,JEEMON P,HEWITT J,et al.Hematocrit predicts long-term mortality in a nonlinear and sex-specifi c manner in hypertensive adults[J].Hypertension,2012,60(3):631-638.
[16]BROWN D W,GILES W H,CROFT J B.Hematocrit and the risk of coronary heart disease mortality[J].Am Heart J,2001,142(4):657-663.
[17]WALTON B L,LEHMANN M,SKORCZEWSKI T,et al.Elevated hematocrit enhances platelet accumulation following vascular injury[J].Blood,2017,129(18):2537-2546.
[18]STUCKER O,TROUVE R,VICAUT E,et al.Effects of different hematocrits on the isolated working rabbit heart reperfused after ischemia[J].Int J Microcirc Clin Exp,1983,2(4):325-335.
[19]SCHLANT R C,FORMAN S,STAMLER J,et al.The natural history of coronary heart disease:prognostic factors after recovery from myocardial infarction in 2789 men.The5-year fi ndings of the coronary drug project[J].Circulation,1982,66(2):401-414.
[20]ERIKSSEN G,THAULOW E,SANDVIK L,et al.Haematocrit:a predictor of cardiovascular mortality[J].JIntern Med,1993,234(5):493-499.
[21]CARTER C,MCGEE D,REED D,et al.Hematocrit and the risk of coronary heart disease:the Honolulu Heart Program[J].Am Heart J,1983,105(4):674-679.
[22]LOWE G D,MACHADO S G,KROL W F,et al.White blood cell count and haematocrit as predictors of coronary recurrence after myocardial infarction[J].Thromb Haemost,1985,54(3):700-703.
[23]MADJID M,FATEMI O.Components of the complete blood count as risk predictors for coronary heart disease:in-depth review and update[J].Tex Heart Inst J,2013,40(1):17-29.
[24]EISENGA M F,KIENEKER L M,TOUW D J,et al.Active smoking and hematocrit and fasting circulating erythropoietin concentrations in the general population[J].Mayo Clin Proc,2018,93(3):337-343.
[25]马仙红,张瑜.银杏达莫与丹参川芎嗪注射液治疗老年急性心肌梗死的临床对照研究[J].药物评价研究,2017,40(10):1449-1452.
[26]时钦,范涛,杨继兵.红花黄色素对急性脑梗死患者血液流变学影响的Meta分析[J].上海中医药杂志,2016,50(9):18-22.
[27]汪永锋,徐晓艳,吴红彦,等.杞菊首乌饮对高血脂大鼠血脂及血流动力学指标的影响[J].中医研究,2016,29(6):68-70.
[28]潘素静,龙晓英,陈梓侠,等.活血中药对血瘀和血栓模型作用的比较研究[J].中药药理与临床,2013,29(5):78-82.
[2]BRUN J F,VARLETMARIE E,RICHOU M,et al.Seeking the optimal hematocrit:May hemorheological modelling provide a solution[J].Clin Hemorheol Microcirc,2018,69(6):1-9.
[3]GOTOH S,HATA J,NINOMIYA T,et al.Hematocrit and the risk of cardiovascular disease in a Japanese community:The Hisayama Study[J].Atherosclerosis,2015,242(1):199-204.
[4]GAGNON D R,ZHANG T J,BRAND F N,et al.Hematocrit and the risk of cardiovascular disease-the Framingham study:a 34-year follow-up[J].Am Heart J,1994,127(3):674-682.
[5]JIN Y Z,ZHENG D H,DUAN Z Y,et al.Relationship between hematocrit level and cardiovascular risk factors in a community-based population[J].J Clin Lab Anal,2015,29(4):289-293.
[6]COGLIANESE E E,QURESHI M M,VASAN R S,et al.Usefulness of the blood hematocrit level to predict development of heart failure in a community[J].Am J Cardiol,2012,109(2):241-245.
[7]WANNAMETHEE G,SHAPER A G,WHINCUP P H.Ischaemic heart disease:association with haematocrit in the British Regional Heart Study[J].J Epidemiol Community Health,1994,48(2):112-118.
[8]TOSS F,NORDSTROM A,NORDSTROM P.Association between hematocrit in late adolescence and subsequent myocardial infarction in Swedish men[J].Int J Cardiol,2013,168(4):3588-3593.
[9]KUNNAS T,SOLAKIVI T,HUUSKONEN K,et al.Hematocrit and the risk of coronary heart disease mortality in the TAMRISK study,a 28-year follow-up[J].Prev Med,2009,49(1):45-47.
[10]SORLIE P D,GARCIA-PALMIERI M R,COSTAS R J,et al.Hematocrit and risk of coronary heart disease:the Puerto Rico Health Program[J].Am Heart J,1981,101(4):456-461.
[11]GOUBALI A,VOUKIKLARIS G,KRITSIKIS S,et al.Relation of hematocrit values to coronary heart disease,arterial hypertension,and respiratory impairment in occupational and population groups of the Athens area[J].Angiology,1995,46(8):719-725.
[12]杨倩倩,崔建国,王树娟,等.红细胞比容与老年冠心病患者冠状动脉病变的相关性研究[J].中华老年心脑血管病杂志,2017,19(4):370-373.
[13]KENYERES P,JURICSKAY I,TARSOLY P,et al.Low hematocrit per blood viscosity ratio as a mortality risk factor in coronary heart disease[J].Clin Hemorheol Microcirc,2008,38(1):51-56.
[14]陈继升,沈法荣,金红峰,等.红细胞压积与冠状动脉病变的相关性研究[J].心脑血管病防治,2013,13(5):355-358.
[15]PAUL L,JEEMON P,HEWITT J,et al.Hematocrit predicts long-term mortality in a nonlinear and sex-specifi c manner in hypertensive adults[J].Hypertension,2012,60(3):631-638.
[16]BROWN D W,GILES W H,CROFT J B.Hematocrit and the risk of coronary heart disease mortality[J].Am Heart J,2001,142(4):657-663.
[17]WALTON B L,LEHMANN M,SKORCZEWSKI T,et al.Elevated hematocrit enhances platelet accumulation following vascular injury[J].Blood,2017,129(18):2537-2546.
[18]STUCKER O,TROUVE R,VICAUT E,et al.Effects of different hematocrits on the isolated working rabbit heart reperfused after ischemia[J].Int J Microcirc Clin Exp,1983,2(4):325-335.
[19]SCHLANT R C,FORMAN S,STAMLER J,et al.The natural history of coronary heart disease:prognostic factors after recovery from myocardial infarction in 2789 men.The5-year fi ndings of the coronary drug project[J].Circulation,1982,66(2):401-414.
[20]ERIKSSEN G,THAULOW E,SANDVIK L,et al.Haematocrit:a predictor of cardiovascular mortality[J].JIntern Med,1993,234(5):493-499.
[21]CARTER C,MCGEE D,REED D,et al.Hematocrit and the risk of coronary heart disease:the Honolulu Heart Program[J].Am Heart J,1983,105(4):674-679.
[22]LOWE G D,MACHADO S G,KROL W F,et al.White blood cell count and haematocrit as predictors of coronary recurrence after myocardial infarction[J].Thromb Haemost,1985,54(3):700-703.
[23]MADJID M,FATEMI O.Components of the complete blood count as risk predictors for coronary heart disease:in-depth review and update[J].Tex Heart Inst J,2013,40(1):17-29.
[24]EISENGA M F,KIENEKER L M,TOUW D J,et al.Active smoking and hematocrit and fasting circulating erythropoietin concentrations in the general population[J].Mayo Clin Proc,2018,93(3):337-343.
[25]马仙红,张瑜.银杏达莫与丹参川芎嗪注射液治疗老年急性心肌梗死的临床对照研究[J].药物评价研究,2017,40(10):1449-1452.
[26]时钦,范涛,杨继兵.红花黄色素对急性脑梗死患者血液流变学影响的Meta分析[J].上海中医药杂志,2016,50(9):18-22.
[27]汪永锋,徐晓艳,吴红彦,等.杞菊首乌饮对高血脂大鼠血脂及血流动力学指标的影响[J].中医研究,2016,29(6):68-70.
[28]潘素静,龙晓英,陈梓侠,等.活血中药对血瘀和血栓模型作用的比较研究[J].中药药理与临床,2013,29(5):78-82.