痛痒伴发的分子和细胞机制
摘要
<正>痛觉和痒觉有着截然不同的行为学表现,比如手指被火苗撩着后会出现手指迅速回缩,蚊虫叮咬则会让手指移动到瘙痒部位进行抓挠。然而,临床上有相当数量的疾病存在痛、痒相伴,甚至同时发生的情况,比如银屑病病人会经历程度不一的瘙痒
引文
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[15]Goldberg YP,MacFarlane J,MacDonald ML,et al Loss-of-function mutations in the NaV1.7 gene underlie congenital indifference to pain in multiple human populations[J].Clin Genet,2007,71(4):311-319.
[16]Dib-Hajj SD,Cummins TR,Black JA,et al.From genes to pain:NaV1.7 and human pain disorders[J].Trends Neurosci,2007,30(11):555-563.
[17]Devigili G,Eleopra R,Pierro T,et al.Paroxysmal itch caused by gain-of-function NaV1.7 mutation[J].Pain2014,155(9):1702-1707.
[18]Gingras J,Smith S,Matson,D,et al.Global NaV1.7knockout mice recapitulate the phenotype of human congenital indifference to pain[J].PloS One,20149(9):e105895.
[19]Lee JH,Park CK,Chen G,et al.A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief[J].Cell,2014,157(6):1393-1404.
[2]Armstrong A,Puig L,Langley R,et al.Validation of psychometric properties and development of response criteria for the psoriasis symptoms and signs diary(PSSD):results from a phase 3 clinical trial[J].JDermatol Treat,2019,30(1):27-34.
[3]Vitale M,Fields-Blache C,Luterman A.Severe itching in the patient with burns[J].J Burn Care Rehabil,199112(4):330-333.
[4]Wiechman SA.Psychosocial recovery,pain,and itch after burn injuries[J].Phys Med Reh Clin,2011,2(2):327-345.
[5]Li CL,Li KC,Wu D,et al.Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity[J].Cell Research,2016,26(1):83.
[6]Mishra SK,Hoon MA.The cells and circuitry for itch responses in mice[J].Science,2013,340(6135):968-971.
[7]Han L,Ma C,Liu Q,et al.A subpopulation of nociceptors specifically linked to itch[J].Nat Neurosci,2013,16(2):174.
[8]Mishra SK,Tisel SM,Orestes P,et al.TRPV1-lineage neurons are required for thermal sensation[J].EMBO J,2011,30(3):582-593.
[9]Imamachi N,Park GH,Lee H,et al.TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms[J].P Natl Acad Sci USA,2009,106(27):11330-11335.
[10]Shim WS,Tak MH,Lee MH,et al.TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase[J].J Neurosci,2007,27(9):2331-2337.
[11]Lagerstr?m MC,Rogoz K,Abrahamsen B,et al.VGLUT2-dependent sensory neurons in the TRPV1population regulate pain and itch[J].Neuron,2010,68(3):529-542.
[12]Sikand P,Shimada SG,Green BG,et al.Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin,histamine and cowhage[J].Pain,2009,144(1-2):66-75.
[13]Simone DA,Ochoa J.Early and late effects of prolonged topical capsaicin on cutaneous sensibility and neurogenic vasodilatation in humans[J].Pain,199147(3):285-294.
[14]Wang H,Papoiu ADP,Coghill RC,et al.Ethnic differences in pain,itch and thermal detection in response to topical capsaicin:African Americans display a notably limited hyperalgesia and neurogenic inflammation[J].Brit J Dermatol,2010,162(5):1023-1029.
[15]Goldberg YP,MacFarlane J,MacDonald ML,et al Loss-of-function mutations in the NaV1.7 gene underlie congenital indifference to pain in multiple human populations[J].Clin Genet,2007,71(4):311-319.
[16]Dib-Hajj SD,Cummins TR,Black JA,et al.From genes to pain:NaV1.7 and human pain disorders[J].Trends Neurosci,2007,30(11):555-563.
[17]Devigili G,Eleopra R,Pierro T,et al.Paroxysmal itch caused by gain-of-function NaV1.7 mutation[J].Pain2014,155(9):1702-1707.
[18]Gingras J,Smith S,Matson,D,et al.Global NaV1.7knockout mice recapitulate the phenotype of human congenital indifference to pain[J].PloS One,20149(9):e105895.
[19]Lee JH,Park CK,Chen G,et al.A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief[J].Cell,2014,157(6):1393-1404.