补肾复元汤对缺血性脑卒中恢复早期炎症因子及神经功能的影响
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摘要
目的观察补肾复元汤对缺血性脑卒中恢复早期炎症因子及神经功能的影响。方法选取缺血性脑卒中恢复早期患者80例,按就诊顺序分为对照组及治疗组,每组40例。对照组使用西医常规治疗,治疗组在对照组治疗基础上,加予补肾复元汤治疗,15 d为1个疗程,连用3个疗程。观察比较2组患者治疗前后炎症因子水平、脑损伤特异性生化指标(S100B蛋白、NSE水平)、NIHSS评分及中医证候积分变化。结果 2组治疗前炎症因子水平、脑损伤特异性生化指标、NIHSS评分及中医证候积分比较差异不具统计学意义(P均>0.05)。经相应治疗后,2组hs-CRP、TNF-α、IL-6、S100B蛋白、NSE水平均较治疗前明显下降(P均<0.05),且观察组均明显低于对照组(P均<0.05);2组治疗后NIHSS评分及中医证候积分均较治疗前明显下降(P均<0.05),且观察组均明显低于对照组(P均<0.05)。结论补肾复元汤可抑制缺血性脑卒中患者恢复早期的炎症反应,改善患者脑损伤及临床症状,促进患者神经功能恢复。
Objective It is to observe the effect of Bushen Fuyuan Decoction on inflammatory factors and neurological function in patients with ischemic stroke at early recovery stage. Methods 80 patients with ischemic stroke at early recovery stage were selected and divided into control group and treatment group according to the order of visits. The control group( n =40) was treated with conventional western medicine. The treatment group( n = 40) was treated with Bushen Fuyuan Decoction on the basis of the control group. 15 days were a course of treatment and 3 courses of treatment were used. The changes of the levels of inflammatory factors,specific biochemical markers of brain injury( S100 B protein,NSE levels),NIHSS scores,and TCM syndrome scores before and after treatment in the two groups were observed and compared. Results Before treatment,the difference in the levels of inflammatory factors,brain injury-specific biochemical markers,NIHSS scores,and scores of TCM syndromes were not significant( P > 0. 05). After treatment,the levels of hs-CRP,TNF-α,IL-6,S100 B protein,NSE,NIHSS scores and TCM syndrome scores in the two groups were significantly lower than that before treatment,and these indexes in the observation group were significantly lower than that in the control group( P < 0. 05).Conclusion Bushen Fuyuan Decoction can inhibit the recovery of early inflammatory response,improve the brain injury and neurologic impairment scores,promote the recovery of neurological function and improve the clinical symptoms of patients with ischemic stroke at early recovery stage.
Objective It is to observe the effect of Bushen Fuyuan Decoction on inflammatory factors and neurological function in patients with ischemic stroke at early recovery stage. Methods 80 patients with ischemic stroke at early recovery stage were selected and divided into control group and treatment group according to the order of visits. The control group( n =40) was treated with conventional western medicine. The treatment group( n = 40) was treated with Bushen Fuyuan Decoction on the basis of the control group. 15 days were a course of treatment and 3 courses of treatment were used. The changes of the levels of inflammatory factors,specific biochemical markers of brain injury( S100 B protein,NSE levels),NIHSS scores,and TCM syndrome scores before and after treatment in the two groups were observed and compared. Results Before treatment,the difference in the levels of inflammatory factors,brain injury-specific biochemical markers,NIHSS scores,and scores of TCM syndromes were not significant( P > 0. 05). After treatment,the levels of hs-CRP,TNF-α,IL-6,S100 B protein,NSE,NIHSS scores and TCM syndrome scores in the two groups were significantly lower than that before treatment,and these indexes in the observation group were significantly lower than that in the control group( P < 0. 05).Conclusion Bushen Fuyuan Decoction can inhibit the recovery of early inflammatory response,improve the brain injury and neurologic impairment scores,promote the recovery of neurological function and improve the clinical symptoms of patients with ischemic stroke at early recovery stage.
引文
[1]王湘庆.缺血性脑卒中后痫性发作临床和基础研究进展[J].中华老年心脑血管病杂志,2016,18(8):785-787
[2]李鸣,李强,张媚,等.丹红注射液对急性脑梗死患者血清S100 B蛋白和神经元特异性烯醇化酶的影响[J].医药导报,2014,21(12):1596-1599
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[5]万海同,侯群,刘华,等.缺血性中风气阴两虚、瘀血阻络证诊断与疗效评定标准(试行)[J].世界中西医结合杂志,2015,7(4):581-582
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[7]朱卫香,刘彦敏,韩亚军,等.缺血性脑卒中患者血清MMP-9、Hs-CRP与脑梗死体积及神经功能缺损的关系[J].中国免疫学杂志,2012,28(4):341-343
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[9]赵莲花,闫英群,郭再玉,等.阿托伐他汀钙对脑梗死患者血清hs-CRP、TNF-α水平变化疗效分析[J].中国生化药物杂志,2017,37(1):179-181
[10]司景荣,王亮,贾晓静,等.急性脑梗死患者血清神经元特异性烯醇化酶和S100β含量与核磁弥散加权成像的对比[J].中国老年学杂志,2016,36(20):5015-5016
[11]费娜.血清心型脂肪酸结合蛋白、S-100B蛋白和神经元特异性烯醇化酶在急性脑梗死早期诊断和评估中的价值[J].中国老年学杂志,2016,36(12):2918-2919
[12]李云.50例缺血性脑卒中患者康复治疗效果观察[J].山东医药,2016,56(32):99-100
[13]徐蕾,龚涛.急性缺血性脑卒中和短暂性脑缺血发作的治疗[J].中华全科医师杂志,2012,11(4):248-250
[14]俞郦,魏江磊.扶正法治疗缺血性脑卒中的理论支持[J].中国中西医结合急救杂志,2013,23(5):297-299
[15]王晶,蒋璐,谭展鹏,等.黄芪注射液联合血必净注射液对缺血性脑卒中急性期神经保护作用的研究[J].中西医结合心脑血管病杂志,2016,14(4):349-351
[16]柏江锋,曹福建,高思宇,等.自拟益气活络汤辨治气虚血瘀证缺血性脑卒中的临床研究[J].世界中医药,2016,11(12):2654-2657
[17]吴晓华,闫金辉,杨桂染,等.通窍活络化痰逐瘀汤对缺血性脑卒中患者抗氧化能力的影响[J].中西医结合心脑血管病杂志,2014,22(11):1306-1308
[2]李鸣,李强,张媚,等.丹红注射液对急性脑梗死患者血清S100 B蛋白和神经元特异性烯醇化酶的影响[J].医药导报,2014,21(12):1596-1599
[3]徐蕾,龚涛.急性缺血性脑卒中和短暂性脑缺血发作的治疗[J].中华全科医师杂志,2012,11(4):248-250
[4]中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J/CD].中国医学前沿杂志:电子版,2010,2(4):50-59
[5]万海同,侯群,刘华,等.缺血性中风气阴两虚、瘀血阻络证诊断与疗效评定标准(试行)[J].世界中西医结合杂志,2015,7(4):581-582
[6]周维金.《缺血性脑卒中患者的早期处理指南》学习体会[J].中国康复理论与实践,2004,10(11):716
[7]朱卫香,刘彦敏,韩亚军,等.缺血性脑卒中患者血清MMP-9、Hs-CRP与脑梗死体积及神经功能缺损的关系[J].中国免疫学杂志,2012,28(4):341-343
[8]刘美,吕静.参附注射液对老年脑梗死患者血清IL-6及TNF-α的影响[J].中国老年学杂志,2015,35(22):6419-6420
[9]赵莲花,闫英群,郭再玉,等.阿托伐他汀钙对脑梗死患者血清hs-CRP、TNF-α水平变化疗效分析[J].中国生化药物杂志,2017,37(1):179-181
[10]司景荣,王亮,贾晓静,等.急性脑梗死患者血清神经元特异性烯醇化酶和S100β含量与核磁弥散加权成像的对比[J].中国老年学杂志,2016,36(20):5015-5016
[11]费娜.血清心型脂肪酸结合蛋白、S-100B蛋白和神经元特异性烯醇化酶在急性脑梗死早期诊断和评估中的价值[J].中国老年学杂志,2016,36(12):2918-2919
[12]李云.50例缺血性脑卒中患者康复治疗效果观察[J].山东医药,2016,56(32):99-100
[13]徐蕾,龚涛.急性缺血性脑卒中和短暂性脑缺血发作的治疗[J].中华全科医师杂志,2012,11(4):248-250
[14]俞郦,魏江磊.扶正法治疗缺血性脑卒中的理论支持[J].中国中西医结合急救杂志,2013,23(5):297-299
[15]王晶,蒋璐,谭展鹏,等.黄芪注射液联合血必净注射液对缺血性脑卒中急性期神经保护作用的研究[J].中西医结合心脑血管病杂志,2016,14(4):349-351
[16]柏江锋,曹福建,高思宇,等.自拟益气活络汤辨治气虚血瘀证缺血性脑卒中的临床研究[J].世界中医药,2016,11(12):2654-2657
[17]吴晓华,闫金辉,杨桂染,等.通窍活络化痰逐瘀汤对缺血性脑卒中患者抗氧化能力的影响[J].中西医结合心脑血管病杂志,2014,22(11):1306-1308