小儿推拿联合中药治疗婴儿湿疹及复发因素的生存分析
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摘要
目的:探析小儿推拿对婴儿湿疹的疗效及影响婴儿湿疹反复发作的因素。方法:随机抽取符合纳入标准的120例婴儿湿疹患者,根据随机数字表法将其分为2组,对照组采用常规中药口服及外洗治疗,试验组在对照组基础上加入小儿推拿,2组均对患儿生产方式、饮食情况等基本信息进行记录。且在治疗结束后第20天、40天、60天进行随访,记录患儿发生终点事件的时间,最后进行生存分析。结果:疗效分析显示试验组痊愈、显效率优于对照组,生存分析显示试验组、无过敏史、具有高学历母亲的患儿湿疹复发率低,生存时间长,差异有统计学意义;多因素COX回归显示试验组婴儿湿疹复发率低,患儿无过敏情况、母亲高学历是婴儿湿疹的保护因素。结论:小儿推拿可提高婴儿湿疹疗效,且推拿疗法、避免婴儿过敏情况的发生、提高母亲文化程度可以降低婴儿湿疹的复发率。
Objective: The effect of infantile tuina on infantile eczema and the factors affecting repeated episodes of infantile eczema were analyzed. Method: 120 cases of infantile eczema patients were randomly selected according to the inclusion criteria. Which were divided into two groups. The control group using conventional oral medicine and external washing treatment,the experimental group were added pediatric taina on the basis of the control group. The mode of birth,diet and other basic information of the two groups were.The patients were followed up at 20 days,40 days,and 60 days after the end of the treatment. The time of the patient's endpoint was recorded and the survival analysis was carried out.Results:The curative effect analysis showed that the test group cured and markedly effective rate is better than the control group,the survival analysis showed that in the experimental group,no history of allergy,with a high degree of mother's children with eczema and low recurrence rate,long survival time,the difference was statistically significant,multi factor COX regression analysis showed that the test group of infant eczema patients without low recurrence rate,no allergy,mother high education are protective factors for infantile eczema. Conclusion: Infantile tuina can improve the curative effect of infantile eczema,and massage therapy,avoiding the occurrence of infant allergy and improving the educational level of mothers can reduce the recurrence rate of infantile eczema.
Objective: The effect of infantile tuina on infantile eczema and the factors affecting repeated episodes of infantile eczema were analyzed. Method: 120 cases of infantile eczema patients were randomly selected according to the inclusion criteria. Which were divided into two groups. The control group using conventional oral medicine and external washing treatment,the experimental group were added pediatric taina on the basis of the control group. The mode of birth,diet and other basic information of the two groups were.The patients were followed up at 20 days,40 days,and 60 days after the end of the treatment. The time of the patient's endpoint was recorded and the survival analysis was carried out.Results:The curative effect analysis showed that the test group cured and markedly effective rate is better than the control group,the survival analysis showed that in the experimental group,no history of allergy,with a high degree of mother's children with eczema and low recurrence rate,long survival time,the difference was statistically significant,multi factor COX regression analysis showed that the test group of infant eczema patients without low recurrence rate,no allergy,mother high education are protective factors for infantile eczema. Conclusion: Infantile tuina can improve the curative effect of infantile eczema,and massage therapy,avoiding the occurrence of infant allergy and improving the educational level of mothers can reduce the recurrence rate of infantile eczema.
引文
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[2]刘冰,伏瑾.婴儿湿疹的临床特征分析[J].中国麻风皮肤病杂志,2006,22(7):541-542.
[3]中华医学会皮肤性病学分会免疫学组.湿疹诊疗指南(2011年)[J].中华皮肤科杂志,2011,44(1):5-6.
[4]何玉华,康静.推拿治疗婴幼儿湿疹120例[J].中国针灸,2012,32(12):1103-1104.
[5]程秀丽.推拿法结合中药治疗婴幼儿湿疹44例临床疗效分析[J].光明中医,2015,31(12):2623-2625.
[6]王根妹,欧阳芸,王梅装.双歧三联活菌联合西替利嗪治疗小儿湿疹的疗效分析[J].重庆医学,2017,46(3):390-391.
[7]赵辨.湿疹面积及严重度指数评分法[J].中华皮肤科杂志,2004,37(1):3-4.
[8]龙剑文.皮先明治疗湿疹临床经验[J].湖北中医杂志,2014,36(3):28-29.
[9]杨桢,高琳,赵红霞,等.热敏通道:“寒者热之,热者寒之”的细胞和分子生物学意义[J].中国中医基础医学杂志,2014,20(10):1358-1361.
[10]何玉华,康静,刘光珍.推拿治疗婴幼儿湿疹近远期疗效观察[J].中国针灸,2009,29(8):655-657.
[11]黄英资,宋迎春.推拿配合中药外洗法治疗婴幼儿湿疹的临床疗效及安全性分析[J].中国中医基础医学杂志,2013,19(8):928-929.
[12]王永午.现代小儿免疫病学[M].北京:人民军医出版社,2001:93.
[13] NG S F,ANUWI N A,TENGKUAHMAD T N. Topical Lyogel Containing Corticosteroid Decreases Ig E Expression and Enhances the Therapeutic Efficacy Against Atopic Eczema.[J]. Aaps Pharmscitech,2015,16(3):656-663.
[14]张志红,钱秋芳.婴幼儿湿疹过敏原检测及分析[J].临床皮肤科杂志,2012,41(4):215-217.
[15] WEST C E,RYDN P,LUNDIN D,et al. Gut microbiome and innate immune response patterns in Ig E‐associated eczema[J].Clinical&Experimental Allergy,2015,45(9):1419-1429.
[16]李静,兰凤荣,赵利媛,等. 5种过敏性皮肤病患儿过敏原检测结果分析[J].中国妇幼保健,2014,29(36):6028-6031.
[17]陶静.婴幼儿湿疹护理体会[J].实用中医药杂志,2013,29(4):301-301.