胆宁颗粒治疗糖尿病合并慢性胆囊炎临床研究
|
摘要
目的:观察胆宁颗粒治疗糖尿病合并慢性胆囊炎的临床疗效。方法:将86例糖尿病合并慢性胆囊炎患者随机分为对照组和观察组,各43例。对照组给予传统的解痉+抗感染治疗,观察组给予胆宁颗粒治疗;统计2组临床疗效、症状缓解时间及治愈时间,检测患者治疗前后胆囊影像学指标(胆囊壁毛糙、胆囊长径、胆囊壁厚度、合并结石、半排空时间)变化情况。结果:治疗后总有效率观察组为90.7%,对照组为81.4%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组胆囊壁毛糙、合并结石例数明显减少,与治疗前比较,差异有统计学意义(P <0.05);且观察组胆囊壁毛糙、合并结石例数明显少于对照组(P <0.05)。治疗后,2组胆囊长径、胆囊壁厚度较治疗前改善(P <0.05),且观察组两项指标改善优于对照组(P <0.05)。治疗后2组胆囊半排空时间均较治疗前减少,且观察组半排空时间少于对照组(P <0.05)。治疗后,观察组患者症状缓解时间、治愈时间均短于对照组,2组比较,差异均有统计学意义(P <0.05)。结论:胆宁颗粒治疗糖尿病合并慢性胆囊炎疗效显著,可改善患者的症状体征,改善患者炎症状态,值得临床推广应用。
Objective: To observe the clinical effect of Danning granules for diabetes complicated with chronic cholecystitis. Methods: Divided 86 cases of patients with diabetes complicated with chronic cholecystitis randomly into the control group and the observation group, 43 cases in each group. The control group was given traditional antispasmodic +anti-infective treatment,and the observation group was given Danning granules. Recorded the clinical effect,symptom relief time and healing time in the two groups,and detected the cystic imaging indicators(coarse wall roughness,gallbladder long diameter, gallbladder wall thickness, combined stones, half-emptying time) of the patients before and after treatment.Results: After treatment, the total effective rate was 90.7% in the observation group and 81.4% in the control group,compared the two groups,difference being significant(P < 0.05). After treatment,the number of gallbladder wall roughness and the combined stones in the two groups were significantly reduced; there was significant difference being found in the comparison of these indexes with those before treatment(P < 0.05); the number of gallbladder wall roughness and the combined stones in the observation group was evidently lower than that in the control group(P < 0.05). After treatment,the long diameter of the gallbladder and the thickness of the gallbladder wall were improved when compared with those before treatment(P < 0.05);the improvement of the two indexes in the observation group was better than that of the control group(P< 0.05). After treatment, the half-emptying time of gallbladder in both groups was lower than that before treatment; the half-emptying time of the observation group was less than that of the control group(P < 0.05). After treatment,the symptom relief time and healing time in the observation group were shorter than those in the control group,compared the two groups,differences being significant(P < 0.05). Conclusion:The application of Danning granules has obvious curative effect in treating diabetes complicated with chronic cholecystitis. It can improve the symptoms and signs of patients and promote the inflammatory state of patients,which is worthy of clinical promotion and application.
Objective: To observe the clinical effect of Danning granules for diabetes complicated with chronic cholecystitis. Methods: Divided 86 cases of patients with diabetes complicated with chronic cholecystitis randomly into the control group and the observation group, 43 cases in each group. The control group was given traditional antispasmodic +anti-infective treatment,and the observation group was given Danning granules. Recorded the clinical effect,symptom relief time and healing time in the two groups,and detected the cystic imaging indicators(coarse wall roughness,gallbladder long diameter, gallbladder wall thickness, combined stones, half-emptying time) of the patients before and after treatment.Results: After treatment, the total effective rate was 90.7% in the observation group and 81.4% in the control group,compared the two groups,difference being significant(P < 0.05). After treatment,the number of gallbladder wall roughness and the combined stones in the two groups were significantly reduced; there was significant difference being found in the comparison of these indexes with those before treatment(P < 0.05); the number of gallbladder wall roughness and the combined stones in the observation group was evidently lower than that in the control group(P < 0.05). After treatment,the long diameter of the gallbladder and the thickness of the gallbladder wall were improved when compared with those before treatment(P < 0.05);the improvement of the two indexes in the observation group was better than that of the control group(P< 0.05). After treatment, the half-emptying time of gallbladder in both groups was lower than that before treatment; the half-emptying time of the observation group was less than that of the control group(P < 0.05). After treatment,the symptom relief time and healing time in the observation group were shorter than those in the control group,compared the two groups,differences being significant(P < 0.05). Conclusion:The application of Danning granules has obvious curative effect in treating diabetes complicated with chronic cholecystitis. It can improve the symptoms and signs of patients and promote the inflammatory state of patients,which is worthy of clinical promotion and application.
引文
[1] LIPATOV D V,CHISTYAKOV T A,KUZMIN A G,et al.The fixed combination efficacy assessment in patients with secondary neovascular glaucoma and diabetes mellitus[J].Current Diabetes Reviews,2015,11(4):281-284.
[2] TANG M,FU Y, WANG Y, et al.Efficacy of intravitreal ranibizumab combined with Ahmed glaucoma valve implantation for the treatment of neovascular glaucoma[J].BMC Ophthalmology,2016,16(1):7.
[3] JALIL A,AU L,KHAN I,ASHWORTH J,et al.Combined trabeculotomy-trabeculectomy augmented with 5-fluorouracil in paediatricglaucoma[J].Clinical&Experimental Ophthalmology,2011,39(3):207-214.
[4]孙秉庸,李楚杰,赵修竹.病理生理学进展(第五册)[M].北京:科学技术文献出版社,1993:364-373.
[5]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[6]《中华消化杂志》编辑委员会.中国慢性胆囊炎、胆囊结石内科诊疗共识意见[J].临床肝胆病杂志,2015,31(1):7.
[7]中华中医药学会.中医外科常见病诊疗指南[M].北京:中国中医药出版社,2011:215-217.
[8]中华人民共和国卫生部.中药新药临床研究指导原则(第一辑)[S].1993:134-136.
[9]袁耀平.胆舒胶囊治疗慢性结石性胆囊炎的疗效和安全性分析[J].当代医学,2013,19(15):150
[10]齐玉祥,于司源,杜德君,等.胆舒胶囊治疗慢性结石性胆囊炎106例临床分析[J].中国现代药物应用,2008,22(11):584-585.
[11] AKKAYA S, CAN E, OZTURK F.Comparison of Optic Nerve Head Topographic Parameters in Patients With Primary Open-Angle Glaucoma With and Without Diabetes Mellitus[J].Journal of Glaucoma,2016,25(1):49-53.
[2] TANG M,FU Y, WANG Y, et al.Efficacy of intravitreal ranibizumab combined with Ahmed glaucoma valve implantation for the treatment of neovascular glaucoma[J].BMC Ophthalmology,2016,16(1):7.
[3] JALIL A,AU L,KHAN I,ASHWORTH J,et al.Combined trabeculotomy-trabeculectomy augmented with 5-fluorouracil in paediatricglaucoma[J].Clinical&Experimental Ophthalmology,2011,39(3):207-214.
[4]孙秉庸,李楚杰,赵修竹.病理生理学进展(第五册)[M].北京:科学技术文献出版社,1993:364-373.
[5]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[6]《中华消化杂志》编辑委员会.中国慢性胆囊炎、胆囊结石内科诊疗共识意见[J].临床肝胆病杂志,2015,31(1):7.
[7]中华中医药学会.中医外科常见病诊疗指南[M].北京:中国中医药出版社,2011:215-217.
[8]中华人民共和国卫生部.中药新药临床研究指导原则(第一辑)[S].1993:134-136.
[9]袁耀平.胆舒胶囊治疗慢性结石性胆囊炎的疗效和安全性分析[J].当代医学,2013,19(15):150
[10]齐玉祥,于司源,杜德君,等.胆舒胶囊治疗慢性结石性胆囊炎106例临床分析[J].中国现代药物应用,2008,22(11):584-585.
[11] AKKAYA S, CAN E, OZTURK F.Comparison of Optic Nerve Head Topographic Parameters in Patients With Primary Open-Angle Glaucoma With and Without Diabetes Mellitus[J].Journal of Glaucoma,2016,25(1):49-53.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |