口腔扁平苔藓组织中α-平滑肌肌动蛋白的表达及临床意义

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英文篇名：Expression and Clinical Significance ofα-SMA in Different Clinical Subtypes of Oral Lichen Planus 作者：王亚敏 ; 孟文霞 ; 周震 ; 郭薇 ; 谢宝仪 英文作者：WANG Ya-min;MENG Wen-xia;ZHOU Zhen;GUO Wei;XIE Bao-yi;Stomatology Hospital,Southern Medical University; 关键词：口腔扁平苔藓 ; α-平滑肌肌动蛋白 ; 免疫组织化学 英文关键词：Oral lichen planus;;α-smooth muscle actin;;Immunohistochemistry 中文刊名：KQYZ 英文刊名：Journal of Oral Science Research 机构：南方医科大学口腔医院黏膜料; 出版日期：2019-04-24 出版单位：口腔医学研究 年：2019 期：v.35 基金：国家自然科学基金(编号:81500850);; 广东省医学科学技术研究基金(编号:A2017074) 语种：中文; 页：KQYZ201904026 页数：4 CN：04 ISSN：42-1682/R 分类号：86-89

摘要

目的:研究α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)在不同类型口腔扁平苔藓患者组织中的表达情况。探讨α-SMA在口腔扁平苔藓病损发展过程中的临床意义。方法:应用免疫组织化学技术分析临床收集的15例口腔正常黏膜组织、22例扁平苔藓组织,以及15例口腔鳞状细胞癌组织中α-SMA的表达。结果:α-SMA在口腔正常黏膜组织、扁平苔藓组织及口腔鳞癌组织中的表达呈逐渐升高趋势,差异有统计学意义(P<0.05)。非糜烂型扁平苔藓与糜烂型扁平苔藓相比,差异无统计学意义(P=0.279)。结论:与正常组织相比,α-SMA在口腔扁平苔藓患者组织中表达存在差异,其可能在扁平苔藓的恶性转化过程中发挥重要作用。
        Objective: To assess the expression of α-smooth muscle actin(α-SMA)and its clinical significance in oral lichen planus. Methods: Fifteeen cases of normal control, 22 cases of oral lichen planus, and 15 cases of oral squamous cell carcinoma were enrolled in the study. Immunohistochemical analysis was used to detect the expresssion level of α-SMA. Results: The expression level of α-SMA in erosive oral lichen planus, nonerosive oral lichen planus, and oral squamous cell carcinoma were higher than that in nomal control(P<0.05). The expression level of α-SMA in OSCC was higher than that in OLP(P<0.05). There was no statistical difference between erosive and nonerosive oral lichen planus(P=0.279). Conclusion: High expression of α-SMA was related to oral lichen planus and OSCC, which may be involved in the malignant transformation of oral lichen planus.

引文

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