依达拉奉联合烟酸治疗急性一氧化碳中毒后迟发性脑病的临床效果
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摘要
目的探讨依达拉奉联合烟酸治疗急性一氧化碳中毒后迟发性脑病的临床效果。方法选择我院收治的60例急性一氧化碳中毒后迟发性脑病患者,根据实际用药方案将患者分为常规组(n=30,采用依达拉奉治疗)和联合组(n=30,采用依达拉奉与烟酸联合治疗)。比较两组患者的治疗效果。结果联合组的治疗总有效率明显高于常规组(P<0.05)。治疗1个月后,两组的NIHSS评分均显著降低、MoCA及BI指数评分均显著升高,且联合组优于常规组(P<0.05)。治疗1个月后,两组的各项SF-36评分均明显高于治疗前,且联合组高于常规组(P<0.05)。联合组与常规组的不良反应总发生率比较,差异不显著(P>0.05)。结论依达拉奉联合烟酸治疗急性一氧化碳中毒后迟发性脑病的效果显著,可促进患者神经修复,改善患者认知功能、日常生活活动能力及生活质量,值得临床推广应用。
Objective To investigate the clinical effect of edaravone combined with niacin on delayed encephalopathy after acute carbon monoxide poisoning. Methods Sixty patients with delayed encephalopathy after acute carbon monoxide poisoning admitted to our hospital were selected and divided into routine group(n=30, treated with edaravone) and combined group(n=30, treated with edaravone and niacin). The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the combined group was significantly higher than that in the routine group(P<0.05). After one month of treatment, the NIHSS scores of both groups decreased significantly, the scores of MoCA and BI index increased significantly,and those of the combined group were better than the routine group(P<0.05). After one month of treatment, the SF-36 various scores of the two groups were significantly higher than those before treatment, and those in the combined group were higher than the routine group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the combined group and the routine group(P >0.05). Conclusion Edaravone combined with niacin has a significant effect on delayed encephalopathy after acute carbon monoxide poisoning. It can promote nerve repair, improve cognitive function,activities of daily living and quality of life of patients, which is worthy of clinical promotion and application.
Objective To investigate the clinical effect of edaravone combined with niacin on delayed encephalopathy after acute carbon monoxide poisoning. Methods Sixty patients with delayed encephalopathy after acute carbon monoxide poisoning admitted to our hospital were selected and divided into routine group(n=30, treated with edaravone) and combined group(n=30, treated with edaravone and niacin). The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the combined group was significantly higher than that in the routine group(P<0.05). After one month of treatment, the NIHSS scores of both groups decreased significantly, the scores of MoCA and BI index increased significantly,and those of the combined group were better than the routine group(P<0.05). After one month of treatment, the SF-36 various scores of the two groups were significantly higher than those before treatment, and those in the combined group were higher than the routine group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the combined group and the routine group(P >0.05). Conclusion Edaravone combined with niacin has a significant effect on delayed encephalopathy after acute carbon monoxide poisoning. It can promote nerve repair, improve cognitive function,activities of daily living and quality of life of patients, which is worthy of clinical promotion and application.
引文
[1]陈惠敏,刘莎莎,胡晓娟,等.应用大株红景天依达拉奉联合高压氧治疗急性一氧化碳中毒迟发脑病182例的临床研究[J].山西医药杂志,2016,45(9):1076-1077.
[2]方建飞,王芳,徐杰,等.丁苯酞联合依达拉奉对急性一氧化碳中毒迟发性脑病患者精神状态与认知功能的影响[J].河北医科大学学报,2016,37(5):501-505.
[3]杨润秀,才立云,王克宇.依达拉奉、神经节苷脂治疗急性一氧化碳中毒疗效分析[J].中国卫生标准管理,2017,8(13):103-104.
[4]周光斗,刘振华,陈俊旭.临床神经疾病诊断学[M].广州:广东科技出版社,2003:697.
[5]孙锡波,于国庆,潘海英,等.通窍活血汤联合高压氧和依达拉奉对一氧化碳中毒后迟发性脑病患者的治疗作用[J].中国中西医结合急救杂志,2016,23(4):427-428.
[6]胡守芹.依达拉奉联合高压氧治疗急性一氧化碳中毒致迟发性脑病的临床观察[J].临床急诊杂志,2016,17(4):289-291,295.
[7]张艳敏,陈惠敏,刘莎莎,等.大株红景天、依达拉奉联合高压氧治疗急性一氧化碳中毒迟发脑病疗效观察[J].现代中西医结合杂志,2016,25(10):1113-1115.
[8]郭建强,郑婷婷,张蓉,等.神经节苷脂联合依达拉奉治疗一氧化碳中毒后迟发性脑病的临床观察[J].中国社区医师,2018,34(2):32,34.
[9]融劭民,张天哲.依达拉奉联合高压氧治疗急性一氧化碳中毒迟发性脑病患者疗效分析[J].医疗装备,2015,28(5):45-47.
[10]杨志家.依达拉奉用于急性一氧化碳中毒的临床疗效及安全性评价[J].中国保健营养,2016,26(24):231-231,232.
[11]高清良,柳建芳.依达拉奉联合烟酸治疗急性一氧化碳中毒迟发性脑病的效果观察[J].河北医科大学学报,2015,36(11):1317-1319.
[2]方建飞,王芳,徐杰,等.丁苯酞联合依达拉奉对急性一氧化碳中毒迟发性脑病患者精神状态与认知功能的影响[J].河北医科大学学报,2016,37(5):501-505.
[3]杨润秀,才立云,王克宇.依达拉奉、神经节苷脂治疗急性一氧化碳中毒疗效分析[J].中国卫生标准管理,2017,8(13):103-104.
[4]周光斗,刘振华,陈俊旭.临床神经疾病诊断学[M].广州:广东科技出版社,2003:697.
[5]孙锡波,于国庆,潘海英,等.通窍活血汤联合高压氧和依达拉奉对一氧化碳中毒后迟发性脑病患者的治疗作用[J].中国中西医结合急救杂志,2016,23(4):427-428.
[6]胡守芹.依达拉奉联合高压氧治疗急性一氧化碳中毒致迟发性脑病的临床观察[J].临床急诊杂志,2016,17(4):289-291,295.
[7]张艳敏,陈惠敏,刘莎莎,等.大株红景天、依达拉奉联合高压氧治疗急性一氧化碳中毒迟发脑病疗效观察[J].现代中西医结合杂志,2016,25(10):1113-1115.
[8]郭建强,郑婷婷,张蓉,等.神经节苷脂联合依达拉奉治疗一氧化碳中毒后迟发性脑病的临床观察[J].中国社区医师,2018,34(2):32,34.
[9]融劭民,张天哲.依达拉奉联合高压氧治疗急性一氧化碳中毒迟发性脑病患者疗效分析[J].医疗装备,2015,28(5):45-47.
[10]杨志家.依达拉奉用于急性一氧化碳中毒的临床疗效及安全性评价[J].中国保健营养,2016,26(24):231-231,232.
[11]高清良,柳建芳.依达拉奉联合烟酸治疗急性一氧化碳中毒迟发性脑病的效果观察[J].河北医科大学学报,2015,36(11):1317-1319.
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