丁苯酞联合依达拉奉治疗急性一氧化碳中毒迟发性脑病的临床观察

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英文篇名：Clinical observation of butylphthalide combined with edaravone in the treatment of delayed encephalopathyafter acute carbon monoxide poisoning 作者：李灰灰 ; 张吾民 英文作者：LI Huihui;ZHANG Wumin;Dept.of Neurology, Ruzhou People’s Hospital;Yimin Hospital of Integrated Traditional Chinese and Western Medicine of Qixian; 关键词：一氧化碳中毒 ; 迟发性脑病 ; 丁苯酞 ; 依达拉奉 英文关键词：carbon monoxide poisoning;;delayed encephalopathy;;butylphthalide;;edaravone 中文刊名：GLYX 英文刊名：Acta Medicinae Sinica 机构：汝州市人民医院神经内科;杞县益民中西医结合医院; 出版日期：2019-02-15 出版单位：华夏医学 年：2019 期：v.32 语种：中文; 页：GLYX201901014 页数：4 CN：01 ISSN：45-1236/R 分类号：49-52

摘要

目的:探讨丁苯酞联合依达拉奉治疗急性一氧化碳中毒迟发性脑病(DEACMP)的临床疗效。方法:选择我院收治的88例DEACMP患者,按随机数字表法将其分为两组,各44例。对照组采用常规治疗,观察组在对照组的基础上采用丁苯酞联合依达拉奉治疗,3个疗程后,比较两组临床疗效、认知功能、日常生活能力及不良反应。结果:观察组治疗总有效率及MMSE、BI评分较对照组高,差异具有统计学意义(P<0.05);两组治疗期间均未出现严重不良反应。结论:丁苯酞联合依达拉奉可提高急性DEACMP临床疗效,改善患者认知功能,提高日常生活能力,安全性高。
        Objective:To investigate the clinical efficacy of butylphthalide combined with edaravone in the treatment of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP). Methods:88 DEACMP patients in our hospital were randomized into two groups with 44 cases each. Patients in the control group were treated with conventional therapy. On the basis of this, patients in the observation group were treated with butylphthalide combined with edaravone. After 3 courses of treatment, the clinical efficacy, cognitive function, daily living ability and adverse reactions were compared between the two groups. Results:The total effective rate, MMSE and BI scores of the observation group were higher than those of the control group, which were of statistical differences(P<0.05). There were no serious adverse reactions for both groups during the treatment period. Conclusion:Butylphthalide combined with edaravone treatment can improve the clinical efficacy of acute DEACMP patients, improve their cognitive functions, daily living abilities. Besides, it is safe for patients.

引文

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