2148例淋巴瘤临床病理分析
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摘要
目的根据2008版WHO造血淋巴组织肿瘤分类标准,探讨淋巴瘤的临床病理学特征。方法回顾性分析四川省肿瘤医院诊治的2148例淋巴瘤,分析其临床病理学特征。结果①非霍奇金淋巴瘤2085例(97. 07%),霍奇金淋巴瘤63例(2. 93%)。其中B细胞淋巴瘤1600例(76. 74%),T/NK细胞淋巴瘤485例(23. 26%)。非霍奇金淋巴瘤中前五位分别是弥漫大B细胞淋巴瘤1171例(56. 16%),结外NK/T细胞淋巴瘤(鼻型) 295例(14. 15%),滤泡淋巴瘤103例(4. 94%),套细胞淋巴瘤97例(4. 65%),结外黏膜相关淋巴组织淋巴瘤83例(3. 98%)。霍奇金淋巴瘤以结节硬化型最常见33例(52. 38%)。②弥漫大B细胞淋巴瘤最常见结外部位为扁桃体169例(14. 43%),结外NK/T细胞淋巴瘤最常见结外部位为鼻腔255例(86. 44%)。结论弥漫大B细胞淋巴瘤是非霍奇金淋巴瘤最常见亚型,结节硬化型是霍奇金淋巴瘤最常见亚型。扁桃体是弥漫大B细胞淋巴瘤最常见结外部位,鼻腔是结外NK/T细胞淋巴瘤最常见结外部位。
Objective To investigate the clinicopathological characteristics of lymphoma according to the 2008 WHO classification criteria for hematopoietic lymphoid tissue tumors.Methods We retrospectively analyzed 2148 cases of lymphoma that were diagnosed and treated in Sichuan Cancer Hospital and analyzed their clinicopathological features. Results ①2085 cases of non-Hodgkin's lymphoma( 97. 07%) and 63 cases of Hodgkin's lymphoma( 2. 93%).Among them,1600 cases were B-cell lymphoma( 76. 74%) and 485 cases were T/NK cell lymphoma( 23. 26%). The top five non-Hodgkin's lymphomas were diffuse large B lymphoma in 1171 cases( 56. 16%),extranodal NK/T lymphoma( nasal type) in 295 cases( 14. 15%),follicular lymphoma in 103 cases( 4. 94%),mantle cell lymphoma in 97 cases( 4. 65%) and extranodal mucosa-associated lymphoid tissue lymphoma in 83 cases( 3. 98%).Thirty-three cases( 52. 38%) of Hodgkin's lymphoma were nodular sclerosis.②The most common extranodal location of diffuse large B-cell lymphoma was tonsil in 169 cases( 14. 43%) and nasal cavity in 255 cases( 86. 44%) of extranodal NK/T-cell lymphoma.Conclusion Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin's lymphoma,and nodular sclerosis is the most common subtype of Hodgkin's lymphoma.Tonsil is the most common extranodal site in diffuse large B-cell lymphoma,and nasal cavity is the most common extranodal site in extranodal NK/T-cell lymphoma.
Objective To investigate the clinicopathological characteristics of lymphoma according to the 2008 WHO classification criteria for hematopoietic lymphoid tissue tumors.Methods We retrospectively analyzed 2148 cases of lymphoma that were diagnosed and treated in Sichuan Cancer Hospital and analyzed their clinicopathological features. Results ①2085 cases of non-Hodgkin's lymphoma( 97. 07%) and 63 cases of Hodgkin's lymphoma( 2. 93%).Among them,1600 cases were B-cell lymphoma( 76. 74%) and 485 cases were T/NK cell lymphoma( 23. 26%). The top five non-Hodgkin's lymphomas were diffuse large B lymphoma in 1171 cases( 56. 16%),extranodal NK/T lymphoma( nasal type) in 295 cases( 14. 15%),follicular lymphoma in 103 cases( 4. 94%),mantle cell lymphoma in 97 cases( 4. 65%) and extranodal mucosa-associated lymphoid tissue lymphoma in 83 cases( 3. 98%).Thirty-three cases( 52. 38%) of Hodgkin's lymphoma were nodular sclerosis.②The most common extranodal location of diffuse large B-cell lymphoma was tonsil in 169 cases( 14. 43%) and nasal cavity in 255 cases( 86. 44%) of extranodal NK/T-cell lymphoma.Conclusion Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin's lymphoma,and nodular sclerosis is the most common subtype of Hodgkin's lymphoma.Tonsil is the most common extranodal site in diffuse large B-cell lymphoma,and nasal cavity is the most common extranodal site in extranodal NK/T-cell lymphoma.
引文
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[13]青晓艳,姚文秀,徐义全,等.原发结外弥漫大B细胞淋巴瘤的免疫分型及其与预后的关系[J].中华临床医师杂志,2012(17):5073-5078.
[14]Schmitz R,Wright GW,Huang DW.Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma[J].N Engl J Med,2018,378(15):1396-1407.
[15]Chen WL,Tsai WC,Chao TY,et al.The clinicopathological analysis of303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan[J].Ann Hematol,2010,89(6):553-562.
[2]Roman E,Smith AG.Epidemiology of lymphomas[J].Histopathology,2011,58(1):4-14.
[3]Chen W,Zheng R,Zhang S,et al.Report of incidence and mortality in China cancer registries,2009[J].Chin J Cancer Res,2013,24(1):171-180.
[4]Sun OY,Suh C,Lee DH,et al.Distribution of lymphoid neoplasms in the Republic of Korea:Analysis of 5318 cases according to the World Health Organization classification[J].Am J Hematol,2010,85(10):760-764.
[5]Szumera-Cieckiewicz A,Galazka K,Szpor J,et al.Distribution of lymphomas in Poland according to World Health Organization classification:analysis of 11718 cases from National Histopathological Lymphoma Register project-the Polish Lymphoma Research Group study[J].Int J Clin Exp Pathol,2014,7(6):3280-3286.
[6]Yang QP,Zhang WY,Yu JB,et al.Subtype distribution of lymphomas in Southwest China:analysis of 6,382 cases using WHO classification in a single institution[J].Diagn Pathol,2011,6(1):77-82.
[7]Morton LM,Wang SS,Devesa SS,et al.Lymphoma incidence patterns by WHO subtype in the United States,1992-2001[J].Blood,2006,107(1):265-276.
[8]Intragumtornchai T,Bunworasate U,Wudhikarn K,et al.Non-Hodgkin lymphoma in South East Asia:An analysis of the histopathology,clinical features,and survival from Thailand[J].Hematol Oncol,2017,36(1):28-36.
[9]Sant M,Allemani C,Tereanu C,et al.Incidence of hematologic malignancies in Europe by morphologic subtype:results of the haemacare project[J].Blood,2010,116(19):3724-3734.
[10]Laurini JA,Perry AM,Boilesen E,et al.Classification of non-Hodgkin lymphoma in Central and South America:a review of 1028 cases[J].Blood,2012,120(24):4795-4801.
[11]Lal A,Bhurgri Y,Vaziri I,et al.Extranodal non-Hodgkin's lymphomas--a retrospective review of clinico-pathologic features and outcomes in comparison with nodal non-Hodgkin's lymphomas[J].Asian Pac J Cancer Prev,2008,9(3):453-458.
[12]Hans CP,Weisenburger DD,Greiner TC,et al.Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray[J].Blood,2004,103(1):275-282.
[13]青晓艳,姚文秀,徐义全,等.原发结外弥漫大B细胞淋巴瘤的免疫分型及其与预后的关系[J].中华临床医师杂志,2012(17):5073-5078.
[14]Schmitz R,Wright GW,Huang DW.Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma[J].N Engl J Med,2018,378(15):1396-1407.
[15]Chen WL,Tsai WC,Chao TY,et al.The clinicopathological analysis of303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan[J].Ann Hematol,2010,89(6):553-562.