马铃薯凝胶剂对致炎小鼠药理作用
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摘要
目的:研究马铃薯凝胶剂的抗静脉炎、消肿的药理活性。方法:选择昆明种小鼠30只,随机分为空白组、喜辽妥软膏组、马铃薯凝胶剂组,采用酒石酸长春瑞滨注射液(Vinorelbine,VIN)致化疗性静脉炎(Chemotherapeutic phlebitis,CIP)模型,考察马铃薯凝胶剂的抗静脉炎活性,采用二甲苯致小鼠耳肿胀模型,评价马铃薯凝胶剂的抗炎消肿作用。结果:与空白对照组比较,马铃薯凝胶剂组对VIN所致的化疗性静脉炎引起的静脉皮肤颜色加深,并伴有疼痛、静脉条索状改变,及对二甲苯所致的耳廓肿胀均具有明显的抑制作用(P<0.05)。结论:本实验采用实验室自制的马铃薯凝胶剂,研究马铃薯凝胶剂的抗静脉炎、消肿作用,研究结果表明,马铃薯凝胶剂有较强的抗静脉炎消肿活性。经文献调研,未见相关马铃薯制剂的研究报道,该文初次研究了马铃薯凝胶剂的抗静脉炎、消肿作用,为马铃薯广泛应用于临床静脉炎的治疗提供了理论依据。
Objective:To study the pharmacological activity of potato gels on anti phlebitis and detumescence. Methods:30 Kunming mice were randomly divided into four groups:blank group,hirudoid forte cream group and potato gels group,vinorelbine tartrate injection(VIN)was used to establish a chemotherapeutic phlebitis(CIP)model to investigate the inhibitory effect of potato gels on CIP,the ear swelling model was established by xylene to investigate the anti-inflammatory and detumescence effects of potato gels. Results:Compared with the blank control group,chemotherapy phlebitis induced by VIN in potato gel group caused the vein skin color deepened and accompanied by pain,venous venous cord like changes,and xylene induced ear swelling were significantly inhibited(P<0.05). Conclusion:In this experient,the potato gel was used in the laboratory to study the anti-phlebitis and swelling effect,the results show that the potato gel has strong anti-phlebitis and detumescence activity. No reports on related potato preparations have been reported in literature. In this paper,the anti phlebitis and swelling effect of potato gel was first studied,which provided a theoretical basis for the wide application of potato to the treatment of clinical phlebitis.
Objective:To study the pharmacological activity of potato gels on anti phlebitis and detumescence. Methods:30 Kunming mice were randomly divided into four groups:blank group,hirudoid forte cream group and potato gels group,vinorelbine tartrate injection(VIN)was used to establish a chemotherapeutic phlebitis(CIP)model to investigate the inhibitory effect of potato gels on CIP,the ear swelling model was established by xylene to investigate the anti-inflammatory and detumescence effects of potato gels. Results:Compared with the blank control group,chemotherapy phlebitis induced by VIN in potato gel group caused the vein skin color deepened and accompanied by pain,venous venous cord like changes,and xylene induced ear swelling were significantly inhibited(P<0.05). Conclusion:In this experient,the potato gel was used in the laboratory to study the anti-phlebitis and swelling effect,the results show that the potato gel has strong anti-phlebitis and detumescence activity. No reports on related potato preparations have been reported in literature. In this paper,the anti phlebitis and swelling effect of potato gel was first studied,which provided a theoretical basis for the wide application of potato to the treatment of clinical phlebitis.
引文
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[21]李艳红,程贤琴.长春瑞滨所致静脉炎的防治进展[J].西南军医,2009,11(4):724-727.
[22]Mori Y,Shiozaki M,Matsuura K,et al. Evaluation of efficacy of acarbose on glucose fluctuation and postprandial glucose using continuous glucose monitoring in type 2 diabetes mellitus[J].Diabetes Technol Ther,2012,13(4):467-470.
[2]杜彦丽,刘晶,蒋菁梅,等.化疗药物性静脉炎的预防与护理[J].中华现代护理杂志,2010,16(26):3152-3153.
[3]陈锦程.止痛消炎膏防治结直肠癌术后化疗性静脉炎的临床研究[D].福州:福建中医药大学,2013.
[4]李时珍.本草纲目[M].北京:人民卫生出版社,1982:2278.
[5]周胜男.马铃薯中酚类物质的提取、纯化及检测方法研究[D].合肥:安徽农业大学,2010.
[6]余静.马铃薯糖苷生物碱的提取与纯化[D].武汉:华中农业大学,2010.
[7]云庆如,杨丽敏,李彩萍.马铃薯提取物皂苷与糖尿病的相关性研究进展[J].内蒙古医科大学学报,2015,37(1):135-138.
[8]王秉鹏,蒙静,郭玫,等.马铃薯茎叶中茄尼醇提取方法优化与比较[J].河南农业科学,2017,46(4):138-142.
[9]Pihlanto A,Akkanen S,Korhonen H J. ACE-inhibitory and antioxidant properties of potato(Solanumtuberosum)[J]. Food Chemistry,2008,109:104-112.
[10]李玲,曹立新,安红,等.对马铃薯外敷治疗液体外渗的临床探讨[J].解放军护理杂志,2000,17(1):5-6.
[11]田莉莉.天然酚酸类对DNA损伤的抑制效应研究[D].天津:天津大学,2010.
[12]姜莉.外敷药物预防化疗性静脉炎的研究进展[J].解放军护理杂志,2013,30(3):35-38.
[13]毛亚平,闫桂花,王建辉.新鲜马铃薯用于输液外漏的护理观察[J].中国药物与临床,2010,10(6):660.
[14]彭风云,谭建兰,林文霞,等.冰敷联合马铃薯外敷在治疗化疗性静脉炎中的应用[J].护理实践与研究,2013,10(5):111-112.
[15]王荣凤,祝秋萍.马铃薯在临床护理中的应用[J].护理学杂志,2009,24(23):79-81.
[16]Olivia M Kenny,Catherine M McCarthy,Nora M O'Brien,et al. Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages[J]. Life Sciences,2013,92:775-782.
[17]钟永香.静脉输液药液外渗土豆片外敷的效果观察[J].中外医疗,2014,12(34):83-84.
[18]江昕昕.马铃薯抗炎活性物质基础研究[D].合肥:安徽医科大学,2013.
[19]刘卫娟,邵霞,温丽云.喜疗妥软膏防治肿瘤患者化疗性静脉炎的Meta分析[J].中华全科医学,2012,10(5):810-812.
[20]于玲,姜桂春,苏兰若.化疗性周围静脉炎发生机制的研究进展[J].中国医药导报,2014,11(30):147-149.
[21]李艳红,程贤琴.长春瑞滨所致静脉炎的防治进展[J].西南军医,2009,11(4):724-727.
[22]Mori Y,Shiozaki M,Matsuura K,et al. Evaluation of efficacy of acarbose on glucose fluctuation and postprandial glucose using continuous glucose monitoring in type 2 diabetes mellitus[J].Diabetes Technol Ther,2012,13(4):467-470.